BRPI0720945A2 - instrumento espalhador - Google Patents
instrumento espalhador Download PDFInfo
- Publication number
- BRPI0720945A2 BRPI0720945A2 BRPI0720945-2A BRPI0720945A BRPI0720945A2 BR PI0720945 A2 BRPI0720945 A2 BR PI0720945A2 BR PI0720945 A BRPI0720945 A BR PI0720945A BR PI0720945 A2 BRPI0720945 A2 BR PI0720945A2
- Authority
- BR
- Brazil
- Prior art keywords
- liquid
- wall
- receptacle
- instrument
- composition
- Prior art date
Links
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- 235000011127 sodium aluminium sulphate Nutrition 0.000 description 1
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- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
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- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
- A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D40/00—Casings or accessories specially adapted for storing or handling solid or pasty toiletry or cosmetic substances, e.g. shaving soaps or lipsticks
- A45D40/26—Appliances specially adapted for applying pasty paint, e.g. using roller, using a ball
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/28—Zirconium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
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- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88448207P | 2007-01-11 | 2007-01-11 | |
| US60/884,482 | 2007-01-11 | ||
| PCT/AU2007/000138 WO2008083423A1 (en) | 2007-01-11 | 2007-02-12 | Spreading implement |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0720945A2 true BRPI0720945A2 (pt) | 2012-12-25 |
Family
ID=39608244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0720945-2A BRPI0720945A2 (pt) | 2007-01-11 | 2007-02-12 | instrumento espalhador |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US8177449B2 (enExample) |
| EP (1) | EP2106272A4 (enExample) |
| JP (1) | JP5114496B2 (enExample) |
| KR (1) | KR101301116B1 (enExample) |
| CN (1) | CN101636194B (enExample) |
| AU (1) | AU2007343579B2 (enExample) |
| BR (1) | BRPI0720945A2 (enExample) |
| CA (1) | CA2674661C (enExample) |
| EA (1) | EA015473B1 (enExample) |
| IN (1) | IN2009KN02397A (enExample) |
| MX (1) | MX2009007366A (enExample) |
| NZ (1) | NZ578883A (enExample) |
| WO (1) | WO2008083423A1 (enExample) |
| ZA (1) | ZA200904568B (enExample) |
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| EA015473B1 (ru) | 2007-01-11 | 2011-08-30 | АКРУКС ДиДиЭс ПиТиУай ЭлТиДи | Инструмент для нанесения объема жидкости на обрабатываемую поверхность, система и способ трансдермального введения физиологически активного вещества в организм больного |
| US20100094249A1 (en) * | 2008-10-09 | 2010-04-15 | Ty Caswell | Wound treatment apparatus and methods |
| FR2950807B1 (fr) * | 2009-10-06 | 2012-02-03 | Lvmh Rech | Composition cosmetique contenant des liposomes encapsules dans un compose oxazolidin-2-one |
| US9526882B2 (en) | 2010-05-01 | 2016-12-27 | Optnics Precision Co., Ltd. | Percutaneous administration device and method for producing the same |
| EP2566630B1 (en) | 2010-05-06 | 2021-03-17 | Flocon, Inc. | Liquid applicator device |
| AU336402S (en) | 2011-03-04 | 2011-05-10 | Acrux Dds Pty Ltd | Spreading applicator |
| JP4923156B1 (ja) * | 2011-05-24 | 2012-04-25 | エム・エフ・ヴィ株式会社 | 塗布用具 |
| AU2012278039A1 (en) | 2011-06-27 | 2013-12-19 | Ferring B.V. | Applicator system for applying a viscous liquid to the human skin |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| EP2825393B1 (en) | 2012-03-16 | 2020-11-11 | Flocon, Inc. | Precision liquid applicator |
| US9950125B2 (en) | 2012-04-06 | 2018-04-24 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US9445762B2 (en) * | 2012-08-30 | 2016-09-20 | Mystic Pharmaceuticals, Inc. | Fully self-contained unit dose devices for allergy skin testing |
| EP2925273A4 (en) * | 2012-11-28 | 2016-08-31 | Jaleva Pharmaceuticals Llc | DOPPELKAMMERAPPLIKATOR |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| USD753492S1 (en) * | 2013-07-19 | 2016-04-12 | Tricorbraun Inc. | Applicator |
| USD750788S1 (en) * | 2013-11-26 | 2016-03-01 | Acrux Dds Pty Ltd | Topical spreading applicator |
| CA2931823A1 (en) * | 2013-11-26 | 2015-06-04 | Acrux Dds Pty Ltd. | A device for dispensing and spreading a liquid |
| CA2931820A1 (en) * | 2013-11-26 | 2015-06-04 | Acrux Dds Pty Ltd. | A device for dispensing and applying a liquid |
| USD749225S1 (en) * | 2013-11-26 | 2016-02-09 | Acrux Dds Pty Ltd | Topical spreading applicator |
| US9227044B2 (en) * | 2013-12-09 | 2016-01-05 | Amneal Pharmaceuticals Llc | Applicator for applying a fluid to a surface |
| USD752287S1 (en) | 2013-12-09 | 2016-03-22 | Amneal Pharmaceuticals Llc | Applicator for applying a liquid to a surface |
| USD752982S1 (en) * | 2014-02-20 | 2016-04-05 | Tricorbraun Inc. | Applicator |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10039364B2 (en) | 2015-12-11 | 2018-08-07 | Randy S. Lee | Antiperspirant-deodorant applicator |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| USD830854S1 (en) * | 2017-01-31 | 2018-10-16 | Gary Kellman | Dispenser |
| US10555592B2 (en) * | 2017-08-31 | 2020-02-11 | Symbiotec Pharma Lab Pvt. Ltd. | Application for topical composition |
| WO2019140087A1 (en) | 2018-01-10 | 2019-07-18 | Celista Pharmaceuticals Llc | Testosterone transdermal spray with film |
| AU2019265004B2 (en) * | 2018-05-11 | 2025-02-27 | Brickell Biotech, Inc. | Applicator and system for pharmaceutical preparation and method of use |
| EP3817731B1 (en) | 2018-07-05 | 2025-09-03 | Celista Pharmaceuticals Llc | Testosterone and estradiol transdermal spray |
| US20210316122A1 (en) * | 2018-08-28 | 2021-10-14 | Institute For Cancer Research d/h/a The Research Institute of Fox Chase Cancer Center | Hematostick/HematoDart |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1573224A (en) | 1924-03-31 | 1926-02-16 | Park N Condit | Liquid applicator |
| GB298783A (en) | 1927-11-01 | 1928-10-18 | Herbert Evans | Improvements in golf ball cleaners |
| US1925019A (en) * | 1932-04-19 | 1933-08-29 | Wilson William | Surface treating device |
| US1982833A (en) | 1933-09-14 | 1934-12-04 | Joseph J Schmerler | Spreader for paste tubes |
| US2361407A (en) * | 1942-08-11 | 1944-10-31 | Mcnair Joseph | Applicator |
| US2608705A (en) | 1946-08-03 | 1952-09-02 | John R Duff | Golf ball cleaner |
| GB1110824A (en) | 1965-06-01 | 1968-04-24 | John William Patrick Faint | Device for treating surfaces |
| FR1461630A (fr) * | 1965-10-27 | 1966-02-25 | Etablissements F Pfirter & Cie | Bouchon avec tampon étaleur, pour tubes de cirage ou autres produits pâteux |
| US3333292A (en) * | 1966-05-23 | 1967-08-01 | Oscar H Chase | Container-integrated applicator |
| JPS4418093Y1 (enExample) * | 1966-06-06 | 1969-08-05 | ||
| US3462230A (en) * | 1967-09-22 | 1969-08-19 | Chester E Beard | Means for carrying and cleaning golf balls |
| US3685913A (en) | 1970-09-22 | 1972-08-22 | Roger D Pass | Cream and lather applicator |
| US3887115A (en) | 1973-11-29 | 1975-06-03 | Johnson & Son Inc S C | Package for an underarm spray product |
| GB1560401A (en) | 1976-01-28 | 1980-02-06 | Unilever Ltd | Skin treatment composition |
| DE2836752A1 (de) * | 1978-08-23 | 1980-03-06 | Richard Kratz | Geraet zum auftragen von hautpflegemitteln |
| US4483636A (en) * | 1983-05-02 | 1984-11-20 | Meyer Tracey K | Suntan oil applicator |
| FR2581569B3 (fr) | 1985-05-13 | 1987-10-02 | Oreal | Dispositif permettant d'appliquer sur un support une substance de consistance liquide a pateuse |
| DE3526109A1 (de) | 1985-07-22 | 1987-01-22 | Deiglmayr Chem Fab Ivo | An einem behaeltnis anzuordnender applikator zum applizieren von zaehfluessigen massen |
| JPS62166839U (enExample) * | 1986-04-10 | 1987-10-23 | ||
| US4726700A (en) * | 1986-05-07 | 1988-02-23 | Gray James R | Rub-on applicator |
| US4787374A (en) | 1986-05-29 | 1988-11-29 | Deyarman James B | Liquid applicator device having cavities to retain drop of liquid |
| US4739778A (en) | 1987-05-13 | 1988-04-26 | Christie Sharon K | Product sampling dispenser |
| US5788983A (en) | 1989-04-03 | 1998-08-04 | Rutgers, The State University Of New Jersey | Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes |
| ES2050976T3 (es) * | 1989-07-25 | 1994-06-01 | Oreal | Conjunto de distribucion de al menos un producto fluido, principalmente cosmetico o farmaceutico. |
| JP3046346B2 (ja) | 1990-03-12 | 2000-05-29 | 昭和電工株式会社 | 外用剤基剤又は補助剤とそれを含有する人又は動物の外用剤 |
| WO1991018535A1 (en) | 1990-05-29 | 1991-12-12 | Kalumburu Pty. Ltd. | Application device |
| US5122383A (en) | 1991-05-17 | 1992-06-16 | Theratech, Inc. | Sorbitan esters as skin permeation enhancers |
| EP0560014A1 (en) | 1992-03-12 | 1993-09-15 | Atrix Laboratories, Inc. | Biodegradable film dressing and method for its formation |
| AU677206B2 (en) | 1992-06-11 | 1997-04-17 | Theratech, Inc. | The use of glycerin in moderating transdermal drug delivery |
| US5613958A (en) | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
| FR2713060B1 (fr) | 1993-11-29 | 1996-02-02 | Oreal | Dispositif applicateur pour liquide. |
| FR2727608B1 (fr) * | 1994-12-06 | 1997-01-10 | Oreal | Distributeur pour un produit de consistance liquide a pateuse |
| US5558874A (en) | 1994-12-12 | 1996-09-24 | Habley Medical Technology Corporation | Multi-compartment applicator for packaging, reconstituting and applying a dehydrated multi-constituent medication |
| FR2732223B1 (fr) | 1995-03-30 | 1997-06-13 | Sanofi Sa | Composition pharmaceutique pour administration transdermique |
| US5568669A (en) * | 1995-05-26 | 1996-10-29 | Godown; Terrye T. | Lotion applicator |
| US5780050A (en) | 1995-07-20 | 1998-07-14 | Theratech, Inc. | Drug delivery compositions for improved stability of steroids |
| FR2739265B1 (fr) | 1995-10-03 | 1997-12-19 | Seb Sa | Dispositif d'epilation a la cire |
| US6916487B2 (en) | 1996-02-19 | 2005-07-12 | Acrux Dds Pty Ltd | Transdermal delivery of antiemetics |
| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US6923983B2 (en) | 1996-02-19 | 2005-08-02 | Acrux Dds Pty Ltd | Transdermal delivery of hormones |
| US6998138B2 (en) | 1996-02-19 | 2006-02-14 | Acrux Dds Pty. Ltd. | Topical delivery of anti-alopecia agents |
| US6916486B2 (en) | 1996-02-19 | 2005-07-12 | Acrux Dds Pty Ltd | Transdermal delivery of analgesics |
| US7094422B2 (en) | 1996-02-19 | 2006-08-22 | Acrux Dds Pty Ltd. | Topical delivery of antifungal agents |
| JPH09299400A (ja) * | 1996-05-20 | 1997-11-25 | Soft Ueebu:Kk | 圧縮綿球 |
| US6099315A (en) * | 1996-09-20 | 2000-08-08 | Block Drug Company, Inc. | Applicator tip for desensitizing agents and method |
| FR2754985B1 (fr) * | 1996-10-31 | 1999-01-08 | Oreal | Applicateur de produit delitable et ensemble d'application comportant un tel applicateur |
| AUPO379596A0 (en) | 1996-11-22 | 1996-12-19 | Soltec Research Pty Ltd | Percutaneous delivery system |
| DE19701949A1 (de) | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| DE19728447A1 (de) * | 1997-07-03 | 1998-04-30 | Ludwig Kefer | Auftragsflasche (Körperpflege) |
| US5968919A (en) | 1997-10-16 | 1999-10-19 | Macrochem Corporation | Hormone replacement therapy drug formulations for topical application to the skin |
| KR100648536B1 (ko) | 1997-11-10 | 2006-11-24 | 셀러지 파마세우티칼스, 인크 | 침투 보강 및 자극 감소를 위한 계 |
| JP3561143B2 (ja) | 1998-04-02 | 2004-09-02 | 矢崎総業株式会社 | ロック構造 |
| US6325565B1 (en) * | 1998-06-30 | 2001-12-04 | The Procter & Gamble Company | Anti-perspirant/deodorant applicator |
| US6315482B1 (en) * | 1998-11-04 | 2001-11-13 | The Procter & Gamble Company | Applicator for applying and distributing substances to target surfaces |
| AU743597B2 (en) * | 1998-06-30 | 2002-01-31 | Procter & Gamble Company, The | Applicator for applying and distributing substances to target surfaces |
| FR2780622B1 (fr) * | 1998-07-03 | 2001-07-20 | Oreal | Applicateur pour produit delitescent, ensemble comportant un tel applicateur et procede |
| FR2781770B1 (fr) * | 1998-07-30 | 2000-10-13 | Valois Sa | Echantillon de produit fluide |
| US6113008A (en) * | 1998-08-20 | 2000-09-05 | 3M Innovative Properties Company | Actuator system for spraying a formulation onto a host |
| DE19858410A1 (de) * | 1998-12-17 | 2000-06-29 | Schwan Stabilo Cosmetics Gmbh | Auftragvorrichtung |
| ATE252380T1 (de) | 1999-02-05 | 2003-11-15 | Cipla Ltd | Topische sprays enthaltend eine filmbildende zusammensetzung |
| DE19906152B4 (de) | 1999-02-10 | 2005-02-10 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige Laminate für Transdermalsysteme |
| FR2799940B1 (fr) * | 1999-10-22 | 2001-12-28 | Oreal | Applicateur en mousse comprenant un ou plusieurs composes particulaires concentres au voisinage de la surface d'application |
| US6562790B2 (en) | 2000-02-05 | 2003-05-13 | Chein Edmund Y M | Hormone therapy methods and hormone products for abating coronary artery blockage |
| WO2001076972A1 (en) * | 2000-04-05 | 2001-10-18 | Sanford Redmond Inc. | Easy opening liquid pouch with swab device |
| US6666216B2 (en) | 2000-07-24 | 2003-12-23 | L'oreal S.A. | Device for applying a product to a surface |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US6945723B1 (en) * | 2000-09-21 | 2005-09-20 | L'oréal | Packaging and application device |
| FR2814651B1 (fr) | 2000-10-03 | 2003-08-15 | Oreal | Dispositif de conditionnement et d'application comportant un element d'application compressible servant a l' application du produit et un logement pour recevoir l' element d'application charge en produit |
| US6682757B1 (en) | 2000-11-16 | 2004-01-27 | Euro-Celtique, S.A. | Titratable dosage transdermal delivery system |
| AU144863S (en) | 2000-12-01 | 2001-08-15 | Acrux Dds Pty Ltd | Dispensing device |
| WO2003092784A1 (en) * | 2002-05-06 | 2003-11-13 | Vectura Limited | Application device for topical administration of pharmaceutical agents |
| US20050181032A1 (en) | 2002-06-25 | 2005-08-18 | Acrux Dds Pty Ltd. | Metastable pharmaceutical compositions |
| US20050186141A1 (en) | 2002-06-25 | 2005-08-25 | Acrux Dds Pty Ltd. | Transdermal aerosol compositions |
| JP5160018B2 (ja) | 2002-06-25 | 2013-03-13 | アクルックス・ディ・ディ・エス・プロプライエタリー・リミテッド | 非晶質医薬組成物を用いる経皮送達速度調節 |
| AU2002300214A1 (en) | 2002-07-19 | 2004-02-05 | Visy Packaging Pty Ltd | Container |
| US8206696B2 (en) | 2002-12-30 | 2012-06-26 | Aplicare, Inc. | Antimicrobial skin preparation |
| US6681945B1 (en) | 2003-02-05 | 2004-01-27 | Valley Design, Inc. | Child resistant overcap for oval container |
| PL1670433T3 (pl) | 2003-10-10 | 2013-03-29 | Ferring Bv | Przezskórna formulacja farmaceutyczna do zmniejszania pozostałości na skórze |
| FR2860770B1 (fr) | 2003-10-13 | 2006-08-04 | Oreal | Dispositif de conditionnement et d'application. |
| AU2003283343A1 (en) * | 2003-11-04 | 2005-06-17 | Rpc Wiko Gmbh And Co. Kg | Dispenser pump |
| CN1882340A (zh) | 2003-11-19 | 2006-12-20 | 艾克若克斯Dds有限公司 | 用于治疗或预防淀粉样变性病的方法和组合物 |
| WO2006005134A1 (en) * | 2004-07-14 | 2006-01-19 | Acrux Dds Pty Ltd | Lotion applicator |
| JP2008510660A (ja) | 2004-07-14 | 2008-04-10 | アクルックス・ディ・ディ・エス・プロプライエタリー・リミテッド | 回転可能なカラーにより移動する封止部を有するキャップ及び塗布面を有するレセプタクル |
| US7344328B2 (en) | 2004-08-31 | 2008-03-18 | Unique Dispensing Systems | Oval applicator |
| EP1634583A1 (en) | 2004-09-09 | 2006-03-15 | Laboratoires Besins International | Testosterone gels comprising propylene glycol as penetration enhancer |
| US8435944B2 (en) | 2005-06-03 | 2013-05-07 | Acrux Dds Pty Ltd. | Method and composition for transdermal drug delivery |
| CA2610708C (en) | 2005-06-03 | 2013-10-08 | Acrux Dds Pty Ltd | Method and composition for transdermal drug delivery |
| US7955016B2 (en) | 2005-12-09 | 2011-06-07 | L'oreal | Cosmetic or dermatological treatment method and devices for application of such a method |
| US7828166B1 (en) | 2006-05-03 | 2010-11-09 | Rexam Closures And Containers Inc. | Dispensing closure with child resistant feature |
| EA015473B1 (ru) | 2007-01-11 | 2011-08-30 | АКРУКС ДиДиЭс ПиТиУай ЭлТиДи | Инструмент для нанесения объема жидкости на обрабатываемую поверхность, система и способ трансдермального введения физиологически активного вещества в организм больного |
| AU2012278039A1 (en) | 2011-06-27 | 2013-12-19 | Ferring B.V. | Applicator system for applying a viscous liquid to the human skin |
-
2007
- 2007-02-12 EA EA200900987A patent/EA015473B1/ru not_active IP Right Cessation
- 2007-02-12 IN IN2397KON2009 patent/IN2009KN02397A/en unknown
- 2007-02-12 BR BRPI0720945-2A patent/BRPI0720945A2/pt not_active IP Right Cessation
- 2007-02-12 CA CA2674661A patent/CA2674661C/en not_active Expired - Fee Related
- 2007-02-12 KR KR1020097016301A patent/KR101301116B1/ko not_active Expired - Fee Related
- 2007-02-12 NZ NZ578883A patent/NZ578883A/en not_active IP Right Cessation
- 2007-02-12 JP JP2009545034A patent/JP5114496B2/ja not_active Expired - Fee Related
- 2007-02-12 ZA ZA200904568A patent/ZA200904568B/xx unknown
- 2007-02-12 AU AU2007343579A patent/AU2007343579B2/en not_active Ceased
- 2007-02-12 CN CN2007800496999A patent/CN101636194B/zh not_active Expired - Fee Related
- 2007-02-12 MX MX2009007366A patent/MX2009007366A/es active IP Right Grant
- 2007-02-12 WO PCT/AU2007/000138 patent/WO2008083423A1/en not_active Ceased
- 2007-02-12 EP EP07701469A patent/EP2106272A4/en not_active Withdrawn
- 2007-02-26 US US11/678,673 patent/US8177449B2/en not_active Expired - Fee Related
-
2012
- 2012-05-04 US US13/464,556 patent/US8419307B2/en active Active
-
2013
- 2013-03-15 US US13/836,056 patent/US8807861B2/en active Active - Reinstated
-
2014
- 2014-06-27 US US14/317,412 patent/US9289586B2/en not_active Expired - Fee Related
-
2016
- 2016-02-18 US US15/047,128 patent/US20160303359A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IN2009KN02397A (enExample) | 2015-08-07 |
| EP2106272A1 (en) | 2009-10-07 |
| ZA200904568B (en) | 2010-09-29 |
| US20150088080A1 (en) | 2015-03-26 |
| HK1136228A1 (en) | 2010-06-25 |
| US20160303359A1 (en) | 2016-10-20 |
| KR101301116B1 (ko) | 2013-09-03 |
| MX2009007366A (es) | 2009-07-16 |
| NZ578883A (en) | 2012-05-25 |
| KR20090110324A (ko) | 2009-10-21 |
| US8807861B2 (en) | 2014-08-19 |
| EA200900987A1 (ru) | 2009-12-30 |
| JP5114496B2 (ja) | 2013-01-09 |
| US8177449B2 (en) | 2012-05-15 |
| EA015473B1 (ru) | 2011-08-30 |
| WO2008083423A1 (en) | 2008-07-17 |
| JP2010515490A (ja) | 2010-05-13 |
| AU2007343579B2 (en) | 2011-11-17 |
| CA2674661C (en) | 2016-10-11 |
| US8419307B2 (en) | 2013-04-16 |
| EP2106272A4 (en) | 2011-05-04 |
| US20120220959A1 (en) | 2012-08-30 |
| CN101636194B (zh) | 2013-01-02 |
| US20080170904A1 (en) | 2008-07-17 |
| CA2674661A1 (en) | 2008-07-17 |
| US9289586B2 (en) | 2016-03-22 |
| US20130211350A1 (en) | 2013-08-15 |
| AU2007343579A1 (en) | 2008-07-17 |
| CN101636194A (zh) | 2010-01-27 |
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