CA1076587A - Prostaglandin derivatives and process for preparing the same - Google Patents

Prostaglandin derivatives and process for preparing the same

Info

Publication number
CA1076587A
CA1076587A CA248,275A CA248275A CA1076587A CA 1076587 A CA1076587 A CA 1076587A CA 248275 A CA248275 A CA 248275A CA 1076587 A CA1076587 A CA 1076587A
Authority
CA
Canada
Prior art keywords
formula
process according
acid
pyrrolidinone
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA248,275A
Other languages
English (en)
French (fr)
Inventor
Jacques Simiand
Charles Pigerol
Pierre L. Eymard
Alain Jean
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Application granted granted Critical
Publication of CA1076587A publication Critical patent/CA1076587A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/16—Saturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA248,275A 1975-03-21 1976-03-19 Prostaglandin derivatives and process for preparing the same Expired CA1076587A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12034/75A GB1529852A (en) 1975-03-21 1975-03-21 8-azaprostaglandins and process for the preparation thereof

Publications (1)

Publication Number Publication Date
CA1076587A true CA1076587A (en) 1980-04-29

Family

ID=9997230

Family Applications (1)

Application Number Title Priority Date Filing Date
CA248,275A Expired CA1076587A (en) 1975-03-21 1976-03-19 Prostaglandin derivatives and process for preparing the same

Country Status (26)

Country Link
JP (1) JPS607602B2 (ja)
AR (1) AR213172A1 (ja)
AT (1) AT348163B (ja)
AU (1) AU501105B2 (ja)
BE (1) BE839761A (ja)
CA (1) CA1076587A (ja)
CH (2) CH611881A5 (ja)
DE (1) DE2612114A1 (ja)
DK (1) DK140937B (ja)
ES (2) ES446239A1 (ja)
FI (1) FI61692C (ja)
FR (1) FR2304340A1 (ja)
GB (1) GB1529852A (ja)
HU (1) HU173348B (ja)
IE (1) IE42966B1 (ja)
IT (1) IT1061011B (ja)
MX (1) MX3301E (ja)
NL (1) NL7602891A (ja)
NO (1) NO144147C (ja)
NZ (1) NZ180251A (ja)
OA (1) OA05279A (ja)
PT (1) PT64919B (ja)
SE (1) SE418290B (ja)
SU (1) SU614746A3 (ja)
YU (1) YU73876A (ja)
ZA (1) ZA761448B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097489A (en) * 1977-06-17 1978-06-27 The Upjohn Company 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds
US5540618A (en) * 1994-10-28 1996-07-30 National University Of Singapore Passive attenuator for shelter protection against explosions
WO2003074483A1 (fr) 2002-03-05 2003-09-12 Ono Pharmaceutical Co., Ltd. Composes derives de 8 azaprostaglandine et medicaments contenant ceux-ci comme principe actif

Also Published As

Publication number Publication date
FR2304340A1 (fr) 1976-10-15
FI760744A (ja) 1976-09-22
GB1529852A (en) 1978-10-25
FI61692C (fi) 1982-09-10
JPS51138671A (en) 1976-11-30
DE2612114A1 (de) 1976-10-07
ES446239A1 (es) 1977-07-01
DK140937C (ja) 1980-05-19
FR2304340B1 (ja) 1979-06-29
ATA195676A (de) 1978-06-15
DK88276A (ja) 1976-09-22
PT64919A (en) 1976-04-01
CH611604A5 (en) 1979-06-15
OA05279A (fr) 1981-02-28
HU173348B (hu) 1979-04-28
ES458389A1 (es) 1978-02-16
IE42966B1 (en) 1980-11-19
BE839761A (fr) 1976-09-20
AU1189976A (en) 1977-09-15
IT1061011B (it) 1982-10-20
YU73876A (en) 1982-10-31
NO144147C (no) 1981-07-15
PT64919B (en) 1977-08-24
JPS607602B2 (ja) 1985-02-26
NZ180251A (en) 1978-07-28
NO760994L (ja) 1976-09-22
MX3301E (es) 1980-09-03
IE42966L (en) 1976-09-21
AU501105B2 (en) 1979-06-14
CH611881A5 (en) 1979-06-29
NL7602891A (nl) 1976-09-23
AR213172A1 (es) 1978-12-29
SU614746A3 (ru) 1978-07-05
SE7603400L (sv) 1976-09-22
AT348163B (de) 1979-02-12
NO144147B (no) 1981-03-23
ZA761448B (en) 1977-03-30
FI61692B (fi) 1982-05-31
DK140937B (da) 1979-12-10
SE418290B (sv) 1981-05-18

Similar Documents

Publication Publication Date Title
EP0011928B1 (en) 3,5-dihydroxypentanoic ester derivatives having antihyperlipaemic activity, their manufacture and pharmaceutical compositions containing them
EP0059158B1 (de) Azaprostacycline, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
DE2659215A1 (de) Prostaglandin-analoga
CH647222A5 (de) 9-desoxy-9a-methylen-isostere von pgi-2 und verfahren zu deren herstellung.
US4115401A (en) Prostaglandin derivatives and process for preparing the same
EP0046082A2 (en) 8-Aza-16,16-difluoroprostanoids
JP2911239B2 (ja) スクアレンエポキシダーゼの抑制剤としてのスクアレンのジ−及びテトラ−フルオロ類似体類
CA1076587A (en) Prostaglandin derivatives and process for preparing the same
WO1995010266A1 (en) Nitrogen monoxide synthesis inhibitor
US3966745A (en) Vinvamine series cycloalkyl-alkyl esters
DE2659217A1 (de) Prostaglandin-analoga
US4262008A (en) 2,4-Disubstituted 5-oxo-5H-hexahydrofuro[3,2b]pyrroles
SU1072801A3 (ru) Способ получени производных простациклина или их эпимеров
US4182759A (en) Arylalkyl and aryloxyalkyl phosphonates and use as antiviral agents
SU1272980A3 (ru) Способ получени оптически активных или рацемических соединений или их фармацевтически или ветеринарно приемлемых солей
DE2542686A1 (de) 2a,2b-dihomo-15-methyl- und -15- aethyl-pgf-und pge-verbindungen und verfahren zu deren herstellung
EP0086404B1 (de) Neue Carbacycline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DD244132A5 (de) Verfahren zur herstellung von /4.2.0/ bicyclooctanderivaten
GB2024807A (en) An imidazole derivative
IE43689B1 (en) 2-(w-haloalkenyl)-cyclopentane-1-heptanoic acids,methods for preparation thereof and their use
US3769316A (en) Prostaglandin intermediates
DE3131616A1 (de) 13-oxaprostansaeurederivate, deren herstellung sowie diese enthaltende arzneimittel
US3799967A (en) Synthetic prostaglandins
JPH07138269A (ja) デオキシシクリトール誘導体、それらの製造方法および薬剤におけるそれらの使用
US4201864A (en) Oxy-alkylamino acids and esters

Legal Events

Date Code Title Description
MKEX Expiry