BRPI0715070B8 - uso de escina na produção de preparados farmacêuticos para tratamento de doenças mediadas ou causadas por granulócitos ativados - Google Patents
uso de escina na produção de preparados farmacêuticos para tratamento de doenças mediadas ou causadas por granulócitos ativadosInfo
- Publication number
- BRPI0715070B8 BRPI0715070B8 BRPI0715070A BRPI0715070A BRPI0715070B8 BR PI0715070 B8 BRPI0715070 B8 BR PI0715070B8 BR PI0715070 A BRPI0715070 A BR PI0715070A BR PI0715070 A BRPI0715070 A BR PI0715070A BR PI0715070 B8 BRPI0715070 B8 BR PI0715070B8
- Authority
- BR
- Brazil
- Prior art keywords
- production
- aescin
- caused
- treatment
- pharmaceutical preparations
- Prior art date
Links
- YFESOSRPNPYODN-RSMWSHJLSA-N (2s,3s,4s,5r,6r)-6-[[(4s,6ar,6bs,8r,8ar,9r,10r,14br)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2s,3r,4s, Chemical compound O([C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)OC1CC[C@]2(C)C3CC=C4[C@@]([C@@]3(CCC2[C@]1(CO)C)C)(C)C[C@@H](O)[C@@]1(CO)[C@@H](OC(C)=O)[C@@H](C(CC14)(C)C)OC(=O)C(\C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O.O([C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)OC1CC[C@]2(C)C3CC=C4[C@@]([C@@]3(CCC2[C@]1(CO)C)C)(C)C[C@@H](O)[C@@]1(CO)[C@@H](OC(C)=O)[C@@H](C(CC14)(C)C)OC(=O)C(/C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YFESOSRPNPYODN-RSMWSHJLSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 3
- AXNVHPCVMSNXNP-GKTCLTPXSA-N Aescin Natural products O=C(O[C@H]1[C@@H](OC(=O)C)[C@]2(CO)[C@@H](O)C[C@@]3(C)[C@@]4(C)[C@@H]([C@]5(C)[C@H]([C@](CO)(C)[C@@H](O[C@@H]6[C@@H](O[C@H]7[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O7)[C@@H](C(=O)O)O6)CC5)CC4)CC=C3[C@@H]2CC1(C)C)/C(=C/C)/C AXNVHPCVMSNXNP-GKTCLTPXSA-N 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 210000003714 granulocyte Anatomy 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
Abstract
escina, bem como seu uso na produção de preparados farmacêuticos. a presente invenção refere-se ao uso da escina para a produção de um preparado farmacêutico para o tratamento de doenças mediadas ou causadas por granulócitos ativados, preferencialmente uma alergia do tipo i ou de tipo iii ou choque séptico.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06450109.1 | 2006-08-04 | ||
| EP06450109A EP1884245A1 (en) | 2006-08-04 | 2006-08-04 | Use of Escin |
| PCT/EP2007/006870 WO2008015007A2 (en) | 2006-08-04 | 2007-08-03 | Use of escin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0715070A2 BRPI0715070A2 (pt) | 2013-06-25 |
| BRPI0715070B1 BRPI0715070B1 (pt) | 2021-04-13 |
| BRPI0715070B8 true BRPI0715070B8 (pt) | 2021-05-25 |
Family
ID=37969918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0715070A BRPI0715070B8 (pt) | 2006-08-04 | 2007-08-03 | uso de escina na produção de preparados farmacêuticos para tratamento de doenças mediadas ou causadas por granulócitos ativados |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20100227830A1 (pt) |
| EP (2) | EP1884245A1 (pt) |
| JP (1) | JP5345933B2 (pt) |
| KR (1) | KR20090034946A (pt) |
| CN (1) | CN101500582B (pt) |
| AU (1) | AU2007280625B2 (pt) |
| BR (1) | BRPI0715070B8 (pt) |
| CA (1) | CA2658279C (pt) |
| DK (1) | DK2046345T3 (pt) |
| EA (1) | EA015404B1 (pt) |
| ES (1) | ES2531516T3 (pt) |
| HR (1) | HRP20141243T1 (pt) |
| IL (1) | IL196606A (pt) |
| MX (1) | MX2009000991A (pt) |
| NZ (1) | NZ574249A (pt) |
| PL (1) | PL2046345T3 (pt) |
| PT (1) | PT2046345E (pt) |
| SI (1) | SI2046345T1 (pt) |
| UA (1) | UA94954C2 (pt) |
| WO (1) | WO2008015007A2 (pt) |
| ZA (1) | ZA200900372B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2445870T3 (es) * | 2008-07-01 | 2014-03-05 | Marinomed Biotechnologie Gmbh | Biopolímeros antialérgicos marinos |
| EP2186523A1 (en) * | 2008-11-18 | 2010-05-19 | Marinomed Biotechnologie GmbH | Use of escin for treatment of Type IV hypersensitivity reaction |
| ES2346844A1 (es) * | 2010-03-17 | 2010-10-20 | Ricardo Lombardero Calzon | Crema para quemaduras. |
| WO2012101618A1 (en) | 2011-01-28 | 2012-08-02 | Barcelcom Têxteis S.A. | Compression stockings and tubes with bioactive agents for the treatment of venous insufficiency and varicose veins |
| EP2968107B1 (en) | 2013-03-15 | 2019-05-08 | Mary Kay, Inc. | Cosmetic compositions and uses thereof |
| KR101681857B1 (ko) | 2013-11-22 | 2016-12-01 | 마리 케이 인코포레이티드 | 민감성 피부를 위한 조성물들 |
| CN104147055A (zh) * | 2014-07-08 | 2014-11-19 | 武汉爱民制药有限公司 | 赖氨酸七叶皂苷及其盐在制备治疗i型超敏反应药物中的用途 |
| US20180154777A1 (en) * | 2016-12-02 | 2018-06-07 | Faraday&Future Inc. | Braking torque blending system and method for automatic emergency braking |
| IT202100014495A1 (it) * | 2021-06-08 | 2022-12-08 | Neilos S R L | "Composizione per l’uso nella prevenzione e/o nel trattamento di patologie osteoarticolari" |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1676561U (de) | 1954-03-27 | 1954-05-20 | Lutz Kg Maschf Eugen | Vorrichtung zum fraesen von nuten u. dgl. mittels einer motor-oberfraese. |
| DE3402259A1 (de) * | 1984-01-24 | 1985-08-01 | Stephan Dr.med. 3000 Hannover Regöczy | Therapeutisch wirksames gemisch, insbesondere zur behandlung von infektionskrankheiten im hals-, nasen- ohrenbereich, stimmbandentzuendungen, schwerer heiserkeit und trombophlebitis |
| DE3445324A1 (de) * | 1984-12-12 | 1986-06-12 | Klinge Pharma GmbH, 8000 München | Arzneimittelkombination mit synergistischer wirkung |
| IT1252866B (it) | 1991-12-31 | 1995-06-28 | Lifegroup Spa | N-acilderivati di aminoalcooli con acidi policarbossilici atti alla modulazione dei mastociti nei processi infiammatori su base neuroimmunogenica |
| US6943236B2 (en) * | 1997-02-25 | 2005-09-13 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6894146B1 (en) * | 1997-02-25 | 2005-05-17 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US7033827B2 (en) * | 1997-02-25 | 2006-04-25 | Corixa Corporation | Prostate-specific polynucleotide compositions |
| US6630305B1 (en) * | 1999-11-12 | 2003-10-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6800746B2 (en) * | 1997-02-25 | 2004-10-05 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6759515B1 (en) * | 1997-02-25 | 2004-07-06 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US7049063B2 (en) * | 1998-03-18 | 2006-05-23 | Corixa Corporation | Methods for diagnosis of lung cancer |
| US6509448B2 (en) * | 1999-06-30 | 2003-01-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6858204B2 (en) * | 1999-06-30 | 2005-02-22 | Corxia Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6504010B1 (en) * | 1999-06-30 | 2003-01-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
-
2006
- 2006-08-04 EP EP06450109A patent/EP1884245A1/en not_active Withdrawn
-
2007
- 2007-08-03 WO PCT/EP2007/006870 patent/WO2008015007A2/en active Application Filing
- 2007-08-03 BR BRPI0715070A patent/BRPI0715070B8/pt not_active IP Right Cessation
- 2007-08-03 PT PT77865392T patent/PT2046345E/pt unknown
- 2007-08-03 DK DK07786539.2T patent/DK2046345T3/en active
- 2007-08-03 US US12/376,419 patent/US20100227830A1/en not_active Abandoned
- 2007-08-03 AU AU2007280625A patent/AU2007280625B2/en not_active Ceased
- 2007-08-03 PL PL07786539T patent/PL2046345T3/pl unknown
- 2007-08-03 EP EP07786539.2A patent/EP2046345B1/en active Active
- 2007-08-03 CN CN200780029119XA patent/CN101500582B/zh active Active
- 2007-08-03 NZ NZ574249A patent/NZ574249A/en not_active IP Right Cessation
- 2007-08-03 KR KR1020097002110A patent/KR20090034946A/ko not_active Application Discontinuation
- 2007-08-03 SI SI200731602T patent/SI2046345T1/sl unknown
- 2007-08-03 JP JP2009523182A patent/JP5345933B2/ja not_active Expired - Fee Related
- 2007-08-03 CA CA2658279A patent/CA2658279C/en active Active
- 2007-08-03 MX MX2009000991A patent/MX2009000991A/es active IP Right Grant
- 2007-08-03 UA UAA200900868A patent/UA94954C2/uk unknown
- 2007-08-03 ES ES07786539.2T patent/ES2531516T3/es active Active
- 2007-08-03 EA EA200900261A patent/EA015404B1/ru not_active IP Right Cessation
-
2009
- 2009-01-16 ZA ZA2009/00372A patent/ZA200900372B/en unknown
- 2009-01-20 IL IL196606A patent/IL196606A/en not_active IP Right Cessation
-
2014
- 2014-12-22 HR HRP20141243TT patent/HRP20141243T1/hr unknown
-
2016
- 2016-09-30 US US15/281,635 patent/US9993512B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101500582A (zh) | 2009-08-05 |
| MX2009000991A (es) | 2009-04-16 |
| EA200900261A1 (ru) | 2009-06-30 |
| KR20090034946A (ko) | 2009-04-08 |
| ES2531516T3 (es) | 2015-03-16 |
| IL196606A0 (en) | 2009-11-18 |
| AU2007280625A1 (en) | 2008-02-07 |
| WO2008015007A3 (en) | 2008-04-03 |
| HRP20141243T1 (hr) | 2015-02-13 |
| SI2046345T1 (sl) | 2015-03-31 |
| DK2046345T3 (en) | 2015-01-26 |
| EP2046345B1 (en) | 2014-12-10 |
| JP5345933B2 (ja) | 2013-11-20 |
| US20170014465A1 (en) | 2017-01-19 |
| BRPI0715070B1 (pt) | 2021-04-13 |
| JP2009545623A (ja) | 2009-12-24 |
| EP2046345A2 (en) | 2009-04-15 |
| PL2046345T3 (pl) | 2015-05-29 |
| EP1884245A1 (en) | 2008-02-06 |
| US20100227830A1 (en) | 2010-09-09 |
| WO2008015007A2 (en) | 2008-02-07 |
| BRPI0715070A2 (pt) | 2013-06-25 |
| PT2046345E (pt) | 2014-12-26 |
| IL196606A (en) | 2015-08-31 |
| EA015404B1 (ru) | 2011-08-30 |
| AU2007280625B2 (en) | 2012-05-17 |
| NZ574249A (en) | 2011-04-29 |
| CA2658279C (en) | 2014-10-28 |
| ZA200900372B (en) | 2009-12-30 |
| CA2658279A1 (en) | 2008-02-07 |
| US9993512B2 (en) | 2018-06-12 |
| CN101500582B (zh) | 2011-08-24 |
| UA94954C2 (uk) | 2011-06-25 |
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