CA1039283A - 2' -trifluoromethyl cinchonine and cinchonidine derivatives - Google Patents
2' -trifluoromethyl cinchonine and cinchonidine derivativesInfo
- Publication number
- CA1039283A CA1039283A CA215,292A CA215292A CA1039283A CA 1039283 A CA1039283 A CA 1039283A CA 215292 A CA215292 A CA 215292A CA 1039283 A CA1039283 A CA 1039283A
- Authority
- CA
- Canada
- Prior art keywords
- trifluoromethyl
- bis
- ethyl
- mixture
- racemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42264573A | 1973-12-07 | 1973-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1039283A true CA1039283A (en) | 1978-09-26 |
Family
ID=23675777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA215,292A Expired CA1039283A (en) | 1973-12-07 | 1974-12-05 | 2' -trifluoromethyl cinchonine and cinchonidine derivatives |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5088076A (enExample) |
| AT (2) | AT339310B (enExample) |
| BE (1) | BE823023A (enExample) |
| BR (1) | BR7410249A (enExample) |
| CA (1) | CA1039283A (enExample) |
| CH (1) | CH605916A5 (enExample) |
| DE (1) | DE2458146A1 (enExample) |
| DK (1) | DK141700B (enExample) |
| FR (1) | FR2292476A1 (enExample) |
| GB (1) | GB1441519A (enExample) |
| IL (1) | IL46181A (enExample) |
| KE (1) | KE2718A (enExample) |
| MY (1) | MY7700239A (enExample) |
| NL (1) | NL7415931A (enExample) |
| PH (1) | PH10837A (enExample) |
| SE (1) | SE415100B (enExample) |
| ZA (1) | ZA747664B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2381044A1 (fr) * | 1977-02-17 | 1978-09-15 | Hoffmann La Roche | Procede pour la preparation de mefloquine |
| HU191508B (en) * | 1982-12-02 | 1987-02-27 | Alkaloida Vegyeszeti Gyar,Hu | Process for preparing new chloromethyl-quinoline derivatives |
| WO1999012532A2 (en) * | 1997-09-08 | 1999-03-18 | F.Hoffmann-La Roche Ag | Piperidine derivatives against malaria |
| JP2002360830A (ja) * | 2001-06-04 | 2002-12-17 | Heiwa Corp | 球貯蔵入賞装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1217427A (en) * | 1967-12-21 | 1970-12-31 | America Home Products Corp | Cinchona alkaloid derivatives |
| CH590274A5 (enExample) * | 1970-03-16 | 1977-07-29 | Hoffmann La Roche | |
| IL38492A (en) * | 1971-01-07 | 1975-08-31 | Sparamedica Ag | Quinoline derivatives,their preparation and pharmaceutical compositions containing them |
-
1974
- 1974-11-30 CH CH1586274A patent/CH605916A5/xx not_active IP Right Cessation
- 1974-12-02 PH PH16586A patent/PH10837A/en unknown
- 1974-12-02 ZA ZA00747664A patent/ZA747664B/xx unknown
- 1974-12-03 SE SE7415160A patent/SE415100B/xx unknown
- 1974-12-04 IL IL46181A patent/IL46181A/xx unknown
- 1974-12-05 CA CA215,292A patent/CA1039283A/en not_active Expired
- 1974-12-05 FR FR7439824A patent/FR2292476A1/fr active Granted
- 1974-12-06 AT AT977974A patent/AT339310B/de not_active IP Right Cessation
- 1974-12-06 NL NL7415931A patent/NL7415931A/xx not_active Application Discontinuation
- 1974-12-06 GB GB5284374A patent/GB1441519A/en not_active Expired
- 1974-12-06 BE BE151217A patent/BE823023A/xx unknown
- 1974-12-06 DK DK637674AA patent/DK141700B/da unknown
- 1974-12-06 BR BR10249/74A patent/BR7410249A/pt unknown
- 1974-12-06 JP JP49140423A patent/JPS5088076A/ja active Pending
- 1974-12-09 DE DE19742458146 patent/DE2458146A1/de not_active Withdrawn
-
1977
- 1977-01-18 AT AT24577A patent/AT353792B/de not_active IP Right Cessation
- 1977-03-30 KE KE2718A patent/KE2718A/xx unknown
- 1977-12-30 MY MY239/77A patent/MY7700239A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK141700B (da) | 1980-05-27 |
| ATA24577A (de) | 1979-05-15 |
| BR7410249A (pt) | 1976-06-29 |
| ZA747664B (en) | 1976-01-28 |
| BE823023A (fr) | 1975-06-06 |
| NL7415931A (nl) | 1975-06-10 |
| IL46181A0 (en) | 1975-03-13 |
| PH10837A (en) | 1977-09-09 |
| KE2718A (en) | 1977-07-15 |
| MY7700239A (en) | 1977-12-31 |
| AT353792B (de) | 1979-12-10 |
| SE7415160L (enExample) | 1975-06-09 |
| SE415100B (sv) | 1980-09-08 |
| FR2292476B1 (enExample) | 1979-05-18 |
| AU7559274A (en) | 1976-05-27 |
| JPS5088076A (enExample) | 1975-07-15 |
| IL46181A (en) | 1978-03-10 |
| DK637674A (enExample) | 1975-07-28 |
| DK141700C (enExample) | 1980-12-08 |
| DE2458146A1 (de) | 1975-06-12 |
| CH605916A5 (enExample) | 1978-10-13 |
| FR2292476A1 (fr) | 1976-06-25 |
| GB1441519A (en) | 1976-07-07 |
| ATA977974A (de) | 1977-02-15 |
| AT339310B (de) | 1977-10-10 |
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