IE790236L - Androstadiene derivative - Google Patents

Androstadiene derivative

Info

Publication number
IE790236L
IE790236L IE790236A IE23679A IE790236L IE 790236 L IE790236 L IE 790236L IE 790236 A IE790236 A IE 790236A IE 23679 A IE23679 A IE 23679A IE 790236 L IE790236 L IE 790236L
Authority
IE
Ireland
Prior art keywords
beta
chloromethyl
derivative
androstadiene
chloride
Prior art date
Application number
IE790236A
Other versions
IE47814B1 (en
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IE790236L publication Critical patent/IE790236L/en
Publication of IE47814B1 publication Critical patent/IE47814B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The novel compound according to Claim 1 has a high local anti-inflammatory action, but only relatively weak systemic actions; it can therefore be used for the local treatment of inflammations with a minimum risk of undesired systemic side effects. It is prepared by esterification of the corresponding 17 beta -carboxylic acid or a functional derivative thereof, in particular with a chloromethyl chloride, bromide or iodide, or by acetylation of the corresponding chloromethyl 17 alpha -hydroxy-17 beta -carboxylate, or by replacement of iodine or bromine by chlorine, e.g. by means of a metal chloride, in a corresponding iodomethyl or bromomethyl ester. [FR2422688A1]
IE236/79A 1978-02-08 1979-02-07 Chloromethyl 17alpha-acetoxy-9alpha fluoro-11beta-hydroxy-16beta-methyl-3-oxoandrosta-1,4-diene-17beta-carboxylate IE47814B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB513178 1978-02-08

Publications (2)

Publication Number Publication Date
IE790236L true IE790236L (en) 1979-08-08
IE47814B1 IE47814B1 (en) 1984-06-27

Family

ID=9790294

Family Applications (1)

Application Number Title Priority Date Filing Date
IE236/79A IE47814B1 (en) 1978-02-08 1979-02-07 Chloromethyl 17alpha-acetoxy-9alpha fluoro-11beta-hydroxy-16beta-methyl-3-oxoandrosta-1,4-diene-17beta-carboxylate

Country Status (20)

Country Link
JP (1) JPS54145648A (en)
AT (1) AT367771B (en)
AU (1) AU520827B2 (en)
BE (1) BE873996A (en)
CA (1) CA1129407A (en)
CH (1) CH639669A5 (en)
DE (1) DE2904614A1 (en)
DK (1) DK145578C (en)
ES (1) ES477523A1 (en)
FI (1) FI790403A (en)
FR (1) FR2422688A1 (en)
IE (1) IE47814B1 (en)
IL (1) IL56613A (en)
IT (1) IT1114534B (en)
NL (1) NL7900967A (en)
NZ (1) NZ189586A (en)
PT (1) PT69192A (en)
SE (1) SE435626B (en)
YU (1) YU26779A (en)
ZA (1) ZA79538B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE449106B (en) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd STEROID WITH ANTI-INFLAMMATORY EFFECT AND COMPOSITION CONTAINING THIS
US5237070A (en) * 1985-07-22 1993-08-17 Riker Laboratories, Inc. Substituted DI-t-butylphenols
JP4847112B2 (en) * 2005-11-29 2011-12-28 株式会社マキタ Gardening hair clipper
HUE034570T2 (en) 2010-10-27 2018-02-28 Hovione Int Ltd Electrophilic reagents for monohalomethylation,their preparation and their uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids

Also Published As

Publication number Publication date
FI790403A (en) 1979-08-09
SE7901100L (en) 1979-08-09
SE435626B (en) 1984-10-08
DK145578C (en) 1983-05-09
DK50179A (en) 1979-08-09
AT367771B (en) 1982-07-26
IE47814B1 (en) 1984-06-27
FR2422688B1 (en) 1982-07-16
CH639669A5 (en) 1983-11-30
IL56613A (en) 1982-12-31
NZ189586A (en) 1981-01-23
JPS54145648A (en) 1979-11-14
ZA79538B (en) 1980-02-27
ES477523A1 (en) 1979-07-16
NL7900967A (en) 1979-08-10
YU26779A (en) 1983-01-21
AU4408479A (en) 1979-08-16
BE873996A (en) 1979-08-07
IL56613A0 (en) 1979-05-31
DE2904614A1 (en) 1979-08-09
PT69192A (en) 1979-03-01
FR2422688A1 (en) 1979-11-09
CA1129407A (en) 1982-08-10
IT7947909A0 (en) 1979-02-06
ATA92379A (en) 1981-12-15
DK145578B (en) 1982-12-13
AU520827B2 (en) 1982-03-04
IT1114534B (en) 1986-01-27

Similar Documents

Publication Publication Date Title
AU531718B2 (en) Production of acetic anhydride
FR2449670A1 (en) PROCESS FOR THE PREPARATION OF ARYLACETIC ACID ESTERS FROM ALPHA-HALO-ALKYLARYLCETONES
ZA846406B (en) Novel carboxylic acid esters
AU526270B2 (en) Acid addition salt of 2beta,16beta diperidino 5 alpha androstane derivatives
IE790236L (en) Androstadiene derivative
ES490132A0 (en) PRODUCTION PROCEDURE OF ACETIC ACID DERIVATIVES.
AU525371B2 (en) Phenylcyclopropane carboxylic acid derivatives
AU525743B2 (en) Connection of tubing to non-tubular parts
GB2014137B (en) Opticallyactive substituted acetic acid derivatives
ES8106693A1 (en) Carboxylic ester compounds for use as insecticides
IE36529B1 (en) Esters of betamethasone and its 9alpha-chloro analogue
JPS55105658A (en) Manufacture of methyleneebiss*44phenylcarbamic ester*
DE3363533D1 (en) Process for preparing esters of aryl alkanoic acids
AU525361B2 (en) Arrangement for attaching a glass envelope to a metal tube
FR2440349A1 (en) PROCESS FOR THE PREPARATION OF ACETIC ACID OR ITS MIXTURES WITH METHYL ACETATE
IE810286L (en) Bromination process
IT7820313A0 (en) PROCEDURE FOR THE PREPARATION OF MONOCHLOROACETIC ACID FROM ACETIC ACID AND ELEMENTAL CHLORINE.
PT70583A (en) NEW PROCESS FOR THE PREPARATION OF URSODESOXYCHOLIC ACID
ES479576A1 (en) Process for preparing 17 beta -carboxy-5-androsten-3-ones
AU525916B2 (en) 3-chlorostyryl-2,2,-dimethyl-cyclopropane carboxylic acid esters
GB1409539A (en) Adenosine-5-carboxylate derivatives
IL62244A0 (en) Preparation of 3-bromo-4-fluorotoluene
GB759745A (en) Steroids
GB2014579A (en) Chloromethyl 17???-acetoxy-9???- fluoro-11-???-hydroxy-16???-methyl-3- oxoandrosta-1,4-diene-17???- carboxylate
KR830002769A (en) Method for preparing 6-β-substituted penicillanic acid derivatives