ECSP099501A - Formulaciones de dosis unitaria y métodos para el tratamiento de la trombosis con un inhibidor oral del factor xa - Google Patents
Formulaciones de dosis unitaria y métodos para el tratamiento de la trombosis con un inhibidor oral del factor xaInfo
- Publication number
- ECSP099501A ECSP099501A EC2009009501A ECSP099501A ECSP099501A EC SP099501 A ECSP099501 A EC SP099501A EC 2009009501 A EC2009009501 A EC 2009009501A EC SP099501 A ECSP099501 A EC SP099501A EC SP099501 A ECSP099501 A EC SP099501A
- Authority
- EC
- Ecuador
- Prior art keywords
- factor
- coagulation
- inhibitors
- patient
- inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Abstract
RESUMEN DEL INVENTOLa modelación comparativa de la medida de cambios en actividad de protominasa a niveles de eficacia antitrombótica ha llevado al descubrimiento de la actividad terapéutica en humanos de inhibidores de factor Xa. Este invento está dirigido a un método para inhibir coagulación en un paciente humano utilizando una cantidad inhibitoria cantidad inhibidora de la coagulación de un inhibidor de factor Xa. Específicamente, inhibidores directos oralmente disponibles de factor Xa son efectivos para inhibir coagulación en un paciente humano cuando se administran al paciente en una cantidad diaria agregada de entre 0.01 y 2.0 miligramos por kilogramo aproximadamente con base en el peso total del paciente ("mg/kg") . Se contempla que esta dosis será efectiva para cualquier compuesto el cual específicamente inhibe factor Xa y particularmente efectiva para inhibidores de factor Xa de las Fórmula I, II, III, IV o V descritas a continuación.El invento también está dirigido a un método de evaluar el estado de la coagulación del paciente. Se contempla que este método de evaluar el estado de la coagulación se puede utilizar para probar un número de clases diferentes de anticoagulantes además de inhibidores de factor Xa.Gráfico (Imagen en formato jpg)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87379206P | 2006-12-08 | 2006-12-08 | |
US94762907P | 2007-07-02 | 2007-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP099501A true ECSP099501A (es) | 2010-01-29 |
Family
ID=39110529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2009009501A ECSP099501A (es) | 2006-12-08 | 2009-07-08 | Formulaciones de dosis unitaria y métodos para el tratamiento de la trombosis con un inhibidor oral del factor xa |
Country Status (19)
Country | Link |
---|---|
US (1) | US8404724B2 (es) |
EP (1) | EP2101760B1 (es) |
KR (1) | KR101472765B1 (es) |
CN (1) | CN105193799A (es) |
AU (1) | AU2007333377B2 (es) |
CA (2) | CA2671502C (es) |
CO (1) | CO6220933A2 (es) |
CR (1) | CR10914A (es) |
EC (1) | ECSP099501A (es) |
ES (1) | ES2409090T3 (es) |
HK (1) | HK1134031A1 (es) |
IL (1) | IL199219A (es) |
MA (1) | MA31086B1 (es) |
NI (1) | NI200900145A (es) |
NZ (1) | NZ578180A (es) |
PT (1) | PT2101760E (es) |
RU (2) | RU2452484C2 (es) |
SG (1) | SG10201504425SA (es) |
WO (1) | WO2008073670A2 (es) |
Families Citing this family (60)
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AU2001250783A1 (en) | 2000-02-29 | 2001-09-12 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
KR101195801B1 (ko) | 2004-06-18 | 2012-11-05 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Xa 인자 억제제 |
CN102225966B (zh) | 2004-10-19 | 2012-12-26 | 隆萨股份公司 | 用于固相肽合成的方法 |
JP2009508835A (ja) | 2005-09-16 | 2009-03-05 | アロー セラピューティクス リミテッド | ビフェニル誘導体及びc型肝炎の治療におけるその使用 |
WO2007112367A2 (en) * | 2006-03-27 | 2007-10-04 | Portola Pharmaceuticals, Inc. | Potassium channel modulators and platelet procoagulant activity |
NZ572418A (en) | 2006-05-05 | 2011-08-26 | Millennium Pharm Inc | Factor xa inhibitors |
CA2667488C (en) * | 2006-11-02 | 2015-07-07 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
EP2114930A2 (en) * | 2007-01-05 | 2009-11-11 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
EP2591783A1 (en) | 2007-04-13 | 2013-05-15 | Millennium Pharmaceuticals, Inc. | Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor |
WO2008137787A2 (en) * | 2007-05-02 | 2008-11-13 | Portola Pharmaceuticals, Inc. | Combination therapy with a compound acting as a platelet adp receptor inhibitor |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
US8273900B2 (en) | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
CN102985557B (zh) | 2009-03-13 | 2018-06-15 | 安吉奥斯医药品有限公司 | 用于细胞增殖相关病症的方法和组合物 |
CN102448951B (zh) | 2009-04-06 | 2017-05-10 | 安吉奥斯医药品有限公司 | 丙酮酸激酶m2调节剂、治疗组合物和相关使用方法 |
NZ622505A (en) | 2009-06-29 | 2015-12-24 | Agios Pharmaceuticals Inc | Therapeutic compounds and compositions |
JP6163304B2 (ja) | 2009-07-15 | 2017-07-12 | ポートラ ファーマシューティカルズ, インコーポレイテッド | 第Xa因子インヒビターの解毒剤の単位用量処方物およびその使用方法 |
EP2491145B1 (en) | 2009-10-21 | 2016-03-09 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
US8742120B2 (en) | 2009-12-17 | 2014-06-03 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
EP2513094B1 (en) | 2009-12-17 | 2015-12-16 | Millennium Pharmaceuticals, Inc. | Crystalline salts of a factor xa inhibitor |
PT2513058T (pt) | 2009-12-17 | 2017-01-26 | Millennium Pharm Inc | Métodos de síntese de inibidores do fator xa |
EA015918B1 (ru) * | 2010-03-03 | 2011-12-30 | Дмитрий Геннадьевич ТОВБИН | УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa |
AR082804A1 (es) | 2010-09-01 | 2013-01-09 | Portola Pharm Inc | Formas cristalinas de un inhibidor del factor xa |
JP5837091B2 (ja) | 2010-12-17 | 2015-12-24 | アジオス ファーマシューティカルズ, インコーポレイテッド | ピルビン酸キナーゼm2(pkm2)調節剤としての新規n−(4−(アゼチジン−1−カルボニル)フェニル)−(ヘテロ−)アリールスルホンアミド誘導体 |
JP6092118B2 (ja) | 2010-12-21 | 2017-03-08 | アジオス ファーマシューティカルズ, インコーポレイテッド | ニ環式pkm2活性化剤 |
TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
CN103764147B (zh) | 2011-05-03 | 2018-05-22 | 安吉奥斯医药品有限公司 | 用于治疗的丙酮酸激酶活化剂 |
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CN105593215B (zh) | 2013-07-11 | 2019-01-15 | 安吉奥斯医药品有限公司 | 用于治疗癌症的作为idh2突变体抑制剂的2,4-或4,6-二氨基嘧啶化合物 |
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US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
GB201314452D0 (en) | 2013-08-13 | 2013-09-25 | Ostara Biomedical Ltd | Embryo implantation |
JP6463366B2 (ja) | 2013-10-10 | 2019-01-30 | イースタン バージニア メディカル スクール | 12−リポキシゲナーゼ阻害物質としての4−((2−ヒドロキシ−3−メトキシベンジル)アミノ)ベンゼンスルホンアミド誘導体 |
GB201322777D0 (en) | 2013-12-20 | 2014-02-05 | Algipharma As | Use of alginate oligomers as blood anticoagulants |
EA036325B1 (ru) | 2014-03-14 | 2020-10-27 | Аджиос Фармасьютикалз, Инк. | Фармацевтическая композиция на основе твердой дисперсии ингибитора idh1 |
GB201501302D0 (en) | 2015-01-27 | 2015-03-11 | Ostara Biomedical Ltd | Embryo implantation |
WO2016201227A1 (en) | 2015-06-11 | 2016-12-15 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
WO2016205062A1 (en) * | 2015-06-15 | 2016-12-22 | Shifa Biomedical Corporation | Antithrombotic therapies |
GB201517523D0 (en) | 2015-10-05 | 2015-11-18 | Ostara Biomedical Ltd | Methods and compositions for managing reproduction |
LT3362066T (lt) | 2015-10-15 | 2022-02-10 | Les Laboratoires Servier Sas | Kombinuota terapija, skirta piktybinių susirgimų gydymui |
KR20180061372A (ko) | 2015-10-15 | 2018-06-07 | 아지오스 파마슈티컬스 아이엔씨. | 악성 종양의 치료를 위한 조합물 요법 |
TW201920081A (zh) | 2017-07-11 | 2019-06-01 | 美商維泰克斯製藥公司 | 作為鈉通道調節劑的羧醯胺 |
SG11202001684PA (en) | 2017-10-06 | 2020-03-30 | Forma Therapeutics Inc | Inhibiting ubiquitin specific peptidase 30 |
EA032764B1 (ru) * | 2018-01-19 | 2019-07-31 | Общество С Ограниченной Ответственностью "Фармадиол" | НОВЫЕ АМИДИНЫ - ИНГИБИТОРЫ ФАКТОРА Xa |
US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
US20210277357A1 (en) * | 2018-06-15 | 2021-09-09 | Naing Bijaj | Methods of detection of mechanically-activated platelet activation and uses thereof |
ES2945834T3 (es) | 2018-10-05 | 2023-07-07 | Forma Therapeutics Inc | Pirrolinas fusionadas que actúan como inhibidores de la proteasa 30 específica de ubiquitina (USP30) |
JOP20220130A1 (ar) | 2019-12-06 | 2023-01-30 | Vertex Pharma | مجموعات تترا هيدروفيوران بها استبدال في صورة عوامل تعديل لقنوات الصوديوم |
CA3166630A1 (en) | 2020-01-03 | 2021-07-08 | Berg Llc | Polycyclic amides as ube2k modulators for treating cancer |
UY39800A (es) | 2021-06-04 | 2023-01-31 | Vertex Pharma | N–(hidroxialquil (hetero)aril) tetrahidrofuran carboxamidas como moduladores de canales de sodio |
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2007
- 2007-11-15 RU RU2009126147/15A patent/RU2452484C2/ru not_active IP Right Cessation
- 2007-11-15 SG SG10201504425SA patent/SG10201504425SA/en unknown
- 2007-11-15 KR KR1020097014306A patent/KR101472765B1/ko active IP Right Grant
- 2007-11-15 AU AU2007333377A patent/AU2007333377B2/en not_active Ceased
- 2007-11-15 NZ NZ578180A patent/NZ578180A/en not_active IP Right Cessation
- 2007-11-15 CA CA2671502A patent/CA2671502C/en not_active Expired - Fee Related
- 2007-11-15 CA CA2913963A patent/CA2913963A1/en not_active Abandoned
- 2007-11-15 EP EP07864488A patent/EP2101760B1/en not_active Revoked
- 2007-11-15 CN CN201510530619.8A patent/CN105193799A/zh active Pending
- 2007-11-15 PT PT78644887T patent/PT2101760E/pt unknown
- 2007-11-15 WO PCT/US2007/084887 patent/WO2008073670A2/en active Application Filing
- 2007-11-15 ES ES07864488T patent/ES2409090T3/es active Active
- 2007-12-07 US US11/999,957 patent/US8404724B2/en not_active Expired - Fee Related
-
2009
- 2009-06-07 IL IL199219A patent/IL199219A/en active IP Right Grant
- 2009-07-06 CR CR10914A patent/CR10914A/es unknown
- 2009-07-08 CO CO09070741A patent/CO6220933A2/es not_active Application Discontinuation
- 2009-07-08 MA MA32076A patent/MA31086B1/fr unknown
- 2009-07-08 EC EC2009009501A patent/ECSP099501A/es unknown
- 2009-07-21 NI NI200900145A patent/NI200900145A/es unknown
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2010
- 2010-02-08 HK HK10101405.5A patent/HK1134031A1/xx not_active IP Right Cessation
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2012
- 2012-02-10 RU RU2012104816/15A patent/RU2012104816A/ru not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HK1134031A1 (en) | 2010-04-16 |
RU2452484C2 (ru) | 2012-06-10 |
AU2007333377A1 (en) | 2008-06-19 |
CR10914A (es) | 2009-08-12 |
US8404724B2 (en) | 2013-03-26 |
ES2409090T3 (es) | 2013-06-24 |
RU2012104816A (ru) | 2013-08-20 |
AU2007333377B2 (en) | 2014-01-16 |
RU2009126147A (ru) | 2011-01-20 |
KR20090107499A (ko) | 2009-10-13 |
CO6220933A2 (es) | 2010-11-19 |
CA2671502A1 (en) | 2008-06-19 |
CA2671502C (en) | 2017-01-24 |
IL199219A0 (en) | 2010-03-28 |
EP2101760A2 (en) | 2009-09-23 |
PT2101760E (pt) | 2013-05-07 |
NZ578180A (en) | 2012-02-24 |
IL199219A (en) | 2013-10-31 |
EP2101760B1 (en) | 2013-02-27 |
CA2913963A1 (en) | 2008-06-19 |
WO2008073670A3 (en) | 2008-11-27 |
WO2008073670A2 (en) | 2008-06-19 |
CN105193799A (zh) | 2015-12-30 |
MA31086B1 (fr) | 2010-01-04 |
KR101472765B1 (ko) | 2014-12-15 |
NI200900145A (es) | 2010-11-29 |
SG10201504425SA (en) | 2015-07-30 |
US20080153876A1 (en) | 2008-06-26 |
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