BRPI0605939A2 - compostos e composições macrocìclicas úteis como inibidores de bace - Google Patents
compostos e composições macrocìclicas úteis como inibidores de baceInfo
- Publication number
- BRPI0605939A2 BRPI0605939A2 BRPI0605939-2A BRPI0605939A BRPI0605939A2 BR PI0605939 A2 BRPI0605939 A2 BR PI0605939A2 BR PI0605939 A BRPI0605939 A BR PI0605939A BR PI0605939 A2 BRPI0605939 A2 BR PI0605939A2
- Authority
- BR
- Brazil
- Prior art keywords
- bace inhibitors
- compositions useful
- macrocyclic compounds
- compounds
- macrocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D245/06—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/5545—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having eight-membered rings not containing additional condensed or non-condensed nitrogen-containing 3-7 membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
COMPOSTOS E COMPOSIçõES MACROCìCLICOCìCLICAS úTEIS COMO INIBIDORES DE BACE. A presente invenção refere-se aos novos compostos macrociclicocíclicos da Fórmula 1 em que R~ 1~, R~ 3~, V~ 1~, V~ 2~, X~ 1~, X~ 2~, Y, Z, Ar, o AA e n são como definidos na especificação, o número dos átomos do anel incluídos no anel macrocíclico sendo 14,15, 16,17 ou 18, na forma de uma base livre ou na forma de sal de adição ácida, às suas preparações, aos seus usos como medicamentos e aos medicamentos compreendendo os mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0500683.8A GB0500683D0 (en) | 2005-01-13 | 2005-01-13 | Organic compounds |
PCT/EP2006/000265 WO2006074940A2 (en) | 2005-01-13 | 2006-01-13 | Macrocyclic compounds and compositions useful as bace inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0605939A2 true BRPI0605939A2 (pt) | 2009-05-26 |
Family
ID=34224555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0605939-2A BRPI0605939A2 (pt) | 2005-01-13 | 2006-01-13 | compostos e composições macrocìclicas úteis como inibidores de bace |
Country Status (12)
Country | Link |
---|---|
US (1) | US8008250B2 (pt) |
EP (1) | EP1838680A2 (pt) |
JP (1) | JP2008526912A (pt) |
KR (1) | KR20070095944A (pt) |
CN (1) | CN101090894A (pt) |
AU (1) | AU2006205893A1 (pt) |
BR (1) | BRPI0605939A2 (pt) |
CA (1) | CA2590664A1 (pt) |
GB (1) | GB0500683D0 (pt) |
MX (1) | MX2007008508A (pt) |
RU (1) | RU2007130798A (pt) |
WO (1) | WO2006074940A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0325830D0 (en) * | 2003-11-05 | 2003-12-10 | Novartis Ag | Organic compounds |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
KR20070102514A (ko) * | 2005-01-13 | 2007-10-18 | 노파르티스 아게 | Bace 억제제로서 유용한 마크로시클릭 화합물 |
GB0500683D0 (en) | 2005-01-13 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0526614D0 (en) * | 2005-12-30 | 2006-02-08 | Novartis Ag | Organic compounds |
CN101484431A (zh) * | 2006-07-20 | 2009-07-15 | 诺瓦提斯公司 | 大环内酰胺 |
MX2009000710A (es) * | 2006-07-20 | 2009-01-30 | Novartis Ag | Compuestos macrociclicos utiles como inhibidores de bace. |
JP6471100B2 (ja) | 2013-02-12 | 2019-02-13 | バック・インスティテュート・フォー・リサーチ・オン・エイジング | Bace仲介性appプロセシングを調節するヒダントイン |
CA3003946A1 (en) | 2015-11-19 | 2017-05-26 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69211637T2 (de) | 1991-04-17 | 1997-01-30 | Hoffmann La Roche | Neue dna-gyrase inhibitoren, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen |
TW343965B (en) | 1994-03-30 | 1998-11-01 | Hoffmann La Roche | Novel mono- and bicyclic DNA gyrase inhibitors |
AUPM982594A0 (en) * | 1994-12-02 | 1995-01-05 | University Of Queensland, The | HIV protease inhibitors |
BR0210391A (pt) * | 2001-06-12 | 2004-06-15 | Elan Pharm Inc | Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto |
ES2261699T3 (es) * | 2001-06-12 | 2006-11-16 | Elan Pharmaceuticals, Inc. | Macrociclos utiles en el tratamiento de la enfermedad de alzheimer. |
CA2512111A1 (en) | 2003-01-07 | 2004-07-29 | Merck And Co., Inc. | Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease |
GB0315654D0 (en) | 2003-07-03 | 2003-08-13 | Novartis Ag | Organic compounds |
AR045218A1 (es) * | 2003-08-08 | 2005-10-19 | Schering Corp | Aminas ciclicas inhibidoras de bace-1 que poseen una benzamida sustituyente; composiciones farmaceuticas que las contienen y su uso en la fabricacion de medicamentos para tratar enfermedades cognitivas o neurodegenerativas. |
CA2535337A1 (en) | 2003-08-14 | 2005-03-03 | Merck & Co., Inc. | Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease |
GB0325830D0 (en) * | 2003-11-05 | 2003-12-10 | Novartis Ag | Organic compounds |
MX2007001102A (es) * | 2004-07-28 | 2007-04-13 | Schering Corp | Inhibidores macrociclicos de beta-secretasa. |
GB0500683D0 (en) | 2005-01-13 | 2005-02-23 | Novartis Ag | Organic compounds |
KR20070102514A (ko) | 2005-01-13 | 2007-10-18 | 노파르티스 아게 | Bace 억제제로서 유용한 마크로시클릭 화합물 |
GB0526614D0 (en) | 2005-12-30 | 2006-02-08 | Novartis Ag | Organic compounds |
MX2009000710A (es) * | 2006-07-20 | 2009-01-30 | Novartis Ag | Compuestos macrociclicos utiles como inhibidores de bace. |
CN101484431A (zh) * | 2006-07-20 | 2009-07-15 | 诺瓦提斯公司 | 大环内酰胺 |
-
2005
- 2005-01-13 GB GBGB0500683.8A patent/GB0500683D0/en not_active Ceased
-
2006
- 2006-01-13 RU RU2007130798/04A patent/RU2007130798A/ru not_active Application Discontinuation
- 2006-01-13 CA CA002590664A patent/CA2590664A1/en not_active Abandoned
- 2006-01-13 MX MX2007008508A patent/MX2007008508A/es not_active Application Discontinuation
- 2006-01-13 EP EP06706226A patent/EP1838680A2/en not_active Withdrawn
- 2006-01-13 US US11/794,412 patent/US8008250B2/en not_active Expired - Fee Related
- 2006-01-13 KR KR1020077015918A patent/KR20070095944A/ko not_active Application Discontinuation
- 2006-01-13 AU AU2006205893A patent/AU2006205893A1/en not_active Abandoned
- 2006-01-13 BR BRPI0605939-2A patent/BRPI0605939A2/pt not_active IP Right Cessation
- 2006-01-13 WO PCT/EP2006/000265 patent/WO2006074940A2/en active Application Filing
- 2006-01-13 CN CNA2006800016450A patent/CN101090894A/zh active Pending
- 2006-01-13 JP JP2007550760A patent/JP2008526912A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2006074940A2 (en) | 2006-07-20 |
CN101090894A (zh) | 2007-12-19 |
AU2006205893A1 (en) | 2006-07-20 |
MX2007008508A (es) | 2007-09-04 |
CA2590664A1 (en) | 2006-07-20 |
KR20070095944A (ko) | 2007-10-01 |
GB0500683D0 (en) | 2005-02-23 |
JP2008526912A (ja) | 2008-07-24 |
RU2007130798A (ru) | 2009-02-20 |
EP1838680A2 (en) | 2007-10-03 |
WO2006074940A3 (en) | 2006-08-31 |
US8008250B2 (en) | 2011-08-30 |
US20080214526A1 (en) | 2008-09-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 5A E 6A ANUIDADES. |