BRPI0819833A2 - 5-[(3,3,3-triflúor-2-hidróxi-1-arilpropil)amino]-1h-quin olin-2-onas, um processo para sua produção e uso das mesmas como agentes anti-inflamatórios - Google Patents

5-[(3,3,3-triflúor-2-hidróxi-1-arilpropil)amino]-1h-quin olin-2-onas, um processo para sua produção e uso das mesmas como agentes anti-inflamatórios

Info

Publication number
BRPI0819833A2
BRPI0819833A2 BRPI0819833-0A BRPI0819833A BRPI0819833A2 BR PI0819833 A2 BRPI0819833 A2 BR PI0819833A2 BR PI0819833 A BRPI0819833 A BR PI0819833A BR PI0819833 A2 BRPI0819833 A2 BR PI0819833A2
Authority
BR
Brazil
Prior art keywords
arylpropyl
quinolin
trifluoro
hydroxy
ones
Prior art date
Application number
BRPI0819833-0A
Other languages
English (en)
Inventor
Markus Berger
Hartmut Rehwinkel
Thomas Zollner
Ekkehard May
Jorma Hasfeld
Heike Schäcke
Original Assignee
Bayer Schering Pharma Ag
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39575536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0819833(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag, Astrazeneca Ab filed Critical Bayer Schering Pharma Ag
Publication of BRPI0819833A2 publication Critical patent/BRPI0819833A2/pt
Publication of BRPI0819833B1 publication Critical patent/BRPI0819833B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
BRPI0819833A 2007-11-22 2008-11-08 5-[(3,3,3-triflúor-2-hidróxi-1-arilpropil)amino]-1h-quinolin-2-onas, seus intermediários, seu uso e seu processos de produção, bem como composição farmacêutica e combinação BRPI0819833B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07076019A EP2062880A1 (en) 2007-11-22 2007-11-22 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents
PCT/EP2008/009440 WO2009065503A1 (en) 2007-11-22 2008-11-08 5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1h-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
BRPI0819833A2 true BRPI0819833A2 (pt) 2015-05-26
BRPI0819833B1 BRPI0819833B1 (pt) 2018-11-27

Family

ID=39575536

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819833A BRPI0819833B1 (pt) 2007-11-22 2008-11-08 5-[(3,3,3-triflúor-2-hidróxi-1-arilpropil)amino]-1h-quinolin-2-onas, seus intermediários, seu uso e seu processos de produção, bem como composição farmacêutica e combinação

Country Status (40)

Country Link
US (3) US8394958B2 (pt)
EP (2) EP2062880A1 (pt)
JP (1) JP5559058B2 (pt)
KR (1) KR101580700B1 (pt)
CN (2) CN103396300A (pt)
AR (1) AR069400A1 (pt)
AU (1) AU2008328307C1 (pt)
BR (1) BRPI0819833B1 (pt)
CA (1) CA2705410C (pt)
CL (1) CL2008003472A1 (pt)
CO (1) CO6280419A2 (pt)
CR (1) CR11452A (pt)
CU (1) CU23889B1 (pt)
CY (1) CY1118173T1 (pt)
DK (1) DK2234979T3 (pt)
DO (1) DOP2010000152A (pt)
EA (1) EA017459B1 (pt)
EC (1) ECSP10010192A (pt)
ES (1) ES2588170T3 (pt)
HK (1) HK1144817A1 (pt)
HN (1) HN2010001060A (pt)
HR (1) HRP20161015T1 (pt)
HU (1) HUE028865T2 (pt)
IL (1) IL205117A (pt)
LT (1) LT2234979T (pt)
MA (1) MA31834B1 (pt)
MX (1) MX2010005528A (pt)
MY (1) MY151017A (pt)
NZ (1) NZ585495A (pt)
PA (1) PA8804601A1 (pt)
PE (1) PE20091066A1 (pt)
PL (1) PL2234979T3 (pt)
PT (1) PT2234979T (pt)
RS (1) RS55012B1 (pt)
SI (1) SI2234979T1 (pt)
TN (1) TN2010000219A1 (pt)
TW (1) TWI520736B (pt)
UA (1) UA100251C2 (pt)
UY (1) UY31479A1 (pt)
WO (1) WO2009065503A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1878717A1 (en) 2006-07-14 2008-01-16 Bayer Schering Pharma Aktiengesellschaft Benzyl amines, a process for their production and their use as anti-inflammatory agents
WO2009151569A2 (en) * 2008-06-09 2009-12-17 Combinatorx, Incorporated Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders
US20100016338A1 (en) * 2008-07-21 2010-01-21 Bayer Schering Pharma Aktiengesellschaft 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents
JP6061373B2 (ja) * 2012-07-24 2017-01-18 国立研究開発法人産業技術総合研究所 ２−ヒドロキシベンズアルデヒド化合物、これを含有するコラーゲン細胞外分泌阻害剤及び医薬品組成物
WO2017025371A1 (en) * 2015-08-07 2017-02-16 Bayer Pharma Aktiengesellschaft Process for the preparation of 5-amino-quinolin-2(1h)-ones and their tautomer forms 5-amino-quinolin-2-ols
US20190008867A1 (en) 2015-11-13 2019-01-10 Ph Pharma Co., Ltd. 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds
WO2017161518A1 (en) 2016-03-23 2017-09-28 Astrazeneca Ab New physical form
WO2018046684A1 (en) 2016-09-08 2018-03-15 Bayer Pharma Aktiengesellschaft Process for the preparation of substituted 5-{[2-(alkoxymethyl)-3,3,3-trifluoro-2-hydroxy-1-phenylpropyl]amino}quinolin-2(1h)-ones
WO2018046685A1 (en) 2016-09-08 2018-03-15 Bayer Aktiengesellschaft Quinoline derivatives for treatment of inflammatory skin diseases
WO2018046678A1 (de) 2016-09-08 2018-03-15 Bayer Aktiengesellschaft Glukokorticoid-rezeptor-agonisten enthaltende formulierungen
WO2018046681A1 (en) 2016-09-08 2018-03-15 Bayer Pharma Aktiengesellschaft Forms of 5-{[(1s,2s)-1-(2-chloro-3-fluoro-4-methoxyphenyl)-3,3,3-trifluoro-2-hydroxy-2-(methoxymethyl)propyl]amino}-7-fluoro-1h-quinolin-2-one
CA3123490A1 (en) * 2019-01-22 2020-07-30 Akribes Biomedical Gmbh Selective glucocorticoid receptor modifiers for treating impaired skin wound healing

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GB1045180A (en) 1963-09-20 1966-10-12 Parke Davis & Co Quinazoline derivatives
US4197209A (en) * 1977-03-10 1980-04-08 Ciba-Geigy Corporation Lubricant compositions containing sulfur-containing esters of phosphoric acid
JPH06172321A (ja) 1992-10-08 1994-06-21 Agro Kanesho Co Ltd 置換アミノピリミジン誘導体、その製造法及びそれを有効成分とする有害生物駆除剤
UA57002C2 (uk) * 1995-10-13 2003-06-16 Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування
WO2000010977A1 (en) 1998-08-21 2000-03-02 The Scripps Research Institute Catalytic asymmetric aminohydroxylation with amino-substituted heterocycles
DE10038639A1 (de) 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
CN1310912C (zh) 2000-12-22 2007-04-18 史密丝克莱恩比彻姆有限公司 5－[4－[2－(n－甲基－n－(2－吡啶基)氨基)乙氧基]苄基]噻唑烷－2,4－二酮甲磺酸盐
CA2477764A1 (en) * 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US20050090559A1 (en) * 2003-07-01 2005-04-28 Markus Berger Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents
MXPA06000169A (es) 2003-07-01 2006-04-27 Schering Ag Derivados de pentanol heterociclicamente sustituidos, procedimiento para su preparacion y su uso como anti-inflamatorios.
US20050009109A1 (en) * 2003-07-08 2005-01-13 Stanford University Fluorophore compounds and their use in biological systems
DE10347385A1 (de) * 2003-10-08 2005-05-12 Schering Ag Umgelagerte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
EP1878717A1 (en) * 2006-07-14 2008-01-16 Bayer Schering Pharma Aktiengesellschaft Benzyl amines, a process for their production and their use as anti-inflammatory agents
US20100016338A1 (en) * 2008-07-21 2010-01-21 Bayer Schering Pharma Aktiengesellschaft 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents

Also Published As

Publication number Publication date
ECSP10010192A (es) 2010-07-30
HUE028865T2 (en) 2017-01-30
CN103396300A (zh) 2013-11-20
HRP20161015T1 (hr) 2016-11-18
CO6280419A2 (es) 2011-05-20
UA100251C2 (uk) 2012-12-10
PL2234979T3 (pl) 2016-11-30
CU20100099A7 (es) 2011-10-14
USRE47047E1 (en) 2018-09-18
EP2062880A1 (en) 2009-05-27
PA8804601A1 (es) 2009-06-23
US20130005766A1 (en) 2013-01-03
TW200927112A (en) 2009-07-01
CY1118173T1 (el) 2017-06-28
CA2705410C (en) 2016-04-12
UY31479A1 (es) 2009-07-17
WO2009065503A1 (en) 2009-05-28
LT2234979T (lt) 2016-11-10
ES2588170T3 (es) 2016-10-31
TN2010000219A1 (en) 2011-11-11
JP5559058B2 (ja) 2014-07-23
AU2008328307C1 (en) 2013-10-24
HK1144817A1 (pt) 2011-03-11
CN101868448A (zh) 2010-10-20
IL205117A (en) 2015-05-31
AR069400A1 (es) 2010-01-20
RS55012B1 (sr) 2016-11-30
IL205117A0 (en) 2010-11-30
MY151017A (en) 2014-03-31
AU2008328307B2 (en) 2013-03-28
JP2011504472A (ja) 2011-02-10
EP2234979B1 (en) 2016-05-25
CR11452A (es) 2010-07-15
HN2010001060A (es) 2012-11-12
US20090137564A1 (en) 2009-05-28
EA017459B1 (ru) 2012-12-28
KR20100092936A (ko) 2010-08-23
NZ585495A (en) 2011-05-27
PE20091066A1 (es) 2009-08-27
EA201000814A1 (ru) 2010-12-30
CL2008003472A1 (es) 2009-11-20
AU2008328307A1 (en) 2009-05-28
KR101580700B1 (ko) 2015-12-28
CN101868448B (zh) 2013-06-12
BRPI0819833B1 (pt) 2018-11-27
MA31834B1 (fr) 2010-11-01
EP2234979A1 (en) 2010-10-06
PT2234979T (pt) 2016-08-29
CA2705410A1 (en) 2009-05-28
US8394958B2 (en) 2013-03-12
US8680117B2 (en) 2014-03-25
MX2010005528A (es) 2010-06-02
SI2234979T1 (sl) 2016-12-30
TWI520736B (zh) 2016-02-11
DK2234979T3 (en) 2016-09-05
CU23889B1 (es) 2013-04-19
DOP2010000152A (es) 2010-08-15

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