PE20080658A1 - Formulaciones de metilnaltrexona en forma de polvo seco - Google Patents

Formulaciones de metilnaltrexona en forma de polvo seco

Info

Publication number
PE20080658A1
PE20080658A1 PE2007001192A PE2007001192A PE20080658A1 PE 20080658 A1 PE20080658 A1 PE 20080658A1 PE 2007001192 A PE2007001192 A PE 2007001192A PE 2007001192 A PE2007001192 A PE 2007001192A PE 20080658 A1 PE20080658 A1 PE 20080658A1
Authority
PE
Peru
Prior art keywords
methylnaltrexone
dry powder
composition
powder form
filler
Prior art date
Application number
PE2007001192A
Other languages
English (en)
Inventor
Syed M Shah
Christian Ofslager
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20080658A1 publication Critical patent/PE20080658A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA DE POLVO SECO QUE COMPRENDE: A) BROMURO DE METILNALTREXONA QUE SE ENCUENTRA EN UNA CANTIDAD DE 5MG A 500MG EN LA COMPOSICION; Y B) UN RELLENADOR TAL COMO MONOHIDRATO DE LACTOSA, MANITOL O DEXTRANO EN DONDE LA RELACION ENTRE LA METILNALTREXONA Y EL RELLENADOR ES DE 1:1 A 1,5 EN PESO. SE REFIERE TAMBIEN A UN PROCESO PARA OBTENER UN PRODUCTO FARMACEUTICO ESTERIL QUE COMPRENDE: i) OBTENER UNA SOLUCION DE LA FORMULACION CON AGUA, EN DONDE LA CONCENTRACION DE METILNALTREXONA ES DE 0,5MG/ML A 25MG/ML; ii) LIOFILIZAR LA COMPOSICION. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE EFECTOS SECUNDARIOS RESULTANTES POR LA UTILIZACION DE OPIODES
PE2007001192A 2006-09-08 2007-09-06 Formulaciones de metilnaltrexona en forma de polvo seco PE20080658A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84343706P 2006-09-08 2006-09-08

Publications (1)

Publication Number Publication Date
PE20080658A1 true PE20080658A1 (es) 2008-07-17

Family

ID=39104339

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001192A PE20080658A1 (es) 2006-09-08 2007-09-06 Formulaciones de metilnaltrexona en forma de polvo seco

Country Status (14)

Country Link
US (3) US20080064743A1 (es)
EP (1) EP2068836A2 (es)
JP (1) JP2010502714A (es)
CN (1) CN101511342A (es)
AR (1) AR062710A1 (es)
AU (1) AU2007292912A1 (es)
BR (1) BRPI0716227A2 (es)
CA (1) CA2661830A1 (es)
CL (1) CL2007002614A1 (es)
MX (1) MX2009002115A (es)
PA (1) PA8746901A1 (es)
PE (1) PE20080658A1 (es)
TW (1) TW200817048A (es)
WO (1) WO2008030567A2 (es)

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US20080064743A1 (en) 2008-03-13
CL2007002614A1 (es) 2008-04-18
JP2010502714A (ja) 2010-01-28
WO2008030567A2 (en) 2008-03-13
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CN101511342A (zh) 2009-08-19
PA8746901A1 (es) 2008-11-19
US20120059025A1 (en) 2012-03-08
CA2661830A1 (en) 2008-03-13
EP2068836A2 (en) 2009-06-17
AR062710A1 (es) 2008-11-26
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US20140228389A1 (en) 2014-08-14
AU2007292912A1 (en) 2008-03-13

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