BRPI0705319A2 - processo para obtenção de um complexo solúvel de resveratrol e/ou seus derivados; complexo de resveratrol e/ou seus derivados; composição nutracêutica - Google Patents

processo para obtenção de um complexo solúvel de resveratrol e/ou seus derivados; complexo de resveratrol e/ou seus derivados; composição nutracêutica

Info

Publication number
BRPI0705319A2
BRPI0705319A2 BRPI0705319-3A BRPI0705319A BRPI0705319A2 BR PI0705319 A2 BRPI0705319 A2 BR PI0705319A2 BR PI0705319 A BRPI0705319 A BR PI0705319A BR PI0705319 A2 BRPI0705319 A2 BR PI0705319A2
Authority
BR
Brazil
Prior art keywords
derivatives
resveratrol
obtaining
resveratrol complex
nutraceutical
Prior art date
Application number
BRPI0705319-3A
Other languages
English (en)
Inventor
Souto Andre Arigony
Original Assignee
Uniao Brasileira De Educacao Manedora Da Pucrs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniao Brasileira De Educacao Manedora Da Pucrs filed Critical Uniao Brasileira De Educacao Manedora Da Pucrs
Priority to BRPI0705319-3A priority Critical patent/BRPI0705319A2/pt
Priority to PCT/BR2008/000216 priority patent/WO2009012551A1/en
Priority to BRPI0814308A priority patent/BRPI0814308B8/pt
Priority to US12/670,310 priority patent/US8476248B2/en
Priority to EP08772766.5A priority patent/EP2178525A4/en
Priority to CA2694343A priority patent/CA2694343C/en
Publication of BRPI0705319A2 publication Critical patent/BRPI0705319A2/pt
Priority to EC2010009982A priority patent/ECSP109982A/es
Priority to CO10021163A priority patent/CO6260022A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16—Cyclodextrin; Derivatives thereof

Abstract

Processo para obtenção de um complexo solúvel de resveratrol e/ou seus derivados; Complexo de resveratrol e/ou seus derivados; Composição nutracêutica. A presente invenção proporciona produtos contendo resveratróis melhorados e composições nutracêuticas e/ou fitoterápicas contendo as referidas substâncias Os processos para sua obtenção envolvem o aumento da solubilidade do polifenol trans-resveratrol e/ou seus derivados em água, através de sua complexação com ciclodextrina. Os produtos da invenção apresentam elevada solubilidade em meio aquoso e elevado grau de pureza, sendo, portanto, úteis na preparação de composições nutracêuticas (farmacêuticas e/ou alimetícias) com ação antioxidante, antiinflamatória, antiviral, cardioprotetora, neuroprotetora e/ou quimiopreventiva de câncer, além de proteger contra infecções e isquemia, reduzir a obesidade e prevenir o envelhecimento. São também proporcionados fitoterápicos úteis para as mesmas ações terapêuticas, preparados a partir do uso do complexo beta-ciclodextrina/trans-resveratrol; e um intermediário de síntese útil na derivatização química para a obtenção de ingredientes ativos melhorados.
BRPI0705319-3A 2007-07-23 2007-07-23 processo para obtenção de um complexo solúvel de resveratrol e/ou seus derivados; complexo de resveratrol e/ou seus derivados; composição nutracêutica BRPI0705319A2 (pt)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BRPI0705319-3A BRPI0705319A2 (pt) 2007-07-23 2007-07-23 processo para obtenção de um complexo solúvel de resveratrol e/ou seus derivados; complexo de resveratrol e/ou seus derivados; composição nutracêutica
PCT/BR2008/000216 WO2009012551A1 (en) 2007-07-23 2008-07-23 Resveratrol complex and process for the preperation
BRPI0814308A BRPI0814308B8 (pt) 2007-07-23 2008-07-23 processo de preparo, complexo compreendendo resveratrol e ciclodextrina, composições e uso
US12/670,310 US8476248B2 (en) 2007-07-23 2008-07-23 Process for the preparation of a water-soluble complex having resveratrol compounds; products comprising said complex; and uses thereof
EP08772766.5A EP2178525A4 (en) 2007-07-23 2008-07-23 RESVERATROL COMPLEX AND METHOD OF MANUFACTURE
CA2694343A CA2694343C (en) 2007-07-23 2008-07-23 Resveratrol complex and process for the preperation
EC2010009982A ECSP109982A (es) 2007-07-23 2010-02-22 Proceso de preparación del complejo soluble en agua conteniendo el compuesto resveratrol, productos formando dicho complejo y usos de los mismos
CO10021163A CO6260022A2 (es) 2007-07-23 2010-02-23 Proceso de preparacion de complejo soluble en agua conteniendo el compuesto resveratrol productos formando dicho complejo y usos del mismos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0705319-3A BRPI0705319A2 (pt) 2007-07-23 2007-07-23 processo para obtenção de um complexo solúvel de resveratrol e/ou seus derivados; complexo de resveratrol e/ou seus derivados; composição nutracêutica

Publications (1)

Publication Number Publication Date
BRPI0705319A2 true BRPI0705319A2 (pt) 2009-07-21

Family

ID=40280935

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0705319-3A BRPI0705319A2 (pt) 2007-07-23 2007-07-23 processo para obtenção de um complexo solúvel de resveratrol e/ou seus derivados; complexo de resveratrol e/ou seus derivados; composição nutracêutica
BRPI0814308A BRPI0814308B8 (pt) 2007-07-23 2008-07-23 processo de preparo, complexo compreendendo resveratrol e ciclodextrina, composições e uso

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0814308A BRPI0814308B8 (pt) 2007-07-23 2008-07-23 processo de preparo, complexo compreendendo resveratrol e ciclodextrina, composições e uso

Country Status (7)

Country Link
US (1) US8476248B2 (pt)
EP (1) EP2178525A4 (pt)
BR (2) BRPI0705319A2 (pt)
CA (1) CA2694343C (pt)
CO (1) CO6260022A2 (pt)
EC (1) ECSP109982A (pt)
WO (1) WO2009012551A1 (pt)

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CA2593576C (en) 2004-01-20 2013-04-23 Brigham Young University Novel sirtuin activating compounds and methods for making the same
BRPI0806044A2 (pt) * 2008-10-17 2010-09-14 Ubea método e kit para determinação de agentes moduladores de sirtuìnas, processo para modulação de sirtuìnas, compostos moduladores de sirtuìnas e composições compreendendo os mesmos
WO2010058242A1 (en) * 2008-11-24 2010-05-27 Giovanni Nicolao Berta New formulations with anti-neoplastic activity
BRPI0900400B1 (pt) * 2009-02-10 2017-12-19 União Brasileira De Educação E Assistência Composition understanding vegetable oil and resveratrol and process for producing them
WO2010102245A1 (en) * 2009-03-05 2010-09-10 Upsher-Smith Laboratories, Inc. Solid dispersion comprising resveratrol
ES2798254T3 (es) 2009-06-22 2020-12-10 Indus Biotech Private Ltd Proceso para la obtención de pteroestilbeno purificado y métodos de uso del mismo
RU2464042C1 (ru) * 2011-03-31 2012-10-20 Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" КЛАТРАТНЫЙ КОМПЛЕКС β-ЦИКЛОДЕКСТРИНА С ПРОИЗВОДНЫМ 5-ГИДРОКСИ-4-АМИНОМЕТИЛ-1-ЦИКЛОГЕКСИЛ(ИЛИ ЦИКЛОГЕПТИЛ)-3-АЛКОКСИКАРБОНИЛИНДОЛА, СПОСОБ ЕГО ПОЛУЧЕНИЯ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО
CN103120310A (zh) * 2011-11-20 2013-05-29 重庆还少堂生物技术有限责任公司 白藜芦醇水溶性干粉的制配方法
CN103356476B (zh) * 2012-03-31 2016-02-17 昆药集团股份有限公司 溶解黄酮类化合物、碳苷类化合物或茋类化合物的方法及注射液或注射用粉针剂的制备方法
ITRM20120275A1 (it) * 2012-06-13 2013-12-14 Noos S R L Associazione di resveratrolo e carbossimetilglucano.
KR101480600B1 (ko) * 2013-01-22 2015-01-08 경북대학교 산학협력단 레스베라트롤 유도체의 피부미백 용도
RU2594281C2 (ru) * 2013-04-03 2016-08-10 Чайна Медикал Юнивёсити Стильбеноидные соединения в качестве ингибиторов плоскоклеточной карциномы и гепатомы и их применения
WO2015027068A1 (en) * 2013-08-21 2015-02-26 Concordia University Dendrimer-resveratrol complex
JP6435158B2 (ja) * 2014-10-17 2018-12-05 森永製菓株式会社 精製スチルベン化合物の製造方法
US20180085392A1 (en) * 2015-04-17 2018-03-29 Sens Research Foundation, Inc. Cyclodextrin compounds for the prevention and treatment of aging
CN110325217B (zh) * 2017-01-09 2023-08-08 塞法姆公司 制备水溶性毛喉萜的新工艺
CN108774290B (zh) * 2018-07-10 2020-09-04 宁夏蓝博思化学技术有限公司 白藜芦醇-羧烷基型环糊精衍生物及其制备方法
WO2020023807A1 (en) * 2018-07-26 2020-01-30 The Regents Of The University Of California Treatment of vascular occlusion by activation of notch signaling
EP3603415B1 (fr) * 2018-07-30 2020-12-30 Universite D'Avignon et Des Pays Du Vaucluse Procede d'extraction de composes phenoliques
US10882012B2 (en) * 2018-08-03 2021-01-05 Wakamono Corporation Process for producing a nano resveratrol microemulsion system
TWI689304B (zh) * 2018-12-04 2020-04-01 高雄醫學大學 抗霧霾組合物
CN111001013B (zh) * 2019-12-12 2023-04-18 安徽工业大学 一种枇杷叶提取物纳米胶囊、制备方法及应用
CN111387393B (zh) * 2020-05-07 2022-09-20 北京维泰力特生物医药有限公司 一种含有小分子肽、白藜芦醇和花青素的饮料及其制备方法
CN114656645B (zh) * 2022-03-23 2023-02-24 齐鲁工业大学 一种在水相中稳定存在的环糊精金属有机框架的制备方法

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US6884885B2 (en) * 2000-12-21 2005-04-26 Cerestar Holding B.V. Production of cyclodextrin complexes
US20060292099A1 (en) * 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
WO2006138418A2 (en) * 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators

Also Published As

Publication number Publication date
CA2694343C (en) 2016-03-29
WO2009012551A4 (en) 2009-03-12
WO2009012551A1 (en) 2009-01-29
BRPI0814308A2 (pt) 2015-02-03
US8476248B2 (en) 2013-07-02
BRPI0814308B1 (pt) 2020-10-27
EP2178525A4 (en) 2013-08-28
CO6260022A2 (es) 2011-03-22
BRPI0814308B8 (pt) 2021-05-25
EP2178525A1 (en) 2010-04-28
ECSP109982A (es) 2010-04-30
CA2694343A1 (en) 2009-01-29
US20100204179A1 (en) 2010-08-12

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