CY1113482T1 - Αναστολεις υποδοχεα σιγμα - Google Patents

Αναστολεις υποδοχεα σιγμα

Info

Publication number
CY1113482T1
CY1113482T1 CY20121101247T CY121101247T CY1113482T1 CY 1113482 T1 CY1113482 T1 CY 1113482T1 CY 20121101247 T CY20121101247 T CY 20121101247T CY 121101247 T CY121101247 T CY 121101247T CY 1113482 T1 CY1113482 T1 CY 1113482T1
Authority
CY
Cyprus
Prior art keywords
suspended
significant signs
compounds
sigma
receptor
Prior art date
Application number
CY20121101247T
Other languages
English (en)
Inventor
Christian Laggner
Maria Rosa Cuberes-Altisent
Joerg Holenz
Juana Maria Berrocal-Romero
María Montserrat Contijoch-Llobet
Original Assignee
Laboratorios Del Dr. Esteve, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04077421A external-priority patent/EP1634872A1/en
Priority claimed from ES200402441A external-priority patent/ES2251316B1/es
Priority claimed from EP05784245A external-priority patent/EP1781618B1/en
Application filed by Laboratorios Del Dr. Esteve, S.A. filed Critical Laboratorios Del Dr. Esteve, S.A.
Publication of CY1113482T1 publication Critical patent/CY1113482T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αφορά ενώσεις του τύπου (I) που έχουν φαρμακολογική δραστηριότητα προς τον σίγμα υποδοχέα, διεργασίες προετοιμασίας των εν λόγω ενώσεων, φαρμακευτικές συνθέσεις που τις περιέχουν και τη χρήση τους στη θεραπεία ή/και την προφύλαξη μιας ασθένειας στην οποία εμπλέκεται ο σίγμα υποδοχέας.
CY20121101247T 2004-08-27 2012-12-21 Αναστολεις υποδοχεα σιγμα CY1113482T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP04077421A EP1634872A1 (en) 2004-08-27 2004-08-27 Pyrazole derivatives as sigma receptor inhibitors
ES200402441A ES2251316B1 (es) 2004-10-14 2004-10-14 Inhibidores del receptor sigma.
US10/978,250 US20060106068A1 (en) 2004-08-27 2004-10-29 Sigma receptor inhibitors
EP05784245A EP1781618B1 (en) 2004-08-27 2005-08-29 Sigma receptor inhibitors

Publications (1)

Publication Number Publication Date
CY1113482T1 true CY1113482T1 (el) 2016-06-22

Family

ID=39927091

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101247T CY1113482T1 (el) 2004-08-27 2012-12-21 Αναστολεις υποδοχεα σιγμα

Country Status (9)

Country Link
US (2) US8293740B2 (el)
CY (1) CY1113482T1 (el)
DK (1) DK1781618T3 (el)
ES (1) ES2396421T3 (el)
HK (1) HK1106532A1 (el)
MX (1) MX2007002341A (el)
PT (1) PT1781618E (el)
RU (1) RU2417987C2 (el)
SI (1) SI1781618T1 (el)

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EP2292236A1 (en) * 2009-08-14 2011-03-09 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention or treatment of pain induced by chemotherapy
EP2335688A1 (en) * 2009-11-25 2011-06-22 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compositions comprising sigma receptor ligands
MX339932B (es) * 2009-11-25 2016-06-17 Laboratorios Del Dr Esteve S A * Sales de 4-[2-[[5-metil-1-(2naftalenil)-1h-pirazol-3-il]oxi]etil]m orfolina.
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2395003A1 (en) * 2010-05-27 2011-12-14 Laboratorios Del. Dr. Esteve, S.A. Pyrazole compounds as sigma receptor inhibitors
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2426111A1 (en) * 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
EP2460519A1 (en) * 2010-12-03 2012-06-06 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in bone cancer pain
EP2524694A1 (en) * 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
KR20160097366A (ko) 2013-12-17 2016-08-17 라보라토리오스 델 드라. 에스테브.에스.에이. 세로토닌-노르에피네프린 재흡수 억제제들(SNRIs) 및 시그마 리셉터 리간드들 조합
KR20180048923A (ko) * 2015-09-02 2018-05-10 라보라토리오스 델 드라. 에스테브.에스.에이. 1-(4-(2-((1-(3,4-디플루오로페닐)-1h-피라졸-3-일)메톡시)에틸)피페라진-1- 일)에타논 염들

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US8293740B2 (en) 2012-10-23
US8314096B2 (en) 2012-11-20
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SI1781618T1 (sl) 2013-01-31
US20100190781A1 (en) 2010-07-29
RU2007111118A (ru) 2008-10-10
MX2007002341A (es) 2007-09-25
US20100190790A1 (en) 2010-07-29
RU2417987C2 (ru) 2011-05-10
PT1781618E (pt) 2012-12-18
HK1106532A1 (en) 2008-03-14

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