BRPI1011439B8 - composição de alta penetração, composição farmacêutica, sistemas de aplicação terapêutico transdérmico e uso da referida composição - Google Patents

composição de alta penetração, composição farmacêutica, sistemas de aplicação terapêutico transdérmico e uso da referida composição

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Publication number
BRPI1011439B8
BRPI1011439B8 BRPI1011439A BRPI1011439A BRPI1011439B8 BR PI1011439 B8 BRPI1011439 B8 BR PI1011439B8 BR PI1011439 A BRPI1011439 A BR PI1011439A BR PI1011439 A BRPI1011439 A BR PI1011439A BR PI1011439 B8 BRPI1011439 B8 BR PI1011439B8
Authority
BR
Brazil
Prior art keywords
composition
high penetration
peptide
transdermal therapeutic
therapeutic application
Prior art date
Application number
BRPI1011439A
Other languages
English (en)
Inventor
Yan Binbing
Yu Chongxi
Xu Lina
Tu Shiqian
Chen Yuhua
Original Assignee
Yu Chongxi
Techfields Biochem Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/463,374 external-priority patent/US9376381B2/en
Application filed by Yu Chongxi, Techfields Biochem Co Ltd filed Critical Yu Chongxi
Publication of BRPI1011439A2 publication Critical patent/BRPI1011439A2/pt
Publication of BRPI1011439B1 publication Critical patent/BRPI1011439B1/pt
Publication of BRPI1011439B8 publication Critical patent/BRPI1011439B8/pt

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    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract

composição de alta penetração, composição farmacêutica, sistema de aplicação terapêutico transdérmico e uso da referida composição. a presente invenção refere-se a uma composição de alta penetração ou profármacos de alta penetração do peptídeo ou composto relacionado ao peptídeo compreendendo uma unidade funcional, ligante e unidade de transporte. a unidade funcional é ligada covalentemente à unidade de transporte através do ligante e compreende uma fração de peptídeo ou o composto relacionado ao peptídeo. a unidade de transporte compreende grupo amida protonável. o ligante compreende ligação química que é capaz de ser clivada após a composição penetrar através da barreira biológica.
BRPI1011439A 2009-05-08 2010-05-10 composição de alta penetração, composição farmacêutica, sistemas de aplicação terapêutico transdérmico e uso da referida composição BRPI1011439B8 (pt)

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US12/463,374 US9376381B2 (en) 2006-11-08 2009-05-08 High penetration prodrug compositions of peptides and peptide-related compounds
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US12/463,374 2009-05-08
CN200910135997 2009-05-08
PCT/CN2010/072561 WO2010127640A1 (en) 2009-05-08 2010-05-10 High penetration prodrug compositions of peptides and peptide-related compounds

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