BRPI0911448A2 - sistemas, métodos e composições para simulação óticas de células alvo - Google Patents

sistemas, métodos e composições para simulação óticas de células alvo

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Publication number
BRPI0911448A2
BRPI0911448A2 BRPI0911448-3A BRPI0911448A BRPI0911448A2 BR PI0911448 A2 BRPI0911448 A2 BR PI0911448A2 BR PI0911448 A BRPI0911448 A BR PI0911448A BR PI0911448 A2 BRPI0911448 A2 BR PI0911448A2
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BR
Brazil
Prior art keywords
ion channel
systems
methods
molecule
light
Prior art date
Application number
BRPI0911448-3A
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English (en)
Inventor
Zhang Feng
Deisseroth Karl
Gradinaru Viviana
Original Assignee
The Board Of Trustees For The Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees For The Leland Stanford Junior University filed Critical The Board Of Trustees For The Leland Stanford Junior University
Publication of BRPI0911448A2 publication Critical patent/BRPI0911448A2/pt

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Abstract

sistemas, métodos e composições para simulação ótica de células alvo. métodos, sistemas e dispositivos são implementados em conexão com as moléculas de canais de íons sensíveis à luz. um tal método é implementado usando uma molécula de canal de íons ativado pela luz, que responde a um estímulo de luz. o método inclui proje-tar a molécula de canal de íons ativado pela luz em uma célula; e ativar a molécula de canal de íon, em resposta ao estímulo de luz que é fornecida à molécula do canal de íon e que tem propriedades que não ativam um canal de íon chr2, para permitir que os íons passem através da molécula ativada pela luz de canal de íon.
BRPI0911448-3A 2008-04-23 2009-04-08 sistemas, métodos e composições para simulação óticas de células alvo BRPI0911448A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4721908P 2008-04-23 2008-04-23
US61/047,219 2008-04-23
PCT/US2009/039949 WO2009131837A2 (en) 2008-04-23 2009-04-08 Systems, methods and compositions for optical stimulation of target cells

Publications (1)

Publication Number Publication Date
BRPI0911448A2 true BRPI0911448A2 (pt) 2019-02-26

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BRPI0911448-3A BRPI0911448A2 (pt) 2008-04-23 2009-04-08 sistemas, métodos e composições para simulação óticas de células alvo

Country Status (14)

Country Link
US (7) US8603790B2 (pt)
EP (2) EP2281039B1 (pt)
JP (2) JP5801188B2 (pt)
KR (1) KR20110005280A (pt)
AU (2) AU2009238467B2 (pt)
BR (1) BRPI0911448A2 (pt)
CA (1) CA2722278C (pt)
ES (2) ES2701349T3 (pt)
IL (1) IL208877A0 (pt)
MX (1) MX2010011657A (pt)
MY (1) MY169771A (pt)
RU (1) RU2010147661A (pt)
SG (1) SG189813A1 (pt)
WO (1) WO2009131837A2 (pt)

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US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
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EP2281039B1 (en) 2008-04-23 2016-09-28 The Board of Trustees of the Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
MY152003A (en) 2008-05-29 2014-08-15 Univ Leland Stanford Junior Cell line, system and method for optical control of secondary messengers
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US9207237B2 (en) 2010-08-23 2015-12-08 President And Fellows Of Harvard College Systems, methods, and workflows for optogenetics analysis
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AU2015203097B2 (en) * 2010-11-05 2017-09-21 The Board Of Trustees Of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
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CN105941328B (zh) * 2010-11-05 2019-04-09 斯坦福大学托管董事会 一种鉴定抑制前额叶皮质中的兴奋性或抑制性神经元的去极化的化合物的系统
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ES2661093T3 (es) 2010-11-05 2018-03-27 The Board Of Trustees Of The University Of The Leland Stanford Junior University Control y caracterización de la función de la memoria
CN103476456B (zh) 2010-11-05 2017-10-03 斯坦福大学托管董事会 奖赏相关行为的光遗传学控制
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