CA1076937A - Method of indicating rheumatoid factors - Google Patents
Method of indicating rheumatoid factorsInfo
- Publication number
- CA1076937A CA1076937A CA283,447A CA283447A CA1076937A CA 1076937 A CA1076937 A CA 1076937A CA 283447 A CA283447 A CA 283447A CA 1076937 A CA1076937 A CA 1076937A
- Authority
- CA
- Canada
- Prior art keywords
- immunoglobulin
- aggregated
- labelled
- sample
- igg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 17
- 108060003951 Immunoglobulin Proteins 0.000 claims abstract description 28
- 102000018358 immunoglobulin Human genes 0.000 claims abstract description 28
- 238000001556 precipitation Methods 0.000 claims abstract description 7
- 230000000295 complement effect Effects 0.000 claims abstract description 4
- 239000002244 precipitate Substances 0.000 claims abstract description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000000243 solution Substances 0.000 description 6
- 229940072221 immunoglobulins Drugs 0.000 description 5
- 238000002372 labelling Methods 0.000 description 5
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 229920002307 Dextran Polymers 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 description 3
- HMFKFHLTUCJZJO-UHFFFAOYSA-N 2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO HMFKFHLTUCJZJO-UHFFFAOYSA-N 0.000 description 2
- 229920005654 Sephadex Polymers 0.000 description 2
- 239000012507 Sephadex™ Substances 0.000 description 2
- 238000002523 gelfiltration Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000012064 sodium phosphate buffer Substances 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- MQJKPEGWNLWLTK-UHFFFAOYSA-N Dapsone Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 MQJKPEGWNLWLTK-UHFFFAOYSA-N 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 206010053614 Type III immune complex mediated reaction Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical compound C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- GHWVXCQZPNWFRO-UHFFFAOYSA-N butane-2,3-diamine Chemical compound CC(N)C(C)N GHWVXCQZPNWFRO-UHFFFAOYSA-N 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical class O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000007863 gel particle Substances 0.000 description 1
- 230000016178 immune complex formation Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/819—Multifunctional antigen or antibody
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/821—Chemistry: analytical and immunological testing involving complement factors or complement systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Rehabilitation Therapy (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7609906A SE441042B (sv) | 1976-09-08 | 1976-09-08 | Sett att pavisa rheumatoida faktorer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1076937A true CA1076937A (en) | 1980-05-06 |
Family
ID=20328828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA283,447A Expired CA1076937A (en) | 1976-09-08 | 1977-07-25 | Method of indicating rheumatoid factors |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4153417A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS6057544B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1076937A (cg-RX-API-DMAC7.html) |
| DE (1) | DE2707881C2 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2364456A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1576400A (cg-RX-API-DMAC7.html) |
| NL (1) | NL7708078A (cg-RX-API-DMAC7.html) |
| SE (1) | SE441042B (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302536A (en) * | 1978-08-15 | 1981-11-24 | Longenecker Robert W | Colorimetric immunoassay process |
| US4342566A (en) * | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
| US4434227A (en) * | 1982-02-08 | 1984-02-28 | Abbott Laboratories | Immunoassay for class specific immunoglobulin antibodies |
| US4450231A (en) * | 1982-03-31 | 1984-05-22 | Biostar Medical Products, Inc. | Immunoassay for determination of immune complexes with polymer-coated plastic base |
| US4582793A (en) * | 1982-10-29 | 1986-04-15 | Research Corporation | Anti-RNA polymerase I antibody test for the diagnosis of rheumatological diseases |
| SE8304836D0 (sv) * | 1983-09-09 | 1983-09-09 | Pharmacia Ab | Sett att bestemma forendringar i ledbrosk |
| CA1261257A (en) * | 1984-09-19 | 1989-09-26 | Helgi Valdimarsson | Prognostic value of rheumatoid factor isotypes and their association with disease activity |
| US4914041A (en) * | 1988-02-12 | 1990-04-03 | Beckman Instruments, Inc. | Reagent and method for detecting rheumatoid factor |
| DE68924783T2 (de) * | 1988-09-30 | 1996-03-28 | Neorx Corp | Wässrige additivsysteme, verfahren und polymerteilchen. |
| US5066789A (en) * | 1988-09-30 | 1991-11-19 | Neorx Corporation | Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages |
| US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
| JPH02144560U (cg-RX-API-DMAC7.html) * | 1989-05-12 | 1990-12-07 | ||
| US6300480B1 (en) | 1996-11-08 | 2001-10-09 | Matsushita Electric Industrial Co., Ltd. | Dye-labeled protein conjugate and method for preparing the same |
| JPH11322798A (ja) * | 1998-05-14 | 1999-11-24 | Matsushita Electric Ind Co Ltd | 色素標識重合抗体およびその製造方法 |
| US6303758B1 (en) | 1996-11-08 | 2001-10-16 | Matsushita Electric Industrial Co., Ltd. | Dye-labeled and polymerized antibody and method for preparing the same |
| JP3601972B2 (ja) * | 1998-05-14 | 2004-12-15 | 松下電器産業株式会社 | 色素標識タンパク質複合体およびその製造方法 |
| JP3625250B2 (ja) * | 1998-05-14 | 2005-03-02 | 松下電器産業株式会社 | 色素標識重合抗体およびその製造方法 |
| US6303759B1 (en) | 1996-11-08 | 2001-10-16 | Matsushita Electric Industrial Co., Ltd. | Dye-labeled and polymerized antibody and method for preparing the same |
| BR0017261A (pt) | 2000-07-14 | 2003-07-29 | Immunivest Corp | Métodos para isolamento de uma bioentidade alvo de uma amostra biológica e de células de tumor com densidade de antìgeno baixa e, kits para inibir a agregação endógena de partìculas magnéticas coloidais no processamento de material biológico e, para isolamento de células de tumor de densidade de antìgeno baixa de uma amostra biológica com agregação ontrolada de partìculas magnéticas coloidais |
| US20060159680A1 (en) * | 2005-01-14 | 2006-07-20 | Smith Henry J | Targeted apherisis for the treatment of rheumatoid arthritis |
| US20130068691A1 (en) * | 2011-08-05 | 2013-03-21 | Henry John Smith | Targeted apheresis for the treatment of rheumatoid arthritis and immune disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1484727A (fr) * | 1966-04-19 | 1967-06-16 | Réactif immunologique et son procédé d'obtention | |
| GB1179435A (en) * | 1966-06-17 | 1970-01-28 | Ortho Pharma Corp | Stable Reagent for the Detection of Rheumatoid Arthritis |
| US3689632A (en) * | 1969-01-06 | 1972-09-05 | Kowa Co | Rheumatoid agglutination test and reagent |
| GB1508132A (en) * | 1974-05-20 | 1978-04-19 | Technicon Instr | Analysis of biological fluids |
-
1976
- 1976-09-08 SE SE7609906A patent/SE441042B/xx not_active IP Right Cessation
-
1977
- 1977-02-24 DE DE2707881A patent/DE2707881C2/de not_active Expired
- 1977-07-20 NL NL7708078A patent/NL7708078A/xx not_active Application Discontinuation
- 1977-07-25 US US05/818,646 patent/US4153417A/en not_active Expired - Lifetime
- 1977-07-25 CA CA283,447A patent/CA1076937A/en not_active Expired
- 1977-07-26 FR FR7722925A patent/FR2364456A1/fr active Granted
- 1977-07-27 GB GB31492/77A patent/GB1576400A/en not_active Expired
- 1977-07-28 JP JP52090878A patent/JPS6057544B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE441042B (sv) | 1985-09-02 |
| JPS6057544B2 (ja) | 1985-12-16 |
| DE2707881A1 (de) | 1978-03-09 |
| JPS5334918A (en) | 1978-03-31 |
| SE7609906L (sv) | 1978-03-09 |
| FR2364456B1 (cg-RX-API-DMAC7.html) | 1981-08-28 |
| DE2707881C2 (de) | 1985-05-30 |
| US4153417A (en) | 1979-05-08 |
| NL7708078A (nl) | 1978-03-10 |
| FR2364456A1 (fr) | 1978-04-07 |
| GB1576400A (en) | 1980-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |