BRPI1014877A8 - compostos diamida tendo antagonista do receptor muscarínico e atividade agonista do receptor b2 adrenérgico. - Google Patents

compostos diamida tendo antagonista do receptor muscarínico e atividade agonista do receptor b2 adrenérgico.

Info

Publication number
BRPI1014877A8
BRPI1014877A8 BRPI1014877A BRPI1014877A BRPI1014877A8 BR PI1014877 A8 BRPI1014877 A8 BR PI1014877A8 BR PI1014877 A BRPI1014877 A BR PI1014877A BR PI1014877 A BRPI1014877 A BR PI1014877A BR PI1014877 A8 BRPI1014877 A8 BR PI1014877A8
Authority
BR
Brazil
Prior art keywords
adrenergic
agonist activity
diamide compounds
receptor antagonist
receptor agonist
Prior art date
Application number
BRPI1014877A
Other languages
English (en)
Inventor
Hughes Adam
Byun Daniel
L Stangeland Eric
R Jacobsen John
Fleury Melissa
D Wilson Richard
Yen Rose
Chen Yan
Original Assignee
Theravance Respiratory Co Llc
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42272140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1014877(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Respiratory Co Llc, Theravance Inc filed Critical Theravance Respiratory Co Llc
Publication of BRPI1014877A2 publication Critical patent/BRPI1014877A2/pt
Publication of BRPI1014877A8 publication Critical patent/BRPI1014877A8/pt
Publication of BRPI1014877B1 publication Critical patent/BRPI1014877B1/pt
Publication of BRPI1014877B8 publication Critical patent/BRPI1014877B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
BRPI1014877A 2009-04-23 2010-04-16 compostos diamida tendo antagonista do receptor muscarínico e atividade agonista do receptor ß2 adrenérgico, composição farmacêutica e seu uso BRPI1014877B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17203909P 2009-04-23 2009-04-23
US61/172,039 2009-04-23
PCT/US2010/031356 WO2010123766A1 (en) 2009-04-23 2010-04-16 DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITY

Publications (4)

Publication Number Publication Date
BRPI1014877A2 BRPI1014877A2 (pt) 2016-04-12
BRPI1014877A8 true BRPI1014877A8 (pt) 2018-03-13
BRPI1014877B1 BRPI1014877B1 (pt) 2020-11-10
BRPI1014877B8 BRPI1014877B8 (pt) 2021-05-25

Family

ID=42272140

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1014877A BRPI1014877B8 (pt) 2009-04-23 2010-04-16 compostos diamida tendo antagonista do receptor muscarínico e atividade agonista do receptor ß2 adrenérgico, composição farmacêutica e seu uso

Country Status (32)

Country Link
US (14) US8138345B2 (pt)
EP (3) EP3210981B1 (pt)
JP (3) JP5671006B2 (pt)
KR (1) KR101769061B1 (pt)
CN (2) CN103936716B (pt)
AR (1) AR076412A1 (pt)
AU (1) AU2010239522B2 (pt)
BR (1) BRPI1014877B8 (pt)
CA (1) CA2758505C (pt)
CL (1) CL2011002637A1 (pt)
CO (1) CO6440584A2 (pt)
CY (2) CY1119008T1 (pt)
DK (3) DK2599778T3 (pt)
ES (3) ES2635358T3 (pt)
HK (1) HK1165799A1 (pt)
HR (3) HRP20130468T1 (pt)
HU (2) HUE035049T2 (pt)
IL (1) IL215554A (pt)
LT (2) LT2599778T (pt)
MX (1) MX2011011156A (pt)
MY (1) MY158339A (pt)
NZ (1) NZ595850A (pt)
PL (3) PL2599778T3 (pt)
PT (3) PT2421849E (pt)
RU (2) RU2543716C2 (pt)
SG (1) SG175330A1 (pt)
SI (3) SI2421849T1 (pt)
SM (1) SMT201300060B (pt)
TR (1) TR201903556T4 (pt)
TW (2) TWI570115B (pt)
WO (1) WO2010123766A1 (pt)
ZA (1) ZA201107743B (pt)

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CA2838777C (en) 2011-06-10 2019-04-30 Chiesi Farmaceutici S.P.A. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
RU2661877C2 (ru) 2012-12-06 2018-07-20 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Соединения, обладающие активностью антагонистов мускариновых рецепторов и агонистов бета-2-адренергических рецепторов
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PE20151414A1 (es) 2012-12-18 2015-09-17 Almirall Sa NUEVOS DERIVADOS CARBAMATO DE CICLOHEXILO Y QUINUCLIDINILO QUE TIENEN ACTIVIDAD COMO AGONISTAS ß2 ADRENERGICOS Y COMO ANTAGONISTAS MUSCARINICOS M3
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TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
TWI703138B (zh) 2015-02-12 2020-09-01 義大利商吉斯藥品公司 具有蕈毒鹼受體拮抗劑及β２腎上腺素受體促效劑活性之化合物
CN107074816B (zh) * 2015-03-27 2020-07-17 四川海思科制药有限公司 一种杂环衍生物及其制备方法和在医药上的用途
CN107108562B (zh) * 2015-05-14 2020-07-10 四川海思科制药有限公司 具有β2受体激动及M受体拮抗活性的含氮杂螺环衍生物及其在医药上的用途
TW201704211A (zh) * 2015-05-14 2017-02-01 Sichuan Haisco Pharmaceutical Co Ltd 具有β２受體激動及Ｍ受體拮抗活性的聯苯衍生物及其在醫藥上的用途
AR104828A1 (es) 2015-06-01 2017-08-16 Chiesi Farm Spa COMPUESTOS CON ACTIVIDAD ANTAGONISTA DE LOS RECEPTORES MUSCARÍNICOS Y ACTIVIDAD AGONISTA DEL RECEPTOR b2 ADRENÉRGICO
EP3383867B1 (en) 2015-12-03 2021-04-14 Chiesi Farmaceutici S.p.A. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
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RU2722720C1 (ru) 2016-12-14 2020-06-03 Бейджинг Шоубай Фармасьютикэл Ко., Лтд. Класс бифункциональных соединений со структурой соли четвертичного аммония
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Also Published As

Publication number Publication date
TW201546057A (zh) 2015-12-16
PL2421849T3 (pl) 2013-08-30
US20100273755A1 (en) 2010-10-28
SI3210981T1 (sl) 2019-05-31
US20200165223A1 (en) 2020-05-28
HRP20170960T1 (hr) 2017-09-22
EP2599778B1 (en) 2017-04-12
CL2011002637A1 (es) 2012-04-27
US8551978B2 (en) 2013-10-08
US8816088B2 (en) 2014-08-26
US9572802B2 (en) 2017-02-21
TR201903556T4 (tr) 2019-04-22
JP5965440B2 (ja) 2016-08-03
US9394275B2 (en) 2016-07-19
JP2015147807A (ja) 2015-08-20
BRPI1014877B1 (pt) 2020-11-10
WO2010123766A1 (en) 2010-10-28
US10358433B2 (en) 2019-07-23
DK2599778T3 (en) 2017-06-26
US20150274697A1 (en) 2015-10-01
US10836744B2 (en) 2020-11-17
MY158339A (en) 2016-09-30
US20170096412A1 (en) 2017-04-06
AU2010239522B2 (en) 2015-07-02
SI2421849T1 (sl) 2013-07-31
JP5671006B2 (ja) 2015-02-18
TWI513693B (zh) 2015-12-21
RU2015101032A (ru) 2015-06-27
RU2011147374A (ru) 2013-05-27
IL215554A (en) 2014-08-31
SG175330A1 (en) 2011-11-28
NZ595850A (en) 2013-05-31
IL215554A0 (en) 2011-12-29
KR20110138292A (ko) 2011-12-26
ES2635358T3 (es) 2017-10-03
TW201041866A (en) 2010-12-01
PL3210981T3 (pl) 2019-06-28
US20140323733A1 (en) 2014-10-30
BRPI1014877A2 (pt) 2016-04-12
US8138345B2 (en) 2012-03-20
CN103936716A (zh) 2014-07-23
DK3210981T3 (en) 2019-04-01
US9682957B2 (en) 2017-06-20
US20170226082A1 (en) 2017-08-10
SI2599778T1 (sl) 2017-08-31
KR101769061B1 (ko) 2017-08-17
CN102405218B (zh) 2014-06-04
BRPI1014877B8 (pt) 2021-05-25
CY1121601T1 (el) 2020-05-29
AR076412A1 (es) 2011-06-08
EP2421849B1 (en) 2013-04-03
HRP20190417T1 (hr) 2019-04-19
HRP20130468T1 (en) 2013-06-30
CO6440584A2 (es) 2012-05-15
US20190300504A1 (en) 2019-10-03
US10590107B2 (en) 2020-03-17
CA2758505C (en) 2017-03-07
EP3210981A1 (en) 2017-08-30
US20160361304A1 (en) 2016-12-15
US10138220B1 (en) 2018-11-27
US20130331364A1 (en) 2013-12-12
JP2014210816A (ja) 2014-11-13
US20130137665A1 (en) 2013-05-30
ES2715965T3 (es) 2019-06-07
MX2011011156A (es) 2011-11-04
EP2599778A1 (en) 2013-06-05
ZA201107743B (en) 2012-06-27
PT3210981T (pt) 2019-04-01
CY1119008T1 (el) 2018-01-10
HUE042975T2 (hu) 2019-07-29
US9000173B2 (en) 2015-04-07
EP3210981B1 (en) 2019-01-02
JP2012524783A (ja) 2012-10-18
LT3210981T (lt) 2019-04-10
LT2599778T (lt) 2017-08-25
CN102405218A (zh) 2012-04-04
ES2417339T3 (es) 2013-08-07
US20210024493A1 (en) 2021-01-28
US9975875B2 (en) 2018-05-22
EP2421849A1 (en) 2012-02-29
HK1165799A1 (en) 2012-10-12
US20170362200A1 (en) 2017-12-21
TWI570115B (zh) 2017-02-11
SMT201300060B (it) 2013-07-09
PT2599778T (pt) 2017-06-06
CA2758505A1 (en) 2010-10-28
PT2421849E (pt) 2013-05-27
US20190047984A1 (en) 2019-02-14
DK2421849T3 (da) 2013-07-01
CN103936716B (zh) 2016-09-07
RU2015101032A3 (pt) 2018-07-30
RU2543716C2 (ru) 2015-03-10
HUE035049T2 (en) 2018-05-02
PL2599778T3 (pl) 2018-01-31
RU2676686C2 (ru) 2019-01-10
AU2010239522A1 (en) 2011-11-10
US9771350B2 (en) 2017-09-26

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