ZA200710000B - Nanoparticulate and controlled release compositions comprising a platelet aggregation inhibitor - Google Patents

Nanoparticulate and controlled release compositions comprising a platelet aggregation inhibitor

Info

Publication number
ZA200710000B
ZA200710000B ZA200710000A ZA200710000A ZA200710000B ZA 200710000 B ZA200710000 B ZA 200710000B ZA 200710000 A ZA200710000 A ZA 200710000A ZA 200710000 A ZA200710000 A ZA 200710000A ZA 200710000 B ZA200710000 B ZA 200710000B
Authority
ZA
South Africa
Prior art keywords
nanoparticulate
controlled release
platelet aggregation
release compositions
aggregation inhibitor
Prior art date
Application number
ZA200710000A
Inventor
Scott Jenkins
Paul Stark
Niall M M Fanning
Gary Liversidge
John G Devane
Singh Gurvinder Rekhi
Original Assignee
Elan Pharma Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharma Int Ltd filed Critical Elan Pharma Int Ltd
Publication of ZA200710000B publication Critical patent/ZA200710000B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200710000A 2005-05-23 2007-11-20 Nanoparticulate and controlled release compositions comprising a platelet aggregation inhibitor ZA200710000B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68362005P 2005-05-23 2005-05-23

Publications (1)

Publication Number Publication Date
ZA200710000B true ZA200710000B (en) 2009-12-30

Family

ID=39153748

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710000A ZA200710000B (en) 2005-05-23 2007-11-20 Nanoparticulate and controlled release compositions comprising a platelet aggregation inhibitor

Country Status (12)

Country Link
US (1) US20090297596A1 (en)
EP (1) EP1937218A2 (en)
JP (1) JP2008545808A (en)
KR (1) KR20080047509A (en)
CN (1) CN101287451A (en)
BR (1) BRPI0609982A2 (en)
CA (1) CA2611506A1 (en)
EA (1) EA200702595A1 (en)
IL (1) IL187567A0 (en)
NO (1) NO20076588L (en)
WO (1) WO2008030209A2 (en)
ZA (1) ZA200710000B (en)

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US9775819B2 (en) 2009-09-16 2017-10-03 R.P. Scherer Technologies, Llc Oral solid dosage form containing nanoparticles and process of formulating the same using fish gelatin
WO2011158110A2 (en) 2010-04-28 2011-12-22 Nuformix Limited Cilostazol cocrystals and compositions
US9012511B2 (en) 2010-05-19 2015-04-21 Alkermes Pharma Ireland Limited Nanoparticulate cinacalcet compositions
KR101282847B1 (en) * 2011-07-27 2013-07-05 조선대학교산학협력단 Solid dispersion containing cilostazol and pharmaceutical composition comprising the same
KR20150027800A (en) * 2012-06-15 2015-03-12 고에키 자이단 호징 센탄 이료 신코 자이단 Prophylactic and/or therapeutic agent for mild cognitive impairment
TWI697337B (en) * 2013-08-07 2020-07-01 學校法人近畿大學 Process for produing nano particle or nano-particle composition, and process for manufacturing stent or balloon catheter
CN103980326A (en) * 2014-05-05 2014-08-13 珀莱雅化妆品股份有限公司 Preparation method of salidroside by supercritical CO2 reverse micelles extraction
KR101869406B1 (en) * 2015-11-25 2018-07-24 한국유나이티드제약 주식회사 Controlled Released Hard Capsule Preparation
CN112592379B (en) * 2020-12-18 2021-11-16 广东药科大学 beta-D-glucose short-chain fatty acid ester compound and preparation method and application thereof
CN114796217A (en) * 2021-01-29 2022-07-29 南京宁丹新药技术有限公司 Application of composition containing cilostazol in cerebrovascular diseases

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US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
ATE150297T1 (en) * 1992-06-10 1997-04-15 Nanosystems Llc SURFACE MODIFIED NSAID NANOPARTICLES
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US6495579B1 (en) * 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
KR20070051953A (en) * 1998-11-02 2007-05-18 엘란 코포레이션, 피엘씨 Multiparticulate modified release composition
JP4748839B2 (en) * 1999-03-25 2011-08-17 大塚製薬株式会社 Cilostazol preparation
EG23951A (en) * 1999-03-25 2008-01-29 Otsuka Pharma Co Ltd Cilostazol preparation
JP4641696B2 (en) * 1999-09-30 2011-03-02 大塚製薬株式会社 Gastrointestinal lower soluble coating formulation
CN1406140A (en) * 2000-02-28 2003-03-26 吉倪塞思公司 Nano capsule encapsulation system and method
JP4541647B2 (en) * 2000-11-20 2010-09-08 エラン ファーマ インターナショナル，リミティド Nanoparticle composition comprising a copolymer as a surface stabilizer
US6573382B2 (en) * 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
EP1423175B1 (en) * 2001-08-08 2013-10-02 Brown University Research Foundation Methods for micronization of hydrophobic drugs
TW200301135A (en) * 2001-12-27 2003-07-01 Otsuka Maryland Res Inst Inc Pharmaceutical compositions comprising a multifunctional phosphodiesterase inhibitor and an adenosine uptake inhibitor
US8512727B2 (en) * 2003-03-03 2013-08-20 Alkermes Pharma Ireland Limited Nanoparticulate meloxicam formulations
WO2005016310A1 (en) * 2003-08-08 2005-02-24 Elan Pharma International Ltd. Novel metaxalone compositions
US20050255155A1 (en) * 2004-05-11 2005-11-17 Glenmark Pharmaceuticals Limited Modified release cilostazol compositions
AU2006336417A1 (en) * 2005-05-10 2007-08-02 Elan Pharma International, Limited Nanoparticulate clopidogrel formulations
KR20080016952A (en) * 2005-06-13 2008-02-22 엘란 파마 인터내셔널 리미티드 Nanoparticulate clopidogrel and aspirin combination formulations

Also Published As

Publication number Publication date
WO2008030209A3 (en) 2008-07-03
CA2611506A1 (en) 2006-11-23
CN101287451A (en) 2008-10-15
BRPI0609982A2 (en) 2010-05-18
US20090297596A1 (en) 2009-12-03
EA200702595A1 (en) 2008-12-30
WO2008030209A2 (en) 2008-03-13
EP1937218A2 (en) 2008-07-02
JP2008545808A (en) 2008-12-18
IL187567A0 (en) 2011-08-01
KR20080047509A (en) 2008-05-29
NO20076588L (en) 2008-02-20

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