CA1075228A - Flunisolide to treat respiratory diseases - Google Patents

Flunisolide to treat respiratory diseases

Info

Publication number
CA1075228A
CA1075228A CA253,267A CA253267A CA1075228A CA 1075228 A CA1075228 A CA 1075228A CA 253267 A CA253267 A CA 253267A CA 1075228 A CA1075228 A CA 1075228A
Authority
CA
Canada
Prior art keywords
prepared
microns
flunisolide
process according
particle size
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA253,267A
Other languages
English (en)
French (fr)
Inventor
John H. Fried
Gisela T. Haringer
Richard E. Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Priority to CA332,220A priority Critical patent/CA1083963A/en
Application granted granted Critical
Publication of CA1075228A publication Critical patent/CA1075228A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
CA253,267A 1975-05-27 1976-05-25 Flunisolide to treat respiratory diseases Expired CA1075228A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA332,220A CA1083963A (en) 1975-05-27 1979-07-20 Use of flunisolide to treat respiratory diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58130075A 1975-05-27 1975-05-27
US58130175A 1975-05-27 1975-05-27

Publications (1)

Publication Number Publication Date
CA1075228A true CA1075228A (en) 1980-04-08

Family

ID=27078279

Family Applications (1)

Application Number Title Priority Date Filing Date
CA253,267A Expired CA1075228A (en) 1975-05-27 1976-05-25 Flunisolide to treat respiratory diseases

Country Status (15)

Country Link
JP (1) JPS51144719A (de)
AT (1) AT357702B (de)
AU (1) AU506080B2 (de)
CA (1) CA1075228A (de)
DE (2) DE2624924C2 (de)
ES (1) ES448220A1 (de)
FR (1) FR2361900A1 (de)
GB (1) GB1525181A (de)
HK (1) HK8580A (de)
IL (1) IL49652A (de)
MX (1) MX3864E (de)
MY (1) MY8000275A (de)
NL (1) NL191234C (de)
NZ (1) NZ180946A (de)
SE (1) SE421426B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55154997A (en) * 1979-05-21 1980-12-02 Syntex Corp Manufacture of flunisolide having peculiar crystal form
EP0039369B1 (de) * 1980-05-02 1983-06-15 Schering Corporation Beclomethason-ester-solvate, Verfahren zu ihrer Herstellung und Herstellung einer Formulierung
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4782047A (en) * 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
AU624421B2 (en) * 1988-10-05 1992-06-11 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
AU721566B2 (en) * 1995-06-27 2000-07-06 Boehringer Ingelheim Kg New stable pharmaceutical preparation for producing propellant-free aerosols
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
ME00220B (me) 2000-05-22 2010-10-10 Chiesi Farm Spa Stabilne farmaceutske formulacije rastvora za inhalatore odmjerene doze pod pritiskom
TR200401980T4 (tr) 2001-07-02 2004-09-21 Chiesi Farmaceutici S.P.A. Aerosol olarak uygulama için en uygun hale getirilmiş tobramisin formülasyonu
JP4632687B2 (ja) * 2003-04-25 2011-02-16 ロート製薬株式会社 点鼻剤
JP5238779B2 (ja) * 2003-04-25 2013-07-17 ロート製薬株式会社 点鼻剤
EP1595531A1 (de) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stabile Arzneimittellösung für Druckdosierinhalatoren
AU2014233362A1 (en) * 2013-03-15 2015-10-01 Medicis Pharmaceutical Corporation Topical compositions of flunisolide and methods of treatment

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
GB933868A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Process for fluorinating steroids
US3282791A (en) * 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) * 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
FR2038105A1 (fr) * 1969-04-01 1971-01-08 Syntex Corp Composition anti-inflammatoire locale et son mode d'utilisation
GB1429184A (en) * 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
DE2332663C2 (de) * 1973-06-23 1986-07-31 Schering AG, 1000 Berlin und 4709 Bergkamen Verwendung von Kortikoid-Wirkstoffen zur Inhalationstherapie
US3934013A (en) 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Also Published As

Publication number Publication date
ES448220A1 (es) 1977-11-01
IL49652A (en) 1979-05-31
AT357702B (de) 1980-07-25
JPS6247880B2 (de) 1987-10-09
FR2361900A1 (fr) 1978-03-17
IL49652A0 (en) 1976-07-30
MY8000275A (en) 1980-12-31
AU1430176A (en) 1977-12-01
NZ180946A (en) 1978-07-28
NL191234B (nl) 1994-11-01
SE7605927L (sv) 1976-11-28
NL7605699A (nl) 1976-11-30
MX3864E (es) 1981-08-26
AU506080B2 (en) 1979-12-13
DE2624924A1 (de) 1977-12-15
DE2624924C2 (de) 1986-11-27
DE2661037C2 (de) 1989-04-06
FR2361900B1 (de) 1979-04-13
NL191234C (nl) 1995-04-03
SE421426B (sv) 1981-12-21
JPS51144719A (en) 1976-12-13
HK8580A (en) 1980-03-14
ATA388376A (de) 1979-12-15
GB1525181A (en) 1978-09-20

Similar Documents

Publication Publication Date Title
CA1075228A (en) Flunisolide to treat respiratory diseases
KR890000664B1 (ko) 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
US4364923A (en) Chemical compounds
EP1102579B1 (de) Medizinische aerosolformulierungen
RU2294737C2 (ru) Медицинские аэрозольные составы
US5292499A (en) Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
EP0806940B1 (de) Aerosol-arzneiformulierungen
US5118494A (en) Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
US4044126A (en) Steroidal aerosol compositions and process for the preparation thereof
US4352789A (en) Aerosol compositions containing finely divided solid materials
EP1014943B1 (de) Medizinische aerosolformulierungen
CA1253806A (en) Physically modified beclomethasone dipropionate suitable for use in aerosols
EP1100465A1 (de) Medizinische aerosolformulierungen
DE2703119C2 (de)
EP1572153B1 (de) Herstellung von sterilen wässrigen suspensionen mit mikronisierten kristallinen wirkstoffen zur inhalation
EP0039369A1 (de) Beclomethason-ester-solvate, Verfahren zu ihrer Herstellung und Herstellung einer Formulierung
JP2004515454A (ja) 気管支肺疾患の治療のためのグルココルチコイド薬物を含有する製剤
US4933168A (en) Stable, crystalline flunisolide
PT927037E (pt) Formulacoes em aerossol de furoato de mometasona sem clorofluorocarbonetos
US4225597A (en) Beclomethasone dipropionate-hexane solvate and aerosols prepared therefrom
CA1083963A (en) Use of flunisolide to treat respiratory diseases
JPS62281817A (ja) 鼻用噴霧液
DE2831419A1 (de) Dispersion oder suspension aus lecithin oder einem sorbitan- oder sorbit-ester in treibmittel 12
KR0175164B1 (ko) 에어로졸 약물 제제
MXPA99011675A (en) Proliposome powders for inhalation stabilised by tocopherol

Legal Events

Date Code Title Description
MKEX Expiry