BRPI0913326C1 - formulação farmacêuticas tópicas contendo uma baixa concentração de peróxido de benzoíla em suspensão aquosa e um solvente orgânico miscível em água - Google Patents

formulação farmacêuticas tópicas contendo uma baixa concentração de peróxido de benzoíla em suspensão aquosa e um solvente orgânico miscível em água

Info

Publication number
BRPI0913326C1
BRPI0913326C1 BRPI0913326A BRPI0913326A BRPI0913326C1 BR PI0913326 C1 BRPI0913326 C1 BR PI0913326C1 BR PI0913326 A BRPI0913326 A BR PI0913326A BR PI0913326 A BRPI0913326 A BR PI0913326A BR PI0913326 C1 BRPI0913326 C1 BR PI0913326C1
Authority
BR
Brazil
Prior art keywords
benzoyl peroxide
organic solvent
formulation
miscible organic
pharmaceutical formulations
Prior art date
Application number
BRPI0913326A
Other languages
English (en)
Inventor
J Dow Gordon
Chang Yunik
Original Assignee
Dow Pharmaceutical Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41398394&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0913326(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dow Pharmaceutical Sciences filed Critical Dow Pharmaceutical Sciences
Publication of BRPI0913326A2 publication Critical patent/BRPI0913326A2/pt
Publication of BRPI0913326B1 publication Critical patent/BRPI0913326B1/pt
Publication of BRPI0913326B8 publication Critical patent/BRPI0913326B8/pt
Publication of BRPI0913326C1 publication Critical patent/BRPI0913326C1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/327—Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/044—Suspensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/38—Percompounds, e.g. peracids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/33—Free of surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

formulações farmacêuticas tópicas contendo uma baixa concentração de peróxido de benzoíla em suspensão aquosa e um solvente orgânico miscível em água é obtida uma formulação aquosa para aplicação tópica à pele, compreendendo água, um solvente orgânico miscível em água, e peróxido de benzoíla, em que a concentração do solvente orgânico é suficiente par obter uma suspenso estável de peróxido de benzoíla na formulação aquosa sem inclusão de um tensoativo na formulação, em que a razão de concentrações de água e solvente orgânico na formulação é suficiente para manter o peróxido de benzoíla em solubilidade saturada na formulação seguinte aplicação à pele, e em que a concentração do peróxido de benzoíla na formulação é menor do que 5,0% sendo de pelo menos 1,0% peso/peso. a formulação por conter adicionalmente, um composto químico, além do peróxido de benzoíla, eficaz no tratamento da acne. as formulações aquosas da invenção são úteis no tratamento da acne e acne rosácea.
BRPI0913326A 2008-06-05 2009-06-03 formulação farmacêuticas tópicas contendo uma baixa concentração de peróxido de benzoíla em suspensão aquosa e um solvente orgânico miscível em água BRPI0913326C1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13101408P 2008-06-05 2008-06-05
US61/131.014 2008-06-05
PCT/US2009/003367 WO2009148584A1 (en) 2008-06-05 2009-06-03 Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent

Publications (4)

Publication Number Publication Date
BRPI0913326A2 BRPI0913326A2 (pt) 2015-09-15
BRPI0913326B1 BRPI0913326B1 (pt) 2019-07-30
BRPI0913326B8 BRPI0913326B8 (pt) 2019-09-03
BRPI0913326C1 true BRPI0913326C1 (pt) 2021-05-25

Family

ID=41398394

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0913326A BRPI0913326C1 (pt) 2008-06-05 2009-06-03 formulação farmacêuticas tópicas contendo uma baixa concentração de peróxido de benzoíla em suspensão aquosa e um solvente orgânico miscível em água

Country Status (15)

Country Link
US (13) US8288434B2 (pt)
EP (1) EP2299810B1 (pt)
JP (2) JP5677693B2 (pt)
KR (1) KR20110014651A (pt)
CN (1) CN102056481A (pt)
AU (1) AU2009255679B2 (pt)
BR (1) BRPI0913326C1 (pt)
CA (1) CA2723029C (pt)
ES (1) ES2773931T3 (pt)
HR (1) HRP20200450T1 (pt)
MX (1) MX2010013152A (pt)
PT (1) PT2299810T (pt)
RU (2) RU2493847C2 (pt)
WO (1) WO2009148584A1 (pt)
ZA (1) ZA201008265B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1919606A2 (en) 2005-08-02 2008-05-14 Sol-Gel Technologies Ltd. Metal oxide coating of water insoluble ingredients
JP5677693B2 (ja) 2008-06-05 2015-02-25 ドウ ファーマシューティカル サイエンシーズ、インク． 水及び水混和性有機溶媒中に懸濁する低濃度過酸化ベンゾイルを含む局所用医薬品製剤
US11298252B2 (en) 2008-09-25 2022-04-12 Advanced Bifurcation Systems Inc. Stent alignment during treatment of a bifurcation
US20100099733A1 (en) * 2008-10-20 2010-04-22 Gordon Jay Dow Method for obtaining a stable dispersion of benzoyl peroxide
AU2009354152B2 (en) * 2009-10-21 2015-07-02 Dow Pharmaceutical Sciences, Inc. Method for wetting a powder containing benzoyl peroxide
US9744150B2 (en) * 2009-10-21 2017-08-29 Dow Pharmaceutical Sciences Inc. Suspension containing micronized benzoyl peroxide
EP2925296B1 (en) * 2012-11-27 2021-01-06 Sol-Gel Technologies Ltd. Compositions for the treatment of rosacea
US9687465B2 (en) 2012-11-27 2017-06-27 Sol-Gel Technologies Ltd. Compositions for the treatment of rosacea
WO2017068673A1 (ja) * 2015-10-21 2017-04-27 マルホ株式会社 皮膚用の医薬組成物
CN107304177B (zh) * 2016-04-20 2020-09-15 武汉诺安药业有限公司 一种过氧苯甲酰微粉化的化学制备方法
CA3070663A1 (en) * 2017-07-21 2019-01-24 Almirall, Llc Treatment of non-inflammatory lesions
CN107375209A (zh) * 2017-08-30 2017-11-24 江苏嘉逸医药有限公司 一种过氧苯甲酰的局部药物制剂
CN107737135A (zh) * 2017-11-28 2018-02-27 江苏万川医疗健康产业集团有限公司 一种药物制剂及其制备方法与应用
JP6811213B2 (ja) * 2018-07-03 2021-01-13 ソル − ゲル テクノロジーズ リミテッド 酒さの治療のための組成物
WO2020170032A2 (en) 2019-02-19 2020-08-27 Sol-Gel Technologies Ltd. Method for treatment of rosacea in patients aged 65 years and older
WO2021019092A1 (en) * 2019-08-01 2021-02-04 Bausch Health Ireland Limited Topical compositions
CN113577022B (zh) * 2021-05-18 2023-03-17 南京欣通瑞亿医药科技有限公司 一种氨苯砜类化合物混悬液及其制备方法和应用

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3535442A (en) 1967-10-19 1970-10-20 John E Jennings Anti-shoplifting and surveillance system
US4056611A (en) 1973-04-16 1977-11-01 Stiefel Laboratories, Inc. Therapeutic composition
US4497794A (en) * 1980-12-08 1985-02-05 Dermik Laboratories, Inc. Erythromycin/benzoyl peroxide composition for the treatment of acne
US4075353A (en) 1976-06-09 1978-02-21 Dermatologics For Veterinary Medicine, Inc. Process for the treatment of acarid skin infections in animals
FR2378523A1 (fr) 1977-01-26 1978-08-25 Grupper Charles Medicament pour le traitement de l'acne
US4189501A (en) 1977-10-07 1980-02-19 A. H. C. Pharmacal, Inc. Composition and method for the treatment of acne
NZ194326A (en) 1979-07-25 1982-05-31 Dermik Lab Inc Stable aqueous benzoyl peroxide compositions and therapeutic compositions
US4387107A (en) 1979-07-25 1983-06-07 Dermik Laboratories, Inc. Stable benzoyl peroxide composition
IT1210608B (it) * 1980-12-08 1989-09-14 Rorer Int Overseas Composizione per il trattamento topico dell'acne
US4411893A (en) 1981-08-14 1983-10-25 Minnesota Mining And Manufacturing Company Topical medicament preparations
US4401835A (en) * 1981-09-17 1983-08-30 Warner-Lambert Company Method for preparing small sized benzoyl peroxide crystals
US4923900A (en) * 1985-01-24 1990-05-08 Board Of Regents, The University Of Texas System Therapeutic compositions containing benzoyl peroxide
US5446028A (en) * 1985-12-12 1995-08-29 Dermik Laboratories, Inc. Anti-acne method and composition
FR2604435B1 (fr) 1986-09-30 1988-12-02 Oreal Peroxydes aromatiques insatures et leur utilisation en therapeutique et cosmetique
TW203552B (en) 1992-02-18 1993-04-11 J Baroody Lloyd Compositions of clindamycin and benzoyl peroxide for acne treatment
US6117843A (en) * 1992-02-18 2000-09-12 Lloyd J. Baroody Compositions for the treatment of acne containing clindamycin and benzoyl peroxide
IL105217A0 (en) 1992-04-09 1993-07-08 Allergan Inc Method and composition for treating acne
US5466446A (en) * 1994-02-16 1995-11-14 Stiefel Laboratories, Inc. Topical compositions containing bensoyl peroxide and clindamycin and method of use thereof
US5470884A (en) 1994-05-19 1995-11-28 Procter & Gamble Anti-acne compositions
DE4418096A1 (de) 1994-05-24 1995-11-30 Cassella Ag Verwendung von Pteridin-Derivaten als Hemmstoffe der NO-Synthase
US5445823A (en) 1994-10-20 1995-08-29 The Procter & Gamble Company Dermatological compositions and method of treatment of skin lesions therewith
US20020039561A1 (en) 1995-11-15 2002-04-04 Doughty Darrell Gene Topical skin care compositions containing thickened polyol carboxylic acid esters as skin conditioning agents
US6071541A (en) * 1998-07-31 2000-06-06 Murad; Howard Pharmaceutical compositions and methods for managing skin conditions
US6433024B1 (en) 2000-05-08 2002-08-13 Karl F. Popp Topical anti-acne composition
US6387383B1 (en) 2000-08-03 2002-05-14 Dow Pharmaceutical Sciences Topical low-viscosity gel composition
US6837383B1 (en) 2001-01-25 2005-01-04 Mcelhaney Jr Wayne Tool organizer mounted to a vehicle lift rack
US20030064084A1 (en) 2001-09-24 2003-04-03 Bradley Pharmaceuticals, Inc. Novel benzoyl peroxide compositions for the treatment of dermatological disorders and methods for their use
US7820186B2 (en) * 2001-12-21 2010-10-26 Galderma Research & Development Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt
FR2833841B1 (fr) * 2001-12-21 2005-07-22 Galderma Res & Dev Gel comprenant au moins un retinoide et du peroxyde de benzoyle
US20040101566A1 (en) 2002-02-04 2004-05-27 Elan Pharma International Limited Novel benzoyl peroxide compositions
EP2289512B8 (en) 2003-01-24 2017-08-02 Stiefel Research Australia Pty Ltd Pharmaceutical foam
GB0403702D0 (en) * 2004-02-19 2004-03-24 Boots Co Plc Skincare compositions
US20050239723A1 (en) * 2004-04-27 2005-10-27 Amin Avinash N Compositions and methods useful for treatment of acne
US7153888B2 (en) * 2004-12-21 2006-12-26 Alpharx Inc. Stabilization of benzoyl peroxide in solution
KR20070115939A (ko) * 2005-03-10 2007-12-06 제이알 켐, 엘엘씨 벤조일 퍼옥사이드 조성물 및 이용 방법
AR054805A1 (es) * 2005-06-29 2007-07-18 Stiefel Laboratories Composiciones topicas para el tratamiento de la piel
WO2008007224A2 (en) 2006-03-31 2008-01-17 Stiefel Research Australia Pty Ltd Foamable suspension gel
MXPA06008988A (es) 2006-08-08 2008-02-07 Fernando Ahumada Ayala Preparaciones topicas antiacne que contienen retinoide (tazaroteno o adapaleno), antibiotico (fosfato de clindamicina) y/o queratolitico (peroxido de bonzoilo en microesponjas).
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
EP1967180A1 (de) 2007-03-06 2008-09-10 Almirall Hermal GmbH Topische Zusammensetzung enthaltend einen Retinoid-Rezeptor-Agonist
JP5677693B2 (ja) 2008-06-05 2015-02-25 ドウ ファーマシューティカル サイエンシーズ、インク． 水及び水混和性有機溶媒中に懸濁する低濃度過酸化ベンゾイルを含む局所用医薬品製剤
WO2013086518A1 (en) * 2011-12-09 2013-06-13 Mary Kay Inc. Skin care formulation
EP3941454A1 (en) * 2019-03-18 2022-01-26 Bausch Health Ireland Limited Topical compositions and methods for treating acne vulgaris

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US20130236549A1 (en) 2013-09-12
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