MX355995B - Composiciones de profarmaco de alta penetracion de peptidos y compuestos relacionados con peptidos. - Google Patents

Composiciones de profarmaco de alta penetracion de peptidos y compuestos relacionados con peptidos.

Info

Publication number
MX355995B
MX355995B MX2011011876A MX2011011876A MX355995B MX 355995 B MX355995 B MX 355995B MX 2011011876 A MX2011011876 A MX 2011011876A MX 2011011876 A MX2011011876 A MX 2011011876A MX 355995 B MX355995 B MX 355995B
Authority
MX
Mexico
Prior art keywords
peptide
high penetration
peptides
related compounds
linker
Prior art date
Application number
MX2011011876A
Other languages
English (en)
Other versions
MX2011011876A (es
Inventor
Yu Chongxi
Xu Lina
Chen Yuhua
Yan Binbing
Tu Shiqian
Original Assignee
Techfields Biochem Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/463,374 external-priority patent/US9376381B2/en
Application filed by Techfields Biochem Co Ltd filed Critical Techfields Biochem Co Ltd
Publication of MX2011011876A publication Critical patent/MX2011011876A/es
Publication of MX355995B publication Critical patent/MX355995B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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Abstract

La presente invención se refiere a una composición de alta penetración o profármacos de alta penetración de péptido o compuesto relacionado con péptido que comprende una unidad funcional, enlazador, y unidad de transportación. Las unidades funcionales se enlazan covalentemente a la unidad de transportación vía el enlazador, y comprende un radical del péptido o el compuesto relacionado con péptido. La unidad de transportación comprende grupo amina protonatable. El enlazador comprende enlace químico que es capaz de ser escindido después de que la composición penetra a través de la barrera biológica.
MX2011011876A 2009-05-08 2010-05-10 Composiciones de profarmaco de alta penetracion de peptidos y compuestos relacionados con peptidos. MX355995B (es)

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PCT/CN2010/072561 WO2010127640A1 (en) 2009-05-08 2010-05-10 High penetration prodrug compositions of peptides and peptide-related compounds

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