BRPI1015943A2 - derivados de 1,2,3,4-tetra - hidro - pirimido [1,2-a] pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica. - Google Patents

derivados de 1,2,3,4-tetra - hidro - pirimido [1,2-a] pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica.

Info

Publication number
BRPI1015943A2
BRPI1015943A2 BRPI1015943A BRPI1015943A BRPI1015943A2 BR PI1015943 A2 BRPI1015943 A2 BR PI1015943A2 BR PI1015943 A BRPI1015943 A BR PI1015943A BR PI1015943 A BRPI1015943 A BR PI1015943A BR PI1015943 A2 BRPI1015943 A2 BR PI1015943A2
Authority
BR
Brazil
Prior art keywords
pyrimido
pyrimidin
tetrahydro
derivatives
preparation
Prior art date
Application number
BRPI1015943A
Other languages
English (en)
Inventor
André Zimmermann
Annie Clauss
Baptiste Ronan
Bertrand Schio
Bruno Filoche-Romme
Eric Bacque
Fabrice Viviani
Frank Halley
Gilbert Marciniak
Karl Andreas Karlsson
Laurent Schio
Maurice Brollo
Youssef El Ahmad
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0903237A external-priority patent/FR2947551B1/fr
Priority claimed from FR0957069A external-priority patent/FR2951174B1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BRPI1015943A2 publication Critical patent/BRPI1015943A2/pt
Publication of BRPI1015943A8 publication Critical patent/BRPI1015943A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
BRPI1015943A 2009-07-02 2010-07-01 derivados de 1,2,3,4-tetra - hidro - pirimido {1,2-a} pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica. BRPI1015943A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0903237A FR2947551B1 (fr) 2009-07-02 2009-07-02 Nouveaux derives de 1,2,3,4-tetrahydro-pyrimido{1,2-a)pyrimidin-6-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt (pkb)
US24109809P 2009-09-10 2009-09-10
FR0957069A FR2951174B1 (fr) 2009-10-09 2009-10-09 Nouveaux derives de 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
PCT/FR2010/051374 WO2011001113A2 (fr) 2009-07-02 2010-07-01 NOUVEAUX DERIVES DE 1,2,3,4-TETRAHYDRO-PYRIMIDO{1,2-a}PYRIMIDIN-6-ONE,LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE

Publications (2)

Publication Number Publication Date
BRPI1015943A2 true BRPI1015943A2 (pt) 2016-04-19
BRPI1015943A8 BRPI1015943A8 (pt) 2018-01-09

Family

ID=43234240

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015943A BRPI1015943A8 (pt) 2009-07-02 2010-07-01 derivados de 1,2,3,4-tetra - hidro - pirimido {1,2-a} pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica.

Country Status (24)

Country Link
US (1) US8846670B2 (pt)
EP (1) EP2448940B1 (pt)
JP (1) JP5655070B2 (pt)
KR (1) KR20120103553A (pt)
CN (1) CN102482286B (pt)
AR (1) AR077363A1 (pt)
AU (1) AU2010267815B2 (pt)
BR (1) BRPI1015943A8 (pt)
CA (1) CA2766909C (pt)
DK (1) DK2448940T3 (pt)
ES (1) ES2487623T3 (pt)
HK (1) HK1169388A1 (pt)
HR (1) HRP20140786T1 (pt)
IL (1) IL217293A (pt)
MX (1) MX2012000103A (pt)
MY (1) MY155661A (pt)
PL (1) PL2448940T3 (pt)
PT (1) PT2448940E (pt)
RU (1) RU2561130C2 (pt)
SG (2) SG177464A1 (pt)
SI (1) SI2448940T1 (pt)
TW (1) TWI455940B (pt)
UY (1) UY32754A (pt)
WO (1) WO2011001113A2 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2969613B1 (fr) * 2010-12-23 2013-02-08 Sanofi Aventis Nouveaux derives de 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one, leur preparation et leur utilisation pharmaceutique
DK2655375T3 (en) * 2010-12-23 2015-03-09 Sanofi Sa PYRIMIDINON DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF
PT2790705T (pt) 2011-12-15 2018-01-24 Novartis Ag Utilização de inibidores da atividade ou função de pi3k
FR2992316A1 (fr) * 2012-06-22 2013-12-27 Sanofi Sa Derives de pyrimidinones, leur preparation et leur application en therapeutique
FR2992314B1 (fr) 2012-06-22 2015-10-16 Sanofi Sa Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique
US20180214452A1 (en) 2015-03-06 2018-08-02 Korea Advanced Institute Of Science And Technology COMPOSITION FOR PREVENTION OR TREATMENT OF INTRACTABLE EPILEPSY COMPRISING mTOR INHIBITOR
RS60900B1 (sr) 2016-02-19 2020-11-30 Sprint Bioscience Ab Jedinjenja 6-heterociklil-4-morfolin-4-ilpiridin-2-ona korisna za lečenje kancera i dijabetesa
SI3416945T1 (sl) 2016-02-19 2020-11-30 Sprint Bioscience Ab Spojine 6-aril-4-(morfolin-4-IL)-1H-piridin-2-ona, uporabne za zdravljenje raka in diabetesa
AU2021264512A1 (en) * 2020-04-27 2022-11-17 Aruna Bio, Inc. Binding agents and uses thereof for central nervous system delivery

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2703712A1 (de) * 1977-01-29 1978-08-03 Bayer Ag Substituierte pyrimidinon eckige klammer auf (di)-thio eckige klammer zu -phosphor-(phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
AU3042601A (en) 2000-01-24 2001-07-31 Thrombogenix Pty Ltd Therapeutic morpholino-substituted compounds
JP2004507546A (ja) * 2000-09-01 2004-03-11 サノフィ−サンテラボ ２−ピリジニル−６，７，８，９−テトラヒドロピリミド［１，２−ａ］ピリミジン−４−オンおよび７−ピリジニル−２，３−ジヒドロイミダゾ［１，２−ａ］ピリミジン−５（１Ｈ）−オン誘導体
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
ES2247398T3 (es) * 2001-09-21 2006-03-01 Sanofi-Aventis Derivados de 2-piridini9l-6,7,8,9-tetrahidropirimido(1,2-a)pirimidin-4-ona y 7-piridinil-2,3-dihidroimidazo(1,2-a)pirimidin-5(1h)ona sustituidos.
EP1340761A1 (en) 2002-02-28 2003-09-03 Sanofi-Synthelabo Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
AU2003221500B9 (en) * 2002-02-28 2008-11-20 Mitsubishi Pharma Corporation Heteroaryl substituted 2-pyridinyl and 2-pyrimidinyl -6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives
WO2004016607A1 (en) 2002-08-16 2004-02-26 Kinacia Pty Ltd. Inhibition of phosphoinositide 3-kinase beta
AU2003292436B2 (en) * 2002-12-27 2009-07-30 Msd Italia S.R.L. Tetrahydro-4H-pyrido[1,2-A]pyrimidines and related compounds useful as HIV integrase inhibitors
EP1454909B1 (en) 2003-03-07 2008-08-20 Sanofi Aventis 8'-pyridinyl-dihydrospiro (cycloalkyl) -pyrimido (1,2-a) pyrimidin-6-one and 8'-pyrimidinyl-dihydrospiro (cycloalkyl) pyrimido (1,2-a) pyrimidin-6 derivatives -one and their use against neurodegenerative diseases
EP1460076A1 (en) 2003-03-21 2004-09-22 Sanofi-Synthelabo Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives
EP1557417B1 (en) 2003-12-19 2007-03-07 Sanofi-Aventis Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives
AR054438A1 (es) 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
EP1895997A2 (en) * 2005-05-26 2008-03-12 Kudos Pharmaceuticals Ltd Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies
WO2008064244A2 (en) 2006-11-20 2008-05-29 The Trustees Of Columbia University In The City Of New York Phosphoinositide modulation for the treatment of neurodegenerative diseases
WO2008148074A2 (en) * 2007-05-24 2008-12-04 Research Foundation Of State University Of New York Inhibitors of mtor and methods of treatment using same

Also Published As

Publication number Publication date
SG177464A1 (en) 2012-02-28
HRP20140786T1 (hr) 2014-11-07
RU2561130C2 (ru) 2015-08-20
WO2011001113A3 (fr) 2011-02-24
SG10201403149YA (en) 2014-08-28
WO2011001113A2 (fr) 2011-01-06
ES2487623T3 (es) 2014-08-22
JP5655070B2 (ja) 2015-01-14
RU2012103477A (ru) 2013-08-10
PL2448940T3 (pl) 2014-10-31
EP2448940A2 (fr) 2012-05-09
BRPI1015943A8 (pt) 2018-01-09
AR077363A1 (es) 2011-08-24
UY32754A (es) 2011-01-31
SI2448940T1 (sl) 2014-10-30
DK2448940T3 (da) 2014-08-25
EP2448940B1 (fr) 2014-05-21
PT2448940E (pt) 2014-09-03
HK1169388A1 (en) 2013-01-25
CN102482286A (zh) 2012-05-30
CA2766909A1 (fr) 2011-01-06
CN102482286B (zh) 2015-07-15
CA2766909C (fr) 2018-06-05
IL217293A (en) 2016-12-29
AU2010267815B2 (en) 2015-07-16
MX2012000103A (es) 2012-05-22
JP2012531463A (ja) 2012-12-10
AU2010267815A1 (en) 2012-02-16
KR20120103553A (ko) 2012-09-19
MY155661A (en) 2015-11-13
TW201105673A (en) 2011-02-16
US20120208810A1 (en) 2012-08-16
US8846670B2 (en) 2014-09-30
TWI455940B (zh) 2014-10-11
IL217293A0 (en) 2012-02-29

Similar Documents

Publication Publication Date Title
BRPI1015943A2 (pt) derivados de 1,2,3,4-tetra - hidro - pirimido [1,2-a] pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica.
EP2157093A4 (en) HETEROCYCLIC PYRROLO-NITROGEN-DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE
SI2069342T1 (sl) Derivati aril fenil imidazo a piridinov njihova priprava in njihova terapevtska uporaba
BRPI0907381A2 (pt) Derivados de carboxamidas azabicíclicos, o respectivo preparo e a respectiva aplicação em terapêutica.
BRPI0810412A2 (pt) Derivados de triazolo piridina-carboxamidas e triazolo pirimidina - carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI1015949A2 (pt) derivados de 2,3-di-hidro-1h-imidazo [1,2-a] pirimidin-5-ona, o respectivo preparo e a respectiva utilização farmacêutica
IL236170A0 (en) 2,3-dihydro-h1-imidazo[a-1,2]pyrimidin-5-one and 1,2,3,4-tetrahydropyrimido[a-1,2]pyrimidin-6-one derivatives containing modified morpholine, their preparation and pharmaceutical use their
IL196008A0 (en) Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine
BRPI1012857A2 (pt) derivados de ciclopenta[c]pirrol-2-carboxilatos, o respectivo preparo e a respectiva aplicação em terapêutica
PL2051975T3 (pl) Podstawione prolinamidy, ich wytwarzanie oraz ich zastosowanie jako środków leczniczych
PT2655375E (pt) Derivados de pirimidinona, sua preparação e sua utilização farmacêutica
EP2184277A4 (en) ARYLPYRIMIDINE DERIVATIVES, METHODS OF PREPARATION AND PHARMACEUTICAL USES OF THE DERIVATIVES
BRPI0923875A2 (pt) Derivados de 2-piridin-2-il-pirazol-3 (2h)-ona, o respectivo preparo e a respectiva aplicação terapêutica.
HK1169387A1 (en) Pyrazole derivatives, their preparation and therapeutical use
BRPI0923182A2 (pt) derivados de 6-cicloamino-2,3-di-piridinil-imidazo[1,2-b]piridazina, o respectivo preparo e a respectivo preparo e a respectiva aplicação terapêutica
BRPI0821992A2 (pt) Derivados de n-heterocíclico-imidazo[1,2-a]piridina-2-carboxamida s, respectivo preparo e respectiva aplicação em terapêutica
BRPI0809936A2 (pt) Composto sulfonado de açúcar e uso do mesmo como medicamento
BRPI0821426A2 (pt) Compostos de n-fenil-imidazol[1,2-a]piridina-2-carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica.
BRPI0806969A2 (pt) Derivados de azabicicloalcano, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0821674A2 (pt) Derivados de n-fenil-imidazo[1,2-a] piridina-2- carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
HK1164862A1 (en) 3-benzofuranyl-indol-2-one derivatives substituted at the 3 position, preparation thereof, and therapeutic use thereof
IL202474A0 (en) 1-benzylpyrazole derivatives, preparation thereof and therapeutic use thereof
BRPI0915884A2 (pt) derivados de 1-benzil-cinolin-4-(1h)-ona substituídos, o respectivo preparo e a respectiva aplicação em terapêutica
ATE530164T1 (de) Wässrige pharmazeutische zubereitung
BRPI0821823A2 (pt) Derivados de n-heterocíclico-6-heterocíclico-imidazo[1,2-a]piridin a-2-carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2521 DE 30-04-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.