GB2014579A - Chloromethyl 17???-acetoxy-9???- fluoro-11-???-hydroxy-16???-methyl-3- oxoandrosta-1,4-diene-17???- carboxylate - Google Patents

Chloromethyl 17???-acetoxy-9???- fluoro-11-???-hydroxy-16???-methyl-3- oxoandrosta-1,4-diene-17???- carboxylate

Info

Publication number
GB2014579A
GB2014579A GB7904428A GB7904428A GB2014579A GB 2014579 A GB2014579 A GB 2014579A GB 7904428 A GB7904428 A GB 7904428A GB 7904428 A GB7904428 A GB 7904428A GB 2014579 A GB2014579 A GB 2014579A
Authority
GB
United Kingdom
Prior art keywords
oxoandrosta
acetoxy
chloromethyl
diene
carboxylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7904428A
Other versions
GB2014579B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to GB7904428A priority Critical patent/GB2014579B/en
Publication of GB2014579A publication Critical patent/GB2014579A/en
Application granted granted Critical
Publication of GB2014579B publication Critical patent/GB2014579B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Abstract

The title compound (claimed per se) is prepared by (i) esterifying its 17???-CO2H analogue or functional equivalent (e.g. salt) thereof; (ii) acetylating its 17???-OH analogue; or (iii) transhalogenating its 17???-CO2CH2Br or 17???-CO2CH2I analogue. Use: Antiinflammatory.
GB7904428A 1978-02-08 1979-02-08 Chloromethyl 17 acetoxy fluoro hydroxy 16 methyl 3 oxoandrosta 1,4 diene 17 carboxylate Expired GB2014579B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7904428A GB2014579B (en) 1978-02-08 1979-02-08 Chloromethyl 17 acetoxy fluoro hydroxy 16 methyl 3 oxoandrosta 1,4 diene 17 carboxylate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB513178 1978-02-08
GB7904428A GB2014579B (en) 1978-02-08 1979-02-08 Chloromethyl 17 acetoxy fluoro hydroxy 16 methyl 3 oxoandrosta 1,4 diene 17 carboxylate

Publications (2)

Publication Number Publication Date
GB2014579A true GB2014579A (en) 1979-08-30
GB2014579B GB2014579B (en) 1982-08-25

Family

ID=26239669

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7904428A Expired GB2014579B (en) 1978-02-08 1979-02-08 Chloromethyl 17 acetoxy fluoro hydroxy 16 methyl 3 oxoandrosta 1,4 diene 17 carboxylate

Country Status (1)

Country Link
GB (1) GB2014579B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0902789A1 (en) * 1996-05-09 1999-03-24 Soft Drugs, Inc. Androstene derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0902789A1 (en) * 1996-05-09 1999-03-24 Soft Drugs, Inc. Androstene derivatives
EP0902789A4 (en) * 1996-05-09 1999-04-14
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives

Also Published As

Publication number Publication date
GB2014579B (en) 1982-08-25

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee