CA1014154A - 3-(2-(4-phenyl-1-piperazinyl)ethyl)indolines - Google Patents

3-(2-(4-phenyl-1-piperazinyl)ethyl)indolines

Info

Publication number
CA1014154A
CA1014154A CA140,989A CA140989A CA1014154A CA 1014154 A CA1014154 A CA 1014154A CA 140989 A CA140989 A CA 140989A CA 1014154 A CA1014154 A CA 1014154A
Authority
CA
Canada
Prior art keywords
indolines
piperazinyl
phenyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA140,989A
Other languages
English (en)
Other versions
CA140989S (en
Inventor
Vern G. Devries
Francis J. Mcevoy
George R. Allen (Jr.)
Daniel B. Moran
Ruddy Littell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to CA276,961A priority Critical patent/CA1056821A/fr
Application granted granted Critical
Publication of CA1014154A publication Critical patent/CA1014154A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA140,989A 1971-05-27 1972-05-01 3-(2-(4-phenyl-1-piperazinyl)ethyl)indolines Expired CA1014154A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA276,961A CA1056821A (fr) 1971-05-27 1977-04-26 Derives de l'indoline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14770071A 1971-05-27 1971-05-27

Publications (1)

Publication Number Publication Date
CA1014154A true CA1014154A (en) 1977-07-19

Family

ID=22522572

Family Applications (1)

Application Number Title Priority Date Filing Date
CA140,989A Expired CA1014154A (en) 1971-05-27 1972-05-01 3-(2-(4-phenyl-1-piperazinyl)ethyl)indolines

Country Status (20)

Country Link
US (1) US3751416A (fr)
AR (4) AR194595A1 (fr)
BE (1) BE784012A (fr)
BG (5) BG18866A3 (fr)
CA (1) CA1014154A (fr)
CH (5) CH583701A5 (fr)
CS (3) CS185203B2 (fr)
DD (1) DD100471A5 (fr)
DE (1) DE2225765A1 (fr)
ES (4) ES403245A1 (fr)
FR (1) FR2139158B1 (fr)
GB (2) GB1382916A (fr)
HU (3) HU166178B (fr)
NL (1) NL7207129A (fr)
NO (1) NO136795C (fr)
PL (4) PL92627B1 (fr)
RO (4) RO63715A (fr)
SE (4) SE397525B (fr)
SU (4) SU489322A3 (fr)
ZA (1) ZA722916B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888860A (en) * 1974-01-07 1975-06-10 Colgate Palmolive Co 3-(2-(4-thienoylpiperazin-1-yl)ethyl)indoles
US4089853A (en) * 1977-02-09 1978-05-16 American Cyanamid Company Process for the preparation of cis-5,6-dimethoxy-2-methyl-3-[2-(4-phenyl-1-piperazinyl)-ethyl]indoline
FR2421900A1 (fr) * 1977-03-17 1979-11-02 Sauba Lab Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques
GR65270B (en) 1978-10-10 1980-07-31 Fujisawa Pharmaceutical Co Isatin derivatives and processes for the preparation thereof
US4224330A (en) * 1979-09-13 1980-09-23 Zoecon Corporation Esters and thiolesters of benzothienyl acids
US4411900A (en) * 1980-01-03 1983-10-25 Fujisawa Pharmaceutical Co., Ltd. Benzhydrylpiperozinyl thiazole derivatives and pharmaceutical composition comprising the same
US4302589A (en) * 1980-05-08 1981-11-24 American Cyanamid Company Cis-mono and disubstituted-2-methyl-3-[(piperazinyl) and (piperidino)ethyl]indolines, intermediates for their preparation and methods of preparation
CA1248531A (fr) * 1984-04-17 1989-01-10 Jeffrey C. Watkins Derives de substitution en 4 d'acides piperazine-2- carboxyliques
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤

Also Published As

Publication number Publication date
HU167203B (fr) 1975-09-27
ES409284A1 (es) 1976-03-16
CH582142A5 (fr) 1976-11-30
AR194595A1 (es) 1973-07-31
SU489321A3 (ru) 1975-10-25
DE2225765A1 (de) 1972-12-07
ES409282A1 (es) 1976-03-16
HU168720B (fr) 1976-07-28
NO136795B (no) 1977-08-01
FR2139158B1 (fr) 1975-10-17
GB1382917A (en) 1975-02-05
SU488408A3 (ru) 1975-10-15
SE395455B (sv) 1977-08-15
ES409281A1 (es) 1976-03-16
PL92634B1 (fr) 1977-04-30
SU575024A3 (ru) 1977-09-30
RO60145A (fr) 1976-09-15
RO63715A (fr) 1978-10-15
CS185245B2 (en) 1978-09-15
CH579563A5 (fr) 1976-09-15
CH583701A5 (fr) 1977-01-14
NL7207129A (fr) 1972-11-29
SE397525B (sv) 1977-11-07
CH582172A5 (fr) 1976-11-30
GB1382916A (en) 1975-02-05
BG19594A3 (bg) 1975-06-25
AR210562A1 (es) 1977-08-31
BE784012A (fr) 1972-11-27
FR2139158A1 (fr) 1973-01-05
PL81987B1 (fr) 1975-10-31
RO64489A (fr) 1979-05-15
AR208647A1 (es) 1977-02-28
AR208646A1 (es) 1977-02-28
ES403245A1 (es) 1975-04-16
CH583700A5 (fr) 1977-01-14
NO136795C (no) 1977-11-09
SU489322A3 (ru) 1975-10-25
PL92627B1 (fr) 1977-04-30
SE397524B (sv) 1977-11-07
US3751416A (en) 1973-08-07
SE7600531L (sv) 1976-01-20
HU166178B (fr) 1975-02-28
BG20791A3 (fr) 1975-12-20
DD100471A5 (fr) 1973-09-20
CS185203B2 (en) 1978-09-15
ZA722916B (en) 1973-02-28
BG19151A3 (bg) 1975-04-30
CS185244B2 (en) 1978-09-15
AU4191872A (en) 1973-11-08
BG18866A3 (bg) 1975-03-20
BG19593A3 (bg) 1975-06-25
PL92635B1 (fr) 1977-04-30
RO63730A (fr) 1978-11-15

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