BRPI0807487A2 - Uso de antagonistas de il-23 para o tratamento de infecção - Google Patents
Uso de antagonistas de il-23 para o tratamento de infecçãoInfo
- Publication number
- BRPI0807487A2 BRPI0807487A2 BRPI0807487-9A BRPI0807487A BRPI0807487A2 BR PI0807487 A2 BRPI0807487 A2 BR PI0807487A2 BR PI0807487 A BRPI0807487 A BR PI0807487A BR PI0807487 A2 BRPI0807487 A2 BR PI0807487A2
- Authority
- BR
- Brazil
- Prior art keywords
- antagonists
- treat infection
- infection
- treat
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88947507P | 2007-02-12 | 2007-02-12 | |
| PCT/US2008/001717 WO2008153610A2 (en) | 2007-02-12 | 2008-02-08 | Use of il-23 antagonists for treatment of infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0807487A2 true BRPI0807487A2 (pt) | 2015-09-01 |
| BRPI0807487A8 BRPI0807487A8 (pt) | 2016-02-10 |
Family
ID=40130357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0807487A BRPI0807487A8 (pt) | 2007-02-12 | 2008-02-08 | Uso de antagonistas de il-23 para o tratamento de infecção |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8586035B2 (pt) |
| EP (1) | EP2064246B1 (pt) |
| JP (2) | JP5320301B2 (pt) |
| CN (1) | CN101668775B (pt) |
| AU (1) | AU2008262544B2 (pt) |
| BR (1) | BRPI0807487A8 (pt) |
| CA (1) | CA2677835A1 (pt) |
| CL (1) | CL2008000418A1 (pt) |
| MX (1) | MX2009008617A (pt) |
| NZ (2) | NZ578955A (pt) |
| TW (1) | TWI426918B (pt) |
| WO (1) | WO2008153610A2 (pt) |
| ZA (1) | ZA200906126B (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI426918B (zh) * | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Il-23拮抗劑於治療感染之用途 |
| EP2254998B1 (en) * | 2008-02-28 | 2015-12-23 | Argos Therapeutics, Inc. | Transient expression of immunomodulatory polypeptides for the prevention and treatment of autoimmune disease, allergy and transplant rejection |
| WO2010027767A1 (en) * | 2008-08-27 | 2010-03-11 | Schering Corporation | Engineered anti-il-23r antibodies |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| SG190006A1 (en) | 2010-11-04 | 2013-06-28 | Boehringer Ingelheim Int | Anti-il-23 antibodies |
| DE112012000404T5 (de) * | 2011-01-04 | 2014-04-17 | Charitè Universitätsmedizin Berlin | Modulatoren von IL-12 und/oder IL-23 zur Prävention oder Behandlung des Morbus Alzheimer |
| EP2583680A3 (en) | 2011-10-21 | 2013-06-12 | Abbvie Inc. | Mono (PSI-7977) or combination treatment of DAAs for use in treating HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| SE1450130A1 (sv) | 2011-10-21 | 2014-05-07 | Abbvie Inc | Förfaranden för att behandla hcv innefattande minst två direktverkande antivirala agenser, ribavirin men inte interferon |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| NZ700802A (en) | 2012-05-03 | 2017-06-30 | Boehringer Ingelheim Int | Anti-il-23p19 antibodies |
| ES2729603T3 (es) | 2012-06-27 | 2019-11-05 | Merck Sharp & Dohme | Anticuerpos IL-23 antihumanos cristalinos |
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| US10406218B2 (en) * | 2014-04-09 | 2019-09-10 | La Jolla Institute For Allergy And Immunology | Specific and unique T cell responses and molecular signatures for the treatment and diagnosis of Mycobacterium tuberculosis |
| EP3708679A1 (en) | 2014-07-24 | 2020-09-16 | Boehringer Ingelheim International GmbH | Biomarkers useful in the treatment of il-23a related diseases |
| MY192824A (en) | 2014-09-03 | 2022-09-12 | Boehringer Ingelheim Int | Compound targeting il-23a and tnf-alpha and uses thereof |
| IL321788A (en) | 2015-02-04 | 2025-08-01 | Boehringer Ingelheim Int | Methods of treating inflammatory diseases |
| CN105420238A (zh) * | 2015-09-08 | 2016-03-23 | 中国农业科学院兰州兽医研究所 | 靶向抑制小鼠白细胞介素17A基因的序列siRNA-136 |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| US11040037B2 (en) | 2016-10-04 | 2021-06-22 | Pop Test Oncology Llc | Therapeutic agents and methods |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| AU2018263868A1 (en) | 2017-05-02 | 2019-12-12 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
| WO2018209307A1 (en) * | 2017-05-12 | 2018-11-15 | The Regents Of The University Of California | Methods for detecting dysbiosis and treating subjects with dysbiosis |
| CN108743603B (zh) * | 2018-06-22 | 2020-06-30 | 山东省千佛山医院 | 利巴韦林单用或联合氟康唑的抗真菌产品及其应用 |
| JP7467438B2 (ja) | 2018-10-18 | 2024-04-15 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗rsv抗体の製剤及びその使用方法 |
| CN113015748B (zh) | 2018-10-31 | 2025-12-12 | 默沙东有限责任公司 | 抗人pd-1抗体晶体及其使用方法 |
| CN113316458B (zh) | 2018-11-07 | 2024-08-02 | 默沙东有限责任公司 | 抗lag3抗体和抗pd-1抗体的共制剂 |
| CN112969473B (zh) * | 2018-11-09 | 2024-06-28 | 学校法人立命馆 | 皮脂腺调节剂 |
| TW202535466A (zh) | 2019-09-09 | 2025-09-16 | 德商百靈佳殷格翰國際股份有限公司 | 抗-il-23p19抗體調配物 |
| CA3164996A1 (en) * | 2019-12-20 | 2021-06-14 | Novarock Biotherapeutics, Ltd. | Anti-interleukin-23 p19 antibodies and methods of use thereof |
| CN112500490B (zh) * | 2020-10-14 | 2022-05-03 | 华南农业大学 | 一种抗左旋氧氟沙星抗体的F(ab)2片段及其制备方法和应用 |
| CN118873519A (zh) * | 2024-08-22 | 2024-11-01 | 首都医科大学附属北京胸科医院 | 萘替芬在抗偶发分枝杆菌感染中的应用 |
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| US4144346A (en) | 1977-01-31 | 1979-03-13 | Janssen Pharmaceutica N.V. | Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| US4267179A (en) | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| EP0069442B1 (en) | 1981-06-06 | 1985-02-20 | Pfizer Limited | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
| CN1235554A (zh) | 1996-09-12 | 1999-11-17 | 麦克公司 | 抗真菌的联合治疗 |
| CO4810232A1 (es) | 1997-07-25 | 1999-06-30 | Schering Corp | Citoquinas de mamiferos y sus secuencias codificadoras |
| US6492497B1 (en) * | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
| EP1950299A1 (en) | 1999-06-01 | 2008-07-30 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
| HK1044170B (en) | 1999-09-09 | 2008-08-01 | Merck Sharp & Dohme Corp. | Mammalian interleukin-12 p40 and interleukin b30. combinations thereof. antibodies. uses in pharmaceutical compositions |
| CZ304022B6 (cs) | 2000-05-10 | 2013-08-28 | Merck Sharp & Dohme Corp. | Savcí receptorové proteiny, cinidla a metody, které se jich týkají |
| AUPR381601A0 (en) * | 2001-03-19 | 2001-04-12 | Monash University | Method of treating respiratory conditions |
| CN1531440A (zh) * | 2001-05-09 | 2004-09-22 | - | 通过调节Th1/Th2比例预防或治疗Th1和Th2细胞相关疾病的药物组合物 |
| EP2108660A1 (en) * | 2002-10-30 | 2009-10-14 | Genentech, Inc. | Inhibition of IL-17 production |
| SI1601694T1 (sl) * | 2003-03-10 | 2010-01-29 | Schering Corp | Uporabe IL-23 antagonistov; sorodni reagenti |
| WO2004091519A2 (en) * | 2003-04-11 | 2004-10-28 | Medimmune, Inc. | Methods of preventing or treating respiratory conditions |
| WO2004101750A2 (en) * | 2003-05-09 | 2004-11-25 | Centocor, Inc. | IL-23p40 SPECIFIC IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES |
| ES2424353T3 (es) * | 2003-07-08 | 2013-10-01 | Genentech, Inc. | Polipéptidos heterólogos IL-17 A/F y usos terapéuticos de los mismos |
| GB0329146D0 (en) | 2003-12-16 | 2004-01-21 | Glaxosmithkline Biolog Sa | Vaccine |
| AU2005215527B2 (en) * | 2004-02-17 | 2011-04-07 | Merck Sharp & Dohme Corp. | Methods of modulating IL-23 activity; related reagents |
| US20060193821A1 (en) | 2004-03-05 | 2006-08-31 | Diener John L | Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics |
| GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| AR051444A1 (es) | 2004-09-24 | 2007-01-17 | Centocor Inc | Proteinas derivadas de inmunoglobulina especifica de il-23p40, composiciones, epitopos, metodos y usos |
| GB0425569D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Biological products |
| GB0507561D0 (en) | 2005-04-14 | 2005-05-18 | Trinity College Dublin | Modulation of an immune response by filamentous haemagglutinin |
| PT2452694T (pt) * | 2005-06-30 | 2019-02-21 | Janssen Biotech Inc | Anticorpos anti-il-23, composições, métodos e utilizações |
| AU2006283194B9 (en) | 2005-08-25 | 2011-02-03 | Eli Lilly And Company | Anti-IL-23 Antibodies |
| LT1931710T (lt) | 2005-08-31 | 2017-03-27 | Merck Sharp & Dohme Corp. | Rekombinantiniai anti-il-23 antikūnai |
| EA035459B1 (ru) | 2005-12-29 | 2020-06-19 | Сентокор, Инк. | Антитело против il-23p19 |
| EP2044118A2 (en) | 2006-06-13 | 2009-04-08 | Zymogenetics, Inc. | Il-17 and il-23 antagonists and methods of using the same |
| CA2660463C (en) | 2006-08-11 | 2013-07-16 | Schering Corporation | Antibodies to il-17a |
| TWI426918B (zh) * | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Il-23拮抗劑於治療感染之用途 |
| PL2059534T3 (pl) | 2007-02-23 | 2012-09-28 | Merck Sharp & Dohme | Przeciwciała Anty-IL-23p19 wytworzone metodą inżynierii genetycznej |
| CN103396489A (zh) | 2007-02-23 | 2013-11-20 | 默沙东公司 | 工程改造的抗IL-23p19抗体 |
| EP2057194B1 (en) | 2007-02-28 | 2013-03-20 | Merck Sharp & Dohme Corp. | Engineered anti-il-23r antibodies |
| WO2010027767A1 (en) | 2008-08-27 | 2010-03-11 | Schering Corporation | Engineered anti-il-23r antibodies |
-
2008
- 2008-02-05 TW TW097104700A patent/TWI426918B/zh not_active IP Right Cessation
- 2008-02-08 EP EP08714214.7A patent/EP2064246B1/en active Active
- 2008-02-08 NZ NZ578955A patent/NZ578955A/en not_active IP Right Cessation
- 2008-02-08 WO PCT/US2008/001717 patent/WO2008153610A2/en not_active Ceased
- 2008-02-08 CN CN200880010208.4A patent/CN101668775B/zh not_active Expired - Fee Related
- 2008-02-08 AU AU2008262544A patent/AU2008262544B2/en not_active Ceased
- 2008-02-08 JP JP2009549119A patent/JP5320301B2/ja not_active Expired - Fee Related
- 2008-02-08 CL CL2008000418A patent/CL2008000418A1/es unknown
- 2008-02-08 NZ NZ599827A patent/NZ599827A/xx not_active IP Right Cessation
- 2008-02-08 CA CA002677835A patent/CA2677835A1/en not_active Abandoned
- 2008-02-08 US US12/525,003 patent/US8586035B2/en not_active Expired - Fee Related
- 2008-02-08 BR BRPI0807487A patent/BRPI0807487A8/pt not_active IP Right Cessation
- 2008-02-08 MX MX2009008617A patent/MX2009008617A/es active IP Right Grant
-
2009
- 2009-09-03 ZA ZA200906126A patent/ZA200906126B/xx unknown
-
2012
- 2012-10-18 JP JP2012230578A patent/JP2013014624A/ja active Pending
-
2013
- 2013-10-28 US US14/065,171 patent/US20140147442A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101668775A (zh) | 2010-03-10 |
| EP2064246A2 (en) | 2009-06-03 |
| CL2008000418A1 (es) | 2008-11-14 |
| US20100291084A1 (en) | 2010-11-18 |
| NZ578955A (en) | 2012-06-29 |
| EP2064246B1 (en) | 2013-05-22 |
| WO2008153610A3 (en) | 2009-03-19 |
| JP2010518087A (ja) | 2010-05-27 |
| WO2008153610A2 (en) | 2008-12-18 |
| BRPI0807487A8 (pt) | 2016-02-10 |
| US20140147442A1 (en) | 2014-05-29 |
| TW200902062A (en) | 2009-01-16 |
| NZ599827A (en) | 2013-11-29 |
| MX2009008617A (es) | 2009-10-14 |
| ZA200906126B (en) | 2010-06-30 |
| CA2677835A1 (en) | 2008-12-18 |
| CN101668775B (zh) | 2014-05-07 |
| JP2013014624A (ja) | 2013-01-24 |
| AU2008262544A1 (en) | 2008-12-18 |
| AU2008262544B2 (en) | 2014-01-16 |
| JP5320301B2 (ja) | 2013-10-23 |
| US8586035B2 (en) | 2013-11-19 |
| TWI426918B (zh) | 2014-02-21 |
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