BRPI0617683A2 - processo para a contracepção hormonal preventiva segundo a necessidade e uso de um emplastro transdérmico - Google Patents
processo para a contracepção hormonal preventiva segundo a necessidade e uso de um emplastro transdérmico Download PDFInfo
- Publication number
- BRPI0617683A2 BRPI0617683A2 BRPI0617683-6A BRPI0617683A BRPI0617683A2 BR PI0617683 A2 BRPI0617683 A2 BR PI0617683A2 BR PI0617683 A BRPI0617683 A BR PI0617683A BR PI0617683 A2 BRPI0617683 A2 BR PI0617683A2
- Authority
- BR
- Brazil
- Prior art keywords
- gestagen
- gestoden
- administered
- process according
- daily
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 28
- 230000003054 hormonal effect Effects 0.000 title claims abstract description 11
- 230000003449 preventive effect Effects 0.000 title abstract description 3
- 239000000583 progesterone congener Substances 0.000 claims abstract description 34
- 239000011505 plaster Substances 0.000 claims abstract description 13
- 230000001568 sexual effect Effects 0.000 claims abstract description 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 6
- SIGSPDASOTUPFS-XUDSTZEESA-N gestodene Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 SIGSPDASOTUPFS-XUDSTZEESA-N 0.000 claims description 24
- 230000000694 effects Effects 0.000 claims description 10
- 229940011871 estrogen Drugs 0.000 claims description 8
- 239000000262 estrogen Substances 0.000 claims description 8
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 7
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 7
- 229960002568 ethinylestradiol Drugs 0.000 claims description 7
- 239000013543 active substance Substances 0.000 claims description 6
- 229960004976 desogestrel Drugs 0.000 claims description 2
- JUNDJWOLDSCTFK-MTZCLOFQSA-N trimegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)[C@@H](O)C)(C)[C@@]1(C)CC2 JUNDJWOLDSCTFK-MTZCLOFQSA-N 0.000 claims description 2
- 229950008546 trimegestone Drugs 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960004400 levonorgestrel Drugs 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 230000001113 coital effect Effects 0.000 description 5
- 230000002254 contraceptive effect Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 229940124558 contraceptive agent Drugs 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 231100000546 inhibition of ovulation Toxicity 0.000 description 2
- HGUFODBRKLSHSI-UHFFFAOYSA-N 2,3,7,8-tetrachloro-dibenzo-p-dioxin Chemical compound O1C2=CC(Cl)=C(Cl)C=C2OC2=C1C=C(Cl)C(Cl)=C2 HGUFODBRKLSHSI-UHFFFAOYSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- 208000031271 Unwanted pregnancy Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- -1 etonorgestrel Chemical compound 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 239000003408 postcoitus contraceptive agent Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005050729.8 | 2005-10-19 | ||
| DE102005050729A DE102005050729A1 (de) | 2005-10-19 | 2005-10-19 | Verfahren zur präventiven bedarfsweisen hormonalen Kontrazeption |
| PCT/EP2006/010273 WO2007045513A1 (de) | 2005-10-19 | 2006-10-19 | Verfahren zur präventiven bedarsweisen hormonalen kontrazeption |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0617683A2 true BRPI0617683A2 (pt) | 2011-08-02 |
Family
ID=37762565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0617683-6A BRPI0617683A2 (pt) | 2005-10-19 | 2006-10-19 | processo para a contracepção hormonal preventiva segundo a necessidade e uso de um emplastro transdérmico |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20070111976A1 (https=) |
| EP (1) | EP1937275A1 (https=) |
| JP (2) | JP2009512658A (https=) |
| KR (1) | KR20080056774A (https=) |
| CN (1) | CN101340915A (https=) |
| BR (1) | BRPI0617683A2 (https=) |
| CA (1) | CA2626567C (https=) |
| CR (1) | CR9908A (https=) |
| DE (1) | DE102005050729A1 (https=) |
| EC (1) | ECSP088390A (https=) |
| GT (1) | GT200800038A (https=) |
| HN (1) | HN2008000621A (https=) |
| WO (1) | WO2007045513A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0819571A2 (pt) * | 2007-12-20 | 2019-09-24 | Teva Womenss Health Inc | "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica" |
| US20120129825A1 (en) * | 2009-04-14 | 2012-05-24 | Andre Ulmann | Method for on-demand contraception using levonorgestrel or norgestrel |
| RS55331B1 (sr) * | 2009-04-14 | 2017-03-31 | Hra Pharma Lab | Postupak za kontracepciju po potrebi |
| DE102010040299A1 (de) | 2010-09-06 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner) |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US9579330B2 (en) | 2012-11-22 | 2017-02-28 | Bayer Pharma Aktiengesellschaft | Use and application regimen of a pharmaceutical composition containing levonorgestrel and a COX inhibitor for on-demand contraception |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9655887B2 (en) | 2013-05-23 | 2017-05-23 | Bayer Pharma Aktiengesellschaft | Pharmaceutical composition and the use thereof, and application regime of said pharmaceutical composition for on-demand contraception |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512292A (en) * | 1990-10-29 | 1996-04-30 | Alza Corporation | Transdermal contraceptive formulations methods and devices |
| DE4229820C2 (de) * | 1992-09-07 | 1998-12-03 | Jenapharm Gmbh | Pharmazeutische Zubereitung auf Gestagen-Basis |
| DE4405898A1 (de) * | 1994-02-18 | 1995-08-24 | Schering Ag | Transdermale therapeutische Systeme enthaltend Sexualsteroide |
| IL115738A (en) * | 1994-10-24 | 2002-05-23 | Schering Ag | Competitive progesterone antagonists for regulating female fertility as required |
| UA77150C2 (en) * | 1999-08-31 | 2006-11-15 | Schering Ag | Use of mesoprogestins j867, j912, or j1042 for female contraception, pharmaceutical composition and kit (variants) |
| US7384650B2 (en) * | 1999-11-24 | 2008-06-10 | Agile Therapeutics, Inc. | Skin permeation enhancement composition for transdermal hormone delivery system |
| WO2003093322A2 (en) * | 2002-04-30 | 2003-11-13 | The Population Council, Inc. | Carrageenan based antimicrobial compositions |
| CA2549916C (en) * | 2003-12-12 | 2013-09-17 | Schering Aktiengesellschaft | Transdermal delivery system of hormones without penetration enhancers |
| UA89766C2 (en) * | 2003-12-12 | 2010-03-10 | Байер Шеринг Фарма Акциенгезельшафт | Transdermal delivery system of gestodene |
-
2005
- 2005-10-19 DE DE102005050729A patent/DE102005050729A1/de not_active Withdrawn
-
2006
- 2006-10-19 KR KR1020087011824A patent/KR20080056774A/ko not_active Ceased
- 2006-10-19 JP JP2008535989A patent/JP2009512658A/ja not_active Withdrawn
- 2006-10-19 WO PCT/EP2006/010273 patent/WO2007045513A1/de not_active Ceased
- 2006-10-19 BR BRPI0617683-6A patent/BRPI0617683A2/pt not_active IP Right Cessation
- 2006-10-19 US US11/583,143 patent/US20070111976A1/en not_active Abandoned
- 2006-10-19 CA CA2626567A patent/CA2626567C/en not_active Expired - Fee Related
- 2006-10-19 CN CNA2006800480426A patent/CN101340915A/zh active Pending
- 2006-10-19 EP EP06828860A patent/EP1937275A1/de not_active Withdrawn
- 2006-10-19 US US12/090,719 patent/US20080311180A1/en not_active Abandoned
-
2008
- 2008-04-18 GT GT200800038A patent/GT200800038A/es unknown
- 2008-04-21 EC EC2008008390A patent/ECSP088390A/es unknown
- 2008-04-21 HN HN2008000621A patent/HN2008000621A/es unknown
- 2008-04-21 CR CR9908A patent/CR9908A/es not_active Application Discontinuation
-
2012
- 2012-05-29 US US13/482,023 patent/US20130089574A1/en not_active Abandoned
-
2013
- 2013-09-24 JP JP2013197047A patent/JP2014001239A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2626567C (en) | 2013-12-03 |
| US20080311180A1 (en) | 2008-12-18 |
| GT200800038A (es) | 2009-04-01 |
| WO2007045513A1 (de) | 2007-04-26 |
| JP2014001239A (ja) | 2014-01-09 |
| JP2009512658A (ja) | 2009-03-26 |
| CA2626567A1 (en) | 2007-04-26 |
| KR20080056774A (ko) | 2008-06-23 |
| DE102005050729A1 (de) | 2007-04-26 |
| US20130089574A1 (en) | 2013-04-11 |
| EP1937275A1 (de) | 2008-07-02 |
| CR9908A (es) | 2008-05-21 |
| US20070111976A1 (en) | 2007-05-17 |
| CN101340915A (zh) | 2009-01-07 |
| HN2008000621A (es) | 2011-07-22 |
| ECSP088390A (es) | 2008-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: BAYER PHARMA AKTIENGESELLSCHAFT (DE) |
|
| B25A | Requested transfer of rights approved |
Owner name: BAYER INTELLECTUAL PROPERTY GMBH. (DE) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2328 DE 18-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |