CA1014947A - Steroids of the pregnane series having anaesthetic activity - Google Patents

Steroids of the pregnane series having anaesthetic activity

Info

Publication number
CA1014947A
CA1014947A CA171,026A CA171026A CA1014947A CA 1014947 A CA1014947 A CA 1014947A CA 171026 A CA171026 A CA 171026A CA 1014947 A CA1014947 A CA 1014947A
Authority
CA
Canada
Prior art keywords
steroids
pregnane series
anaesthetic activity
anaesthetic
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA171,026A
Other languages
English (en)
Other versions
CA171026S (en
Inventor
Barry E. Ayres
Leslie Stephenson
Robin Lawrence
Gordon H. Phillipps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Application granted granted Critical
Publication of CA1014947A publication Critical patent/CA1014947A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA171,026A 1972-05-12 1973-05-11 Steroids of the pregnane series having anaesthetic activity Expired CA1014947A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2248972A GB1436324A (en) 1972-05-12 1972-05-12 Anaesthetic 3alpha-hydroxy pregnanes

Publications (1)

Publication Number Publication Date
CA1014947A true CA1014947A (en) 1977-08-02

Family

ID=10180241

Family Applications (1)

Application Number Title Priority Date Filing Date
CA171,026A Expired CA1014947A (en) 1972-05-12 1973-05-11 Steroids of the pregnane series having anaesthetic activity

Country Status (13)

Country Link
US (1) US3998829A (ja)
JP (1) JPS4948652A (ja)
AU (1) AU474687B2 (ja)
BE (1) BE799433A (ja)
CA (1) CA1014947A (ja)
DE (1) DE2323950A1 (ja)
DK (1) DK135775B (ja)
FR (1) FR2184711B1 (ja)
GB (1) GB1436324A (ja)
IE (1) IE38863B1 (ja)
LU (1) LU67585A1 (ja)
NL (1) NL7306606A (ja)
ZA (1) ZA733218B (ja)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613463A (en) * 1984-11-01 1986-09-23 The Upjohn Company Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid
US5099019A (en) * 1985-09-12 1992-03-24 Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
USRE35053E (en) * 1985-09-12 1995-10-10 The Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5380839A (en) * 1985-09-12 1995-01-10 The Upjohn Company Phenylpiperazinyl steroids
US5232917A (en) * 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
JPH072555Y2 (ja) * 1991-06-03 1995-01-25 日野自動車工業株式会社 車輛の前後方向兼用ウインチ
CZ394197A3 (cs) * 1995-06-06 1998-06-17 Cocensys, Inc. Neuroaktivní steroidy androstanové a pregnanové řady
US6780853B1 (en) 1995-06-06 2004-08-24 Euro-Celtique S.A. Neuroactive steroids of the androstane and pregnane series
US6143737A (en) * 1995-06-23 2000-11-07 Georgetown University Progesterone analogs to reverse multidrug resistance
WO2000066614A1 (en) * 1999-04-29 2000-11-09 Purdue Pharma Ltd. 3α-HYDROXY-3β METHOXYMETHYL-21-HETEROCYCLE SUBSTITUTED STEROIDS WITH ANESTHETIC ACTIVITY
US20050101581A1 (en) * 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
CN108976272B (zh) 2011-10-14 2021-05-25 萨奇治疗股份有限公司 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
ES2807264T3 (es) 2013-04-17 2021-02-22 Sage Therapeutics Inc Esteroides neuroactivos 19-nor para métodos de tratamiento
HUE041369T2 (hu) 2013-04-17 2019-05-28 Sage Therapeutics Inc 19-nor C3,3-diszubsztituált C21-N-pirazolil-szteroidok és eljárás ezek alkalmazására
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
CA3199003A1 (en) 2013-07-19 2015-01-22 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
CA3235088A1 (en) 2013-08-23 2015-02-26 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
MX2017005002A (es) 2014-10-16 2018-01-23 Sage Therapeutics Inc Composiciones y metodos para el tratamiento de trastornos del snc.
US20170233433A1 (en) 2014-10-16 2017-08-17 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP3719029A1 (en) 2014-11-27 2020-10-07 Sage Therapeutics, Inc. Compositions for inducing sedation
RS61530B1 (sr) 2015-01-26 2021-04-29 Sage Therapeutics Inc Kompozicije i postupci za lečenje poremećaja cns
DK3258939T3 (da) 2015-02-20 2022-12-12 Sage Therapeutics Inc Neuroaktive steroider, sammensætninger og anvendelser heraf
IL309259A (en) 2016-07-11 2024-02-01 Sage Therapeutics Inc C17, C20 and C21 converted neuroactive steroids and methods of using them
JP7065825B2 (ja) 2016-07-11 2022-05-12 セージ セラピューティクス， インコーポレイテッド Ｃ７、ｃ１２、およびｃ１６置換神経刺激性ステロイドおよびそれらの使用方法
MA56046A (fr) 2019-05-31 2022-04-06 Sage Therapeutics Inc Stéroïdes neuroactifs et compositions associées

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1107662B (de) * 1959-07-04 1961-05-31 Merck Ag E Verfahren zur Herstellung von Mannichbasen von Steroiden bzw. von deren Saeureadditionssalzen
US3042691A (en) * 1960-05-11 1962-07-03 Pfizer & Co C 5alpha,21-dibromo-6beta-fluoro-21-methyl-pregnanes and process for making same
FR1764M (fr) * 1962-02-20 1963-04-08 Roussel Uclaf Nouveau médicament notamment pour le traitement des spasmes d'origine coronarienne ou viscérale.
US3201425A (en) * 1963-12-10 1965-08-17 American Cyanamid Co 20-alkoxy-delta20-21-carboxaldehydes of the pregnane series and method of preparing the same
GB1089945A (en) * 1965-09-23 1967-11-08 British Drug Houses Ltd Steroidal-6-spirocyclopropyl-4-en-3-ones
GB1317184A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Steroid-containing pharmaceutical preparations
DE1941226A1 (de) * 1969-08-13 1971-02-18 Degussa Basisch substituierte Ketosteroide
US3661940A (en) * 1970-04-13 1972-05-09 Sandoz Ag Derivatives of 21-methyl-19-norpregnanes
GB1377609A (en) * 1970-12-17 1974-12-18 Glaxo Lab Ltd 3alpha-hydroxy-5alpha-pregnane compounds
GB1416427A (en) * 1972-01-12 1975-12-03 Akzo Nv Alkylated pregnanes and process for obtaining same

Also Published As

Publication number Publication date
FR2184711A1 (ja) 1973-12-28
IE38863L (en) 1973-11-12
BE799433A (fr) 1973-11-12
AU5561673A (en) 1974-11-14
IE38863B1 (en) 1978-06-21
JPS4948652A (ja) 1974-05-11
GB1436324A (en) 1976-05-19
LU67585A1 (ja) 1973-07-24
DE2323950A1 (de) 1973-12-13
NL7306606A (ja) 1973-11-14
FR2184711B1 (ja) 1977-01-07
DK135775B (da) 1977-06-20
DK135775C (ja) 1977-11-21
AU474687B2 (en) 1976-07-29
ZA733218B (en) 1974-05-29
US3998829A (en) 1976-12-21

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