CA1055493A - Phenothiazines, phenoxazines, and acridan bis-pyrrolinyl derivatives - Google Patents

Phenothiazines, phenoxazines, and acridan bis-pyrrolinyl derivatives

Info

Publication number
CA1055493A
CA1055493A CA242,165A CA242165A CA1055493A CA 1055493 A CA1055493 A CA 1055493A CA 242165 A CA242165 A CA 242165A CA 1055493 A CA1055493 A CA 1055493A
Authority
CA
Canada
Prior art keywords
pyrrolin
acid addition
addition salt
pharmaceutically acceptable
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA242,165A
Other languages
English (en)
French (fr)
Inventor
Walter G. Lobeck (Jr.)
Yao H. Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to CA242,165A priority Critical patent/CA1055493A/en
Priority to ZA412A priority patent/ZA76412B/xx
Priority to SE7600806A priority patent/SE411756B/xx
Priority to GB336076A priority patent/GB1474364A/en
Priority to DE19762603627 priority patent/DE2603627A1/de
Priority to BE164074A priority patent/BE838243A/xx
Priority to CH133276A priority patent/CH629801A5/de
Priority to FR7602950A priority patent/FR2340091A1/fr
Priority to JP1044976A priority patent/JPS5295677A/ja
Priority to NL7601276A priority patent/NL7601276A/xx
Application granted granted Critical
Publication of CA1055493A publication Critical patent/CA1055493A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA242,165A 1975-12-19 1975-12-19 Phenothiazines, phenoxazines, and acridan bis-pyrrolinyl derivatives Expired CA1055493A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA242,165A CA1055493A (en) 1975-12-19 1975-12-19 Phenothiazines, phenoxazines, and acridan bis-pyrrolinyl derivatives
ZA412A ZA76412B (en) 1975-12-19 1976-01-26 Phenothiazines phenoxazines and acridan bis-pyrrolinyl derivatives
SE7600806A SE411756B (sv) 1975-12-19 1976-01-27 Forfarande for framstellning av fenotiaziner, fenoxaziner och akridan-bis-pyrrolinylderivat
GB336076A GB1474364A (en) 1975-12-19 1976-01-28 Amidine compounds
DE19762603627 DE2603627A1 (de) 1975-12-19 1976-01-30 Neue amidinverbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
BE164074A BE838243A (fr) 1975-12-19 1976-02-03 Nouvelles amidines, leur procede de preparation et medicament les contenant
CH133276A CH629801A5 (en) 1975-12-19 1976-02-03 Process for the preparation of bispyrrolinyl derivatives of phenothiazines, phenoxazines and acridans
FR7602950A FR2340091A1 (fr) 1975-12-19 1976-02-03 Nouvelles amidines, leur procede de preparation et medicament les contenant
JP1044976A JPS5295677A (en) 1975-12-19 1976-02-04 Phenothiazines* phenoxazines and acridane biss pyrrolinyl derivatives
NL7601276A NL7601276A (nl) 1975-12-19 1976-02-09 Werkwijze voor het bereiden van nieuwe amidine- verbindingen en dergelijke verbindingen bevat- tende farmaceutische preparaten.

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
CA242,165A CA1055493A (en) 1975-12-19 1975-12-19 Phenothiazines, phenoxazines, and acridan bis-pyrrolinyl derivatives
ZA412A ZA76412B (en) 1975-12-19 1976-01-26 Phenothiazines phenoxazines and acridan bis-pyrrolinyl derivatives
SE7600806A SE411756B (sv) 1975-12-19 1976-01-27 Forfarande for framstellning av fenotiaziner, fenoxaziner och akridan-bis-pyrrolinylderivat
GB336076A GB1474364A (en) 1975-12-19 1976-01-28 Amidine compounds
DE19762603627 DE2603627A1 (de) 1975-12-19 1976-01-30 Neue amidinverbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
BE164074A BE838243A (fr) 1975-12-19 1976-02-03 Nouvelles amidines, leur procede de preparation et medicament les contenant
CH133276A CH629801A5 (en) 1975-12-19 1976-02-03 Process for the preparation of bispyrrolinyl derivatives of phenothiazines, phenoxazines and acridans
FR7602950A FR2340091A1 (fr) 1975-12-19 1976-02-03 Nouvelles amidines, leur procede de preparation et medicament les contenant
JP1044976A JPS5295677A (en) 1975-12-19 1976-02-04 Phenothiazines* phenoxazines and acridane biss pyrrolinyl derivatives
NL7601276A NL7601276A (nl) 1975-12-19 1976-02-09 Werkwijze voor het bereiden van nieuwe amidine- verbindingen en dergelijke verbindingen bevat- tende farmaceutische preparaten.

Publications (1)

Publication Number Publication Date
CA1055493A true CA1055493A (en) 1979-05-29

Family

ID=27578993

Family Applications (1)

Application Number Title Priority Date Filing Date
CA242,165A Expired CA1055493A (en) 1975-12-19 1975-12-19 Phenothiazines, phenoxazines, and acridan bis-pyrrolinyl derivatives

Country Status (10)

Country Link
JP (1) JPS5295677A (ja)
BE (1) BE838243A (ja)
CA (1) CA1055493A (ja)
CH (1) CH629801A5 (ja)
DE (1) DE2603627A1 (ja)
FR (1) FR2340091A1 (ja)
GB (1) GB1474364A (ja)
NL (1) NL7601276A (ja)
SE (1) SE411756B (ja)
ZA (1) ZA76412B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430973A (en) * 1977-08-09 1979-03-07 Kaoru Hasegawa Production of high grade carpets with long tuft by utilizing hand hook or automatic hook machine
JPH08657U (ja) * 1992-01-14 1996-04-16 長沢 巌 簡易ガスコンロにおける残留ガスの防止装置
JPH0731992A (ja) * 1993-06-30 1995-02-03 Takara Kogyo Kk 濾 材

Also Published As

Publication number Publication date
GB1474364A (en) 1977-05-25
FR2340091B1 (ja) 1981-12-24
BE838243A (fr) 1976-08-03
JPS5295677A (en) 1977-08-11
FR2340091A1 (fr) 1977-09-02
ZA76412B (en) 1977-01-26
DE2603627A1 (de) 1977-08-11
SE411756B (sv) 1980-02-04
CH629801A5 (en) 1982-05-14
SE7600806L (sv) 1977-07-28
NL7601276A (nl) 1977-08-11

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