HUP0102785A2 - Matrix típusú, transzdermális hatóanyag-szolgáltató rendszer szteroid hormonok felszabadítására - Google Patents

Matrix típusú, transzdermális hatóanyag-szolgáltató rendszer szteroid hormonok felszabadítására

Info

Publication number
HUP0102785A2
HUP0102785A2 HU0102785A HUP0102785A HUP0102785A2 HU P0102785 A2 HUP0102785 A2 HU P0102785A2 HU 0102785 A HU0102785 A HU 0102785A HU P0102785 A HUP0102785 A HU P0102785A HU P0102785 A2 HUP0102785 A2 HU P0102785A2
Authority
HU
Hungary
Prior art keywords
matrix
transdermal patch
patch
steroid hormones
type transdermal
Prior art date
Application number
HU0102785A
Other languages
English (en)
Inventor
Lucio C. Rovati
Antonino Santoro
Original Assignee
Rottapharm B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm B.V. filed Critical Rottapharm B.V.
Publication of HUP0102785A2 publication Critical patent/HUP0102785A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

A találmány tárgya transzdermális tapasz, amely ösztradiol és legalábbegy progesztogén hatóanyag felszabadítására alkalmazható bőrönkeresztül. A tapasz külső alapfóliából, matrixból és védő alátétbőláll, ahol a) az ösztradiol és progesztogén hatóanyag a matrixbantúltelített oldatban vannak jelen; b) a matrix 1-5 tömeg% aktiváltszilícium-dioxidot tartalmaz; és c) a matrix nedvességtartalma 0,7tömeg%-nál kisebb. A tapasz hormonszubsztituciós terápiábanalkalmazható. Ó
HU0102785A 1998-06-22 1999-06-22 Matrix típusú, transzdermális hatóanyag-szolgáltató rendszer szteroid hormonok felszabadítására HUP0102785A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19827732A DE19827732A1 (de) 1998-06-22 1998-06-22 Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie
PCT/EP1999/004305 WO1999066908A1 (en) 1998-06-22 1999-06-22 Matrix-type transdermal patch for steroid hormones

Publications (1)

Publication Number Publication Date
HUP0102785A2 true HUP0102785A2 (hu) 2002-01-28

Family

ID=7871628

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102785A HUP0102785A2 (hu) 1998-06-22 1999-06-22 Matrix típusú, transzdermális hatóanyag-szolgáltató rendszer szteroid hormonok felszabadítására

Country Status (17)

Country Link
US (1) US6440454B1 (hu)
EP (1) EP1089722B1 (hu)
JP (1) JP2002518434A (hu)
KR (1) KR20010053072A (hu)
CN (1) CN1306421A (hu)
AT (1) ATE217793T1 (hu)
AU (1) AU4775499A (hu)
BR (1) BR9911411A (hu)
CA (1) CA2333586A1 (hu)
DE (2) DE19827732A1 (hu)
DK (1) DK1089722T3 (hu)
ES (1) ES2177295T3 (hu)
HU (1) HUP0102785A2 (hu)
IL (1) IL140335A0 (hu)
PL (1) PL345061A1 (hu)
PT (1) PT1089722E (hu)
WO (1) WO1999066908A1 (hu)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010033858A1 (en) * 2000-02-29 2001-10-25 Jie Zhang Transdermal drug patch
DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
US7198801B2 (en) * 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
KR100856523B1 (ko) 2000-08-03 2008-09-04 안타레스 파르마 아이피엘 에이쥐 충분한 치료효과를 보장하는 활성 화합물의 경피 및/또는경점막 투여용 신규 조성물
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US20040062794A1 (en) * 2002-09-30 2004-04-01 Lee Shulman 17Beta- estradiol/levonorgestrel transdermal patch for hormone replacement therapy
US20040086551A1 (en) 2002-10-30 2004-05-06 Miller Kenneth J. Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
PT1594483E (pt) 2003-02-21 2006-12-29 Schering Ag Penso transdérmico estável aos uv
JP5619337B2 (ja) 2003-10-10 2014-11-05 フェリング ビー．ブイ． 皮膚残渣を最小限に抑えるための経皮的医薬製剤
US8668925B2 (en) 2003-12-12 2014-03-11 Bayer Intellectual Property Gmbh Transdermal delivery of hormones without the need of penetration enhancers
GB0409498D0 (en) * 2004-04-28 2004-06-02 Hunter Fleming Ltd Transdermal steroid formulation
US7425340B2 (en) * 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
US8962013B2 (en) 2005-05-02 2015-02-24 Bayer Intellectual Property Gmbh Multi-layered transdermal system with triazine UV absorber
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
WO2007035942A2 (en) * 2005-09-23 2007-03-29 Alza Corporation Transdermal risperidone delivery system
KR101170705B1 (ko) * 2005-09-23 2012-08-07 헨켈 아게 운트 코. 카게아아 아크릴 폴리머계 접착제
CA2646667C (en) 2006-04-21 2014-03-11 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2008067991A2 (en) * 2006-12-08 2008-06-12 Antares Pharma Ipl Ag Skin-friendly drug complexes for transdermal administration
US20080152592A1 (en) * 2006-12-21 2008-06-26 Bayer Healthcare Llc Method of therapeutic drug monitoring
US20080226698A1 (en) * 2007-03-16 2008-09-18 Mylan Technologies, Inc. Amorphous drug transdermal systems, manufacturing methods, and stabilization
US20100210932A1 (en) * 2007-03-20 2010-08-19 Bayer Healthcare Llc Method of analyzing an analyte
KR20110082142A (ko) * 2008-10-06 2011-07-18 밀란 테크놀로지즈 인코포레이티드 비정질 로티고틴 경피 시스템
HUE031326T2 (hu) 2010-09-06 2017-07-28 Bayer Ip Gmbh Alacsony dózisú transzdermális tapaszok magas hatóanyagleadással
DE102010040299A1 (de) * 2010-09-06 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner)
AU2015203180B2 (en) * 2010-09-06 2016-06-30 Bayer Intellectual Property Gmbh Transdermal therapeutic systems with crystallization-inhibiting protective film (release liner)
HUE055562T2 (hu) 2011-11-23 2021-11-29 Therapeuticsmd Inc Természetes kombinációjú hormon helyettesítõ kiszerelések, és terápiák ezekkel
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
JP2015518854A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
US9498461B2 (en) 2012-05-23 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
WO2016018993A1 (en) 2014-07-29 2016-02-04 Therapeuticsmd, Inc. Transdermal cream
WO2016046835A1 (en) 2014-09-26 2016-03-31 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
CA2967908C (en) 2014-09-29 2020-11-17 Mahesh Kandula Compositions and methods for the treatment of multiple sclerosis
WO2016067297A1 (en) 2014-10-27 2016-05-06 Cellix Bio Private Limited Salts of valproic acid with piperazine, ethylenediamine, lysine and/or eicosapentaenoic ecid (epa) amine derivatives for the treatment of epilepsy
AU2014414316B2 (en) 2014-10-27 2020-04-09 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
JP2017537088A (ja) 2014-12-01 2017-12-14 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ 多発性硬化症の治療のための組成物及び方法
CN107106184B (zh) * 2015-01-09 2022-01-11 金珂生物医疗公司 经皮血管伤口处理系统和方法
JP6698669B2 (ja) 2015-02-09 2020-05-27 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ 粘膜炎の治療のための組成物及び方法
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
CA3031893A1 (en) 2016-08-11 2018-02-15 Cellix Bio Private Limited Compositions and methods for the treatment of irritable bowel syndrome
RU2749189C2 (ru) 2016-10-04 2021-06-07 Целликс Био Прайвет Лимитед Композиции и способы лечения ксеростомии
EP3554494A4 (en) 2016-12-19 2021-02-17 Cellixbio Private Limited COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATION
US20200171026A1 (en) 2017-07-27 2020-06-04 Allergan, Inc. Prostacyclin receptor agonists for reduction of body fat
AU2018369853B2 (en) 2017-11-17 2022-07-14 Cellix Bio Private Limited Compounds, compositions and methods for treatment of eye disorders and skin diseases
CN111372576A (zh) 2017-11-17 2020-07-03 塞尔利克斯生物私人有限公司 用于治疗眼部病症的组合物和方法
EP4007581A4 (en) 2019-08-02 2023-10-25 Enterin, Inc. DOSAGE PROTOCOLS AND REGIMES FOR AMINOSTEROL TREATMENT
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559222A (en) * 1983-05-04 1985-12-17 Alza Corporation Matrix composition for transdermal therapeutic system
CA2065311C (en) * 1989-09-08 2000-01-11 Chia-Ming Chiang Solid matrix system for transdermal drug delivery
US5252334A (en) * 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
US5676968A (en) * 1991-10-31 1997-10-14 Schering Aktiengesellschaft Transdermal therapeutic systems with crystallization inhibitors
DE4210711A1 (de) * 1991-10-31 1993-05-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Transdermale therapeutische systeme mit kristallisationsinhibitoren
DE4223360C1 (hu) * 1992-07-16 1993-04-08 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
US5989586A (en) * 1992-10-05 1999-11-23 Cygnus, Inc. Two-phase matrix for sustained release drug delivery device
DE4237453C1 (hu) * 1992-11-06 1993-08-19 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE4333595A1 (de) * 1993-10-01 1995-04-06 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Arzneimitteln auf die Haut
DE4405898A1 (de) * 1994-02-18 1995-08-24 Schering Ag Transdermale therapeutische Systeme enthaltend Sexualsteroide
JPH0827003A (ja) * 1994-07-22 1996-01-30 Sekisui Chem Co Ltd 経皮吸収製剤
DE4429667C2 (de) * 1994-08-20 1996-07-11 Lohmann Therapie Syst Lts Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung
DE4429664C2 (de) * 1994-08-20 1997-09-11 Lohmann Therapie Syst Lts Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung
DE19548332A1 (de) * 1995-12-22 1997-07-10 Rotta Res Bv Hormonpflaster
DE19600347A1 (de) * 1996-01-08 1997-07-10 Lohmann Therapie Syst Lts Hauthaftende pharmazeutische Zubereitung, insbesondere TTS zur Abgabe von 17-beta-Estradiol an den menschlichen Organismus

Also Published As

Publication number Publication date
PL345061A1 (en) 2001-11-19
BR9911411A (pt) 2001-10-23
ATE217793T1 (de) 2002-06-15
IL140335A0 (en) 2002-02-10
US6440454B1 (en) 2002-08-27
DE69901561D1 (de) 2002-06-27
DK1089722T3 (da) 2002-07-01
DE19827732A1 (de) 1999-12-23
ES2177295T3 (es) 2002-12-01
CA2333586A1 (en) 1999-12-29
PT1089722E (pt) 2002-09-30
CN1306421A (zh) 2001-08-01
JP2002518434A (ja) 2002-06-25
DE69901561T2 (de) 2002-10-10
AU4775499A (en) 2000-01-10
EP1089722A1 (en) 2001-04-11
EP1089722B1 (en) 2002-05-22
WO1999066908A1 (en) 1999-12-29
KR20010053072A (ko) 2001-06-25

Similar Documents

Publication Publication Date Title
HUP0102785A2 (hu) Matrix típusú, transzdermális hatóanyag-szolgáltató rendszer szteroid hormonok felszabadítására
US5980932A (en) Solid matrix system for transdermal drug delivery
US4863738A (en) Skin permeation enhancer compositions using glycerol monooleate
HUP9802326A2 (hu) 17-Dezacetil-norgesztimát vagy valamely ösztrogénnel kombinált hatóanyag bevitelére alkalmas transzdermális készítmény
AU644815B2 (en) Solid matrix system for transdermal drug delivery
US4900555A (en) Skin permeation enhancer compositions using sucrose esters
RU98100451A (ru) Трансдермальный пластырь и способ введения 17-деацетилноргестимата отдельно или в сочетании с эстрогеном
NZ247549A (en) Adhesive plaster for transdermal administration of estradiol (optionally with progestin) having an adhesive matrix or reservoir layer of polyacrylate or polyisobutylene
KR970701039A (ko) 성 스테로이드를 함유하는 경피 치료 시스템(Sexual Steroid-Containing Transdermal Therapeutic Systems)
MY106628A (en) Estrogen-containing active substance plaster
HUP0204349A2 (en) Novel topical oestroprogestational compositions with systemic effect
PT748190E (pt) Metodos e formulacoes para uso no tratamento de disturbios ginecologicos benignos
KR19980066583A (ko) 스테로이드계 약물의 경피흡수투여용 조성물 및 이를 포함하는 경피흡수투여용 제형
ITTO910907A1 (it) Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.
HUP0402213A2 (hu) Propilénglikolmonokaprilátot tartalmazó szteroid hormontartalmú transzdermális terápiás rendszer
HUP9904344A2 (hu) Egyfázisú fogamzásgátló eljárás és progesztin és ösztrogén kombinációját tartalmazó kit
CA2338859A1 (en) Estradiol-containing patch for transdermal administration of hormones
CA2259584A1 (en) Plasters containing isosorbide dinitrate
IL125160A0 (en) A transdermal therapeutic composition a process for its preparation and use thereof
AU729898B2 (en) Transdermal therapeutic system having an active compound combination comprising oestriol
MXPA05003364A (es) Parche transdermico de 17(-estradiol/levonorgestrel para hormonoterapia restitutiva.
Zufferey Risques des nouvelles méthodes en contraception
RU96118406A (ru) Средство для чрескожного применения, содержащее дезогестрел