BRPI0519656A2 - terapia de combinaÇço compreendendo telmisartan e hidroclorotiazida - Google Patents
terapia de combinaÇço compreendendo telmisartan e hidroclorotiazidaInfo
- Publication number
- BRPI0519656A2 BRPI0519656A2 BRPI0519656-6A BRPI0519656A BRPI0519656A2 BR PI0519656 A2 BRPI0519656 A2 BR PI0519656A2 BR PI0519656 A BRPI0519656 A BR PI0519656A BR PI0519656 A2 BRPI0519656 A2 BR PI0519656A2
- Authority
- BR
- Brazil
- Prior art keywords
- telmisartan
- hydrochlorothiazide
- combination therapy
- angiotensin
- treatment
- Prior art date
Links
- 238000002648 combination therapy Methods 0.000 title abstract 2
- OZCVMXDGSSXWFT-UHFFFAOYSA-N 6-chloro-1,1-dioxo-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide;2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O.CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O OZCVMXDGSSXWFT-UHFFFAOYSA-N 0.000 title 1
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 abstract 6
- 239000005537 C09CA07 - Telmisartan Substances 0.000 abstract 3
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 abstract 3
- 229960002003 hydrochlorothiazide Drugs 0.000 abstract 3
- 229960005187 telmisartan Drugs 0.000 abstract 3
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 2
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicinal Preparation (AREA)
Abstract
TERAPIA DE COMBINAÇçO COMPREENDENDO TELMISARTAN E HIDROCLOROTIAZIDA. A presente invenção refere-se a uma composição farmacêutica que compreende cerca de 80 mg de telmisartan e cerca de 25 mg de hidroclorotiazida ou cerca de 160 mg de telmisartan e cerca de 50 mg de hidroclorotiazida para o tratamento de hipertensão em pacientes com uma redução insuficiente na pressão sangúínea quando do tratamento com um antagonista do receptor da angiotensina II, ou uma composição farmacêutica de um antagonista do receptor da angiotensina II e uma dose baixa de hidroclorotiazida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63706204P | 2004-12-17 | 2004-12-17 | |
| PCT/EP2005/013224 WO2006063737A1 (en) | 2004-12-17 | 2005-12-09 | Combination therapy comprising telmisartan and hydrochlorothiazide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0519656A2 true BRPI0519656A2 (pt) | 2009-03-03 |
Family
ID=35589356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519656-6A BRPI0519656A2 (pt) | 2004-12-17 | 2005-12-09 | terapia de combinaÇço compreendendo telmisartan e hidroclorotiazida |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1827424A1 (pt) |
| JP (1) | JP2008524136A (pt) |
| KR (1) | KR20070097511A (pt) |
| CN (1) | CN101080225A (pt) |
| AR (1) | AR052052A1 (pt) |
| AU (1) | AU2005315855A1 (pt) |
| BR (1) | BRPI0519656A2 (pt) |
| CA (1) | CA2589493A1 (pt) |
| EA (1) | EA200701159A1 (pt) |
| IL (1) | IL183944A0 (pt) |
| NO (1) | NO20072325L (pt) |
| PE (1) | PE20060768A1 (pt) |
| TW (1) | TW200637546A (pt) |
| UY (1) | UY29274A1 (pt) |
| WO (1) | WO2006063737A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7232828B2 (en) | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| US8637078B2 (en) * | 2005-11-24 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Bilayer tablet comprising telmisartan and diuretic |
| EP1970053A1 (en) * | 2007-03-14 | 2008-09-17 | Boehringer Ingelheim Pharma GmbH & Co. KG | Pharmaceutical composition |
| CN101854920B (zh) * | 2007-10-19 | 2013-05-01 | 大塚制药株式会社 | 基质型药物固体制剂 |
| EP2203158A4 (en) | 2007-10-30 | 2012-12-26 | Reddys Lab Ltd Dr | PHARMACEUTICAL FORMULATIONS WITH TELMISARTAN AND HYDROCHLORTHIAZIDE |
| ES2623329T3 (es) | 2008-03-19 | 2017-07-11 | Ratiopharm Gmbh | Composición farmacéutica sólida que comprende un antagonista no peptídico de receptor de la angiotensina II y un diurético |
| JP5635491B2 (ja) * | 2008-07-31 | 2014-12-03 | 武田薬品工業株式会社 | 固形医薬組成物 |
| GB0822170D0 (en) * | 2008-12-04 | 2009-01-14 | Arrow Int Ltd | Telmisartan with diuretic formulations |
| EP2443094B1 (en) | 2009-06-19 | 2013-03-20 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of telmisartan |
| EP2448576A2 (en) * | 2009-07-02 | 2012-05-09 | Mahmut Bilgic | Solubility enhancing pharmaceutical composition |
| WO2011002425A2 (en) * | 2009-07-02 | 2011-01-06 | Bilgig Mahmut | Pharmaceutical composition increasing solubility and stability |
| TR200906506A2 (tr) | 2009-08-24 | 2011-03-21 | Bi̇lgi̇ç Mahmut | Telmisartan içeren katı dozaj formları. |
| WO2011161123A2 (en) | 2010-06-21 | 2011-12-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Multilayer pharmaceutical tablet comprising telmisartan and a diuretic |
| EP2952196A4 (en) * | 2013-01-31 | 2016-08-03 | Sawai Seiyaku Kk | MULTILAYER TABLET WITH TELMISARTAN AND HYDROCHLOROTHIAZIDE |
| EP3025711B1 (en) * | 2013-07-23 | 2020-11-18 | Daiichi Sankyo Company, Limited | Medicine for preventing or treating hypertension |
| CN106562973A (zh) * | 2016-11-06 | 2017-04-19 | 成都先先先生物科技有限公司 | 一种抗高血压药物复方制剂 |
| CN107501192A (zh) * | 2017-08-15 | 2017-12-22 | 中国科学院上海药物研究所 | 替米沙坦与氢氯噻嗪的共晶 |
| CN108653227A (zh) * | 2018-08-09 | 2018-10-16 | 湖北舒邦药业有限公司 | 一种替米沙坦氢氯噻嗪片及其制备方法 |
| EP4029867A1 (en) * | 2021-01-13 | 2022-07-20 | Alpha Cognition Inc. | Solid forms of galantamine benzoate gluconate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4229085C2 (de) * | 1992-09-01 | 1996-07-11 | Boehringer Mannheim Gmbh | Längliche, teilbare Tablette |
| EP1467712B2 (en) * | 2002-01-16 | 2011-08-31 | Boehringer Ingelheim Pharma GmbH & Co. KG | Method of producing a bilayer pharmaceutical tablet comprising telmisartan and hydrochlorothiazide |
-
2005
- 2005-12-09 EA EA200701159A patent/EA200701159A1/ru unknown
- 2005-12-09 AU AU2005315855A patent/AU2005315855A1/en not_active Abandoned
- 2005-12-09 CN CNA2005800434334A patent/CN101080225A/zh active Pending
- 2005-12-09 EP EP05814002A patent/EP1827424A1/en not_active Withdrawn
- 2005-12-09 CA CA002589493A patent/CA2589493A1/en not_active Abandoned
- 2005-12-09 KR KR1020077016354A patent/KR20070097511A/ko not_active Withdrawn
- 2005-12-09 WO PCT/EP2005/013224 patent/WO2006063737A1/en not_active Ceased
- 2005-12-09 BR BRPI0519656-6A patent/BRPI0519656A2/pt not_active Application Discontinuation
- 2005-12-09 JP JP2007545905A patent/JP2008524136A/ja active Pending
- 2005-12-15 PE PE2005001465A patent/PE20060768A1/es not_active Application Discontinuation
- 2005-12-16 AR ARP050105303A patent/AR052052A1/es unknown
- 2005-12-16 TW TW094144909A patent/TW200637546A/zh unknown
- 2005-12-20 UY UY29274A patent/UY29274A1/es not_active Application Discontinuation
-
2007
- 2007-05-04 NO NO20072325A patent/NO20072325L/no not_active Application Discontinuation
- 2007-06-14 IL IL183944A patent/IL183944A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UY29274A1 (es) | 2006-07-31 |
| AU2005315855A1 (en) | 2006-06-22 |
| CA2589493A1 (en) | 2006-06-22 |
| KR20070097511A (ko) | 2007-10-04 |
| AR052052A1 (es) | 2007-02-28 |
| TW200637546A (en) | 2006-11-01 |
| EP1827424A1 (en) | 2007-09-05 |
| PE20060768A1 (es) | 2006-09-29 |
| IL183944A0 (en) | 2007-10-31 |
| JP2008524136A (ja) | 2008-07-10 |
| EA200701159A1 (ru) | 2007-12-28 |
| NO20072325L (no) | 2007-07-06 |
| CN101080225A (zh) | 2007-11-28 |
| WO2006063737A1 (en) | 2006-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |