BRPI1007046B1 - Inibidores axl para uso em terapia de combinação para evitar, tratar ou controlar o câncer metastático. - Google Patents

Inibidores axl para uso em terapia de combinação para evitar, tratar ou controlar o câncer metastático. Download PDF

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Publication number
BRPI1007046B1
BRPI1007046B1 BRPI1007046-0A BRPI1007046A BRPI1007046B1 BR PI1007046 B1 BRPI1007046 B1 BR PI1007046B1 BR PI1007046 A BRPI1007046 A BR PI1007046A BR PI1007046 B1 BRPI1007046 B1 BR PI1007046B1
Authority
BR
Brazil
Prior art keywords
optionally substituted
benzo
dihydro
cycloepta
diamine
Prior art date
Application number
BRPI1007046-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Yasumichi Hitoshi
Sacha Holland
Donald G. Payan
Original Assignee
Rigel Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals, Inc. filed Critical Rigel Pharmaceuticals, Inc.
Publication of BRPI1007046A2 publication Critical patent/BRPI1007046A2/pt
Publication of BRPI1007046B1 publication Critical patent/BRPI1007046B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/502Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI1007046-0A 2009-01-16 2010-01-15 Inibidores axl para uso em terapia de combinação para evitar, tratar ou controlar o câncer metastático. BRPI1007046B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14544809P 2009-01-16 2009-01-16
US61/145,448 2009-01-16
PCT/US2010/021275 WO2010083465A1 (en) 2009-01-16 2010-01-15 Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer

Publications (2)

Publication Number Publication Date
BRPI1007046A2 BRPI1007046A2 (pt) 2015-07-21
BRPI1007046B1 true BRPI1007046B1 (pt) 2019-07-16

Family

ID=41683427

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1007046-0A BRPI1007046B1 (pt) 2009-01-16 2010-01-15 Inibidores axl para uso em terapia de combinação para evitar, tratar ou controlar o câncer metastático.

Country Status (13)

Country Link
US (5) US8546433B2 (https=)
EP (1) EP2387395B1 (https=)
JP (2) JP5858789B2 (https=)
CN (1) CN102281875B (https=)
AU (1) AU2010204578B2 (https=)
BR (1) BRPI1007046B1 (https=)
CA (1) CA2749843C (https=)
ES (1) ES2528032T3 (https=)
PL (1) PL2387395T3 (https=)
PT (1) PT2387395E (https=)
RU (1) RU2555326C2 (https=)
SG (1) SG172997A1 (https=)
WO (1) WO2010083465A1 (https=)

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Also Published As

Publication number Publication date
BRPI1007046A2 (pt) 2015-07-21
US8546433B2 (en) 2013-10-01
WO2010083465A1 (en) 2010-07-22
AU2010204578B2 (en) 2016-05-12
CN102281875A (zh) 2011-12-14
EP2387395A1 (en) 2011-11-23
US20100196511A1 (en) 2010-08-05
SG172997A1 (en) 2011-08-29
HK1164146A1 (en) 2012-09-21
ES2528032T3 (es) 2015-02-03
US20130338161A1 (en) 2013-12-19
CA2749843C (en) 2017-09-05
RU2555326C2 (ru) 2015-07-10
JP2015007135A (ja) 2015-01-15
JP5858789B2 (ja) 2016-02-10
US20190336500A1 (en) 2019-11-07
CA2749843A1 (en) 2011-07-22
EP2387395B1 (en) 2014-10-15
PT2387395E (pt) 2015-02-04
US20170042891A1 (en) 2017-02-16
AU2010204578A1 (en) 2011-07-28
US20210379064A1 (en) 2021-12-09
RU2011132118A (ru) 2013-02-27
JP2012515225A (ja) 2012-07-05
CN102281875B (zh) 2017-09-22
PL2387395T3 (pl) 2015-03-31

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B65Y Grant of priority examination of the patent application (request complies with dec. 132/06 of 20061117)
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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