BRPI0519165A2 - unidade de expressço, cassete de expressço, vetor, microorganismo geneticamente modificado, processo para preparar um produto biossintÉtico, e, uso de uma unidade de expressço - Google Patents
unidade de expressço, cassete de expressço, vetor, microorganismo geneticamente modificado, processo para preparar um produto biossintÉtico, e, uso de uma unidade de expressçoInfo
- Publication number
- BRPI0519165A2 BRPI0519165A2 BRPI0519165-3A BRPI0519165A BRPI0519165A2 BR PI0519165 A2 BRPI0519165 A2 BR PI0519165A2 BR PI0519165 A BRPI0519165 A BR PI0519165A BR PI0519165 A2 BRPI0519165 A2 BR PI0519165A2
- Authority
- BR
- Brazil
- Prior art keywords
- expression unit
- vector
- expression
- genetically modified
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
UNIDADE DE EXPRESSçO, CASSETE DE EXPRESSçO, VETOR, MICROORGANISMO GENETICAMENTE MODIFICADO, PROCESSO PARA PREPARAR UM PRODUTO BIOSSINTETICO, E, USO DE UMA UNIDADE DE EXPRESSçO. A invenção diz respeito a promotores múltiplos e unidades de expressão de gene, ao uso destes para regular a transcrição e expressão de gene, aos cassetes de expressão contendo os ditos promotores múltiplos ou unidades de expressão, aos vetores contendo os ditos cassetes de expressão, aos microorganismos geneticamente modificados contendo os ditos vetores e/ou as ditas unidades de expressão e aos métodos para preparar produtos biossintéticos pelo cultivo de microorganismos geneticamente modificados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004061846A DE102004061846A1 (de) | 2004-12-22 | 2004-12-22 | Mehrfachpromotoren |
PCT/EP2005/013809 WO2006069711A1 (de) | 2004-12-22 | 2005-12-21 | Mehrfachpromotoren und deren verwendung zur genexpression |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0519165A2 true BRPI0519165A2 (pt) | 2008-12-30 |
Family
ID=36052084
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0520842-4A BRPI0520842A2 (pt) | 2004-12-22 | 2005-12-21 | unidade de expressão recombinante compreendendo promotor múltiplo, cassete de expressão, vetor, microorganismo geneticamente modificado, processo para preparar um produto biossintético diferente de lisina, e, uso de uma unidade de expressão |
BRPI0519165-3A BRPI0519165A2 (pt) | 2004-12-22 | 2005-12-21 | unidade de expressço, cassete de expressço, vetor, microorganismo geneticamente modificado, processo para preparar um produto biossintÉtico, e, uso de uma unidade de expressço |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0520842-4A BRPI0520842A2 (pt) | 2004-12-22 | 2005-12-21 | unidade de expressão recombinante compreendendo promotor múltiplo, cassete de expressão, vetor, microorganismo geneticamente modificado, processo para preparar um produto biossintético diferente de lisina, e, uso de uma unidade de expressão |
Country Status (17)
Country | Link |
---|---|
US (1) | US7968699B2 (pt) |
EP (2) | EP1831374A1 (pt) |
JP (2) | JP2008523834A (pt) |
KR (1) | KR101155461B1 (pt) |
CN (2) | CN101087883A (pt) |
AT (1) | ATE542906T1 (pt) |
AU (1) | AU2005321577A1 (pt) |
BR (2) | BRPI0520842A2 (pt) |
CA (1) | CA2591311A1 (pt) |
DE (1) | DE102004061846A1 (pt) |
DK (1) | DK1908841T3 (pt) |
ES (1) | ES2380000T3 (pt) |
MX (1) | MX2007007392A (pt) |
PL (1) | PL1908841T3 (pt) |
RU (1) | RU2007127792A (pt) |
WO (1) | WO2006069711A1 (pt) |
ZA (1) | ZA200704451B (pt) |
Families Citing this family (36)
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KR101557509B1 (ko) | 2007-01-12 | 2015-10-06 | 액토제닉스 엔.브이. | 락토코커스 프로모터 및 그것의 용도 |
JP2010518827A (ja) * | 2007-02-19 | 2010-06-03 | エボニック デグサ ゲーエムベーハー | ペントースリン酸経路の酵素を過剰発現させることによりコリネバクテリウムにおいてメチオニンを生産する方法 |
EP2431476B1 (en) | 2007-02-19 | 2014-08-20 | Evonik Degussa GmbH | Coryneform bacteria with glycine cleavage activity |
GB0715416D0 (en) | 2007-08-07 | 2007-09-19 | Phico Therapeutics Ltd | Modified bacteriophage |
EP2235194B1 (de) | 2008-01-23 | 2011-07-20 | Basf Se | Verfahren zur fermentativen Herstellung von 1,5-Diaminopentan |
US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
DE102009030342A1 (de) | 2009-06-25 | 2010-12-30 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von organisch chemischen Verbindungen |
WO2011073278A1 (en) | 2009-12-17 | 2011-06-23 | Basf Se | Processes and recombinant microorganisms for the production of cadaverine |
DE102010003419B4 (de) | 2010-03-30 | 2019-09-12 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von L-Ornithin |
CN103492553B (zh) | 2011-02-22 | 2018-06-12 | 巴斯夫欧洲公司 | 用于生产尸胺的方法和重组微生物 |
DE102011006716A1 (de) | 2011-04-04 | 2012-10-04 | Evonik Degussa Gmbh | Mikroorganismus und Verfahren zur fermentativen Herstellung einer organisch-chemischen Verbindung |
DE102011118019A1 (de) | 2011-06-28 | 2013-01-03 | Evonik Degussa Gmbh | Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens |
DK2841568T3 (en) | 2012-04-27 | 2018-05-22 | Evonik Technochemie Gmbh | FEEDBACK-RESISTANT ALFA ISOPROPYL MALATE SYNTHETAS |
US20150353940A1 (en) * | 2013-08-05 | 2015-12-10 | Absci, Llc | Vectors for use in an inducible coexpression system |
EP2762571A1 (de) | 2013-01-30 | 2014-08-06 | Evonik Industries AG | Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren |
ES2623161T3 (es) | 2013-06-03 | 2017-07-10 | Evonik Degussa Gmbh | Procedimiento para la preparación de L-valina utilizando corinebacterias recombinantes que contienen el operón ilvBN inducible por propionato |
JP2016523088A (ja) * | 2013-06-26 | 2016-08-08 | フィロジカ リミテッドPhylogica Limited | ペプチドの細胞輸送をモニタリングする方法 |
CN104845923B (zh) * | 2014-02-14 | 2018-03-23 | 中国科学院微生物研究所 | 生产l‑组氨酸的方法及其专用重组菌 |
CN105779447B (zh) * | 2014-12-22 | 2018-09-14 | 中国科学院大连化学物理研究所 | 3-磷酸甘油醛脱氢酶启动子和终止子及其应用 |
CN105779446B (zh) * | 2014-12-22 | 2018-09-14 | 中国科学院大连化学物理研究所 | 3-磷酸甘油酸激酶启动子和终止子及其应用 |
CN105779445B (zh) * | 2014-12-22 | 2018-09-28 | 中国科学院大连化学物理研究所 | 果糖-1,6-二磷酸醛缩酶启动子和终止子及其应用 |
US11208649B2 (en) | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
KR20180084756A (ko) | 2015-12-07 | 2018-07-25 | 지머젠 인코포레이티드 | 코리네박테리움 글루타미컴으로부터의 프로모터 |
US9988624B2 (en) | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
JP2019519241A (ja) | 2016-06-30 | 2019-07-11 | ザイマージェン インコーポレイテッド | グルコース透過酵素ライブラリーを生成するための方法およびその使用 |
JP2019519242A (ja) | 2016-06-30 | 2019-07-11 | ザイマージェン インコーポレイテッド | 細菌ヘモグロビンライブラリーを生成するための方法およびその使用 |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
DK3562940T3 (da) * | 2016-12-30 | 2022-07-11 | Natures Toolbox Inc | Cellefrit ekspressionssystem med hidtil ukendt, uorganisk polyphosphatbaseret energiregeneration |
CN110869504A (zh) | 2017-06-07 | 2020-03-06 | 齐默尔根公司 | 来自谷氨酸棒状杆菌的启动子及其在调节辅助基因表达中的用途 |
CN109142578B (zh) * | 2018-09-12 | 2021-08-10 | 中国人民解放军军事科学院军事医学研究院 | 检测生物细胞中两种基因对目标代谢物调控关系的方法 |
JP7498598B2 (ja) | 2020-05-29 | 2024-06-12 | 花王株式会社 | 新規プロモーター |
CN115322990A (zh) * | 2021-05-10 | 2022-11-11 | 中国科学院天津工业生物技术研究所 | 具有启动子活性的多核苷酸及其在生产目标化合物中的用途 |
KR102604399B1 (ko) | 2021-07-21 | 2023-11-21 | 성균관대학교산학협력단 | 코리네박테리움 글루타미쿰의 모듈화 클로닝용 벡터 및 이의 용도 |
KR102632294B1 (ko) | 2021-08-27 | 2024-02-01 | 성균관대학교산학협력단 | 코리네박테리움 글루타미쿰의 모듈화 클로닝을 위한 프로모터 라이브러리 및 터미네이터 라이브러리, 및 이의 용도 |
CN114717237B (zh) * | 2022-06-10 | 2022-08-19 | 北京中科伊品生物科技有限公司 | 一种ep6启动子与其相关生物材料及应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5835197A (ja) | 1981-08-26 | 1983-03-01 | Kyowa Hakko Kogyo Co Ltd | プラスミドpcg2 |
US4601893A (en) | 1984-02-08 | 1986-07-22 | Pfizer Inc. | Laminate device for controlled and prolonged release of substances to an ambient environment and method of use |
GB2165546B (en) | 1984-08-21 | 1989-05-17 | Asahi Chemical Ind | A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom |
DE4027453A1 (de) | 1990-08-30 | 1992-03-05 | Degussa | Neue plasmide aus corynebacterium glutamicum und davon abgeleitete plasmidvektoren |
DE4440118C1 (de) | 1994-11-11 | 1995-11-09 | Forschungszentrum Juelich Gmbh | Die Genexpression in coryneformen Bakterien regulierende DNA |
JPH10229891A (ja) | 1997-02-20 | 1998-09-02 | Mitsubishi Rayon Co Ltd | マロン酸誘導体の製造法 |
JP4623825B2 (ja) * | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
DE10046870A1 (de) | 2000-09-20 | 2002-03-28 | Basf Ag | Verfahren zur Veränderung des Genoms von Corynebakterien |
AU2002230431A1 (en) | 2000-11-15 | 2002-05-27 | Archer-Daniels-Midland Company | Corynebacterium glutamicum promoters |
CN1140628C (zh) * | 2001-11-02 | 2004-03-03 | 武汉大学 | 人白细胞白介素-12重组昆虫病毒株及其制备方法 |
DE10154180A1 (de) * | 2001-11-05 | 2003-05-15 | Basf Ag | gene die für genetische Stabilitäts-, genexpressions-und Faltungsproteine codieren |
DE10359595A1 (de) * | 2003-12-18 | 2005-07-28 | Basf Ag | Pgro-Expressionseinheiten |
DE10359660A1 (de) * | 2003-12-18 | 2005-07-28 | Basf Ag | Psod-Expressionseinheiten |
DE10359594A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | PEF-TU-Expressionseinheiten |
DE102004035065A1 (de) | 2004-07-20 | 2006-02-16 | Basf Ag | P-ET-TS-Expressionseinheiten |
-
2004
- 2004-12-22 DE DE102004061846A patent/DE102004061846A1/de not_active Withdrawn
-
2005
- 2005-12-21 CN CNA2005800444228A patent/CN101087883A/zh active Pending
- 2005-12-21 CN CN200710301192XA patent/CN101230345B/zh not_active Expired - Fee Related
- 2005-12-21 MX MX2007007392A patent/MX2007007392A/es not_active Application Discontinuation
- 2005-12-21 RU RU2007127792/13A patent/RU2007127792A/ru not_active Application Discontinuation
- 2005-12-21 PL PL07123772T patent/PL1908841T3/pl unknown
- 2005-12-21 ES ES07123772T patent/ES2380000T3/es active Active
- 2005-12-21 DK DK07123772.1T patent/DK1908841T3/da active
- 2005-12-21 AT AT07123772T patent/ATE542906T1/de active
- 2005-12-21 AU AU2005321577A patent/AU2005321577A1/en not_active Abandoned
- 2005-12-21 BR BRPI0520842-4A patent/BRPI0520842A2/pt not_active Application Discontinuation
- 2005-12-21 BR BRPI0519165-3A patent/BRPI0519165A2/pt not_active IP Right Cessation
- 2005-12-21 CA CA002591311A patent/CA2591311A1/en not_active Abandoned
- 2005-12-21 WO PCT/EP2005/013809 patent/WO2006069711A1/de active Application Filing
- 2005-12-21 EP EP05850322A patent/EP1831374A1/de not_active Withdrawn
- 2005-12-21 JP JP2007547344A patent/JP2008523834A/ja not_active Withdrawn
- 2005-12-21 KR KR1020077016617A patent/KR101155461B1/ko active IP Right Grant
- 2005-12-21 EP EP07123772A patent/EP1908841B1/de not_active Revoked
-
2007
- 2007-05-30 ZA ZA200704451A patent/ZA200704451B/xx unknown
-
2008
- 2008-03-14 US US12/048,599 patent/US7968699B2/en not_active Expired - Fee Related
- 2008-04-02 JP JP2008095920A patent/JP4763017B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE102004061846A1 (de) | 2006-07-13 |
WO2006069711A1 (de) | 2006-07-06 |
EP1908841B1 (de) | 2012-01-25 |
KR20070092745A (ko) | 2007-09-13 |
EP1908841A1 (de) | 2008-04-09 |
KR101155461B1 (ko) | 2012-09-07 |
US7968699B2 (en) | 2011-06-28 |
BRPI0520842A2 (pt) | 2012-07-03 |
ZA200704451B (en) | 2009-05-27 |
RU2007127792A (ru) | 2009-01-27 |
ES2380000T3 (es) | 2012-05-07 |
EP1831374A1 (de) | 2007-09-12 |
DK1908841T3 (da) | 2012-05-14 |
CA2591311A1 (en) | 2006-07-06 |
ATE542906T1 (de) | 2012-02-15 |
CN101087883A (zh) | 2007-12-12 |
JP2008212157A (ja) | 2008-09-18 |
US20080268502A1 (en) | 2008-10-30 |
JP2008523834A (ja) | 2008-07-10 |
PL1908841T3 (pl) | 2012-07-31 |
CN101230345A (zh) | 2008-07-30 |
MX2007007392A (es) | 2007-07-16 |
AU2005321577A1 (en) | 2006-07-06 |
JP4763017B2 (ja) | 2011-08-31 |
CN101230345B (zh) | 2013-03-20 |
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