BRPI0718591A2 - Compostos antiangiogênicos. - Google Patents
Compostos antiangiogênicos. Download PDFInfo
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- BRPI0718591A2 BRPI0718591A2 BRPI0718591-0A BRPI0718591A BRPI0718591A2 BR PI0718591 A2 BRPI0718591 A2 BR PI0718591A2 BR PI0718591 A BRPI0718591 A BR PI0718591A BR PI0718591 A2 BRPI0718591 A2 BR PI0718591A2
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Landscapes
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- Chemical & Material Sciences (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86536006P | 2006-11-10 | 2006-11-10 | |
| US60/865,360 | 2006-11-10 | ||
| US93983007P | 2007-05-23 | 2007-05-23 | |
| US60/939,830 | 2007-05-23 | ||
| US94532907P | 2007-06-20 | 2007-06-20 | |
| US60/945,329 | 2007-06-20 | ||
| PCT/IE2007/000110 WO2008056346A2 (en) | 2006-11-10 | 2007-11-12 | Anti-angiogenic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0718591A2 true BRPI0718591A2 (pt) | 2013-12-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0718591-0A BRPI0718591A2 (pt) | 2006-11-10 | 2007-11-12 | Compostos antiangiogênicos. |
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| EP (2) | EP2089425B1 (enExample) |
| JP (2) | JP4897050B2 (enExample) |
| KR (2) | KR20120043028A (enExample) |
| CN (1) | CN101611053B (enExample) |
| AT (1) | ATE520712T1 (enExample) |
| AU (1) | AU2007318912B2 (enExample) |
| BR (1) | BRPI0718591A2 (enExample) |
| CA (1) | CA2669207A1 (enExample) |
| DK (1) | DK2089425T3 (enExample) |
| IL (1) | IL198581A (enExample) |
| MX (1) | MX2009005045A (enExample) |
| MY (1) | MY146985A (enExample) |
| NO (1) | NO20092203L (enExample) |
| NZ (1) | NZ576751A (enExample) |
| PL (1) | PL2089425T3 (enExample) |
| PT (1) | PT2089425E (enExample) |
| WO (1) | WO2008056346A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20120043028A (ko) * | 2006-11-10 | 2012-05-03 | 씨오브이엑스 테크놀로지스 아일랜드 리미티드 | 혈관 신생 억제 화합물 |
| US20090098130A1 (en) * | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| US8293714B2 (en) * | 2008-05-05 | 2012-10-23 | Covx Technology Ireland, Ltd. | Anti-angiogenic compounds |
| WO2010036930A1 (en) * | 2008-09-26 | 2010-04-01 | Javad Parvizi | Methods and kits for detecting joint infection |
| EP2593142B8 (en) * | 2010-07-12 | 2018-12-26 | Pfizer Healthcare Ireland | Multifunctional antibody conjugates |
| RU2013118441A (ru) | 2010-11-05 | 2014-12-10 | КовЭкс Текнолоджиз Айэлэнд Лимитед | Антидиабетические соединения |
| JP6069312B2 (ja) | 2011-06-29 | 2017-02-01 | アムジェン インコーポレイテッド | 腎細胞癌の治療における生存の予測バイオマーカー |
| CA2860109C (en) * | 2011-12-20 | 2016-08-09 | Javier Magano | Improved processes for preparing peptide conjugates and linkers |
| TW201341401A (zh) * | 2012-01-09 | 2013-10-16 | Covx Technologies Ireland Ltd | 突變抗體及其共軛 |
| JP6219923B2 (ja) | 2012-03-28 | 2017-10-25 | アムジェン インコーポレイテッド | Ｄｒ５受容体アゴニストの組み合わせ |
| EP3007717B1 (en) | 2013-06-12 | 2018-08-29 | Pharis Biotec GmbH | Peptides with antagonistic activities against natural cxcr4 |
| WO2015014376A1 (en) * | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
| BR112016007622A2 (pt) | 2013-10-15 | 2018-01-23 | Seattle Genetics, Inc. | composto, composição farmacêutica, conjugado de ligante-droga, e, método para tratar câncer |
| WO2016209972A1 (en) | 2015-06-26 | 2016-12-29 | Amgen Inc. | Biomarker of survival in the treatment of renal cell carcinoma with a vegfr inhibitor and an ang2 inhibitor |
| SG11201804268RA (en) | 2015-12-04 | 2018-06-28 | Seattle Genetics Inc | Conjugates of quaternized tubulysin compounds |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| BR112018069273A2 (pt) | 2016-03-25 | 2019-01-22 | Seattle Genetics Inc | métodos para preparação de um composto e para tratamento de um indivíduo com uma malignidade hematológica, composto, composição, e, intermediário ligante de fármaco ou composto ligante de fármaco |
| MX2019008449A (es) | 2017-02-08 | 2019-09-09 | Bristol Myers Squibb Co | Polipetidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos. |
| US11730822B2 (en) | 2017-03-24 | 2023-08-22 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
| EP3617235A4 (en) | 2017-04-28 | 2020-12-16 | Ajinomoto Co., Inc. | COMPOUND CONTAINING A SUBSTANCE HAVING AFFINITY FOR A SOLUBLE PROTEIN, CLIVABLE FRACTION, AND REACTIVE GROUP, OR SALT OF THE SAME |
Family Cites Families (28)
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|---|---|---|---|---|
| US3719667A (en) | 1970-08-24 | 1973-03-06 | Lilly Co Eli | Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters |
| US3840556A (en) | 1971-05-28 | 1974-10-08 | Lilly Co Eli | Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5216132A (en) | 1990-01-12 | 1993-06-01 | Protein Design Labs, Inc. | Soluble t-cell antigen receptor chimeric antigens |
| DE69126871T2 (de) | 1990-04-06 | 1998-03-12 | Jolla Cancer Res Found | Verfahren und verbindung zur behandlung von thrombose |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US6080840A (en) | 1992-01-17 | 2000-06-27 | Slanetz; Alfred E. | Soluble T cell receptors |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| US5733757A (en) | 1995-12-15 | 1998-03-31 | The Scripps Research Institute | Aldolase catalytic antibody |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US6326176B1 (en) | 1997-12-18 | 2001-12-04 | The Scripps Research Institute | Aldol condensations by catalytic antibodies |
| AU1190101A (en) | 1999-09-27 | 2001-04-30 | Regents Of The University Of California, The | Engineering antibodies that bind irreversibly |
| US6294374B1 (en) | 1999-10-08 | 2001-09-25 | The Scripps Research Institute | Use of catalytic antibodies for synthesizing epothilone |
| DE60237282D1 (de) | 2001-06-28 | 2010-09-23 | Domantis Ltd | Doppelspezifischer ligand und dessen verwendung |
| US20030045477A1 (en) | 2001-07-26 | 2003-03-06 | Fortuna Haviv | Peptides having antiangiogenic activity |
| US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| KR20040058229A (ko) * | 2001-10-22 | 2004-07-03 | 더 스크립스 리서치 인스티튜트 | 항체 표적화 화합물 |
| US6737524B2 (en) * | 2002-03-25 | 2004-05-18 | Paul K. Smith | Activated polyethylene glycol compounds |
| DK1517921T3 (da) | 2002-06-28 | 2006-10-09 | Domantis Ltd | Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf |
| CA2511910A1 (en) | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| JP2008505928A (ja) | 2004-07-08 | 2008-02-28 | アムジェン インコーポレーテッド | 治療用ペプチド |
| WO2006036834A2 (en) * | 2004-09-24 | 2006-04-06 | Amgen Inc. | MODIFIED Fc MOLECULES |
| KR20120043028A (ko) * | 2006-11-10 | 2012-05-03 | 씨오브이엑스 테크놀로지스 아일랜드 리미티드 | 혈관 신생 억제 화합물 |
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2007
- 2007-11-12 KR KR1020127005049A patent/KR20120043028A/ko not_active Ceased
- 2007-11-12 PL PL07827123T patent/PL2089425T3/pl unknown
- 2007-11-12 EP EP07827123A patent/EP2089425B1/en not_active Not-in-force
- 2007-11-12 EP EP20110170480 patent/EP2368908A3/en not_active Withdrawn
- 2007-11-12 NZ NZ576751A patent/NZ576751A/en not_active IP Right Cessation
- 2007-11-12 AU AU2007318912A patent/AU2007318912B2/en not_active Ceased
- 2007-11-12 MX MX2009005045A patent/MX2009005045A/es active IP Right Grant
- 2007-11-12 CN CN200780049649.0A patent/CN101611053B/zh not_active Expired - Fee Related
- 2007-11-12 PT PT07827123T patent/PT2089425E/pt unknown
- 2007-11-12 CA CA002669207A patent/CA2669207A1/en not_active Abandoned
- 2007-11-12 US US11/938,766 patent/US8288349B2/en not_active Expired - Fee Related
- 2007-11-12 KR KR1020097011924A patent/KR101309948B1/ko not_active Expired - Fee Related
- 2007-11-12 AT AT07827123T patent/ATE520712T1/de active
- 2007-11-12 WO PCT/IE2007/000110 patent/WO2008056346A2/en not_active Ceased
- 2007-11-12 MY MYPI20091889A patent/MY146985A/en unknown
- 2007-11-12 BR BRPI0718591-0A patent/BRPI0718591A2/pt not_active IP Right Cessation
- 2007-11-12 JP JP2009535878A patent/JP4897050B2/ja not_active Expired - Fee Related
- 2007-11-12 DK DK07827123.6T patent/DK2089425T3/da active
-
2009
- 2009-05-05 IL IL198581A patent/IL198581A/en active IP Right Grant
- 2009-06-08 NO NO20092203A patent/NO20092203L/no not_active Application Discontinuation
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2011
- 2011-12-26 JP JP2011283619A patent/JP2012121886A/ja not_active Ceased
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2012
- 2012-08-13 US US13/584,721 patent/US8912148B2/en not_active Expired - Fee Related
-
2014
- 2014-10-31 US US14/530,444 patent/US20150057431A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008056346A2 (en) | 2008-05-15 |
| KR20120043028A (ko) | 2012-05-03 |
| KR20090090331A (ko) | 2009-08-25 |
| US8912148B2 (en) | 2014-12-16 |
| AU2007318912A1 (en) | 2008-05-15 |
| WO2008056346A3 (en) | 2008-10-23 |
| CA2669207A1 (en) | 2008-05-15 |
| NZ576751A (en) | 2011-10-28 |
| EP2089425A2 (en) | 2009-08-19 |
| KR101309948B1 (ko) | 2013-09-23 |
| IL198581A (en) | 2015-10-29 |
| EP2089425B1 (en) | 2011-08-17 |
| PT2089425E (pt) | 2011-10-17 |
| DK2089425T3 (da) | 2011-10-10 |
| WO2008056346B1 (en) | 2008-12-04 |
| CN101611053A (zh) | 2009-12-23 |
| AU2007318912B2 (en) | 2011-03-03 |
| US20080166364A1 (en) | 2008-07-10 |
| JP2010509315A (ja) | 2010-03-25 |
| US8288349B2 (en) | 2012-10-16 |
| NO20092203L (no) | 2009-08-10 |
| MX2009005045A (es) | 2009-11-10 |
| EP2368908A3 (en) | 2011-10-12 |
| JP4897050B2 (ja) | 2012-03-14 |
| JP2012121886A (ja) | 2012-06-28 |
| US20120301431A1 (en) | 2012-11-29 |
| MY146985A (en) | 2012-10-15 |
| IL198581A0 (en) | 2011-08-01 |
| PL2089425T3 (pl) | 2012-02-29 |
| EP2368908A2 (en) | 2011-09-28 |
| CN101611053B (zh) | 2015-06-03 |
| US20150057431A1 (en) | 2015-02-26 |
| ATE520712T1 (de) | 2011-09-15 |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2540 DE 10-09-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |