CA1073356A - Vaginal uvula for contraception, having a predetermined lactalbumin content - Google Patents
Vaginal uvula for contraception, having a predetermined lactalbumin contentInfo
- Publication number
- CA1073356A CA1073356A CA257,714A CA257714A CA1073356A CA 1073356 A CA1073356 A CA 1073356A CA 257714 A CA257714 A CA 257714A CA 1073356 A CA1073356 A CA 1073356A
- Authority
- CA
- Canada
- Prior art keywords
- foam
- percent
- water
- weight
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000004407 Lactalbumin Human genes 0.000 title claims abstract description 30
- 108090000942 Lactalbumin Proteins 0.000 title claims abstract description 30
- 210000002396 uvula Anatomy 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 claims abstract description 25
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 20
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 18
- 239000000829 suppository Substances 0.000 claims abstract description 18
- 239000006216 vaginal suppository Substances 0.000 claims abstract description 16
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 14
- 239000004872 foam stabilizing agent Substances 0.000 claims abstract description 14
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 14
- 239000004088 foaming agent Substances 0.000 claims abstract description 13
- 239000007787 solid Substances 0.000 claims abstract description 12
- 229940120293 vaginal suppository Drugs 0.000 claims abstract description 12
- 239000000934 spermatocidal agent Substances 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 8
- 239000000155 melt Substances 0.000 claims abstract description 8
- 239000004094 surface-active agent Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000002253 acid Substances 0.000 claims abstract description 5
- 239000012736 aqueous medium Substances 0.000 claims abstract description 5
- 230000036760 body temperature Effects 0.000 claims abstract description 5
- 239000006260 foam Substances 0.000 claims description 24
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 16
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000011975 tartaric acid Substances 0.000 claims description 12
- 235000002906 tartaric acid Nutrition 0.000 claims description 12
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 8
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims 4
- 239000004615 ingredient Substances 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract description 4
- 229940113116 polyethylene glycol 1000 Drugs 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 239000002304 perfume Substances 0.000 description 4
- 229960001407 sodium bicarbonate Drugs 0.000 description 4
- -1 advantageously Chemical compound 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000002511 suppository base Substances 0.000 description 3
- OFQCQIGMURIECL-UHFFFAOYSA-N 2-[2-(diethylamino)ethyl]-2',6'-dimethylspiro[isoquinoline-4,4'-oxane]-1,3-dione;phosphoric acid Chemical compound OP(O)(O)=O.O=C1N(CCN(CC)CC)C(=O)C2=CC=CC=C2C21CC(C)OC(C)C2 OFQCQIGMURIECL-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 241000428199 Mustelinae Species 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 101100409194 Rattus norvegicus Ppargc1b gene Proteins 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- CAMXVZOXBADHNJ-UHFFFAOYSA-N ammonium nitrite Chemical compound [NH4+].[O-]N=O CAMXVZOXBADHNJ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/14—Topical contraceptives and spermacides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/15—Suppositories
Landscapes
- Health & Medical Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762602297 DE2602297B1 (de) | 1976-01-22 | 1976-01-22 | Vaginalzaepfchen zur empfaengnisverhuetung mit einem gehalt an milchalbumin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1073356A true CA1073356A (en) | 1980-03-11 |
Family
ID=5968002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA257,714A Expired CA1073356A (en) | 1976-01-22 | 1976-07-23 | Vaginal uvula for contraception, having a predetermined lactalbumin content |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4323548A (enExample) |
| JP (1) | JPS5294415A (enExample) |
| AT (1) | AT344913B (enExample) |
| AU (1) | AU510861B2 (enExample) |
| BE (1) | BE845941A (enExample) |
| CA (1) | CA1073356A (enExample) |
| CH (1) | CH621259A5 (enExample) |
| DE (1) | DE2602297B1 (enExample) |
| DK (1) | DK147153C (enExample) |
| ES (1) | ES450235A1 (enExample) |
| FI (1) | FI63171C (enExample) |
| FR (1) | FR2338697A1 (enExample) |
| GB (1) | GB1508396A (enExample) |
| GR (1) | GR61119B (enExample) |
| IE (1) | IE43410B1 (enExample) |
| MX (1) | MX3971E (enExample) |
| NL (1) | NL7608599A (enExample) |
| NO (1) | NO145816C (enExample) |
| NZ (1) | NZ181585A (enExample) |
| PT (1) | PT65427B (enExample) |
| SE (1) | SE428344B (enExample) |
| TR (1) | TR19800A (enExample) |
| ZA (1) | ZA764397B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322399A (en) * | 1979-10-19 | 1982-03-30 | Ortho Pharmaceutical Corporation | Vaginal suppository |
| JPS58152809A (ja) * | 1982-03-05 | 1983-09-10 | Eisai Co Ltd | 安定な発泡性「膣」坐剤 |
| HU186134B (en) * | 1982-10-07 | 1985-06-28 | Andras Kovacs | Process for the production of contraceptive suppository tablets |
| US4511558A (en) * | 1983-05-16 | 1985-04-16 | University Patents, Inc. | Alpha-lactalbumin contraceptive |
| US4816257A (en) * | 1985-09-20 | 1989-03-28 | Research & Education Institute, Harbor-Ucla Medical Center Inc. | Method for producing an in vivo environment suitable for human embryo transfer |
| JPH08510923A (ja) * | 1992-06-30 | 1996-11-19 | アメリカ合衆国 | ウイルス防御バリア材の生産方法 |
| RU2129422C1 (ru) * | 1998-08-05 | 1999-04-27 | Аваков Анатолий Эдуардович | Промышленный способ изготовления суппозиториев, содержащих живые бактерии, и устройство для его осуществления |
| ATE369868T1 (de) * | 2000-06-27 | 2007-09-15 | Qualilife Pharmaceuticals Inc | Zusammensetzungen und verfahren zur behandlung der weiblichen sexuellen reaktion |
| DE10221089A1 (de) * | 2002-05-11 | 2003-11-27 | Ferdinand Schmitt | Suppositorium |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2467884A (en) * | 1944-02-02 | 1949-04-19 | Nathaniel M Elias | Spermicides |
| DE2129570C3 (de) * | 1971-06-15 | 1980-06-26 | Hermes Suesstoff Ag, Zuerich (Schweiz) | Mit Milch- oder Sojaeiweiß feuchtigkeitsstabilisierte Brausemischung |
| DE2213604C2 (de) * | 1972-03-21 | 1975-08-14 | Merz & Co, 6000 Frankfurt | Vaginalzäpfchen zur Empfängnisverhütung |
-
1976
- 1976-01-22 DE DE19762602297 patent/DE2602297B1/de active Granted
- 1976-07-20 FI FI762084A patent/FI63171C/fi not_active IP Right Cessation
- 1976-07-20 NO NO762524A patent/NO145816C/no unknown
- 1976-07-20 DK DK327176A patent/DK147153C/da not_active IP Right Cessation
- 1976-07-20 SE SE7608274A patent/SE428344B/xx unknown
- 1976-07-22 ZA ZA764397A patent/ZA764397B/xx unknown
- 1976-07-23 CA CA257,714A patent/CA1073356A/en not_active Expired
- 1976-07-26 JP JP8831776A patent/JPS5294415A/ja active Pending
- 1976-07-27 GR GR51352A patent/GR61119B/el unknown
- 1976-07-27 NZ NZ181585A patent/NZ181585A/xx unknown
- 1976-07-28 ES ES450235A patent/ES450235A1/es not_active Expired
- 1976-07-29 IE IE1692/76A patent/IE43410B1/en unknown
- 1976-07-30 GB GB31398/76A patent/GB1508396A/en not_active Expired
- 1976-07-30 PT PT65427A patent/PT65427B/pt unknown
- 1976-08-02 NL NL7608599A patent/NL7608599A/xx not_active Application Discontinuation
- 1976-08-03 CH CH965476A patent/CH621259A5/de not_active IP Right Cessation
- 1976-09-06 AU AU17473/76A patent/AU510861B2/en not_active Expired
- 1976-09-06 AT AT658976A patent/AT344913B/de not_active IP Right Cessation
- 1976-09-08 BE BE170427A patent/BE845941A/xx not_active IP Right Cessation
- 1976-09-17 FR FR7628034A patent/FR2338697A1/fr active Granted
- 1976-10-08 MX MX764967U patent/MX3971E/es unknown
-
1977
- 1977-01-10 TR TR19800A patent/TR19800A/xx unknown
-
1978
- 1978-12-22 US US05/972,228 patent/US4323548A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK147153B (da) | 1984-04-30 |
| AU510861B2 (en) | 1980-07-17 |
| DK147153C (da) | 1984-10-29 |
| ES450235A1 (es) | 1978-06-01 |
| FI63171C (fi) | 1983-05-10 |
| DE2602297C2 (enExample) | 1977-10-27 |
| NL7608599A (nl) | 1977-07-26 |
| NO145816C (no) | 1982-06-09 |
| GR61119B (en) | 1978-09-14 |
| TR19800A (tr) | 1979-12-12 |
| PT65427B (en) | 1978-02-08 |
| ATA658976A (de) | 1977-12-15 |
| AT344913B (de) | 1978-08-25 |
| NZ181585A (en) | 1978-09-20 |
| FI762084A7 (enExample) | 1977-07-23 |
| ZA764397B (en) | 1977-07-27 |
| DK327176A (da) | 1977-07-23 |
| SE7608274L (sv) | 1977-07-23 |
| PT65427A (en) | 1976-08-01 |
| IE43410L (en) | 1977-07-22 |
| SE428344B (sv) | 1983-06-27 |
| AU1747376A (en) | 1978-03-16 |
| US4323548A (en) | 1982-04-06 |
| CH621259A5 (enExample) | 1981-01-30 |
| MX3971E (es) | 1981-10-20 |
| FR2338697A1 (fr) | 1977-08-19 |
| DE2602297B1 (de) | 1977-01-13 |
| JPS5294415A (en) | 1977-08-09 |
| FI63171B (fi) | 1983-01-31 |
| IE43410B1 (en) | 1981-02-25 |
| GB1508396A (en) | 1978-04-26 |
| NO762524L (no) | 1977-07-25 |
| NO145816B (no) | 1982-03-01 |
| BE845941A (fr) | 1976-12-31 |
| FR2338697B1 (enExample) | 1978-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |