CA1166574A - Galenical preparation of metoclopramide, process for preparing the same and medicament comprising this preparation - Google Patents
Galenical preparation of metoclopramide, process for preparing the same and medicament comprising this preparationInfo
- Publication number
- CA1166574A CA1166574A CA000388666A CA388666A CA1166574A CA 1166574 A CA1166574 A CA 1166574A CA 000388666 A CA000388666 A CA 000388666A CA 388666 A CA388666 A CA 388666A CA 1166574 A CA1166574 A CA 1166574A
- Authority
- CA
- Canada
- Prior art keywords
- metoclopramide
- neutral
- weight
- microgranules
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 229960004503 metoclopramide Drugs 0.000 title claims abstract description 42
- 239000003814 drug Substances 0.000 title claims abstract description 6
- 238000002360 preparation method Methods 0.000 title description 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000007935 neutral effect Effects 0.000 claims abstract description 20
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000008117 stearic acid Substances 0.000 claims abstract description 8
- 239000000454 talc Substances 0.000 claims abstract description 8
- 229910052623 talc Inorganic materials 0.000 claims abstract description 8
- 229920001800 Shellac Polymers 0.000 claims abstract description 7
- 229930006000 Sucrose Natural products 0.000 claims abstract description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 7
- 235000013681 dietary sucrose Nutrition 0.000 claims abstract description 7
- 239000004208 shellac Substances 0.000 claims abstract description 7
- 235000013874 shellac Nutrition 0.000 claims abstract description 7
- 229940113147 shellac Drugs 0.000 claims abstract description 7
- 229960004793 sucrose Drugs 0.000 claims abstract description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 6
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims abstract description 6
- 229920002472 Starch Polymers 0.000 claims abstract description 5
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 5
- 239000008107 starch Substances 0.000 claims abstract description 5
- 235000019698 starch Nutrition 0.000 claims abstract description 5
- 239000001913 cellulose Substances 0.000 claims abstract description 4
- 235000010980 cellulose Nutrition 0.000 claims abstract description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims abstract description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229920000084 Gum arabic Polymers 0.000 claims abstract description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 3
- 239000000205 acacia gum Substances 0.000 claims abstract description 3
- 235000010489 acacia gum Nutrition 0.000 claims abstract description 3
- 229920002678 cellulose Polymers 0.000 claims abstract description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims abstract description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims abstract description 3
- 239000008101 lactose Substances 0.000 claims abstract description 3
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims abstract description 3
- 229920001059 synthetic polymer Polymers 0.000 claims abstract description 3
- 229920002284 Cellulose triacetate Polymers 0.000 claims abstract 2
- 241000978776 Senegalia senegal Species 0.000 claims abstract 2
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims abstract 2
- 229920002285 poly(styrene-co-acrylonitrile) Polymers 0.000 claims abstract 2
- 239000002775 capsule Substances 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 239000001828 Gelatine Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 235000012222 talc Nutrition 0.000 claims description 2
- 229920005615 natural polymer Polymers 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 abstract description 5
- 230000002496 gastric effect Effects 0.000 abstract description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract description 3
- 238000011282 treatment Methods 0.000 abstract description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 7
- 239000004480 active ingredient Substances 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- 229920002261 Corn starch Polymers 0.000 description 2
- 235000019759 Maize starch Nutrition 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000518994 Conta Species 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- XJUCJNCTEBRXRN-UHFFFAOYSA-N O.ClOCl Chemical compound O.ClOCl XJUCJNCTEBRXRN-UHFFFAOYSA-N 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 206010057362 Underdose Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000002156 adsorbate Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 229940106135 cellulose Drugs 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 231100000029 gastro-duodenal ulcer Toxicity 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- -1 suppusitories Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Digital Computer Display Output (AREA)
- Mobile Radio Communication Systems (AREA)
- Telephonic Communication Services (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8023028 | 1980-10-28 | ||
| FR8023028A FR2492661A1 (fr) | 1980-10-28 | 1980-10-28 | Nouvelle forme galenique d'administration du metoclopramide, son procede de preparation et medicament comprenant cette nouvelle forme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1166574A true CA1166574A (en) | 1984-05-01 |
Family
ID=9247410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000388666A Expired CA1166574A (en) | 1980-10-28 | 1981-10-23 | Galenical preparation of metoclopramide, process for preparing the same and medicament comprising this preparation |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4656024A (en, 2012) |
| EP (1) | EP0063132B1 (en, 2012) |
| JP (1) | JPH0428685B2 (en, 2012) |
| AU (1) | AU555512B2 (en, 2012) |
| BE (1) | BE890808A (en, 2012) |
| CA (1) | CA1166574A (en, 2012) |
| CH (1) | CH650922A5 (en, 2012) |
| ES (1) | ES8301633A1 (en, 2012) |
| FR (1) | FR2492661A1 (en, 2012) |
| GR (1) | GR74683B (en, 2012) |
| IT (1) | IT1139645B (en, 2012) |
| WO (1) | WO1982001468A1 (en, 2012) |
| ZA (1) | ZA816993B (en, 2012) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2534139B1 (fr) * | 1982-10-07 | 1986-08-29 | Laruelle Claude | Nouvelle forme galenique du sulpiride, son procede de preparation et medicament comprenant cette nouvelle forme |
| FR2539995B1 (fr) * | 1983-01-28 | 1985-08-16 | Sanofi Sa | Medicament a liberation programmee a base d'acide acetylsalicylique |
| FR2556964A1 (fr) * | 1983-12-23 | 1985-06-28 | Ile De France | Nouvelles formes galeniques du sulpiride utilisables par voie orale |
| DE3403329A1 (de) * | 1984-02-01 | 1985-08-01 | Horst Dr. 4019 Monheim Zerbe | Pharmazeutisches produkt in form von pellets mit kontinuierlicher, verzoegerter wirkstoffabgabe |
| GB8412585D0 (en) * | 1984-05-17 | 1984-06-20 | Beecham Group Plc | Composition |
| IT1176853B (it) * | 1984-10-02 | 1987-08-18 | Eurand Spa | Procedimento per ottenere una formulazione a rilascio controllato di componenti solubili in acqua |
| JPS6261916A (ja) * | 1985-09-12 | 1987-03-18 | Fujisawa Pharmaceut Co Ltd | 持続性製剤 |
| LU86077A1 (fr) * | 1985-09-18 | 1987-04-02 | Pharlyse Sa | Nouvelles formes galeniques du verapamil,leur fabrication et medicaments contenant ces nouvelles formes galeniques |
| DE3712095A1 (de) * | 1987-04-10 | 1988-10-20 | Lentia Gmbh | Bindemittelfreies granulat mit verzoegerter wirkstoffabgabe |
| DE4131276B4 (de) * | 1990-09-28 | 2007-07-19 | Solvay Pharmaceuticals Gmbh | Peroral applizierbare Metoclopramidlösungen |
| US5286495A (en) * | 1992-05-11 | 1994-02-15 | University Of Florida | Process for microencapsulating cells |
| WO2001012221A1 (en) * | 1999-08-16 | 2001-02-22 | Henceforth Hibernia, Inc. | Therapeutic and prophylactic compositions including catalytic biomimetic solids and methods to prepare and use them |
| KR20040045034A (ko) * | 2001-09-28 | 2004-05-31 | 맥네일-피피씨, 인코포레이티드 | 변형된 방출형 제형 |
| MX2008004268A (es) * | 2008-03-28 | 2009-09-28 | Posi Visionary Solutions Llp | Metoclopramida de liberacion prolongada de 24 horas. |
| MX2008004267A (es) * | 2008-03-28 | 2009-09-28 | Posi Visionary Solutions Llp | Metoclopramida de liberacion prolongada de 12 horas. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2963402A (en) * | 1955-01-18 | 1960-12-06 | Nysco Lab Inc | Sustained release medicament |
| FR1347413A (fr) * | 1963-01-29 | 1963-12-27 | Italnysco S P A | Sphérules ou globules à action étalée et procédé pour leur préparation |
| BE787973A (fr) * | 1971-09-04 | 1973-02-26 | Beecham Group Ltd | Comprimes pharmaceutiques a effet retard |
| FR2313915A1 (fr) * | 1976-01-26 | 1977-01-07 | Corneille Gilbert | Nouvelle forme galenique d'administration de la vincamine et de ses derives, son procede de preparation et medicaments comprenant cette nouvelle forme |
| LU77353A1 (en, 2012) * | 1977-05-16 | 1979-01-19 | ||
| FR2397840B1 (en, 2012) * | 1977-07-22 | 1981-03-20 | Cherqui Jean | |
| FR2432313A1 (fr) * | 1978-08-01 | 1980-02-29 | Foulhoux Pierre | Nouvelle forme galenique de la betahistine et son procede d'obtention |
| BE876857A (fr) * | 1979-06-08 | 1979-10-01 | Trenker Ady | Resinate de metoclopramide. |
-
1980
- 1980-10-28 FR FR8023028A patent/FR2492661A1/fr active Granted
-
1981
- 1981-10-09 ZA ZA816993A patent/ZA816993B/xx unknown
- 1981-10-21 IT IT24601/81A patent/IT1139645B/it active
- 1981-10-21 BE BE1/10338A patent/BE890808A/fr not_active IP Right Cessation
- 1981-10-22 WO PCT/FR1981/000134 patent/WO1982001468A1/en active IP Right Grant
- 1981-10-22 EP EP81902835A patent/EP0063132B1/fr not_active Expired
- 1981-10-22 US US06/607,401 patent/US4656024A/en not_active Expired - Fee Related
- 1981-10-22 JP JP56503317A patent/JPH0428685B2/ja not_active Expired - Lifetime
- 1981-10-22 AU AU77204/81A patent/AU555512B2/en not_active Ceased
- 1981-10-23 CA CA000388666A patent/CA1166574A/en not_active Expired
- 1981-10-26 GR GR66362A patent/GR74683B/el unknown
- 1981-10-27 CH CH6860/81A patent/CH650922A5/fr not_active IP Right Cessation
- 1981-10-28 ES ES506654A patent/ES8301633A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GR74683B (en, 2012) | 1984-07-03 |
| JPH0428685B2 (en, 2012) | 1992-05-15 |
| FR2492661B1 (en, 2012) | 1983-07-18 |
| IT1139645B (it) | 1986-09-24 |
| ES506654A0 (es) | 1983-01-01 |
| BE890808A (fr) | 1982-04-21 |
| ZA816993B (en) | 1982-09-29 |
| EP0063132A1 (fr) | 1982-10-27 |
| ES8301633A1 (es) | 1983-01-01 |
| CH650922A5 (fr) | 1985-08-30 |
| IT8124601A0 (it) | 1981-10-21 |
| JPS57502121A (en, 2012) | 1982-12-02 |
| AU7720481A (en) | 1982-05-21 |
| EP0063132B1 (fr) | 1986-07-30 |
| US4656024A (en) | 1987-04-07 |
| AU555512B2 (en) | 1986-09-25 |
| FR2492661A1 (fr) | 1982-04-30 |
| WO1982001468A1 (en) | 1982-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |