CA1079269A - Process of separating precipitated proteins from albumin - containing suspensions - Google Patents
Process of separating precipitated proteins from albumin - containing suspensionsInfo
- Publication number
- CA1079269A CA1079269A CA268,010A CA268010A CA1079269A CA 1079269 A CA1079269 A CA 1079269A CA 268010 A CA268010 A CA 268010A CA 1079269 A CA1079269 A CA 1079269A
- Authority
- CA
- Canada
- Prior art keywords
- albumin
- process according
- filtration
- filter
- filtering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 45
- 102000009027 Albumins Human genes 0.000 title claims abstract description 38
- 108010088751 Albumins Proteins 0.000 title claims abstract description 38
- 239000000725 suspension Substances 0.000 title claims abstract description 21
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 18
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 18
- 238000001914 filtration Methods 0.000 claims abstract description 63
- 210000002381 plasma Anatomy 0.000 claims abstract description 10
- 239000004744 fabric Substances 0.000 claims abstract description 7
- 238000000746 purification Methods 0.000 claims abstract description 6
- 238000011084 recovery Methods 0.000 claims abstract description 6
- 239000002002 slurry Substances 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 239000000470 constituent Substances 0.000 claims description 5
- 238000011010 flushing procedure Methods 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 238000000502 dialysis Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims 1
- 239000000706 filtrate Substances 0.000 abstract description 11
- 238000005352 clarification Methods 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 239000000126 substance Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000000926 separation method Methods 0.000 description 6
- 102000006395 Globulins Human genes 0.000 description 5
- 108010044091 Globulins Proteins 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000011026 diafiltration Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 239000003114 blood coagulation factor Substances 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 238000011083 clear filtration Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229960005480 sodium caprylate Drugs 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- BYKRNSHANADUFY-UHFFFAOYSA-M sodium octanoate Chemical compound [Na+].CCCCCCCC([O-])=O BYKRNSHANADUFY-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229960004132 diethyl ether Drugs 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 229960000301 factor viii Drugs 0.000 description 1
- 239000011152 fibreglass Substances 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000010451 perlite Substances 0.000 description 1
- 235000019362 perlite Nutrition 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 229960004319 trichloroacetic acid Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2556733A DE2556733C3 (de) | 1975-12-17 | 1975-12-17 | Verfahren zum Isolieren von Albumin aus Blutplasma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1079269A true CA1079269A (en) | 1980-06-10 |
Family
ID=5964580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA268,010A Expired CA1079269A (en) | 1975-12-17 | 1976-12-16 | Process of separating precipitated proteins from albumin - containing suspensions |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS6033089B2 (Direct) |
| AT (1) | AT346491B (Direct) |
| AU (1) | AU508955B2 (Direct) |
| BE (1) | BE849464R (Direct) |
| CA (1) | CA1079269A (Direct) |
| CH (1) | CH632277A5 (Direct) |
| DD (1) | DD128726A6 (Direct) |
| DE (1) | DE2556733C3 (Direct) |
| DK (1) | DK149135C (Direct) |
| EG (1) | EG12610A (Direct) |
| ES (1) | ES454379A2 (Direct) |
| FI (1) | FI56844C (Direct) |
| FR (1) | FR2335521A2 (Direct) |
| GB (1) | GB1569168A (Direct) |
| HU (1) | HU181926B (Direct) |
| IE (1) | IE44048B1 (Direct) |
| IL (1) | IL51110A (Direct) |
| MX (1) | MX3915E (Direct) |
| NL (1) | NL7613906A (Direct) |
| PL (1) | PL106430B3 (Direct) |
| SE (1) | SE445517B (Direct) |
| ZA (1) | ZA767503B (Direct) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4483807A (en) * | 1981-01-27 | 1984-11-20 | Japan Atomic Energy Research Institute | Process for producing a slow release composite |
| DE3307871C2 (de) * | 1983-03-05 | 1986-10-30 | R & Z Biologicals S.A. (Pty.) Ltd., Cape Town | Verfahren zur Gewinnung von hochreinem Albumin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2705230A (en) * | 1949-09-23 | 1955-03-29 | Allen F Reid | Method of purifying albumin |
| US2765299A (en) * | 1952-06-27 | 1956-10-02 | Armour & Co | Recovery of serum albumin |
| FR2247471A1 (en) * | 1973-10-15 | 1975-05-09 | Ts Institu | Pure serum albumin isolated from biological liquids - by treatment with alcohol and aliphatic carboxylic acid salt |
| DE2415079C3 (de) * | 1974-03-28 | 1980-02-14 | Plasmesco Ag, Zug (Schweiz) | Verfahren zum Isolieren von Albumin aus Blutplasma |
-
1975
- 1975-12-17 DE DE2556733A patent/DE2556733C3/de not_active Expired
-
1976
- 1976-12-10 IE IE2712/76A patent/IE44048B1/en unknown
- 1976-12-13 SE SE7613968A patent/SE445517B/xx unknown
- 1976-12-14 DK DK559876A patent/DK149135C/da not_active IP Right Cessation
- 1976-12-15 FI FI763610A patent/FI56844C/fi not_active IP Right Cessation
- 1976-12-15 DD DD7600196377A patent/DD128726A6/xx unknown
- 1976-12-15 GB GB52438/76A patent/GB1569168A/en not_active Expired
- 1976-12-15 NL NL7613906A patent/NL7613906A/xx not_active Application Discontinuation
- 1976-12-15 EG EG769/76A patent/EG12610A/xx active
- 1976-12-15 IL IL51110A patent/IL51110A/xx unknown
- 1976-12-16 AU AU20599/76A patent/AU508955B2/en not_active Expired
- 1976-12-16 HU HU76PA1271A patent/HU181926B/hu unknown
- 1976-12-16 BE BE173309A patent/BE849464R/xx not_active IP Right Cessation
- 1976-12-16 FR FR7637897A patent/FR2335521A2/fr active Granted
- 1976-12-16 PL PL1976194451A patent/PL106430B3/pl unknown
- 1976-12-16 CA CA268,010A patent/CA1079269A/en not_active Expired
- 1976-12-16 AT AT932976A patent/AT346491B/de not_active IP Right Cessation
- 1976-12-17 JP JP51150986A patent/JPS6033089B2/ja not_active Expired
- 1976-12-17 ES ES454379A patent/ES454379A2/es not_active Expired
- 1976-12-17 CH CH1593176A patent/CH632277A5/de not_active IP Right Cessation
- 1976-12-17 ZA ZA767503A patent/ZA767503B/xx unknown
- 1976-12-17 MX MX76100452U patent/MX3915E/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK559876A (da) | 1977-06-18 |
| EG12610A (en) | 1979-06-30 |
| BE849464R (fr) | 1977-04-15 |
| FR2335521B2 (Direct) | 1982-10-29 |
| ATA932976A (de) | 1978-03-15 |
| DE2556733C3 (de) | 1986-10-02 |
| AT346491B (de) | 1978-11-10 |
| DE2556733A1 (de) | 1977-11-17 |
| DD128726A6 (de) | 1977-12-07 |
| IL51110A (en) | 1979-11-30 |
| JPS6033089B2 (ja) | 1985-08-01 |
| IE44048B1 (en) | 1981-07-29 |
| FI763610A7 (Direct) | 1977-06-18 |
| NL7613906A (nl) | 1977-06-21 |
| DK149135B (da) | 1986-02-10 |
| FI56844C (fi) | 1980-04-10 |
| FR2335521A2 (fr) | 1977-07-15 |
| DE2556733B2 (de) | 1981-05-14 |
| PL106430B3 (pl) | 1979-12-31 |
| SE7613968L (sv) | 1977-06-18 |
| SE445517B (sv) | 1986-06-30 |
| MX3915E (es) | 1981-09-18 |
| CH632277A5 (en) | 1982-09-30 |
| FI56844B (fi) | 1979-12-31 |
| AU508955B2 (en) | 1980-04-17 |
| IL51110A0 (en) | 1977-02-28 |
| JPS5283926A (en) | 1977-07-13 |
| GB1569168A (en) | 1980-06-11 |
| ES454379A2 (es) | 1978-07-16 |
| DK149135C (da) | 1986-07-14 |
| AU2059976A (en) | 1978-06-22 |
| HU181926B (en) | 1983-11-28 |
| ZA767503B (en) | 1977-11-30 |
| IE44048L (en) | 1977-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |