BRPI0609177A2 - uso de um composto, kit, e, composição farmacêutica - Google Patents
uso de um composto, kit, e, composição farmacêutica Download PDFInfo
- Publication number
- BRPI0609177A2 BRPI0609177A2 BRPI0609177-6A BRPI0609177A BRPI0609177A2 BR PI0609177 A2 BRPI0609177 A2 BR PI0609177A2 BR PI0609177 A BRPI0609177 A BR PI0609177A BR PI0609177 A2 BRPI0609177 A2 BR PI0609177A2
- Authority
- BR
- Brazil
- Prior art keywords
- effective amount
- compound
- pharmaceutically acceptable
- alkyl
- pharmaceutically effective
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 116
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 44
- 229940125782 compound 2 Drugs 0.000 claims abstract description 58
- 150000003839 salts Chemical class 0.000 claims abstract description 54
- 239000003814 drug Substances 0.000 claims abstract description 47
- 208000018737 Parkinson disease Diseases 0.000 claims abstract description 30
- 238000011282 treatment Methods 0.000 claims abstract description 23
- 208000015122 neurodegenerative disease Diseases 0.000 claims abstract description 20
- 230000004770 neurodegeneration Effects 0.000 claims abstract description 18
- OUBCNLGXQFSTLU-UHFFFAOYSA-N nitisinone Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=CC=C1C(=O)C1C(=O)CCCC1=O OUBCNLGXQFSTLU-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- 239000003112 inhibitor Substances 0.000 claims description 106
- 241001465754 Metazoa Species 0.000 claims description 58
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims description 51
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims description 51
- 229960004502 levodopa Drugs 0.000 claims description 42
- 239000003085 diluting agent Substances 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 22
- 229940123736 Decarboxylase inhibitor Drugs 0.000 claims description 20
- 239000003954 decarboxylase inhibitor Substances 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- KKADPXVIOXHVKN-UHFFFAOYSA-N 4-hydroxyphenylpyruvic acid Chemical compound OC(=O)C(=O)CC1=CC=C(O)C=C1 KKADPXVIOXHVKN-UHFFFAOYSA-N 0.000 claims description 17
- KXFJZKUFXHWWAJ-UHFFFAOYSA-N p-hydroxybenzoylformic acid Natural products OC(=O)C(=O)C1=CC=C(O)C=C1 KXFJZKUFXHWWAJ-UHFFFAOYSA-N 0.000 claims description 17
- 239000004480 active ingredient Substances 0.000 claims description 16
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims description 14
- 230000002401 inhibitory effect Effects 0.000 claims description 11
- 239000003543 catechol methyltransferase inhibitor Substances 0.000 claims description 10
- 239000002899 monoamine oxidase inhibitor Substances 0.000 claims description 9
- 229940099362 Catechol O methyltransferase inhibitor Drugs 0.000 claims description 8
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- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 claims description 8
- 239000007900 aqueous suspension Substances 0.000 claims description 7
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- -1 2-Nitro-4-Trifluoromethylbenzoyl Chemical group 0.000 description 153
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 36
- 238000012360 testing method Methods 0.000 description 30
- 239000001257 hydrogen Substances 0.000 description 27
- 229910052739 hydrogen Inorganic materials 0.000 description 27
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 26
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- 125000004093 cyano group Chemical group *C#N 0.000 description 23
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 23
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- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 description 13
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- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 12
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- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 10
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- 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
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- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 6
- JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 description 6
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- 125000000623 heterocyclic group Chemical group 0.000 description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0504103.3A GB0504103D0 (en) | 2005-02-28 | 2005-02-28 | Novel method |
| GB0504103.3 | 2005-02-28 | ||
| PCT/GB2006/000684 WO2006090177A1 (en) | 2005-02-28 | 2006-02-27 | USE OF 2-(2-NITRO-4-TRIFLUOROMETHYLBENZOYL)-l,3- CYCLOHEXANEDIONE IN THE TREATMENT OF PARKINSON'S DISEASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0609177A2 true BRPI0609177A2 (pt) | 2010-02-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0609177-6A BRPI0609177A2 (pt) | 2005-02-28 | 2006-02-27 | uso de um composto, kit, e, composição farmacêutica |
Country Status (17)
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|---|---|---|---|---|
| KR101669432B1 (ko) * | 2007-08-27 | 2016-10-26 | 다트 뉴로사이언스 (케이만) 엘티디. | 치료적 이속사졸 화합물 |
| CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| BRPI0921431A2 (pt) * | 2008-11-06 | 2017-06-06 | Biotie Therapies Ag | método para tratar ou prevenir síndrome das pernas inquietas, composição farmacêutica, e, métodos para tratar ou prevenir distúrbios do sono, e para melhorar a quantidade do sono ou adequação do sono |
| HRP20160286T1 (hr) * | 2011-06-23 | 2016-05-06 | Swedish Orphan Biovitrum International Ab | Tekuća farmaceutska kompozicija koja sadrži nitizinon |
| CN103622942A (zh) * | 2013-11-04 | 2014-03-12 | 江苏大学 | 左旋多巴/卡比多巴复方缓释混悬剂及其制备方法 |
| EP3328381A1 (en) * | 2015-07-29 | 2018-06-06 | Takeda GmbH | Pde4 inhibitor for the treatment of diabetic nephropathy |
| ITUB20160650A1 (it) | 2016-02-11 | 2017-08-11 | Dipharma S A | Formulazioni farmaceutiche solide stabili contenenti 2-(2-nitro-4-trifluorometilbenzoil)-1,3-cicloesandione |
| US9783485B1 (en) | 2016-11-30 | 2017-10-10 | Dipharma S.A. | Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and a process of synthesis and crystallization thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4780127A (en) * | 1982-03-25 | 1988-10-25 | Stauffer Chemical Company | Certain 2-(substituted benzoyl)-1,3-cyclohexanediones and their use as herbicides |
| US5092919A (en) * | 1991-01-15 | 1992-03-03 | Imperial Chemical Industries Plc | Certain 2-(2'-methyl-3',4'-trisubstituted benzoyl)-1,3-cyclohexanediones |
| WO1993000080A1 (en) * | 1991-06-24 | 1993-01-07 | Zeneca Ltd. | Use of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione in the treatment of tyrosinaemia and pharmaceutical compositions |
| FR2777781B1 (fr) * | 1998-04-24 | 2004-04-09 | Rhone Poulenc Rorer Sa | Associations riluzole et l-dopa pour le traitement de la maladie de parkinson |
| US20050288187A1 (en) * | 2002-07-03 | 2005-12-29 | Hanauske-Abel Hartmut M | Inhibitor development for 4-hydroxyphenylpyruvate dioxygenase, employing tyrosinemia 1 as a model for human diseases mediated by 2-oxoacid utilizing dioxygenases |
| US20060166972A1 (en) * | 2003-07-11 | 2006-07-27 | Conn P J | Treatment of movement disorders with a metabotropic glutamate 4 receptor positive allosteric modulator |
| JP2010501532A (ja) * | 2006-08-18 | 2010-01-21 | シンジェンタ リミテッド | うつ病、および／または常習性薬物の使用に伴う禁断症状の治療のための、ｈｐｐｄ阻害薬の使用 |
| BRPI0921431A2 (pt) * | 2008-11-06 | 2017-06-06 | Biotie Therapies Ag | método para tratar ou prevenir síndrome das pernas inquietas, composição farmacêutica, e, métodos para tratar ou prevenir distúrbios do sono, e para melhorar a quantidade do sono ou adequação do sono |
-
2005
- 2005-02-28 GB GBGB0504103.3A patent/GB0504103D0/en not_active Ceased
-
2006
- 2006-02-27 CA CA002598517A patent/CA2598517A1/en not_active Abandoned
- 2006-02-27 PT PT06709910T patent/PT1853241E/pt unknown
- 2006-02-27 RU RU2007131934/15A patent/RU2420272C2/ru not_active IP Right Cessation
- 2006-02-27 AU AU2006217650A patent/AU2006217650B2/en not_active Ceased
- 2006-02-27 WO PCT/GB2006/000684 patent/WO2006090177A1/en not_active Ceased
- 2006-02-27 AT AT06709910T patent/ATE524171T1/de active
- 2006-02-27 ES ES06709910T patent/ES2374761T3/es active Active
- 2006-02-27 ZA ZA200707486A patent/ZA200707486B/xx unknown
- 2006-02-27 DK DK06709910.1T patent/DK1853241T3/da active
- 2006-02-27 US US12/090,645 patent/US20090326072A1/en not_active Abandoned
- 2006-02-27 CN CN2006800133878A patent/CN101163466B/zh not_active Expired - Fee Related
- 2006-02-27 BR BRPI0609177-6A patent/BRPI0609177A2/pt not_active IP Right Cessation
- 2006-02-27 JP JP2007557572A patent/JP2008531665A/ja active Pending
- 2006-02-27 EP EP06709910A patent/EP1853241B1/en active Active
- 2006-02-27 MX MX2007010480A patent/MX2007010480A/es not_active Application Discontinuation
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2007
- 2007-08-21 IL IL185410A patent/IL185410A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0504103D0 (en) | 2005-04-06 |
| WO2006090177A1 (en) | 2006-08-31 |
| AU2006217650B2 (en) | 2011-06-09 |
| EP1853241B1 (en) | 2011-09-14 |
| MX2007010480A (es) | 2008-02-07 |
| RU2420272C2 (ru) | 2011-06-10 |
| RU2007131934A (ru) | 2009-02-27 |
| ES2374761T3 (es) | 2012-02-21 |
| CN101163466B (zh) | 2011-12-07 |
| EP1853241A1 (en) | 2007-11-14 |
| CN101163466A (zh) | 2008-04-16 |
| PT1853241E (pt) | 2012-01-11 |
| US20090326072A1 (en) | 2009-12-31 |
| JP2008531665A (ja) | 2008-08-14 |
| AU2006217650A1 (en) | 2006-08-31 |
| ZA200707486B (en) | 2009-02-25 |
| CA2598517A1 (en) | 2006-08-31 |
| IL185410A0 (en) | 2008-08-07 |
| ATE524171T1 (de) | 2011-09-15 |
| DK1853241T3 (da) | 2012-01-16 |
| HK1110211A1 (en) | 2008-07-11 |
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