BRPI0606408A2 - tratamento local de defeitos ósseos com matriz que libera bmp ou pth - Google Patents
tratamento local de defeitos ósseos com matriz que libera bmp ou pthInfo
- Publication number
- BRPI0606408A2 BRPI0606408A2 BRPI0606408-6A BRPI0606408A BRPI0606408A2 BR PI0606408 A2 BRPI0606408 A2 BR PI0606408A2 BR PI0606408 A BRPI0606408 A BR PI0606408A BR PI0606408 A2 BRPI0606408 A2 BR PI0606408A2
- Authority
- BR
- Brazil
- Prior art keywords
- cysts
- matrix
- bmp
- pth
- bone defects
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 5
- 210000000988 bone and bone Anatomy 0.000 title abstract 3
- 230000007547 defect Effects 0.000 title abstract 2
- 208000031513 cyst Diseases 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000008884 Aneurysmal Bone Cysts Diseases 0.000 abstract 1
- 208000022316 Arachnoid cyst Diseases 0.000 abstract 1
- 101150061927 BMP2 gene Proteins 0.000 abstract 1
- 208000017234 Bone cyst Diseases 0.000 abstract 1
- 101100165560 Mus musculus Bmp7 gene Proteins 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 108090000445 Parathyroid hormone Proteins 0.000 abstract 1
- 208000003664 Tarlov Cysts Diseases 0.000 abstract 1
- 230000011712 cell development Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000025661 ovarian cyst Diseases 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/225—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
TRATAMENTO LOCAL DE DEFEITOS óSSEOS COM MATRIZ QUE LIBERA BMP OU PTH. A presente invenção refere-se a um método de tratamento local de defeitos ósseos específicos tais como osteoporose ou cistos ásseos que compreende a etapa de administração local de uma formulação que compreende um peptídeo de fusão contendo um primeiro domínio que compreende PTH ou BMP 2 ou BMP 7, e um segundo domínio que compreende um domínio de substrato covalentemente reticulado; e um material adequado de formar uma matriz biodegradável adequada para crescimento ou desenvolvimento celular, em que o peptídeo de fusão é covalentemente ligado à matriz. Em uma modalidade a matriz contém um ou mais agentes de contraste, e é preferivelmente formada na ausência de um fator de crescimento. A matriz pode ser usada no tratamento de cistos preenchidos com fluido tais como cistos de Tarlov, cistos ovarianos, cistos aracnóides, cistos de osso aneurismático ou cistos hepáticos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64183005P | 2005-01-06 | 2005-01-06 | |
US64284805P | 2005-01-10 | 2005-01-10 | |
PCT/EP2006/050070 WO2006072623A1 (en) | 2005-01-06 | 2006-01-06 | Local treatment of bone defects with matrix releasing bmp or pth |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0606408A2 true BRPI0606408A2 (pt) | 2009-06-23 |
Family
ID=36572036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0606408-6A BRPI0606408A2 (pt) | 2005-01-06 | 2006-01-06 | tratamento local de defeitos ósseos com matriz que libera bmp ou pth |
Country Status (11)
Country | Link |
---|---|
US (1) | US8318674B2 (pt) |
EP (1) | EP1833505B1 (pt) |
JP (1) | JP2008526811A (pt) |
KR (1) | KR20070108868A (pt) |
AU (1) | AU2006204462A1 (pt) |
BR (1) | BRPI0606408A2 (pt) |
CA (1) | CA2592877A1 (pt) |
ES (1) | ES2476996T3 (pt) |
MX (1) | MX2007008329A (pt) |
RU (1) | RU2007129845A (pt) |
WO (2) | WO2006073711A2 (pt) |
Families Citing this family (26)
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US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
EP1833522B1 (en) * | 2005-01-06 | 2016-06-22 | Kuros Biosurgery AG | Supplemented matrices for the repair of bone fractures |
BRPI0712910B8 (pt) | 2006-05-26 | 2021-05-25 | Baxter Int | sistema de múltiplos componentes para uma composição de aumento ósseo injetável, e, composição de aumento ósseo injetável |
EP2021043B1 (en) * | 2006-05-26 | 2011-01-12 | Baxter International Inc. | Injectable bone void filler |
AU2014200027B2 (en) * | 2007-03-26 | 2015-10-29 | Baxter Healthcare Sa | Injectable void filler for soft tissue augmentation |
US20080241072A1 (en) | 2007-03-26 | 2008-10-02 | Baxter International Inc. | Injectable void filler for soft tissue augmentation |
EP2155874B1 (en) | 2007-04-09 | 2016-05-11 | The Board Of Trustees Of The University Of Arkansas | Fusion proteins of collagen-binding domain and parathyroid hormone |
MX2009011005A (es) | 2007-04-13 | 2009-11-02 | Kuros Biosurgery Ag | Sellador polimerico para tejido. |
US8062364B1 (en) | 2007-04-27 | 2011-11-22 | Knee Creations, Llc | Osteoarthritis treatment and device |
WO2009047361A2 (en) * | 2007-10-12 | 2009-04-16 | Kuros Biosurgery Ag | Injectable fibrin compositions for tissue augmentation comprising strontium salt |
WO2009083544A2 (en) * | 2007-12-28 | 2009-07-09 | Kuros Biosurgery Ag | Pdgf fusion proteins incorporated into fibrin foams |
EP2279021B1 (en) | 2008-04-18 | 2013-02-13 | Kuros Biosurgery AG | Dispensing device, kit containing the device, and method of operating the device |
CN101868245B (zh) * | 2008-05-16 | 2013-10-23 | 全南大学校产学协力团 | 含有用于刺激成骨细胞分化的骨形成肽1(bfp1)的合成肽及含有上述合成肽的药物组合物 |
US8025872B2 (en) | 2008-05-16 | 2011-09-27 | Industry Foundation Of Chonnam National University | Osteogenic synthetic peptides, pharmaceutical compositions comprising the same, and medium containing the same |
WO2009154330A1 (en) * | 2008-06-20 | 2009-12-23 | Industry Foundation Of Chonnam National University | An synthetic peptide containing bone forming peptide 2(bfp 2) for stimulating osteoblast differentiation, and pharmaceutical composition comprising the synthetic peptide |
EP2311482A1 (en) * | 2009-10-12 | 2011-04-20 | Industry Foundation Of Chonnam National University | Osteogenic synthetic BMP-7 peptides, pharmaceutical compositions cell culture medium containing same |
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WO2012123028A1 (en) | 2011-03-16 | 2012-09-20 | Kuros Biosurgery Ag | Pharmaceutical formulation for use in spinal fusion |
WO2013120060A1 (en) | 2012-02-09 | 2013-08-15 | The Board Of Trustees Of The University Of Arkansas | Delivery of therapeutic agents by a collagen binding protein |
CA2859412C (en) | 2011-12-14 | 2021-05-25 | The Board Of Trustees Of The University Of Arkansas | Delivery of therapeutic agents using bacterial collagen-binding polypeptide segments |
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US7052856B2 (en) * | 1999-10-05 | 2006-05-30 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
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CA2367636C (en) * | 2001-04-12 | 2010-05-04 | Lisa Mckerracher | Fusion proteins |
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US20040002770A1 (en) * | 2002-06-28 | 2004-01-01 | King Richard S. | Polymer-bioceramic composite for orthopaedic applications and method of manufacture thereof |
WO2004071543A1 (en) * | 2003-02-13 | 2004-08-26 | Synthes Ag Chur | Injectable bone-replacement mixture |
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DE10355992A1 (de) * | 2003-11-27 | 2005-06-30 | Curasan Ag | Bioresorbierbares Kompositmaterial |
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-
2005
- 2005-12-14 WO PCT/US2005/045287 patent/WO2006073711A2/en active Application Filing
-
2006
- 2006-01-06 CA CA002592877A patent/CA2592877A1/en not_active Abandoned
- 2006-01-06 BR BRPI0606408-6A patent/BRPI0606408A2/pt not_active IP Right Cessation
- 2006-01-06 EP EP06701133.8A patent/EP1833505B1/en active Active
- 2006-01-06 JP JP2007549893A patent/JP2008526811A/ja active Pending
- 2006-01-06 US US11/326,924 patent/US8318674B2/en active Active
- 2006-01-06 KR KR1020077018080A patent/KR20070108868A/ko not_active Application Discontinuation
- 2006-01-06 ES ES06701133.8T patent/ES2476996T3/es active Active
- 2006-01-06 RU RU2007129845/15A patent/RU2007129845A/ru not_active Application Discontinuation
- 2006-01-06 AU AU2006204462A patent/AU2006204462A1/en not_active Abandoned
- 2006-01-06 MX MX2007008329A patent/MX2007008329A/es not_active Application Discontinuation
- 2006-01-06 WO PCT/EP2006/050070 patent/WO2006072623A1/en active Application Filing
Also Published As
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MX2007008329A (es) | 2008-01-16 |
ES2476996T3 (es) | 2014-07-15 |
EP1833505A1 (en) | 2007-09-19 |
RU2007129845A (ru) | 2009-02-20 |
WO2006073711A2 (en) | 2006-07-13 |
JP2008526811A (ja) | 2008-07-24 |
US20070010440A1 (en) | 2007-01-11 |
WO2006072623A1 (en) | 2006-07-13 |
AU2006204462A1 (en) | 2006-07-13 |
WO2006073711A3 (en) | 2007-03-01 |
KR20070108868A (ko) | 2007-11-13 |
EP1833505B1 (en) | 2014-04-02 |
US8318674B2 (en) | 2012-11-27 |
CA2592877A1 (en) | 2006-07-13 |
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