JP5162250B2 - プリオン特異的ペプチド試薬を使用するelisaアッセイ - Google Patents

プリオン特異的ペプチド試薬を使用するelisaアッセイ Download PDF

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JP5162250B2
JP5162250B2 JP2007551450A JP2007551450A JP5162250B2 JP 5162250 B2 JP5162250 B2 JP 5162250B2 JP 2007551450 A JP2007551450 A JP 2007551450A JP 2007551450 A JP2007551450 A JP 2007551450A JP 5162250 B2 JP5162250 B2 JP 5162250B2
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peptide
prion
pathogenic
reagent
seq
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JP2008527382A (ja
JP2008527382A5 (enExample
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デイビッド ペレツ,
メリッサ ミシェリッチ,
セリーヌ フー,
シューメイ ワン,
メン ガオ,
マイケル コノリー,
トーマス ホーン,
ロナルド ズッカーマン,
デイビッド チェン,
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ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2828Prion diseases

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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2007551450A 2005-01-13 2006-01-13 プリオン特異的ペプチド試薬を使用するelisaアッセイ Expired - Fee Related JP5162250B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64431405P 2005-01-13 2005-01-13
US60/644,314 2005-01-13
US65249305P 2005-02-11 2005-02-11
US60/652,493 2005-02-11
PCT/US2006/001437 WO2006076687A2 (en) 2005-01-13 2006-01-13 Elisa assays using prion-specific peptide reagents

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2009001994A Division JP2009115815A (ja) 2005-01-13 2009-01-07 プリオン特異的ペプチド試薬を使用するelisaアッセイ
JP2012142163A Division JP2012181210A (ja) 2005-01-13 2012-06-25 プリオン特異的ペプチド試薬を使用するelisaアッセイ

Publications (3)

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JP2008527382A JP2008527382A (ja) 2008-07-24
JP2008527382A5 JP2008527382A5 (enExample) 2009-02-26
JP5162250B2 true JP5162250B2 (ja) 2013-03-13

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JP2007551450A Expired - Fee Related JP5162250B2 (ja) 2005-01-13 2006-01-13 プリオン特異的ペプチド試薬を使用するelisaアッセイ
JP2009001994A Pending JP2009115815A (ja) 2005-01-13 2009-01-07 プリオン特異的ペプチド試薬を使用するelisaアッセイ
JP2012142163A Withdrawn JP2012181210A (ja) 2005-01-13 2012-06-25 プリオン特異的ペプチド試薬を使用するelisaアッセイ

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JP2009001994A Pending JP2009115815A (ja) 2005-01-13 2009-01-07 プリオン特異的ペプチド試薬を使用するelisaアッセイ
JP2012142163A Withdrawn JP2012181210A (ja) 2005-01-13 2012-06-25 プリオン特異的ペプチド試薬を使用するelisaアッセイ

Country Status (10)

Country Link
US (1) US20090130774A1 (enExample)
EP (1) EP1848831A4 (enExample)
JP (3) JP5162250B2 (enExample)
CN (1) CN101166976B (enExample)
AU (1) AU2006204705C1 (enExample)
BR (1) BRPI0606529A2 (enExample)
CA (1) CA2594840A1 (enExample)
MX (1) MX2007008497A (enExample)
NZ (2) NZ587255A (enExample)
WO (1) WO2006076687A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
BRPI0615618A2 (pt) 2005-09-09 2011-05-24 Novartis Ag reagentes peptóides especìficos para prìon
JP2010523977A (ja) * 2007-04-04 2010-07-15 ノバルティス アーゲー プリオンアッセイ
US20110189692A1 (en) * 2008-04-30 2011-08-04 Novartis Ag Assay for pathogenic conformers
WO2010003227A1 (en) * 2008-07-08 2010-01-14 Amorfix Life Sciences Ltd. Detection of protein aggregates
WO2011057029A1 (en) * 2009-11-04 2011-05-12 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
GB201015569D0 (en) * 2010-09-16 2010-10-27 Medical Res Council Blood assay for prions
WO2012099576A1 (en) * 2011-01-18 2012-07-26 Baxter International Inc. Measurement of anti-amyloid antibodies in human blood
DE102011057019A1 (de) * 2011-12-23 2013-06-27 Forschungszentrum Jülich GmbH Standard zur Quantifizierung von pathogenen Aggregaten aus körpereigenen Proteinen
CN102879577B (zh) * 2012-11-01 2014-04-09 山东龙美生物医学科技有限公司 一种检测朊病毒的试剂盒及其制备方法
WO2017066454A2 (en) 2015-10-14 2017-04-20 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
WO2024254043A2 (en) * 2023-06-07 2024-12-12 The Regents Of The University Of California Nmda-r activating peptides in inflammation and neuronal differentiation

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US658619A (en) * 1900-02-02 1900-09-25 George L Clark Tire-supporting frame.
US4006117A (en) * 1973-01-24 1977-02-01 Hooker Chemicals & Plastics Corporation Amine phosphite antioxidants
US4244721A (en) * 1979-01-31 1981-01-13 Pedro Buarque De Macedo Method of making composite borosilicate glass articles
US4666160A (en) * 1980-07-02 1987-05-19 Hamilton Clarence Q Apparatus for playing
US4569526A (en) * 1980-07-02 1986-02-11 Gamma-Delta Games, Inc. Vectorial and Mancala-like games, apparatus and methods
US4507230A (en) * 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
US4952496A (en) * 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
DE3500180A1 (de) * 1985-01-04 1986-07-10 Ernst Prof. Dr. 7400 Tübingen Bayer Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung
US4695053A (en) * 1986-03-07 1987-09-22 Bally Manufacturing Corporation Gaming device having player selectable winning combinations
US5292814A (en) * 1987-04-29 1994-03-08 Ernst Bayer Process for the preparation of monodispersed polymer beads
CA2047244C (en) * 1989-02-24 2002-09-17 Zanetti Maurizio Genetically engineered immunoglobulins
US5306812A (en) * 1989-09-08 1994-04-26 The Regents Of The University Of California Immunoglobulin-binding polypeptides
US5231167A (en) * 1989-09-08 1993-07-27 The Regents Of The University Of California Immunoglobulin-binding polypeptides
US6075121A (en) * 1990-05-15 2000-06-13 Chiron Corporation Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
EP0592423B1 (en) * 1990-08-06 2000-11-15 Chiron Corporation Methods for the identification of cytokine convertase inhibitors
CA2099574A1 (en) * 1991-01-04 1992-07-05 Noubar B. Afeyan Sulfonamide bonded hydrophilic coatings
US5665539A (en) * 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
AU675053B2 (en) * 1991-12-03 1997-01-23 Proteus Molecular Design Limited Fragments of prion proteins
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5652138A (en) * 1992-09-30 1997-07-29 The Scripps Research Institute Human neutralizing monoclonal antibodies to human immunodeficiency virus
US5524888A (en) * 1994-04-28 1996-06-11 Bally Gaming International, Inc. Gaming machine having electronic circuit for generating game results with non-uniform probabilities
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5792901A (en) * 1994-05-13 1998-08-11 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same
US5908969A (en) * 1994-05-13 1999-06-01 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US6376170B1 (en) * 1994-10-03 2002-04-23 The Scripps Research Institute Ligand capture-directed selection of antibody
US5639581A (en) * 1994-10-24 1997-06-17 Fuji Xerox Co., Ltd. Charge transporting polymer, process for producing the same, and organic electronic device containing the same
EP0852011B1 (en) * 1995-09-14 2004-03-31 The Regents of the University of California ANTIBODIES SPECIFIC FOR NATIVE PrP?Sc
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6090606A (en) * 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
US5713793A (en) * 1996-04-05 1998-02-03 Oris, L.L.C. Sporting event options market trading game
DE69724619T2 (de) * 1996-05-14 2004-07-01 Winnacker, Ernst-Ludwig, Prof. Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können
US5743525A (en) * 1996-07-01 1998-04-28 Haddad; George N. Sporting event wagering system
JP4320054B2 (ja) * 1996-08-13 2009-08-26 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド ポリヌクレオチド送達のための組成物および方法
US6043347A (en) * 1996-10-10 2000-03-28 Probe International Inc. Compositions and methods for treating viral infections
EP1015013A4 (en) * 1997-01-10 2002-07-24 Massachusetts Inst Technology TREATMENTS RELATING TO NEUROTOXICITY IN ALZHEIMER'S DISEASE CAUSED BY beta-AMYLOID PEPTIDES
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
EP0861900A1 (en) * 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunological detection of prions
US6617119B2 (en) * 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
US20010001061A1 (en) * 1997-02-21 2001-05-10 Prusiner Stanley B. Assay for disease related conformation of a protein
US5888136A (en) * 1997-03-13 1999-03-30 Herbert; Richard A. Wagering system and method of wagering
US7160189B2 (en) * 1997-04-03 2007-01-09 Walker Jay S Systems and methods for determining an outcome of a game on a gaming device based on a factor other than a random number
US6010404A (en) * 1997-04-03 2000-01-04 Walker Asset Management Limited Partnership Method and apparatus for using a player input code to affect a gambling outcome
US7005295B1 (en) * 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
WO1998049187A1 (en) * 1997-04-28 1998-11-05 Chiron Corporation Apparatus for synthesis of oligomers, especially peptoids, with reagent recycling
US6227972B1 (en) * 1997-07-01 2001-05-08 Walker Digital, Llc Method and apparatus for expiration of prepaid slot machine plays
EP1015888B1 (de) * 1997-09-19 2002-08-28 Evotec OAI AG Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
KR100608542B1 (ko) * 1997-11-19 2006-08-09 로버트 에이. 사르노 컴퓨터 통신망에서 복권 게임을 제공하는 시스템 및 그 방법
US6214565B1 (en) * 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
DE69909442T2 (de) * 1998-02-20 2004-04-22 The Regents Of The University Of California, Oakland Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen
CA2369172A1 (en) * 1998-04-14 1999-10-21 Sugen, Inc. Ste20-related protein kinases
US6211149B1 (en) * 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
US6358150B1 (en) * 1998-10-29 2002-03-19 Racetech Llc Methods and apparatus for parimutuel historical gaming
GB2348203B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
JP5122705B2 (ja) * 1999-01-25 2013-01-16 ミナーヴァ・バイオテクノロジーズ・コーポレーション 神経変性疾患における異常型タンパク質凝集の迅速かつ高感度の検出
US6551843B1 (en) * 1999-01-29 2003-04-22 Immunivest Corporation Methods for enhancing binding interactions between members of specific binding pairs
US6709330B1 (en) * 1999-08-20 2004-03-23 Ameritrade Holding Corporation Stock simulation engine for an options trading game
US6394899B1 (en) * 1999-10-29 2002-05-28 Stephen Tobin Walker Method of playing a knowledge based wagering game
FR2801106B1 (fr) * 1999-11-12 2007-10-05 Commissariat Energie Atomique Procede de diagnostic d'une esst provoquee par une souche d'atnc dans un echantillon biologique et son utilisation dans le diagnostic differentiel des differentes souches d'atnc
US6235483B1 (en) * 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
KR20020081330A (ko) * 2000-02-16 2002-10-26 노오쓰웨스턴 유니버시티 폴리펩토이드 폐 계면활성제
JP2004513409A (ja) * 2000-05-01 2004-04-30 シーエフピーエイチ, エル.エル.シー. イベント結果についてのリアルタイムの双方向賭博
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
AU6887101A (en) * 2000-06-20 2002-01-02 Caprion Pharmaceuticals, Inc. Copolymers and methods of treating prion-related diseases
CN1176407C (zh) * 2000-06-22 2004-11-17 京瓷株式会社 彩色图像形成装置及其方法
US6537548B1 (en) * 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
US20030092613A1 (en) * 2000-08-14 2003-05-15 Lee Daniel H. S. Alpha7 nicotinic receptor peptides as ligands for beta amyloid peptides
US20020087447A1 (en) * 2000-09-19 2002-07-04 Gazebo Inc. System and method for managing and executing event based investments
US6721761B2 (en) * 2000-12-20 2004-04-13 American Management Systems, Inc. System for assigning digital identifiers to telephone numbers and IP numbers
US20020137114A1 (en) * 2001-01-19 2002-09-26 Dirk Voelkel Method of detecting PrP protein and kits therefor
US6527270B2 (en) * 2001-02-13 2003-03-04 Casino Advisory Services, Inc. Method of effecting multiple wagers on a sports or other event
US20020115488A1 (en) * 2001-02-22 2002-08-22 Nicholas Berry System and method for conducting an online competition
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
WO2002097444A2 (en) * 2001-05-31 2002-12-05 Arete Associates Misfolded protein sensor method
US6869360B2 (en) * 2001-09-20 2005-03-22 Konami Gaming, Inc. Gaming apparatus and method including a multiplier feature and bonus features
EP1572894B1 (en) * 2001-11-21 2016-04-13 New York University Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid beta, prion protein, amylin, alpha synuclein, or polyglutamine repeats for induction of an immune response thereto
US7040982B1 (en) * 2001-11-23 2006-05-09 Igt Financial trading game
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
ES2564293T5 (es) * 2002-02-28 2019-04-04 Microsens Biophage Ltd Enlazamiento de formas patológicas de proteínas priónicas
NZ536054A (en) * 2002-04-09 2009-10-30 Scripps Research Inst Motif-grafted hybrid polypeptides and uses thereof
US20050119962A1 (en) * 2002-07-03 2005-06-02 Bowen Christopher K. Method and system for securitizing contracts valued on an index
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
EP1382971A1 (en) * 2002-07-17 2004-01-21 Pepscan Systems B.V. Detection of prion disease
US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
WO2004077368A2 (en) * 2003-02-21 2004-09-10 Walker, Digital, Llc Et Al. Method and apparatus for setting game parameters
US7962400B2 (en) * 2003-04-02 2011-06-14 Cfph, Llc System and method for wagering based on the movement of financial markets
DK1615992T3 (da) * 2003-04-04 2013-12-09 Pathogen Removal & Diagnostic Technologies Inc Prionproteinbindende materialer og fremgangsmåder til anvendelse
WO2004092197A2 (en) * 2003-04-07 2004-10-28 The Regents Of The University Of California Amyloid-specific peptides and uses thereof
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
KR101166012B1 (ko) * 2003-08-13 2012-07-23 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 프리온-특이적 펩티드 시약
US7311600B2 (en) * 2003-08-22 2007-12-25 Gameline, Llc Game based upon fluctuations of an objective environment
US7614948B2 (en) * 2003-09-15 2009-11-10 Igt Multi-player bingo with slept awards reverting to progressive jackpot pool
KR100505713B1 (ko) * 2003-10-22 2005-08-03 삼성전자주식회사 쉘로우 트렌치 소자 분리막 및 쉘로우 트렌치 소자분리막의 형성 방법
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
US7482172B2 (en) * 2005-09-19 2009-01-27 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
US20060105839A1 (en) * 2004-11-15 2006-05-18 Delta Rangers, Inc. Casino game based on financial market activity
EP1848830A4 (en) * 2005-01-13 2009-05-06 Novartis Vaccines & Diagnostic Osplation of pathogenic prions

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Publication number Publication date
JP2009115815A (ja) 2009-05-28
CA2594840A1 (en) 2006-07-20
US20090130774A1 (en) 2009-05-21
JP2008527382A (ja) 2008-07-24
JP2012181210A (ja) 2012-09-20
AU2006204705C1 (en) 2012-07-05
MX2007008497A (es) 2007-09-14
CN101166976A (zh) 2008-04-23
WO2006076687A3 (en) 2007-12-13
WO2006076687A2 (en) 2006-07-20
EP1848831A4 (en) 2008-11-05
BRPI0606529A2 (pt) 2009-06-30
AU2006204705B2 (en) 2011-12-01
NZ587255A (en) 2012-03-30
CN101166976B (zh) 2013-06-12
EP1848831A2 (en) 2007-10-31
NZ560535A (en) 2011-01-28
AU2006204705A1 (en) 2006-07-20
HK1118336A1 (en) 2009-02-06

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