CA1047922A - Live influenza virus vaccines and preparation thereof - Google Patents
Live influenza virus vaccines and preparation thereofInfo
- Publication number
- CA1047922A CA1047922A CA218,508A CA218508A CA1047922A CA 1047922 A CA1047922 A CA 1047922A CA 218508 A CA218508 A CA 218508A CA 1047922 A CA1047922 A CA 1047922A
- Authority
- CA
- Canada
- Prior art keywords
- virus
- strain
- atcc
- influenza type
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960005486 vaccine Drugs 0.000 title claims description 40
- 238000002360 preparation method Methods 0.000 title description 8
- 241000712461 unidentified influenza virus Species 0.000 title description 7
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 claims abstract description 37
- 206010022000 influenza Diseases 0.000 claims abstract description 32
- 230000002238 attenuated effect Effects 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- 230000000890 antigenic effect Effects 0.000 claims abstract description 7
- 239000003550 marker Substances 0.000 claims abstract description 6
- 235000013601 eggs Nutrition 0.000 claims description 52
- 241000700605 Viruses Species 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 20
- 239000001888 Peptone Substances 0.000 claims description 19
- 108010080698 Peptones Proteins 0.000 claims description 19
- 235000019319 peptone Nutrition 0.000 claims description 19
- 241000287828 Gallus gallus Species 0.000 claims description 17
- 239000003381 stabilizer Substances 0.000 claims description 10
- 238000003306 harvesting Methods 0.000 claims description 5
- 239000000758 substrate Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 238000005215 recombination Methods 0.000 claims description 3
- 230000006798 recombination Effects 0.000 claims description 3
- 229940124873 Influenza virus vaccine Drugs 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 229960003971 influenza vaccine Drugs 0.000 abstract description 2
- 210000002966 serum Anatomy 0.000 description 33
- 239000012530 fluid Substances 0.000 description 15
- 230000035931 haemagglutination Effects 0.000 description 12
- 239000000725 suspension Substances 0.000 description 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 9
- 229930006000 Sucrose Natural products 0.000 description 9
- 238000010790 dilution Methods 0.000 description 9
- 239000012895 dilution Substances 0.000 description 9
- 239000005720 sucrose Substances 0.000 description 9
- 238000002255 vaccination Methods 0.000 description 9
- 239000011521 glass Substances 0.000 description 8
- 239000003112 inhibitor Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 241001494479 Pecora Species 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000003612 virological effect Effects 0.000 description 7
- 239000012297 crystallization seed Substances 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 239000002054 inoculum Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 101710154606 Hemagglutinin Proteins 0.000 description 5
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 5
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 5
- 101710176177 Protein A56 Proteins 0.000 description 5
- 239000000185 hemagglutinin Substances 0.000 description 5
- 230000036512 infertility Effects 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 241000282339 Mustela Species 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 210000001643 allantois Anatomy 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- ABAFKQHGFDZEJO-UHFFFAOYSA-N 4,6,6-trimethylbicyclo[3.1.1]heptane-4-carbaldehyde Chemical compound C1C2C(C)(C)C1CCC2(C)C=O ABAFKQHGFDZEJO-UHFFFAOYSA-N 0.000 description 2
- 241000271566 Aves Species 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241000218633 Pinidae Species 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000007918 pathogenicity Effects 0.000 description 2
- 238000009021 pre-vaccination Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 210000005084 renal tissue Anatomy 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000000405 serological effect Effects 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 241000353621 Eilat virus Species 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 241000713196 Influenza B virus Species 0.000 description 1
- 241000726306 Irus Species 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 241000831652 Salinivibrio sharmensis Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000027645 antigenic variation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229940031416 bivalent vaccine Drugs 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000003067 hemagglutinative effect Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 229940037525 nasal preparations Drugs 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000008024 pharmaceutical diluent Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43917674A | 1974-02-04 | 1974-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1047922A true CA1047922A (en) | 1979-02-06 |
Family
ID=23743623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA218,508A Expired CA1047922A (en) | 1974-02-04 | 1975-01-23 | Live influenza virus vaccines and preparation thereof |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS50107122A (en)) |
| AT (1) | AT338416B (en)) |
| BE (1) | BE824970A (en)) |
| CA (1) | CA1047922A (en)) |
| CH (1) | CH596316A5 (en)) |
| CS (1) | CS202545B2 (en)) |
| DD (1) | DD116474A5 (en)) |
| DE (1) | DE2504373A1 (en)) |
| DK (1) | DK141926B (en)) |
| ES (1) | ES434384A1 (en)) |
| FI (1) | FI750260A7 (en)) |
| FR (1) | FR2259616B1 (en)) |
| GB (1) | GB1439742A (en)) |
| HU (1) | HU170522B (en)) |
| IE (1) | IE42043B1 (en)) |
| IL (1) | IL46446A (en)) |
| LU (1) | LU71784A1 (en)) |
| NL (1) | NL7501028A (en)) |
| NO (1) | NO750295L (en)) |
| SE (1) | SE424503B (en)) |
| ZA (1) | ZA75248B (en)) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2588918A (en) * | 1947-11-07 | 1952-03-11 | William T Graham | Mechanism for raising and lowering plow frames relative to the ground wheels |
| JPS6042209B2 (ja) * | 1974-05-31 | 1985-09-20 | 北里研究所（社団法人） | インフルエンザウイルスの新鮮分離株を発育鶏卵へ短期間で順化させる方法 |
-
1975
- 1975-01-14 ZA ZA00750248A patent/ZA75248B/xx unknown
- 1975-01-16 IL IL46446A patent/IL46446A/xx unknown
- 1975-01-16 DK DK9775AA patent/DK141926B/da not_active IP Right Cessation
- 1975-01-20 SE SE7500549A patent/SE424503B/xx unknown
- 1975-01-23 CA CA218,508A patent/CA1047922A/en not_active Expired
- 1975-01-24 FR FR7502331A patent/FR2259616B1/fr not_active Expired
- 1975-01-27 IE IE160/75A patent/IE42043B1/en unknown
- 1975-01-29 NL NL7501028A patent/NL7501028A/xx not_active Application Discontinuation
- 1975-01-30 BE BE152864A patent/BE824970A/xx not_active IP Right Cessation
- 1975-01-30 NO NO750295A patent/NO750295L/no unknown
- 1975-01-31 FI FI750260A patent/FI750260A7/fi not_active Application Discontinuation
- 1975-02-01 ES ES434384A patent/ES434384A1/es not_active Expired
- 1975-02-03 GB GB453575A patent/GB1439742A/en not_active Expired
- 1975-02-03 AT AT76675A patent/AT338416B/de not_active IP Right Cessation
- 1975-02-03 DD DD183973A patent/DD116474A5/xx unknown
- 1975-02-03 CH CH124275A patent/CH596316A5/xx not_active IP Right Cessation
- 1975-02-03 JP JP50014790A patent/JPS50107122A/ja active Pending
- 1975-02-03 HU HUTE805A patent/HU170522B/hu unknown
- 1975-02-03 DE DE19752504373 patent/DE2504373A1/de not_active Withdrawn
- 1975-02-03 CS CS75669A patent/CS202545B2/cs unknown
- 1975-02-03 LU LU71784A patent/LU71784A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE424503B (sv) | 1982-07-26 |
| ATA76675A (de) | 1976-12-15 |
| LU71784A1 (en)) | 1975-06-24 |
| DK9775A (en)) | 1975-09-29 |
| HU170522B (en)) | 1977-06-28 |
| NL7501028A (nl) | 1975-08-06 |
| NO750295L (en)) | 1975-09-01 |
| DD116474A5 (en)) | 1975-11-20 |
| CH596316A5 (en)) | 1978-03-15 |
| FR2259616B1 (en)) | 1980-01-04 |
| FR2259616A1 (en)) | 1975-08-29 |
| CS202545B2 (en) | 1981-01-30 |
| GB1439742A (en) | 1976-06-16 |
| ES434384A1 (es) | 1976-12-01 |
| ZA75248B (en) | 1976-01-28 |
| AT338416B (de) | 1977-08-25 |
| IE42043B1 (en) | 1980-05-21 |
| DE2504373A1 (de) | 1975-08-07 |
| JPS50107122A (en)) | 1975-08-23 |
| BE824970A (fr) | 1975-07-30 |
| DK141926B (da) | 1980-07-21 |
| SE7500549L (en)) | 1975-08-05 |
| FI750260A7 (en)) | 1975-08-05 |
| AU7734675A (en) | 1976-07-15 |
| DK141926C (en)) | 1981-01-19 |
| IL46446A (en) | 1978-01-31 |
| IL46446A0 (en) | 1975-04-25 |
| IE42043L (en) | 1975-08-04 |
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