BRPI0606529A2 - método para a detecção da presença de um prìon patogênico em uma amostra e controle e substituto para uso em um ensaio de detecção de prìon - Google Patents

método para a detecção da presença de um prìon patogênico em uma amostra e controle e substituto para uso em um ensaio de detecção de prìon

Info

Publication number
BRPI0606529A2
BRPI0606529A2 BRPI0606529-5A BRPI0606529A BRPI0606529A2 BR PI0606529 A2 BRPI0606529 A2 BR PI0606529A2 BR PI0606529 A BRPI0606529 A BR PI0606529A BR PI0606529 A2 BRPI0606529 A2 BR PI0606529A2
Authority
BR
Brazil
Prior art keywords
prion
detecting
control
substitute
sample
Prior art date
Application number
BRPI0606529-5A
Other languages
English (en)
Portuguese (pt)
Inventor
David Peretz
Melissa D Michelitsch
Celine Hu
Xuemei Wang
Man Gao
Michael D Connolly
Thomas Horn
Ronald N Zuckermann
David Chien
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Publication of BRPI0606529A2 publication Critical patent/BRPI0606529A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BRPI0606529-5A 2005-01-13 2006-01-13 método para a detecção da presença de um prìon patogênico em uma amostra e controle e substituto para uso em um ensaio de detecção de prìon BRPI0606529A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64431405P 2005-01-13 2005-01-13
US65249305P 2005-02-11 2005-02-11
PCT/US2006/001437 WO2006076687A2 (en) 2005-01-13 2006-01-13 Elisa assays using prion-specific peptide reagents

Publications (1)

Publication Number Publication Date
BRPI0606529A2 true BRPI0606529A2 (pt) 2009-06-30

Family

ID=36678266

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606529-5A BRPI0606529A2 (pt) 2005-01-13 2006-01-13 método para a detecção da presença de um prìon patogênico em uma amostra e controle e substituto para uso em um ensaio de detecção de prìon

Country Status (10)

Country Link
US (1) US20090130774A1 (enExample)
EP (1) EP1848831A4 (enExample)
JP (3) JP5162250B2 (enExample)
CN (1) CN101166976B (enExample)
AU (1) AU2006204705C1 (enExample)
BR (1) BRPI0606529A2 (enExample)
CA (1) CA2594840A1 (enExample)
MX (1) MX2007008497A (enExample)
NZ (2) NZ587255A (enExample)
WO (1) WO2006076687A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
NZ594844A (en) 2005-09-09 2013-04-26 Novartis Ag Prion-specific peptoid reagents
JP2010523977A (ja) * 2007-04-04 2010-07-15 ノバルティス アーゲー プリオンアッセイ
US20110189692A1 (en) * 2008-04-30 2011-08-04 Novartis Ag Assay for pathogenic conformers
WO2010003227A1 (en) * 2008-07-08 2010-01-14 Amorfix Life Sciences Ltd. Detection of protein aggregates
AU2010315133B2 (en) * 2009-11-04 2015-09-10 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
GB201015569D0 (en) * 2010-09-16 2010-10-27 Medical Res Council Blood assay for prions
JP2014507649A (ja) * 2011-01-18 2014-03-27 バクスター・インターナショナル・インコーポレイテッド ヒト血液中の抗βアミロイド抗体の測定
DE102011057019A1 (de) * 2011-12-23 2013-06-27 Forschungszentrum Jülich GmbH Standard zur Quantifizierung von pathogenen Aggregaten aus körpereigenen Proteinen
CN102879577B (zh) * 2012-11-01 2014-04-09 山东龙美生物医学科技有限公司 一种检测朊病毒的试剂盒及其制备方法
SG11201802777XA (en) 2015-10-14 2018-05-30 X Therma Inc Compositions and methods for reducing ice crystal formation
WO2024254043A2 (en) * 2023-06-07 2024-12-12 The Regents Of The University Of California Nmda-r activating peptides in inflammation and neuronal differentiation

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US658619A (en) * 1900-02-02 1900-09-25 George L Clark Tire-supporting frame.
WO1999015903A1 (de) * 1997-09-19 1999-04-01 Evotec Biosystems Ag Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
US4006117A (en) * 1973-01-24 1977-02-01 Hooker Chemicals & Plastics Corporation Amine phosphite antioxidants
US4244721A (en) * 1979-01-31 1981-01-13 Pedro Buarque De Macedo Method of making composite borosilicate glass articles
US4666160A (en) * 1980-07-02 1987-05-19 Hamilton Clarence Q Apparatus for playing
US4569526A (en) * 1980-07-02 1986-02-11 Gamma-Delta Games, Inc. Vectorial and Mancala-like games, apparatus and methods
US4507230A (en) * 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
US4952496A (en) * 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
DE3500180A1 (de) * 1985-01-04 1986-07-10 Ernst Prof. Dr. 7400 Tübingen Bayer Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung
US4695053A (en) * 1986-03-07 1987-09-22 Bally Manufacturing Corporation Gaming device having player selectable winning combinations
US5292814A (en) * 1987-04-29 1994-03-08 Ernst Bayer Process for the preparation of monodispersed polymer beads
ES2082850T3 (es) * 1989-02-24 1996-04-01 Univ California Inmunoglobulinas preparadas geneticamente.
US5306812A (en) * 1989-09-08 1994-04-26 The Regents Of The University Of California Immunoglobulin-binding polypeptides
US5231167A (en) * 1989-09-08 1993-07-27 The Regents Of The University Of California Immunoglobulin-binding polypeptides
US5965695A (en) * 1990-05-15 1999-10-12 Chiron Corporation Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
ATE197646T1 (de) * 1990-08-06 2000-12-15 Chiron Corp Verfahren zum nachweis von cytokinkonvertasehemmern
EP0620761A1 (en) * 1991-01-04 1994-10-26 Perseptive Biosystems, Inc. Sulfonamide bonded hydrophilic coatings
US5665539A (en) * 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
DK0616613T3 (da) * 1991-12-03 1999-09-27 Proteus Molecular Design Fragmenter af prionprotein
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5652138A (en) * 1992-09-30 1997-07-29 The Scripps Research Institute Human neutralizing monoclonal antibodies to human immunodeficiency virus
US5524888A (en) * 1994-04-28 1996-06-11 Bally Gaming International, Inc. Gaming machine having electronic circuit for generating game results with non-uniform probabilities
US5792901A (en) * 1994-05-13 1998-08-11 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5908969A (en) * 1994-05-13 1999-06-01 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US6376170B1 (en) * 1994-10-03 2002-04-23 The Scripps Research Institute Ligand capture-directed selection of antibody
US5639581A (en) * 1994-10-24 1997-06-17 Fuji Xerox Co., Ltd. Charge transporting polymer, process for producing the same, and organic electronic device containing the same
EP0852011B1 (en) * 1995-09-14 2004-03-31 The Regents of the University of California ANTIBODIES SPECIFIC FOR NATIVE PrP?Sc
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
US6090606A (en) * 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US5713793A (en) * 1996-04-05 1998-02-03 Oris, L.L.C. Sporting event options market trading game
JP3745380B2 (ja) * 1996-05-14 2006-02-15 ヴィンアッカー，エルンスト―ルートヴィッヒ プリオンタンパク質に結合し、イソ型ＰｒＰ▲上ｃ▼とＰｒＰ▲上ｓｃ▼を識別することが可能なシャペロン
US5743525A (en) * 1996-07-01 1998-04-28 Haddad; George N. Sporting event wagering system
ATE252914T1 (de) * 1996-08-13 2003-11-15 Chiron Corp Zusammensetzungen zur polynukleotidabgabe
CN1327896C (zh) * 1996-10-10 2007-07-25 探针国际公司 治疗病毒感染的组合物及方法
US6172043B1 (en) * 1997-01-10 2001-01-09 Massachusetts Institute Of Technology Treatments for neurotoxicity in Alzheimer's disease caused by β amyloid peptides
EP0861900A1 (en) * 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunological detection of prions
US20010001061A1 (en) * 1997-02-21 2001-05-10 Prusiner Stanley B. Assay for disease related conformation of a protein
US6617119B2 (en) * 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US5888136A (en) * 1997-03-13 1999-03-30 Herbert; Richard A. Wagering system and method of wagering
US6010404A (en) * 1997-04-03 2000-01-04 Walker Asset Management Limited Partnership Method and apparatus for using a player input code to affect a gambling outcome
US7160189B2 (en) * 1997-04-03 2007-01-09 Walker Jay S Systems and methods for determining an outcome of a game on a gaming device based on a factor other than a random number
US7005295B1 (en) * 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
ES2329955T3 (es) * 1997-04-28 2009-12-02 Novartis Vaccines And Diagnostics, Inc. Aparato para la sintesis de oligomeros, especialmente peptoides, con reciclado de reactivos.
US6227972B1 (en) * 1997-07-01 2001-05-08 Walker Digital, Llc Method and apparatus for expiration of prepaid slot machine plays
US6024641A (en) * 1997-11-19 2000-02-15 Sarno; Robert A. Method, apparatus and system for lottery gaming
ATE244889T1 (de) * 1998-02-20 2003-07-15 Univ California Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen
US6214565B1 (en) * 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
DK1073723T3 (da) * 1998-04-14 2006-01-02 Sugen Inc STE20-relaterede proteinkinaser
US6211149B1 (en) * 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
US6358150B1 (en) * 1998-10-29 2002-03-19 Racetech Llc Methods and apparatus for parimutuel historical gaming
GB2348203B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
JP5122705B2 (ja) * 1999-01-25 2013-01-16 ミナーヴァ・バイオテクノロジーズ・コーポレーション 神経変性疾患における異常型タンパク質凝集の迅速かつ高感度の検出
US6551843B1 (en) * 1999-01-29 2003-04-22 Immunivest Corporation Methods for enhancing binding interactions between members of specific binding pairs
US6709330B1 (en) * 1999-08-20 2004-03-23 Ameritrade Holding Corporation Stock simulation engine for an options trading game
US6394899B1 (en) * 1999-10-29 2002-05-28 Stephen Tobin Walker Method of playing a knowledge based wagering game
FR2801106B1 (fr) * 1999-11-12 2007-10-05 Commissariat Energie Atomique Procede de diagnostic d'une esst provoquee par une souche d'atnc dans un echantillon biologique et son utilisation dans le diagnostic differentiel des differentes souches d'atnc
US6235483B1 (en) * 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
KR20020081330A (ko) * 2000-02-16 2002-10-26 노오쓰웨스턴 유니버시티 폴리펩토이드 폐 계면활성제
CA2986978A1 (en) * 2000-05-01 2001-11-08 Cfph, L.L.C. Real-time interactive wagering on event outcomes
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
WO2001097785A2 (en) * 2000-06-20 2001-12-27 Caprion Pharmaceuticals Inc. Basic copolymers for the treatment of prion-related-disease
CN1176407C (zh) * 2000-06-22 2004-11-17 京瓷株式会社 彩色图像形成装置及其方法
US6537548B1 (en) * 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
US20030092613A1 (en) * 2000-08-14 2003-05-15 Lee Daniel H. S. Alpha7 nicotinic receptor peptides as ligands for beta amyloid peptides
US20020087447A1 (en) * 2000-09-19 2002-07-04 Gazebo Inc. System and method for managing and executing event based investments
US6721761B2 (en) * 2000-12-20 2004-04-13 American Management Systems, Inc. System for assigning digital identifiers to telephone numbers and IP numbers
AU2002241909A1 (en) * 2001-01-19 2002-07-30 Baxter Healthcare S.A. Method of detecting prp protein and kits therefor
US6527270B2 (en) * 2001-02-13 2003-03-04 Casino Advisory Services, Inc. Method of effecting multiple wagers on a sports or other event
US20020115488A1 (en) * 2001-02-22 2002-08-22 Nicholas Berry System and method for conducting an online competition
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
US7166471B2 (en) * 2001-05-31 2007-01-23 Arete Associates Misfolded protein sensor method in body fluids
US6869360B2 (en) * 2001-09-20 2005-03-22 Konami Gaming, Inc. Gaming apparatus and method including a multiplier feature and bonus features
AU2002357007A1 (en) * 2001-11-21 2003-06-10 New York University SYNTHETIC IMMUNOGENIC BUT NON-DEPOSIT-FORMING POLYPEPTIDES AND PEPTIDES HOMOLOGOUS TO AMYLOID Beta, PRION PROTEIN, AMYLIN, Alpha-SYNUCLEIN, OR POLYGLUTAMINE REPEATS FOR INDUCTION OF AN IMMUNE RESPONSE THERETO
US7040982B1 (en) * 2001-11-23 2006-05-09 Igt Financial trading game
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
MXPA04008275A (es) * 2002-02-28 2005-04-25 Microsens Biophage Ltd Enlace de formas patologicas de proteinas de prion.
JP4421900B2 (ja) * 2002-04-09 2010-02-24 ザ スクリップス リサーチ インスティテュート モチーフ・グラフトされたハイブリッドポリペプチドおよびその使用
US20050119962A1 (en) * 2002-07-03 2005-06-02 Bowen Christopher K. Method and system for securitizing contracts valued on an index
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
EP1382971A1 (en) * 2002-07-17 2004-01-21 Pepscan Systems B.V. Detection of prion disease
US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
WO2004077368A2 (en) * 2003-02-21 2004-09-10 Walker, Digital, Llc Et Al. Method and apparatus for setting game parameters
US7962400B2 (en) * 2003-04-02 2011-06-14 Cfph, Llc System and method for wagering based on the movement of financial markets
WO2004090102A2 (en) * 2003-04-04 2004-10-21 American Red Cross Prion protein binding materials and methods of use
US7745569B2 (en) * 2003-04-07 2010-06-29 The Regents Of The University Of California Amyloid specific binding peptides and detecting abeta peptide
WO2005016127A2 (en) * 2003-08-13 2005-02-24 Chiron Corporation Prion-specific peptide reagents
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US7311600B2 (en) * 2003-08-22 2007-12-25 Gameline, Llc Game based upon fluctuations of an objective environment
US7614948B2 (en) * 2003-09-15 2009-11-10 Igt Multi-player bingo with slept awards reverting to progressive jackpot pool
KR100505713B1 (ko) * 2003-10-22 2005-08-03 삼성전자주식회사 쉘로우 트렌치 소자 분리막 및 쉘로우 트렌치 소자분리막의 형성 방법
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
US7482172B2 (en) * 2005-09-19 2009-01-27 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
US20060105839A1 (en) * 2004-11-15 2006-05-18 Delta Rangers, Inc. Casino game based on financial market activity
EP1848830A4 (en) * 2005-01-13 2009-05-06 Novartis Vaccines & Diagnostic Osplation of pathogenic prions

Also Published As

Publication number Publication date
CN101166976A (zh) 2008-04-23
HK1118336A1 (en) 2009-02-06
CN101166976B (zh) 2013-06-12
JP2012181210A (ja) 2012-09-20
EP1848831A4 (en) 2008-11-05
AU2006204705B2 (en) 2011-12-01
NZ587255A (en) 2012-03-30
JP2008527382A (ja) 2008-07-24
WO2006076687A3 (en) 2007-12-13
MX2007008497A (es) 2007-09-14
EP1848831A2 (en) 2007-10-31
JP5162250B2 (ja) 2013-03-13
AU2006204705C1 (en) 2012-07-05
WO2006076687A2 (en) 2006-07-20
JP2009115815A (ja) 2009-05-28
CA2594840A1 (en) 2006-07-20
NZ560535A (en) 2011-01-28
AU2006204705A1 (en) 2006-07-20
US20090130774A1 (en) 2009-05-21

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]