CA1030538A - Derive de la n-(trimethoxy-3,4,5 cynnamoyl) piperazine, ses sels d'addition d'acides, son procede de preparation et son application en therapeutique - Google Patents

Derive de la n-(trimethoxy-3,4,5 cynnamoyl) piperazine, ses sels d'addition d'acides, son procede de preparation et son application en therapeutique

Info

Publication number
CA1030538A
CA1030538A CA231,613A CA231613A CA1030538A CA 1030538 A CA1030538 A CA 1030538A CA 231613 A CA231613 A CA 231613A CA 1030538 A CA1030538 A CA 1030538A
Authority
CA
Canada
Prior art keywords
formule
cinnamoyl
pipérazine
triméthoxy
pyrrolidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA231,613A
Other languages
English (en)
Inventor
Patrick Guerret
Michel Turin
Guy Raynaud
Bernard Pourrias
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Application granted granted Critical
Publication of CA1030538A publication Critical patent/CA1030538A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Abstract

PRECIS DE LA DIVULGATION:
.
La présente invention se rapporte à un procédé de pré-paration d'un nouveau dérivé de la N-(triméthoxy-3,4,5 cinnamoyl) pipérazine de formule (I) :

(I) et ses sels d'addition avec les acides pharmaceutiquement accep-tables, caractérisé en ce que l'on condense la N-(triméthoxy-3,4,5 cinnamoyl) pipérazine de formule (II) :

(II) avec le N-(pyrrolidinone-2) chloracétamide de iormule (III) :
CA231,613A 1974-07-17 1975-07-16 Derive de la n-(trimethoxy-3,4,5 cynnamoyl) piperazine, ses sels d'addition d'acides, son procede de preparation et son application en therapeutique Expired CA1030538A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7424831A FR2278340A1 (fr) 1974-07-17 1974-07-17 Nouveau derive de la n-(trimethoxy-3,4,5 cinnamoyl) piperazine, ses sels d'addition d'acides, son procede de preparation et son application en therapeutique

Publications (1)

Publication Number Publication Date
CA1030538A true CA1030538A (fr) 1978-05-02

Family

ID=9141387

Family Applications (1)

Application Number Title Priority Date Filing Date
CA231,613A Expired CA1030538A (fr) 1974-07-17 1975-07-16 Derive de la n-(trimethoxy-3,4,5 cynnamoyl) piperazine, ses sels d'addition d'acides, son procede de preparation et son application en therapeutique

Country Status (15)

Country Link
US (1) US4016154A (fr)
JP (1) JPS5134177A (fr)
BE (1) BE830874A (fr)
CA (1) CA1030538A (fr)
CH (1) CH593966A5 (fr)
DE (1) DE2531829C2 (fr)
ES (1) ES439291A1 (fr)
FR (1) FR2278340A1 (fr)
GB (1) GB1452878A (fr)
IT (1) IT1044530B (fr)
LU (1) LU72983A1 (fr)
NL (1) NL7508530A (fr)
SE (1) SE417428B (fr)
SU (1) SU569289A3 (fr)
ZA (1) ZA754268B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387971A1 (fr) * 1977-04-19 1978-11-17 Delalande Sa Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
FR2460942A1 (fr) * 1979-07-12 1981-01-30 Delalande Sa Nouveaux derives de l'acide a-amino butyrique, leur procede de preparation et leur application en therapeutique
US4368199A (en) * 1980-01-21 1983-01-11 Delalande S.A. Novel derivatives of 3,4,5-trimethoxy cinnamoyl piperazine, their salts, the process for preparing the same and their application in therapeutics
JPS5888370A (ja) * 1981-11-19 1983-05-26 Hokuriku Seiyaku Co Ltd １−（３，４，５−トリメトキシシンナモイル）−４−アミノカルボニルエチル置換ピペラジン及びホモピペラジン誘導体、及びその製造方法
ES8302692A1 (es) * 1982-03-24 1983-02-01 Prodes Sa "procedimiento para la obtencion de n-(2-oxo-1-pirrolidinil)acetil piperazinas sustituidas".
FR2552762B1 (fr) * 1983-09-30 1986-07-25 Delalande Sa Nouveaux amides piperaziniques et homopiperaziniques derives de l'acide 3,4-dioxymethylene cinnamique, leur procede de preparation et leur application en therapeutique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1218591A (en) * 1968-04-03 1971-01-06 Delalande Sa Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation
BE754642A (fr) * 1969-08-11 1971-02-10 Geigy Ag J R Derives de l'imidazolidinone et medicaments contenant de tels derives
BE754640A (fr) * 1969-08-11 1971-02-10 Geigy Ag J R Derives de l'imidazolidinone et medicaments contenant de tels derives
GB1391007A (en) * 1971-06-17 1975-04-16 Ciba Geigy Ag Imidazolidinone derivatives and processes for the production thereof
US3784545A (en) * 1972-05-31 1974-01-08 Abbott Lab 1-(5-phenyl-4-oxo-2-oxazolin-2-yl)-4-cinnamoylpiperazines
US3806510A (en) * 1972-09-18 1974-04-23 Parke Davis & Co 4(orthoalkylthio phenyl)piperazin-1-yl hydantoins

Also Published As

Publication number Publication date
SE7508153L (sv) 1976-01-19
JPS5134177A (en) 1976-03-23
LU72983A1 (fr) 1976-05-31
ES439291A1 (es) 1977-02-16
FR2278340A1 (fr) 1976-02-13
SE417428B (sv) 1981-03-16
BE830874A (fr) 1976-01-02
NL7508530A (nl) 1976-01-20
DE2531829A1 (de) 1976-02-05
DE2531829C2 (de) 1985-12-12
SU569289A3 (ru) 1977-08-15
ZA754268B (en) 1976-06-30
FR2278340B1 (fr) 1978-07-21
CH593966A5 (fr) 1977-12-30
IT1044530B (it) 1980-03-31
JPS61337B2 (fr) 1986-01-08
GB1452878A (en) 1976-10-20
US4016154A (en) 1977-04-05
AU8308075A (en) 1977-01-20

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