BRPI0609982A2 - composição nanoparticulada estável, método para preparar uma composição nanoparticulada, uso de uma composição, e, composição de liberação controlada - Google Patents

Info

Publication number

BRPI0609982A2

BRPI0609982A2 BRPI0609982-3A BRPI0609982A BRPI0609982A2 BR PI0609982 A2 BRPI0609982 A2 BR PI0609982A2 BR PI0609982 A BRPI0609982 A BR PI0609982A BR PI0609982 A2 BRPI0609982 A2 BR PI0609982A2

Authority

BR

Brazil

Prior art keywords

less

platelet aggregation

composition

aggregation inhibitor

composition according

Prior art date

2005-05-23

Links

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• 239000000203 mixture Substances 0.000 title claims abstract description 341
• 238000000034 method Methods 0.000 title claims abstract description 63
• 238000013270 controlled release Methods 0.000 title claims abstract description 27
• 229940127218 antiplatelet drug Drugs 0.000 claims abstract description 301
• 239000000106 platelet aggregation inhibitor Substances 0.000 claims abstract description 300
• 101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 claims abstract description 291
• 101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 claims abstract description 291
• 239000002245 particle Substances 0.000 claims abstract description 165
• 239000003381 stabilizer Substances 0.000 claims abstract description 67
• RRGUKTPIGVIEKM-UHFFFAOYSA-N cilostazol Chemical compound C=1C=C2NC(=O)CCC2=CC=1OCCCCC1=NN=NN1C1CCCCC1 RRGUKTPIGVIEKM-UHFFFAOYSA-N 0.000 claims abstract description 64
• 229960004588 cilostazol Drugs 0.000 claims abstract description 56
• 150000003839 salts Chemical class 0.000 claims abstract description 30
• 230000000541 pulsatile effect Effects 0.000 claims abstract description 20
• 208000024891 symptom Diseases 0.000 claims abstract description 20
• 230000000302 ischemic effect Effects 0.000 claims abstract description 19
• 238000011282 treatment Methods 0.000 claims abstract description 18
• 230000002265 prevention Effects 0.000 claims abstract description 8
• -1 sachets Substances 0.000 claims description 72
• 238000009472 formulation Methods 0.000 claims description 48
• 229920000642 polymer Polymers 0.000 claims description 43
• 239000002552 dosage form Substances 0.000 claims description 42
• 239000004480 active ingredient Substances 0.000 claims description 38
• 238000000576 coating method Methods 0.000 claims description 37
• 239000011248 coating agent Substances 0.000 claims description 33
• 239000011159 matrix material Substances 0.000 claims description 33
• 150000001875 compounds Chemical class 0.000 claims description 31
• 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 31
• 229920001223 polyethylene glycol Polymers 0.000 claims description 23
• 239000003826 tablet Substances 0.000 claims description 23
• 239000000243 solution Substances 0.000 claims description 22
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
• 239000003112 inhibitor Substances 0.000 claims description 19
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 18
• 230000003111 delayed effect Effects 0.000 claims description 18
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 16
• 239000006185 dispersion Substances 0.000 claims description 15
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 14
• 239000002253 acid Substances 0.000 claims description 13
• CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 12
• 125000002091 cationic group Chemical group 0.000 claims description 12
• 238000010521 absorption reaction Methods 0.000 claims description 11
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• 239000012530 fluid Substances 0.000 claims description 11
• 208000010110 spontaneous platelet aggregation Diseases 0.000 claims description 11
• 239000001768 carboxy methyl cellulose Substances 0.000 claims description 10
• 229920001577 copolymer Polymers 0.000 claims description 10
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• 235000019270 ammonium chloride Nutrition 0.000 claims description 9
• 239000002775 capsule Substances 0.000 claims description 9
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• 235000019322 gelatine Nutrition 0.000 claims description 8
• 235000011852 gelatine desserts Nutrition 0.000 claims description 8
• 235000011187 glycerol Nutrition 0.000 claims description 8
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
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• 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 7
• 229910019142 PO4 Inorganic materials 0.000 claims description 7
• 239000004372 Polyvinyl alcohol Substances 0.000 claims description 7
• 230000002776 aggregation Effects 0.000 claims description 7
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• 229940016286 microcrystalline cellulose Drugs 0.000 claims description 7
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• 239000008108 microcrystalline cellulose Substances 0.000 claims description 7
• 235000021317 phosphate Nutrition 0.000 claims description 7
• 229920002451 polyvinyl alcohol Polymers 0.000 claims description 7
• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 6
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
• 238000004220 aggregation Methods 0.000 claims description 6
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 6
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 6
• 150000002148 esters Chemical class 0.000 claims description 6
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
• ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical class CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 5
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 5
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
• 210000004369 blood Anatomy 0.000 claims description 5
• 239000008280 blood Substances 0.000 claims description 5
• 239000011575 calcium Substances 0.000 claims description 5
• 229910052791 calcium Inorganic materials 0.000 claims description 5
• 235000001465 calcium Nutrition 0.000 claims description 5
• 239000003623 enhancer Substances 0.000 claims description 5
• 238000000265 homogenisation Methods 0.000 claims description 5
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 5
• 229920000609 methyl cellulose Polymers 0.000 claims description 5
• 235000010981 methylcellulose Nutrition 0.000 claims description 5
• 239000001923 methylcellulose Substances 0.000 claims description 5
• 239000008185 minitablet Substances 0.000 claims description 5
• 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 5
• JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 4
• YJHSJERLYWNLQL-UHFFFAOYSA-N 2-hydroxyethyl(dimethyl)azanium;chloride Chemical compound Cl.CN(C)CCO YJHSJERLYWNLQL-UHFFFAOYSA-N 0.000 claims description 4
• 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
• 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 4
• CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 4
• 125000000129 anionic group Chemical group 0.000 claims description 4
• CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 4
• 239000004359 castor oil Substances 0.000 claims description 4
• 235000019438 castor oil Nutrition 0.000 claims description 4
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
• 230000001419 dependent effect Effects 0.000 claims description 4
• DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical class [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 claims description 4
• 239000007903 gelatin capsule Substances 0.000 claims description 4
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
• 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 4
• 229960003943 hypromellose Drugs 0.000 claims description 4
• 229920001282 polysaccharide Polymers 0.000 claims description 4
• 239000005017 polysaccharide Substances 0.000 claims description 4
• 230000002035 prolonged effect Effects 0.000 claims description 4
• 239000011734 sodium Substances 0.000 claims description 4
• 229910052708 sodium Inorganic materials 0.000 claims description 4
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
• 229920002554 vinyl polymer Polymers 0.000 claims description 4
• 241000416162 Astragalus gummifer Species 0.000 claims description 3
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
• 240000007472 Leucaena leucocephala Species 0.000 claims description 3
• 235000010643 Leucaena leucocephala Nutrition 0.000 claims description 3
• 102000016943 Muramidase Human genes 0.000 claims description 3
• 108010014251 Muramidase Proteins 0.000 claims description 3
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 3
• 229920001615 Tragacanth Polymers 0.000 claims description 3
• NJSSICCENMLTKO-HRCBOCMUSA-N [(1r,2s,4r,5r)-3-hydroxy-4-(4-methylphenyl)sulfonyloxy-6,8-dioxabicyclo[3.2.1]octan-2-yl] 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)O[C@H]1C(O)[C@@H](OS(=O)(=O)C=2C=CC(C)=CC=2)[C@@H]2OC[C@H]1O2 NJSSICCENMLTKO-HRCBOCMUSA-N 0.000 claims description 3
• 239000000443 aerosol Substances 0.000 claims description 3
• 239000005018 casein Substances 0.000 claims description 3
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 3
• 235000021240 caseins Nutrition 0.000 claims description 3
• 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 3
• 125000005131 dialkylammonium group Chemical group 0.000 claims description 3
• 238000009826 distribution Methods 0.000 claims description 3
• 239000003937 drug carrier Substances 0.000 claims description 3
• 239000000499 gel Substances 0.000 claims description 3
• YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims description 3
• SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims description 3
• 239000004325 lysozyme Substances 0.000 claims description 3
• 235000010335 lysozyme Nutrition 0.000 claims description 3
• 229960000274 lysozyme Drugs 0.000 claims description 3
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
• 239000002674 ointment Substances 0.000 claims description 3
• 229940055076 parasympathomimetics choline ester Drugs 0.000 claims description 3
• XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 3
• 229920001983 poloxamer Polymers 0.000 claims description 3
• 238000001556 precipitation Methods 0.000 claims description 3
• 230000003248 secreting effect Effects 0.000 claims description 3
• APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 claims description 3
• 235000010487 tragacanth Nutrition 0.000 claims description 3
• 239000000196 tragacanth Substances 0.000 claims description 3
• 229940116362 tragacanth Drugs 0.000 claims description 3
• AISMNBXOJRHCIA-UHFFFAOYSA-N trimethylazanium;bromide Chemical class Br.CN(C)C AISMNBXOJRHCIA-UHFFFAOYSA-N 0.000 claims description 3
• 229940124549 vasodilator Drugs 0.000 claims description 3
• 239000003071 vasodilator agent Substances 0.000 claims description 3
• QAQSNXHKHKONNS-UHFFFAOYSA-N 1-ethyl-2-hydroxy-4-methyl-6-oxopyridine-3-carboxamide Chemical compound CCN1C(O)=C(C(N)=O)C(C)=CC1=O QAQSNXHKHKONNS-UHFFFAOYSA-N 0.000 claims description 2
• ISAVYTVYFVQUDY-UHFFFAOYSA-N 4-tert-Octylphenol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 ISAVYTVYFVQUDY-UHFFFAOYSA-N 0.000 claims description 2
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
• 229920002307 Dextran Polymers 0.000 claims description 2
• RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 2
• CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical compound OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 claims description 2
• 241000124008 Mammalia Species 0.000 claims description 2
• 239000004721 Polyphenylene oxide Substances 0.000 claims description 2
• 235000021355 Stearic acid Nutrition 0.000 claims description 2
• GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
• XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 2
• SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 claims description 2
• 150000003926 acrylamides Chemical group 0.000 claims description 2
• 229940072056 alginate Drugs 0.000 claims description 2
• 125000002877 alkyl aryl group Chemical group 0.000 claims description 2
• 125000006177 alkyl benzyl group Chemical group 0.000 claims description 2
• 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 claims description 2
• 150000001412 amines Chemical class 0.000 claims description 2
• 239000004004 anti-anginal agent Substances 0.000 claims description 2
• 229940124345 antianginal agent Drugs 0.000 claims description 2
• 239000003146 anticoagulant agent Substances 0.000 claims description 2
• 229940127219 anticoagulant drug Drugs 0.000 claims description 2
• 239000002220 antihypertensive agent Substances 0.000 claims description 2
• 229940030600 antihypertensive agent Drugs 0.000 claims description 2
• 239000003524 antilipemic agent Substances 0.000 claims description 2
• CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims description 2
• JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims description 2
• UUZYBYIOAZTMGC-UHFFFAOYSA-M benzyl(trimethyl)azanium;bromide Chemical compound [Br-].C[N+](C)(C)CC1=CC=CC=C1 UUZYBYIOAZTMGC-UHFFFAOYSA-M 0.000 claims description 2
• BCOZLGOHQFNXBI-UHFFFAOYSA-M benzyl-bis(2-chloroethyl)-ethylazanium;bromide Chemical compound [Br-].ClCC[N+](CC)(CCCl)CC1=CC=CC=C1 BCOZLGOHQFNXBI-UHFFFAOYSA-M 0.000 claims description 2
• WMLFGKCFDKMAKB-UHFFFAOYSA-M benzyl-diethyl-tetradecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](CC)(CC)CC1=CC=CC=C1 WMLFGKCFDKMAKB-UHFFFAOYSA-M 0.000 claims description 2
• 239000000480 calcium channel blocker Substances 0.000 claims description 2
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 2
• 239000008116 calcium stearate Substances 0.000 claims description 2
• 235000013539 calcium stearate Nutrition 0.000 claims description 2
• 239000002368 cardiac glycoside Substances 0.000 claims description 2
• 229940097217 cardiac glycoside Drugs 0.000 claims description 2
• 150000001805 chlorine compounds Chemical class 0.000 claims description 2
• 235000012000 cholesterol Nutrition 0.000 claims description 2
• 239000006071 cream Substances 0.000 claims description 2
• CDJGWBCMWHSUHR-UHFFFAOYSA-M decyl(triethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](CC)(CC)CC CDJGWBCMWHSUHR-UHFFFAOYSA-M 0.000 claims description 2
• PLMFYJJFUUUCRZ-UHFFFAOYSA-M decyltrimethylammonium bromide Chemical compound [Br-].CCCCCCCCCC[N+](C)(C)C PLMFYJJFUUUCRZ-UHFFFAOYSA-M 0.000 claims description 2
• 229960000878 docusate sodium Drugs 0.000 claims description 2
• XKBGEWXEAPTVCK-UHFFFAOYSA-M methyltrioctylammonium chloride Chemical compound [Cl-].CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC XKBGEWXEAPTVCK-UHFFFAOYSA-M 0.000 claims description 2
• 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
• VHYYJWLKCODCNM-OIMNJJJWSA-N n-methyl-n-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]heptanamide Chemical compound CCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO VHYYJWLKCODCNM-OIMNJJJWSA-N 0.000 claims description 2
• GCRLIVCNZWDCDE-SJXGUFTOSA-N n-methyl-n-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]nonanamide Chemical compound CCCCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO GCRLIVCNZWDCDE-SJXGUFTOSA-N 0.000 claims description 2
• SBWGZAXBCCNRTM-CTHBEMJXSA-N n-methyl-n-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]octanamide Chemical compound CCCCCCCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SBWGZAXBCCNRTM-CTHBEMJXSA-N 0.000 claims description 2
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
• 229940094443 oxytocics prostaglandins Drugs 0.000 claims description 2
• 150000003904 phospholipids Chemical class 0.000 claims description 2
• 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 2
• 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 2
• 229920000570 polyether Polymers 0.000 claims description 2
• 239000004926 polymethyl methacrylate Substances 0.000 claims description 2
• 150000003180 prostaglandins Chemical class 0.000 claims description 2
• 150000003248 quinolines Chemical class 0.000 claims description 2
• 239000008117 stearic acid Substances 0.000 claims description 2
• 229930002534 steroid glycoside Natural products 0.000 claims description 2
• 150000008143 steroidal glycosides Chemical class 0.000 claims description 2
• 125000005208 trialkylammonium group Chemical group 0.000 claims description 2
• 239000011719 vitamin A Substances 0.000 claims description 2
• 239000011709 vitamin E Substances 0.000 claims description 2
• 229940046009 vitamin E Drugs 0.000 claims description 2
• 229940045997 vitamin a Drugs 0.000 claims description 2
• QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 claims 3
• DZGUJOWBVDZNNF-UHFFFAOYSA-N azanium;2-methylprop-2-enoate Chemical compound [NH4+].CC(=C)C([O-])=O DZGUJOWBVDZNNF-UHFFFAOYSA-N 0.000 claims 3
• MBABOKRGFJTBAE-UHFFFAOYSA-N methyl methanesulfonate Chemical compound COS(C)(=O)=O MBABOKRGFJTBAE-UHFFFAOYSA-N 0.000 claims 3
• GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims 3
• HOBGCONPBCCQHM-UHFFFAOYSA-N 2-(methylamino)ethane-1,1-diol Chemical compound CNCC(O)O HOBGCONPBCCQHM-UHFFFAOYSA-N 0.000 claims 2
• 229920006317 cationic polymer Polymers 0.000 claims 2
• YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical group [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims 2
• 230000003628 erosive effect Effects 0.000 claims 2
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