BRPI1006189A2 - uso de uma combinação terapêutica, formulação farmacêutica, artigo de manufatura, produto, método para determinar compostos a serem utilizados em combinação para o tratamento de uma malignidade hematopoiética e método para selecionar compostos a serem utilizados em combinação para o tratamento de câncer - Google Patents
uso de uma combinação terapêutica, formulação farmacêutica, artigo de manufatura, produto, método para determinar compostos a serem utilizados em combinação para o tratamento de uma malignidade hematopoiética e método para selecionar compostos a serem utilizados em combinação para o tratamento de câncer Download PDFInfo
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- BRPI1006189A2 BRPI1006189A2 BRPI1006189-4A BRPI1006189A BRPI1006189A2 BR PI1006189 A2 BRPI1006189 A2 BR PI1006189A2 BR PI1006189 A BRPI1006189 A BR PI1006189A BR PI1006189 A2 BRPI1006189 A2 BR PI1006189A2
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- A61K31/33—Heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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| PCT/US2010/026903 WO2010105008A2 (en) | 2009-03-12 | 2010-03-11 | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies |
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| BRPI1006189A2 true BRPI1006189A2 (pt) | 2020-08-18 |
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| HUE035182T2 (hu) | 2008-03-18 | 2018-05-02 | Genentech Inc | Anti-HER2 antitest-hatóanyag-konjugátum és pertuzumab kombinációi |
| CA2749228C (en) | 2009-01-08 | 2016-05-17 | Curis, Inc. | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| CA2787714C (en) | 2010-01-22 | 2019-04-09 | Joaquin Pastor Fernandez | Inhibitors of pi3 kinase |
| WO2011121317A1 (en) | 2010-04-01 | 2011-10-06 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Imidazo [2,1-b] [1,3,4] thiadiazoles as protein or lipid kinase inhibitors |
| WO2012052745A1 (en) | 2010-10-21 | 2012-04-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Combinations of pi3k inhibitors with a second anti -tumor agent |
| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| US20140213630A1 (en) * | 2011-03-08 | 2014-07-31 | Thomas Diacovo | Methods and pharmaceutical compositions for treating lymphoid malignancy |
| SI2694075T1 (sl) | 2011-04-01 | 2016-07-29 | Curis, Inc. | Fosfoinozitid 3-kinazni inhibitor z delom, ki veže cink |
| TW201311683A (zh) * | 2011-04-29 | 2013-03-16 | Exelixis Inc | 使用吡啶并嘧啶酮pi3k/mtor抑制劑治療淋巴瘤之方法 |
| PT2710018T (pt) | 2011-05-19 | 2022-03-01 | Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio | Compostos macrocíclicos como inibidores de proteína quinases |
| EP2524918A1 (en) | 2011-05-19 | 2012-11-21 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Imidazopyrazines derivates as kinase inhibitors |
| AR086647A1 (es) | 2011-06-03 | 2014-01-15 | Hoffmann La Roche | Metodos para tratar el mesotelioma con un compuesto inhibidor de la pi3k |
| KR20140074995A (ko) | 2011-10-13 | 2014-06-18 | 제넨테크, 인크. | 약리학적-유발 저염산증의 치료 |
| BR112014011144A2 (pt) * | 2011-11-09 | 2017-05-16 | Bristol Myers Squibb Co | tratamento de malignidades hematológicas com um anticorpo anti-cxcr4 |
| AU2013235479A1 (en) * | 2012-03-23 | 2014-10-02 | Memorial Sloan-Kettering Cancer Center | Potentiating antibody-induced complement-mediated cytotoxicity via PI3K inhibition |
| CN103467482B (zh) | 2012-04-10 | 2017-05-10 | 上海璎黎药业有限公司 | 稠合嘧啶类化合物,其制备方法,中间体,组合物和应用 |
| BR112014028881A2 (pt) | 2012-05-23 | 2017-06-27 | Hoffmann La Roche | populações de células, banco de células, métodos de obtenção de uma população de células, métodos de identificação de um fator, métodos de seleção, métodos de fornecimento de terapia, populações de hepatócitos e método de obtenção de células |
| EP2858666B1 (en) | 2012-06-08 | 2019-09-04 | F.Hoffmann-La Roche Ag | Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer |
| KR101698283B1 (ko) * | 2012-10-10 | 2017-01-19 | 에프. 호프만-라 로슈 아게 | 티에노피리미딘 화합물의 제조 방법 |
| CN110269941A (zh) * | 2012-11-02 | 2019-09-24 | Tg疗法有限公司 | 抗cd20抗体和pi3激酶选择性抑制剂的组合 |
| WO2014144858A1 (en) * | 2013-03-15 | 2014-09-18 | Icahn School Of Medicine At Mount Sinai | Therapeutic methods for treating solid tumors and related diagnostic methods |
| RU2016148441A (ru) | 2014-05-21 | 2018-06-22 | Ф. Хоффманн-Ля Рош Аг | Способ лечения pr-положительного люминального а-типа рака молочной железы ингибитором pi3k пиктилисибом |
| AU2016278040B2 (en) | 2015-06-16 | 2019-07-04 | Nanophagix LLC | Drug delivery and imaging chemical conjugate, formulations and methods of use thereof |
| AU2016287189A1 (en) | 2015-06-29 | 2017-10-12 | F. Hoffmann-La Roche Ag | Methods of treatment with taselisib |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| EP3476949A1 (en) * | 2017-10-31 | 2019-05-01 | Centre National De La Recherche Scientifique | Prognosis method of multiple myeloma |
| BR112021004371A2 (pt) | 2018-09-11 | 2021-05-25 | Curis Inc. | terapia em combinação com um inibidor de fosfoinositídeo 3-quinase com uma porção de ligação a zinco |
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| JP7592601B2 (ja) * | 2019-01-10 | 2024-12-02 | ミラティ セラピューティクス, インコーポレイテッド | Kras g12c阻害剤 |
| EP4010326A4 (en) * | 2019-09-11 | 2023-08-16 | Ohio State Innovation Foundation | KINASE INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| JP2025540246A (ja) * | 2022-12-07 | 2025-12-11 | エスケー バイオファーマシューティカルズ カンパニー リミテッド | Kras g12d阻害剤として新規な3環化合物およびその用途 |
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- 2010-03-11 BR BRPI1006189-4A patent/BRPI1006189A2/pt not_active IP Right Cessation
- 2010-03-11 EP EP10708866.8A patent/EP2405916B1/en active Active
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| AU2010224125B2 (en) | 2015-05-14 |
| JP2012520313A (ja) | 2012-09-06 |
| CA2753285A1 (en) | 2010-09-16 |
| US9335320B2 (en) | 2016-05-10 |
| US20130330765A1 (en) | 2013-12-12 |
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| US8536161B2 (en) | 2013-09-17 |
| AU2010224125A1 (en) | 2011-08-04 |
| IL214132A (en) | 2015-02-26 |
| JP5709766B2 (ja) | 2015-04-30 |
| US20100233164A1 (en) | 2010-09-16 |
| EP2405916A2 (en) | 2012-01-18 |
| KR101781654B1 (ko) | 2017-09-25 |
| EP2405916B1 (en) | 2018-02-07 |
| MX2011009167A (es) | 2011-09-15 |
| CN102369011A (zh) | 2012-03-07 |
| KR20110132442A (ko) | 2011-12-07 |
| WO2010105008A3 (en) | 2010-11-25 |
| WO2010105008A2 (en) | 2010-09-16 |
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