CA1129407A - Antiinflammatory steroid of the androstane series - Google Patents

Antiinflammatory steroid of the androstane series

Info

Publication number
CA1129407A
CA1129407A CA321,032A CA321032A CA1129407A CA 1129407 A CA1129407 A CA 1129407A CA 321032 A CA321032 A CA 321032A CA 1129407 A CA1129407 A CA 1129407A
Authority
CA
Canada
Prior art keywords
beta
alpha
methyl
fluoro
diene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA321,032A
Other languages
English (en)
French (fr)
Inventor
Gordon H. Phillipps
Edward A. Woollett
Brian M. Bain
Alan F. English
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of CA1129407A publication Critical patent/CA1129407A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J51/00Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J3/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA321,032A 1978-02-08 1979-02-07 Antiinflammatory steroid of the androstane series Expired CA1129407A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB513178 1978-02-08
GB5131/78 1978-02-08

Publications (1)

Publication Number Publication Date
CA1129407A true CA1129407A (en) 1982-08-10

Family

ID=9790294

Family Applications (1)

Application Number Title Priority Date Filing Date
CA321,032A Expired CA1129407A (en) 1978-02-08 1979-02-07 Antiinflammatory steroid of the androstane series

Country Status (20)

Country Link
JP (1) JPS54145648A (xx)
AT (1) AT367771B (xx)
AU (1) AU520827B2 (xx)
BE (1) BE873996A (xx)
CA (1) CA1129407A (xx)
CH (1) CH639669A5 (xx)
DE (1) DE2904614A1 (xx)
DK (1) DK145578C (xx)
ES (1) ES477523A1 (xx)
FI (1) FI790403A (xx)
FR (1) FR2422688A1 (xx)
IE (1) IE47814B1 (xx)
IL (1) IL56613A (xx)
IT (1) IT1114534B (xx)
NL (1) NL7900967A (xx)
NZ (1) NZ189586A (xx)
PT (1) PT69192A (xx)
SE (1) SE435626B (xx)
YU (1) YU26779A (xx)
ZA (1) ZA79538B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
US5237070A (en) * 1985-07-22 1993-08-17 Riker Laboratories, Inc. Substituted DI-t-butylphenols
JP4847112B2 (ja) * 2005-11-29 2011-12-28 株式会社マキタ 園芸バリカン
HUE034570T2 (en) 2010-10-27 2018-02-28 Hovione Int Ltd Electrophilic reagents for mono-gene methylation, their preparation and use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids

Also Published As

Publication number Publication date
DK145578B (da) 1982-12-13
YU26779A (en) 1983-01-21
NL7900967A (nl) 1979-08-10
SE7901100L (sv) 1979-08-09
ZA79538B (en) 1980-02-27
AU4408479A (en) 1979-08-16
SE435626B (sv) 1984-10-08
FR2422688A1 (fr) 1979-11-09
IE47814B1 (en) 1984-06-27
IT7947909A0 (it) 1979-02-06
AT367771B (de) 1982-07-26
AU520827B2 (en) 1982-03-04
DK145578C (da) 1983-05-09
ES477523A1 (es) 1979-07-16
CH639669A5 (en) 1983-11-30
IE790236L (en) 1979-08-08
FR2422688B1 (xx) 1982-07-16
IT1114534B (it) 1986-01-27
DK50179A (da) 1979-08-09
BE873996A (fr) 1979-08-07
ATA92379A (de) 1981-12-15
JPS54145648A (en) 1979-11-14
IL56613A0 (en) 1979-05-31
DE2904614A1 (de) 1979-08-09
NZ189586A (en) 1981-01-23
IL56613A (en) 1982-12-31
PT69192A (en) 1979-03-01
FI790403A (fi) 1979-08-09

Similar Documents

Publication Publication Date Title
US4093721A (en) Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
US4335121A (en) Androstane carbothioates
US4188385A (en) Thioetianic acid derivatives
US4242334A (en) Corticoid 17-(alkyl carbonates) and processes for their preparation
US4267173A (en) Use of 6β-fluoro-7α-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor
FI80888C (fi) Foerfarande foer framstaellning av terapeutiskt verkande steroida karboxylsyraestrar.
GB2088877A (en) Androstane 17 beta carbothioates
US4172132A (en) 1,3,5(10),6,8,14-19-Nor-pregnahexaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
US4187301A (en) 17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
IL38589A (en) 11beta-hydroxy-17alpha-acyloxy-3-oxo-androst-4-ene-17beta-carboxylic acid esters
CS209919B2 (en) Method of making the esters of the 4-halogen-9-fluor-3-oxo-androst-4-en and 4-halogen-9-fluor-3-oxoandrosta -1,4-dien-17beta-thiocarboxyl acid
EP0143764B1 (en) Novel androstane-17 beta-carboxylic acid esters, a process and intermediates for their preparation, composition and method for the treatment of inflammatory conditions
CA1278293C (en) Androstane-17 beta-carboxylic acid esters
CA1129407A (en) Antiinflammatory steroid of the androstane series
IE43452B1 (en) Terpenoid esters of steroids
IE41663B1 (en) Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene17-carboxylates
JPS6043358B2 (ja) 9α−ハロ−18−メチル−21−デスオキシプレドニンロンのエステル類の製造法
US4655971A (en) Novel process for the preparation of steroidal esters
CA1251784A (en) Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments
US3845085A (en) Steroids of the pregnane series
GB1563638A (en) 21-halogenopregnane compounds
US4011315A (en) 21-acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation
US4185101A (en) 1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
EP0165526B1 (en) 17-(substituted thio) 17-(substituted dithio) androstenes
EP0000609B1 (en) Novel 19-nor-pregnahexaenes, process for the preparation thereof, and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
MKEX Expiry