BRPI0809076A2 - Ensaio com base na fluorescência para a detecção de compostos para a modulação do trocador de sódio-cálcio (ncx) nos compostos de modulação em "modo de avanço" - Google Patents

Ensaio com base na fluorescência para a detecção de compostos para a modulação do trocador de sódio-cálcio (ncx) nos compostos de modulação em "modo de avanço"

Info

Publication number
BRPI0809076A2
BRPI0809076A2 BRPI0809076-9A2A BRPI0809076A BRPI0809076A2 BR PI0809076 A2 BRPI0809076 A2 BR PI0809076A2 BR PI0809076 A BRPI0809076 A BR PI0809076A BR PI0809076 A2 BRPI0809076 A2 BR PI0809076A2
Authority
BR
Brazil
Prior art keywords
modulation
ncx
fluorescence
based test
calcium sodium
Prior art date
Application number
BRPI0809076-9A2A
Other languages
English (en)
Inventor
Martin Hug
Thomas Licher
Sven Geibel
Henning Vollert
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0809076A2 publication Critical patent/BRPI0809076A2/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
BRPI0809076-9A2A 2007-03-13 2008-03-04 Ensaio com base na fluorescência para a detecção de compostos para a modulação do trocador de sódio-cálcio (ncx) nos compostos de modulação em "modo de avanço" BRPI0809076A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007011913A DE102007011913A1 (de) 2007-03-13 2007-03-13 Fluoreszenz-basiertes Assay zum Erkennen von Verbindungen zum Modulieren des Natrium-Calcium-Austauschers (NCX) im "Vorwärtsmodus"
PCT/EP2008/001707 WO2008110285A1 (de) 2007-03-13 2008-03-04 Fluoreszenz-basiertes assay zum erkennen von verbindungen zum modulieren des natrium-calcium-austauschers (ncx) im 'vorwärtsmodus'

Publications (1)

Publication Number Publication Date
BRPI0809076A2 true BRPI0809076A2 (pt) 2014-11-04

Family

ID=39563393

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809076-9A2A BRPI0809076A2 (pt) 2007-03-13 2008-03-04 Ensaio com base na fluorescência para a detecção de compostos para a modulação do trocador de sódio-cálcio (ncx) nos compostos de modulação em "modo de avanço"

Country Status (14)

Country Link
US (1) US20100151497A1 (pt)
EP (1) EP2135092A1 (pt)
JP (1) JP2010520759A (pt)
KR (1) KR20090122287A (pt)
CN (1) CN101636658A (pt)
AR (1) AR065685A1 (pt)
AU (1) AU2008226101B2 (pt)
BR (1) BRPI0809076A2 (pt)
CA (1) CA2680768A1 (pt)
DE (1) DE102007011913A1 (pt)
IL (1) IL200789A0 (pt)
MX (1) MX2009009681A (pt)
TW (1) TW200907340A (pt)
WO (1) WO2008110285A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2103944A1 (en) * 2008-03-20 2009-09-23 sanofi-aventis Fluorescence based assay to detect sodium/calcium exchanger "forward mode" modulating compounds
JP5127783B2 (ja) * 2009-06-29 2013-01-23 日本電信電話株式会社 においセンサおよびにおい検知方法
US8808353B2 (en) * 2010-01-30 2014-08-19 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds having a low crossing profile
US8568471B2 (en) * 2010-01-30 2013-10-29 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714666A (en) 1993-02-09 1998-02-03 Children's Hospital Of Philadelphia Measurement of intracellular calcium using bioluminescent apoaequorin expressed in mammalian cells
AU735185B2 (en) 1997-10-20 2001-07-05 Taisho Pharmaceutical Co., Ltd. 2-phenoxyaniline derivatives
US20020132303A1 (en) * 2001-03-12 2002-09-19 Millennium Pharmaceuticals, Inc. 69318, a human sodium/calcium exchanger (transporter) family member and uses therefor
US20020168625A1 (en) * 2000-10-13 2002-11-14 Weaver Charles David Methods for detecting modulators of ion channels using thallium (I) sensitive assays
KR20040062623A (ko) * 2001-11-09 2004-07-07 화이자 프로덕츠 인크. 작용제에 의한 수용체의 활성화에 대한 기능 분석법
KR100514090B1 (ko) * 2003-01-17 2005-09-13 한국과학기술연구원 Ncx2 단백질의 활성을 억제함으로써 학습능력 및기억력을 증진시키는 방법
US20050112701A1 (en) * 2003-09-11 2005-05-26 Aventis Pharma Deutschland Gmbh Test system for the identification of APJ receptor ligands

Also Published As

Publication number Publication date
AR065685A1 (es) 2009-06-24
CA2680768A1 (en) 2008-09-18
CN101636658A (zh) 2010-01-27
TW200907340A (en) 2009-02-16
KR20090122287A (ko) 2009-11-26
AU2008226101A1 (en) 2008-09-18
DE102007011913A1 (de) 2008-10-23
MX2009009681A (es) 2009-09-24
US20100151497A1 (en) 2010-06-17
EP2135092A1 (de) 2009-12-23
JP2010520759A (ja) 2010-06-17
IL200789A0 (en) 2010-05-17
AU2008226101B2 (en) 2013-09-19
WO2008110285A1 (de) 2008-09-18

Similar Documents

Publication Publication Date Title
BRPI0907521A2 (pt) Placa ortopédica para uso na articulação mtp
BRPI0716975A2 (pt) Agentes de peso precipitados para uso em fluidos de perfuração
DE602006009656D1 (de) 1-ä(3-hydroxy-adamant-1-ylamino)-acetylü-pyrrolidin-2(s)-carbonitril-formulierung mit modifizierter freisetzung
BRPI0819410A2 (pt) "dispositivo com múltiplas camadas para detecção de analitos"
DK1910270T3 (da) For PPAR-receptorer og EGF-receptorer specifikke forbindelser og deres salte samt deres anvendelse på det medicinske område
BRPI0809076A2 (pt) Ensaio com base na fluorescência para a detecção de compostos para a modulação do trocador de sódio-cálcio (ncx) nos compostos de modulação em "modo de avanço"
BRPI0911136A2 (pt) ensaio baseado em fluorescência para detectar compostos de modulação de "modo reverso" de trocador de sódio/cálcio (ncx)
DE602005005945D1 (de) Sekundärseitiger Nachregler mit PBM
DE502006008999D1 (de) Betätigungsvorrichtung für eine schnellanschlusskupplung
ATE488493T1 (de) Biphenyl- und naphthylphenylhydroxamsäurederivate
BRPI0807724A2 (pt) Composição para uso na odontologia
DE602006004904D1 (de) Drucker für Streifen
ITBS20050156A1 (it) Pinza pneumatica parallela perfezionata
DE602005014754D1 (de) Leistungsübertrager für eine flüssigkeitskupplung einsetzende fahrzeuge
BRPI0716304A2 (pt) " método para reabastecer um cartucho usado de tinta"
DE602005026953D1 (de) Trockenmittelbeutel mit ausrichtungsanzeiger
DE112006001881A5 (de) Nanomarkierung
BRPI0714809A2 (pt) faixa para substratos de clichê litográfico.
BRPI0719433A2 (pt) Dispositivo para a fixação de pelo menos um acoplamento em uma peça de suporte
FI20050252A (fi) Faasinmuutosta hyödyntävä lämmönvaihdin
IL208174A0 (en) Fluorescence based assay to detect soduim /calcimum exchanger " forward mode" modulating compounds
ES1064048Y (es) Dispositivo para refrigerar brocas
HK1107144A1 (en) Process for identification of compounds for modulating the activity of a sodium/calcium exchange transporter
WO2007089578A3 (en) Method for selecting phosphate binder and its uses thereof
ES1062353Y (es) Uña perfeccionada para flexometro

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]