BRPI0518007A - formulação terapêutica capaz de produzir uma resposta imune contra a interleucina-2 e uso da mesma - Google Patents
formulação terapêutica capaz de produzir uma resposta imune contra a interleucina-2 e uso da mesmaInfo
- Publication number
- BRPI0518007A BRPI0518007A BRPI0518007-4A BRPI0518007A BRPI0518007A BR PI0518007 A BRPI0518007 A BR PI0518007A BR PI0518007 A BRPI0518007 A BR PI0518007A BR PI0518007 A BRPI0518007 A BR PI0518007A
- Authority
- BR
- Brazil
- Prior art keywords
- immune response
- relates
- present
- response against
- therapeutic
- Prior art date
Links
- 102000000588 Interleukin-2 Human genes 0.000 title abstract 6
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 6
- 230000001225 therapeutic effect Effects 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000028993 immune response Effects 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 5
- 230000000903 blocking effect Effects 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 108700008924 Neisseria meningitidis lpdA Proteins 0.000 abstract 1
- 102000009618 Transforming Growth Factors Human genes 0.000 abstract 1
- 108010009583 Transforming Growth Factors Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000011254 conventional chemotherapy Methods 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000771 oncological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
FORMULAçãO TERAPêUTICA CAPAZ DE PRODUZIR UMA RESPOSTA IMUNE CONTRA A INTERLEUCINA-2 E USO DA MESMA. A presente invenção se relaciona com formulações farmacêuticas úteis no câncer mediante o bloqueio da união da interleucina 2 (IL-2) a seu receptor. Mais particularmente a presente invenção se relaciona com formulações terapêuticas capazes de incrementar a imunogenicidade e da IL-2 por seu acoplamento à proteína transportadora P64k da Neisseria Meningitidis em adjuvante Montanide ISA 51 para a indução de autoanticorpos bloqueadores da IL-2 a seu receptor e métodos efetivos para o tratamento de tumores, incluindo o câncer de mama. Em outro aspecto a presente invenção se refere à combinação terapêutica da vacina baseada em IL-2 com outras vacinas de câncer baseadas em antígenos específicos de tumores ou fatores de crescimento tumoral, assim como medicamentos quimioterapêuticos ou radioterapia de uso convencional na prática oncológica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20040261A CU23297A1 (es) | 2004-11-16 | 2004-11-16 | Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer |
PCT/CU2005/000009 WO2006053508A1 (es) | 2004-11-16 | 2005-11-16 | Formulaciones inmunoterapeuticas con capacidad neutralizante de la interleucina-2. |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0518007A true BRPI0518007A (pt) | 2008-10-21 |
Family
ID=40122436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0518007-4A BRPI0518007A (pt) | 2004-11-16 | 2005-11-16 | formulação terapêutica capaz de produzir uma resposta imune contra a interleucina-2 e uso da mesma |
Country Status (25)
Country | Link |
---|---|
US (1) | US20090274647A1 (pt) |
EP (2) | EP2112160B1 (pt) |
JP (1) | JP5227028B2 (pt) |
KR (1) | KR101240457B1 (pt) |
CN (1) | CN101061136B (pt) |
AR (1) | AR051494A1 (pt) |
AT (1) | ATE525393T1 (pt) |
AU (1) | AU2005306186B2 (pt) |
BR (1) | BRPI0518007A (pt) |
CA (1) | CA2588573C (pt) |
CR (1) | CR9097A (pt) |
CU (1) | CU23297A1 (pt) |
EA (1) | EA012072B1 (pt) |
GE (1) | GEP20105039B (pt) |
HK (1) | HK1113374A1 (pt) |
MA (1) | MA29044B1 (pt) |
MX (1) | MX2007005808A (pt) |
MY (1) | MY162106A (pt) |
PE (1) | PE20061172A1 (pt) |
SG (1) | SG122897A1 (pt) |
TN (1) | TNSN07187A1 (pt) |
TR (1) | TR200704213T2 (pt) |
TW (1) | TWI433853B (pt) |
WO (1) | WO2006053508A1 (pt) |
ZA (1) | ZA200703528B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009542592A (ja) * | 2006-07-06 | 2009-12-03 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Il−2媒介性免疫応答の有効性を高める組成物および方法 |
US10114018B2 (en) | 2014-04-22 | 2018-10-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | IL-2 peptide derivatives, and uses thereof for the diagnosis and treatment of an autoimmune disease |
TW201722989A (zh) * | 2015-10-23 | 2017-07-01 | 輝瑞大藥廠 | 抗il-2抗體及其組合物及用途 |
CU20210021A7 (es) * | 2021-03-30 | 2022-11-07 | Ct Inmunologia Molecular | Composicones vacunales depletantes de factores de crecimiento hematopoyéticos para el tratamiento de enfermedades inflamatorias |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5939832A (ja) * | 1982-08-28 | 1984-03-05 | Ajinomoto Co Inc | モノクロ−ナル抗体ならびにその製法、使用法 |
EP0111344A2 (en) * | 1982-12-13 | 1984-06-20 | Sloan-Kettering Institute For Cancer Research | Anti-interleukin-2 monoclonal antibodies |
US4569790A (en) * | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
US5643565A (en) * | 1985-09-20 | 1997-07-01 | Chiron Corporation | Human IL-2 as a vaccine adjuvant |
WO1991001146A1 (en) * | 1989-07-14 | 1991-02-07 | Praxis Biologics, Inc. | Cytokine and hormone carriers for conjugate vaccines |
HUT60768A (en) * | 1990-03-16 | 1992-10-28 | Sandoz Ag | Process for producing cd25 fixing molecules |
CU22302A1 (es) * | 1990-09-07 | 1995-01-31 | Cigb | Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales |
US5830452A (en) * | 1990-11-20 | 1998-11-03 | Chiron Corporation | Method for enhancing the anti-tumor therapeutic index of interleukin-2 |
JPH10147952A (ja) | 1996-11-18 | 1998-06-02 | Komatsu Ltd | ブルドーザのドージング装置 |
US20040156824A1 (en) * | 1996-12-23 | 2004-08-12 | Epstein Alan L. | Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof |
CA2219961C (en) * | 1998-01-09 | 2010-06-01 | The University Of Southern California | Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof |
CU22731A1 (es) * | 1998-02-05 | 2002-02-28 | Centro Inmunologia Molecular | Anticuerpo monoclonal que reconoce el oligosacárido ácido siálico n´glicolilado-galactosa-glucosa (ngcneu-gal-glu) en tumores malignos y composiciones farmacéuticas que los contienen |
US6168785B1 (en) * | 1998-07-16 | 2001-01-02 | Institut Pasteur | Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents |
PL200919B1 (pl) * | 1999-02-12 | 2009-02-27 | Lexigen Pharm Corp | Zastosowanie kompozycji czynnika hamującego angiogenezę i czynnika przeciwnowotworowego, kompozycja terapeutyczna do leczenia nowotworów i zestaw do traktowania komórki nowotworowej |
AU2001259253A1 (en) * | 2000-04-26 | 2001-11-07 | National Jewish Medical And Research Center | Product and process for regulation of t cell responses |
CU23011A1 (es) * | 2000-11-03 | 2004-12-17 | Ct Ingenieria Genetica Biotech | Método de obtención de estructuras antigénicas quemétodo de obtención de estructuras antigénicas que potencian la reactividad cruzada específica y su potencian la reactividad cruzada específica y su uso en formulaciones uso en formulaciones |
CU23077A1 (es) * | 2000-12-06 | 2005-08-17 | Centro Inmunologia Molecular | Composicion vacunal que contiene factor de crecimiento transformante (tgf-alfa). su uso en la terapia de enfermedades malignas |
CU22979A1 (es) * | 2000-12-08 | 2004-09-09 | Centro Inmunologia Molecular | Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina |
CU22999A1 (es) * | 2001-12-04 | 2004-10-12 | Centro Inmunologia Molecular | Método de tratamiento de enfermedades malignas e infecciosas crónicas |
WO2002087304A2 (de) * | 2001-04-30 | 2002-11-07 | Frohnhofen, Wilfried | Il2-peptide; von interleukin 2 abgeleitete peptide und peptid-dimere |
US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
ITMI20012527A1 (it) | 2001-11-30 | 2003-05-30 | Unihart Corp | Proteine di fusione contenenti peptidi tlp |
JP4364643B2 (ja) * | 2001-11-30 | 2009-11-18 | アメリカ合衆国 | 前立腺特異抗原のペプチドアゴニストおよびその使用 |
US20040208869A1 (en) * | 2003-01-30 | 2004-10-21 | Medimmune, Inc. | Uses of anti-integrin alphanubeta3 antibody formulations |
US7569215B2 (en) * | 2003-07-18 | 2009-08-04 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
-
2004
- 2004-11-16 CU CU20040261A patent/CU23297A1/es unknown
-
2005
- 2005-11-15 AR ARP050104787A patent/AR051494A1/es not_active Application Discontinuation
- 2005-11-15 PE PE2005001336A patent/PE20061172A1/es not_active Application Discontinuation
- 2005-11-16 CA CA2588573A patent/CA2588573C/en not_active Expired - Fee Related
- 2005-11-16 MX MX2007005808A patent/MX2007005808A/es active IP Right Grant
- 2005-11-16 SG SG200507053A patent/SG122897A1/en unknown
- 2005-11-16 GE GEAP200510066A patent/GEP20105039B/en unknown
- 2005-11-16 WO PCT/CU2005/000009 patent/WO2006053508A1/es active Application Filing
- 2005-11-16 EP EP09164216.5A patent/EP2112160B1/en active Active
- 2005-11-16 US US11/719,326 patent/US20090274647A1/en not_active Abandoned
- 2005-11-16 MY MYPI20055353A patent/MY162106A/en unknown
- 2005-11-16 AT AT05811052T patent/ATE525393T1/de not_active IP Right Cessation
- 2005-11-16 TR TR2007/04213T patent/TR200704213T2/xx unknown
- 2005-11-16 BR BRPI0518007-4A patent/BRPI0518007A/pt not_active IP Right Cessation
- 2005-11-16 KR KR1020077010317A patent/KR101240457B1/ko not_active IP Right Cessation
- 2005-11-16 TW TW094140326A patent/TWI433853B/zh not_active IP Right Cessation
- 2005-11-16 AU AU2005306186A patent/AU2005306186B2/en not_active Ceased
- 2005-11-16 CN CN2005800391860A patent/CN101061136B/zh not_active Expired - Fee Related
- 2005-11-16 EA EA200701071A patent/EA012072B1/ru not_active IP Right Cessation
- 2005-11-16 EP EP05811052A patent/EP1829893B1/en active Active
- 2005-11-16 JP JP2007541654A patent/JP5227028B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-02 ZA ZA200703528A patent/ZA200703528B/en unknown
- 2007-05-04 CR CR9097A patent/CR9097A/es not_active Application Discontinuation
- 2007-05-15 TN TNP2007000187A patent/TNSN07187A1/fr unknown
- 2007-05-30 MA MA29960A patent/MA29044B1/fr unknown
-
2008
- 2008-03-05 HK HK08102535.0A patent/HK1113374A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |