BRPI0920228B1 - Alimento fortificado com ferro e processo para obtenção do mesmo - Google Patents
Alimento fortificado com ferro e processo para obtenção do mesmo Download PDFInfo
- Publication number
- BRPI0920228B1 BRPI0920228B1 BRPI0920228-5A BRPI0920228A BRPI0920228B1 BR PI0920228 B1 BRPI0920228 B1 BR PI0920228B1 BR PI0920228 A BRPI0920228 A BR PI0920228A BR PI0920228 B1 BRPI0920228 B1 BR PI0920228B1
- Authority
- BR
- Brazil
- Prior art keywords
- iron
- capsules
- food
- alginate
- fortified
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 456
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 230
- 235000013305 food Nutrition 0.000 title claims abstract description 72
- 238000000034 method Methods 0.000 title claims abstract description 17
- 230000008569 process Effects 0.000 title claims abstract description 10
- 239000002775 capsule Substances 0.000 claims abstract description 211
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 55
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 40
- 229920000615 alginic acid Polymers 0.000 claims abstract description 40
- 229940072056 alginate Drugs 0.000 claims abstract description 31
- 239000007787 solid Substances 0.000 claims abstract description 22
- 241000282414 Homo sapiens Species 0.000 claims abstract description 15
- 206010022971 Iron Deficiencies Diseases 0.000 claims abstract description 12
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 9
- 239000000648 calcium alginate Substances 0.000 claims abstract description 9
- 229960002681 calcium alginate Drugs 0.000 claims abstract description 9
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 61
- 235000013618 yogurt Nutrition 0.000 claims description 43
- 150000002505 iron Chemical class 0.000 claims description 40
- 235000013336 milk Nutrition 0.000 claims description 32
- 210000004080 milk Anatomy 0.000 claims description 32
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 31
- 235000010413 sodium alginate Nutrition 0.000 claims description 31
- 239000000661 sodium alginate Substances 0.000 claims description 31
- 229940005550 sodium alginate Drugs 0.000 claims description 31
- 239000008267 milk Substances 0.000 claims description 30
- 239000011788 ferric saccharate Substances 0.000 claims description 25
- 235000008824 ferric saccharate Nutrition 0.000 claims description 25
- XRDYWGSODBNAIE-BQGRAUOOSA-K iron(3+);(2r,3s,4s,5s)-2,3,4,5,6-pentahydroxy-6-oxohexanoate Chemical group [Fe+3].OC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O XRDYWGSODBNAIE-BQGRAUOOSA-K 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 21
- 239000000243 solution Substances 0.000 claims description 17
- 239000007864 aqueous solution Substances 0.000 claims description 15
- 235000014106 fortified food Nutrition 0.000 claims description 14
- 235000013372 meat Nutrition 0.000 claims description 12
- 235000013580 sausages Nutrition 0.000 claims description 10
- 159000000007 calcium salts Chemical class 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 4
- RLSFDUAUKXKPCZ-UITAMQMPSA-N (z)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5h-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)but-2-en-1-one Chemical group C1CN(C(=NN=2)C(F)(F)F)C=2CN1C(=O)\C=C(/N)CC1=CC(F)=C(F)C=C1F RLSFDUAUKXKPCZ-UITAMQMPSA-N 0.000 claims 1
- 238000003860 storage Methods 0.000 abstract description 31
- 238000011068 loading method Methods 0.000 abstract description 2
- 239000011575 calcium Substances 0.000 description 49
- 229910052791 calcium Inorganic materials 0.000 description 45
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- 239000000047 product Substances 0.000 description 36
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 34
- JARKCYVAAOWBJS-UHFFFAOYSA-N hexanal Chemical compound CCCCCC=O JARKCYVAAOWBJS-UHFFFAOYSA-N 0.000 description 22
- 241001465754 Metazoa Species 0.000 description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
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- 239000002609 medium Substances 0.000 description 18
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- 235000011148 calcium chloride Nutrition 0.000 description 17
- 239000001110 calcium chloride Substances 0.000 description 16
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- 239000003925 fat Substances 0.000 description 14
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 13
- 230000003647 oxidation Effects 0.000 description 13
- 238000007254 oxidation reaction Methods 0.000 description 13
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- 208000007502 anemia Diseases 0.000 description 10
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- -1 iron cation Chemical class 0.000 description 9
- SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 description 9
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 9
- 150000002739 metals Chemical class 0.000 description 9
- 239000000902 placebo Substances 0.000 description 9
- 235000019640 taste Nutrition 0.000 description 9
- 229960001126 alginic acid Drugs 0.000 description 8
- 239000000783 alginic acid Substances 0.000 description 8
- 150000004781 alginic acids Chemical class 0.000 description 8
- 150000001768 cations Chemical class 0.000 description 8
- 239000002738 chelating agent Substances 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 8
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- 238000002360 preparation method Methods 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 7
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- 238000000265 homogenisation Methods 0.000 description 7
- 238000011084 recovery Methods 0.000 description 7
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical class [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 6
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000002354 inductively-coupled plasma atomic emission spectroscopy Methods 0.000 description 6
- 159000000014 iron salts Chemical class 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
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- 239000006228 supernatant Substances 0.000 description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 5
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- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
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- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
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- FRHBOQMZUOWXQL-UHFFFAOYSA-L ammonium ferric citrate Chemical compound [NH4+].[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FRHBOQMZUOWXQL-UHFFFAOYSA-L 0.000 description 3
- MDXRFOWKIZPNTA-UHFFFAOYSA-L butanedioate;iron(2+) Chemical compound [Fe+2].[O-]C(=O)CCC([O-])=O MDXRFOWKIZPNTA-UHFFFAOYSA-L 0.000 description 3
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 3
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| CN102940037B (zh) * | 2012-05-23 | 2014-06-04 | 四川农业大学 | 制备共沉淀氢氧化铁酸奶的方法 |
| ES2729839T3 (es) | 2012-06-01 | 2019-11-06 | Dsm Ip Assets Bv | Suplementación con minerales de bebidas |
| CN105377059A (zh) * | 2013-07-05 | 2016-03-02 | 雀巢产品技术援助有限公司 | 乳铁蛋白-骨桥蛋白-铁络合物 |
| RU2548777C2 (ru) * | 2013-07-09 | 2015-04-20 | Александр Александрович Кролевец | Способ получения частиц инкапсулированных жирорастворимой полимерной оболочкой солей металлов, обладающих супрамолекулярными свойствами |
| EP3086654A1 (en) * | 2013-12-27 | 2016-11-02 | Nestec S.A. | Composition comprising ferric saccharate and high concentrations of microencapsulated lc-pufa with a reduced off taste |
| US10863753B2 (en) | 2015-10-01 | 2020-12-15 | The Governing Council Of The University Of Toronto | Iron-fortified tea preparations and methods of making same |
| RU2623593C1 (ru) * | 2016-02-10 | 2017-06-28 | Александр Александрович Кролевец | Способ получения мармелада с повышенным содержанием железа |
| WO2020172623A1 (en) | 2019-02-21 | 2020-08-27 | Ingenuity Foods, Inc. | Compositions comprising choline and omega-3 fatty acid to nutritionally enhance food products |
| IT201900025393A1 (it) | 2019-12-23 | 2021-06-23 | Pharma Line S R L | Formulazione microincapsulata comprendente ferro e cistina, sue composizioni e loro uso per il trattamento di anemia o una deficienza di ferro |
| CN111493257A (zh) * | 2020-04-27 | 2020-08-07 | 郑州瑞普生物工程有限公司 | 一种蛋白固体饮料及其制备方法 |
| US11776118B2 (en) * | 2020-12-02 | 2023-10-03 | International Business Machines Corporation | Recognition of partially digested medications |
| GB2617580B (en) * | 2022-04-12 | 2024-05-22 | Foster & Freeman Ltd | Latent fingermark validation strips |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3228231A1 (de) * | 1982-07-28 | 1984-02-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München | Arzneimittel, calciummischsalze von polymeren, anionischen carbonsaeuren und/oder schwefelsaeureestern, verfahren zu ihrer herstellung und ihre verwendung |
| JPH03285654A (ja) * | 1990-03-30 | 1991-12-16 | Snow Brand Milk Prod Co Ltd | 機能性物質を高濃度に内包したカプセル体及びその製造法 |
| US20030190355A1 (en) * | 2002-04-05 | 2003-10-09 | Hermelin Marc S. | Modified release minerals |
| GB0310673D0 (en) * | 2003-05-09 | 2003-06-11 | Givaudan Sa | Alginate matrix particles |
| BR0305871B1 (pt) | 2003-11-24 | 2014-10-21 | Inst Pesquisas Tech | Produto à base de sulfato ferroso para fortificação de alimentos desidratados e método de preparação |
| RU2287302C2 (ru) * | 2004-05-13 | 2006-11-20 | Федеральное Государственное образовательное учреждение Высшего профессионального образования Вологодская государственная молочнохозяйственная академия им. Н.В. Верещагина | Способ обогащения минеральными веществами пищевого продукта |
| EP1743530B1 (en) * | 2005-07-15 | 2011-08-31 | Unilever N.V. | Iron fortified food product and additive |
| BRPI0716157A2 (pt) * | 2006-09-05 | 2013-09-17 | Ct Brasileiro De Pesquisa Fisica Cbpf | processo para produÇço microcÁpsulas dotadas de propriedades magnÉticas, produto obtido e mÉtodo para a liberaÇço controlada de substÂncias ativas |
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