BRPI0823084A2 - Método de síntese de uma mistura de oligômeros substancialmente monodispersa - Google Patents
Método de síntese de uma mistura de oligômeros substancialmente monodispersaInfo
- Publication number
- BRPI0823084A2 BRPI0823084A2 BRPI0823084-6A BRPI0823084A BRPI0823084A2 BR PI0823084 A2 BRPI0823084 A2 BR PI0823084A2 BR PI0823084 A BRPI0823084 A BR PI0823084A BR PI0823084 A2 BRPI0823084 A2 BR PI0823084A2
- Authority
- BR
- Brazil
- Prior art keywords
- synthesis method
- oligomer mixture
- substantially monodispersed
- monodispersed oligomer
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
- C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1694CH2008 | 2008-07-14 | ||
IN01694/CHE/2008 | 2008-07-14 | ||
PCT/IN2008/000545 WO2010007626A1 (en) | 2008-07-14 | 2008-08-28 | A method of synthesizing a substantially monodispersed mixture of oligomers |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0823084A2 true BRPI0823084A2 (pt) | 2015-06-16 |
BRPI0823084B1 BRPI0823084B1 (pt) | 2019-07-16 |
Family
ID=41550060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0823084-6A BRPI0823084B1 (pt) | 2008-07-14 | 2008-08-28 | Método de síntese de uma mistura de oligômeros substancialmente monodispersa |
Country Status (14)
Country | Link |
---|---|
US (1) | US9040723B2 (pt) |
EP (1) | EP2300514B1 (pt) |
JP (1) | JP5480257B2 (pt) |
KR (1) | KR101311597B1 (pt) |
CN (1) | CN102099397B (pt) |
BR (1) | BRPI0823084B1 (pt) |
DK (1) | DK2300514T3 (pt) |
ES (1) | ES2572891T3 (pt) |
HK (1) | HK1156335A1 (pt) |
IL (1) | IL210598A (pt) |
MY (1) | MY155612A (pt) |
PL (1) | PL2300514T3 (pt) |
PT (1) | PT2300514E (pt) |
WO (1) | WO2010007626A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8758802B2 (en) | 2009-12-14 | 2014-06-24 | University Of Massachusetts | Methods of inhibiting cataracts and presbyopia |
US8993614B2 (en) | 2012-03-15 | 2015-03-31 | F. Hoffmann-La Roche Ag | Substituted pyrrolidine-2-carboxamides |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
PE20151747A1 (es) * | 2013-03-14 | 2015-12-18 | Univ Massachusetts | Metodo para inhibir cataratas y presbicia |
CA3004585A1 (en) | 2015-11-13 | 2017-05-18 | The University Of Massachusetts | Bifunctional molecules containing peg for use in inhibiting cataracts and presbyopia |
WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
CN109179838A (zh) * | 2018-10-11 | 2019-01-11 | 凯莱英生命科学技术(天津)有限公司 | 含三乙胺的dmf废水的处理方法 |
US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU575038B2 (en) * | 1983-01-28 | 1988-07-21 | Fujisawa Pharmaceutical Co., Ltd. | Aminoglycoside derivatives, eg 2'n-palmitoyl-kasugamycin |
US4980482A (en) | 1988-01-19 | 1990-12-25 | The Dow Chemical Company | Process for the preparation of N-maleoyl activated esters of amino acids |
ES2247656T3 (es) * | 1989-04-19 | 2006-03-01 | Enzon, Inc. | Un proceso para formar un polipeptido modificado que comprende un polipeptido y un oxido de polialquileno. |
US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
US6703381B1 (en) | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6913903B2 (en) | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
AU2002357806A1 (en) * | 2001-12-11 | 2003-06-23 | Sun Bio, Inc. | Novel monofunctional polyethylene glycol aldehydes |
JP2006519262A (ja) * | 2003-02-28 | 2006-08-24 | アルザ・コーポレーシヨン | リポソームにより誘導される補体活性化の減少のためのリポソーム組成物 |
EP1614419B1 (en) * | 2003-04-17 | 2012-08-08 | Toyama Chemical Co., Ltd. | Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof |
WO2005025498A2 (en) | 2003-09-08 | 2005-03-24 | Corus Pharma | Substituted acetanilides and benzamides for the treatment of asthma and pulmonary inflammation |
WO2005070973A2 (en) * | 2004-01-21 | 2005-08-04 | Nektar Therapeutics Al, Corporation | Method of preparing propionic acid-terminated polymers |
KR101276754B1 (ko) * | 2004-07-19 | 2013-06-19 | 바이오콘 리미티드 | 인슐린―올리고머 접합체,제형 및 이들의 용도 |
-
2008
- 2008-08-28 MY MYPI2011000187A patent/MY155612A/en unknown
- 2008-08-28 DK DK08808172.4T patent/DK2300514T3/en active
- 2008-08-28 ES ES08808172.4T patent/ES2572891T3/es active Active
- 2008-08-28 PT PT08808172T patent/PT2300514E/pt unknown
- 2008-08-28 WO PCT/IN2008/000545 patent/WO2010007626A1/en active Application Filing
- 2008-08-28 CN CN2008801303593A patent/CN102099397B/zh not_active Expired - Fee Related
- 2008-08-28 PL PL08808172.4T patent/PL2300514T3/pl unknown
- 2008-08-28 EP EP08808172.4A patent/EP2300514B1/en active Active
- 2008-08-28 JP JP2011518060A patent/JP5480257B2/ja not_active Expired - Fee Related
- 2008-08-28 BR BRPI0823084-6A patent/BRPI0823084B1/pt not_active IP Right Cessation
- 2008-08-28 KR KR1020117003255A patent/KR101311597B1/ko active IP Right Grant
- 2008-08-28 US US13/054,418 patent/US9040723B2/en active Active
-
2011
- 2011-01-12 IL IL210598A patent/IL210598A/en active IP Right Grant
- 2011-09-26 HK HK11110151.1A patent/HK1156335A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP2300514B1 (en) | 2016-03-23 |
US9040723B2 (en) | 2015-05-26 |
EP2300514A4 (en) | 2012-12-12 |
BRPI0823084B1 (pt) | 2019-07-16 |
EP2300514A1 (en) | 2011-03-30 |
PL2300514T3 (pl) | 2016-09-30 |
MY155612A (en) | 2015-11-13 |
JP2011528032A (ja) | 2011-11-10 |
CN102099397B (zh) | 2012-12-12 |
CN102099397A (zh) | 2011-06-15 |
IL210598A0 (en) | 2011-03-31 |
ES2572891T3 (es) | 2016-06-02 |
KR101311597B1 (ko) | 2013-09-26 |
DK2300514T3 (en) | 2016-06-27 |
US20110118480A1 (en) | 2011-05-19 |
PT2300514E (pt) | 2016-06-20 |
WO2010007626A1 (en) | 2010-01-21 |
KR20110040916A (ko) | 2011-04-20 |
HK1156335A1 (zh) | 2012-06-08 |
JP5480257B2 (ja) | 2014-04-23 |
IL210598A (en) | 2014-06-30 |
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Legal Events
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 3A ANUIDADE |
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B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 NA RPI 2336 DE 13/10/2015 |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
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B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/07/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/07/2019, OBSERVADAS AS CONDICOES LEGAIS |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 15A ANUIDADE. |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2737 DE 20-06-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |