BRPI0611326A2 - receptores de células t melano-a de alta afinidade - Google Patents

Info

Publication number

BRPI0611326A2

BRPI0611326A2 BRPI0611326-5A BRPI0611326A BRPI0611326A2 BR PI0611326 A2 BRPI0611326 A2 BR PI0611326A2 BR PI0611326 A BRPI0611326 A BR PI0611326A BR PI0611326 A2 BRPI0611326 A2 BR PI0611326A2

Authority

BR

Brazil

Prior art keywords

tcr

seq

gly

gln

val

Prior art date

2005-06-01

Links

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• 102000016266 T-Cell Antigen Receptors Human genes 0.000 title claims abstract description 409
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• 229940124597 therapeutic agent Drugs 0.000 claims abstract description 30
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 19
• 201000011510 cancer Diseases 0.000 claims abstract description 12
• 238000000926 separation method Methods 0.000 claims abstract description 6
• 230000009258 tissue cross reactivity Effects 0.000 claims abstract 12
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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 48
• 230000027455 binding Effects 0.000 claims description 37
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 36
• 238000000034 method Methods 0.000 claims description 36
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• 230000035772 mutation Effects 0.000 claims description 14
• 239000012634 fragment Substances 0.000 claims description 12
• 229920001515 polyalkylene glycol Polymers 0.000 claims description 12
• 229920001223 polyethylene glycol Polymers 0.000 claims description 12
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 11
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