BRPI0516200A - forma cristalina do cloridrato de (3-ciano-1h-indol-7-il)-[4-(4-fluorfenetril)piperazin-1-i l]metanona - Google Patents
forma cristalina do cloridrato de (3-ciano-1h-indol-7-il)-[4-(4-fluorfenetril)piperazin-1-i l]metanonaInfo
- Publication number
- BRPI0516200A BRPI0516200A BRPI0516200-9A BRPI0516200A BRPI0516200A BR PI0516200 A BRPI0516200 A BR PI0516200A BR PI0516200 A BRPI0516200 A BR PI0516200A BR PI0516200 A BRPI0516200 A BR PI0516200A
- Authority
- BR
- Brazil
- Prior art keywords
- piperazin
- cyano
- crystalline form
- fluorophenetryl
- indol
- Prior art date
Links
- -1 3-cyano-1h-indol-7-yl Chemical group 0.000 title abstract 2
- WTDFFADXONGQOM-UHFFFAOYSA-N formaldehyde;hydrochloride Chemical compound Cl.O=C WTDFFADXONGQOM-UHFFFAOYSA-N 0.000 title 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- BGQLKIRZQYRJPH-UHFFFAOYSA-N piperazine-1-carbaldehyde;hydrochloride Chemical compound Cl.O=CN1CCNCC1 BGQLKIRZQYRJPH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004047517A DE102004047517A1 (de) | 2004-09-28 | 2004-09-28 | Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid |
| PCT/EP2005/009647 WO2006034774A1 (de) | 2004-09-28 | 2005-09-08 | Neuartige kristallform von (3-cyan-1h-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, hydrochlorid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0516200A true BRPI0516200A (pt) | 2008-08-26 |
Family
ID=35285234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0516200-9A BRPI0516200A (pt) | 2004-09-28 | 2005-09-08 | forma cristalina do cloridrato de (3-ciano-1h-indol-7-il)-[4-(4-fluorfenetril)piperazin-1-i l]metanona |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7981897B2 (https=) |
| EP (1) | EP1794121B1 (https=) |
| JP (1) | JP5160892B2 (https=) |
| KR (1) | KR20070057872A (https=) |
| CN (1) | CN101027284B (https=) |
| AR (1) | AR051043A1 (https=) |
| AU (1) | AU2005289169B2 (https=) |
| BR (1) | BRPI0516200A (https=) |
| CA (1) | CA2581834A1 (https=) |
| DE (1) | DE102004047517A1 (https=) |
| MX (1) | MX2007003471A (https=) |
| PE (1) | PE20060964A1 (https=) |
| RU (1) | RU2383532C2 (https=) |
| TW (1) | TW200616952A (https=) |
| WO (1) | WO2006034774A1 (https=) |
| ZA (1) | ZA200703440B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090017569A (ko) * | 2006-05-05 | 2009-02-18 | 메르크 파텐트 게엠베하 | 결정질 (３-시아노-１ｈ-인돌-７-일)-[４-(４-플루오로펜에틸)피페라진-１-일]메탄온 포스페이트 |
| CN101437793B (zh) * | 2006-05-05 | 2012-08-22 | 默克专利股份有限公司 | 结晶的（3-氰基-1h-吲哚-7-基）-[4-（4-氟苯乙基）哌嗪-1-基]甲酮磷酸盐 |
| EP2155200B1 (en) * | 2007-05-11 | 2016-12-07 | Richter Gedeon Nyrt. | Crystalline form of a carbamoyl-cyclohexane derivative |
| HUP0700353A2 (en) * | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| US7875610B2 (en) * | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| CA2715760C (en) * | 2008-02-21 | 2017-06-13 | Mitsubishi Tanabe Pharma Corporation | Solid preparation for oral administration of cariprazine hydrochloride |
| RS53866B1 (sr) | 2008-07-16 | 2015-08-31 | Richter Gedeon Nyrt. | Farmaceutske formulacije koje sadrže ligande dopaminskih receptora |
| HU230067B1 (hu) | 2008-12-17 | 2015-06-29 | Richter Gedeon Nyrt | Új piperazin só és eljárás előállítására |
| HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| HUP0800766A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
| US8912197B2 (en) | 2012-08-20 | 2014-12-16 | Forest Laboratories Holdings Ltd. | Crystalline form of carbamoyl-cyclohexane derivatives |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2084531A1 (en) * | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
| DE19934433A1 (de) * | 1999-07-22 | 2001-01-25 | Merck Patent Gmbh | N-(Indolcarbonyl-)piperazinderivate |
| DE10102944A1 (de) * | 2001-01-23 | 2002-07-25 | Merck Patent Gmbh | Verfahren zur Herstellung von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon und dessen Salzen |
| DE10157673A1 (de) * | 2001-11-24 | 2003-06-05 | Merck Patent Gmbh | Verwendung von N-(Indolcarbonyl-)piperazinderivaten |
| DE10246357A1 (de) * | 2002-10-04 | 2004-04-15 | Merck Patent Gmbh | Verwendung von 5-HT2Rezeptorantagonisten |
-
2004
- 2004-09-28 DE DE102004047517A patent/DE102004047517A1/de not_active Withdrawn
-
2005
- 2005-09-08 EP EP05782871.7A patent/EP1794121B1/de not_active Expired - Lifetime
- 2005-09-08 JP JP2007532794A patent/JP5160892B2/ja not_active Expired - Fee Related
- 2005-09-08 BR BRPI0516200-9A patent/BRPI0516200A/pt not_active IP Right Cessation
- 2005-09-08 US US11/576,086 patent/US7981897B2/en not_active Expired - Fee Related
- 2005-09-08 MX MX2007003471A patent/MX2007003471A/es not_active Application Discontinuation
- 2005-09-08 AU AU2005289169A patent/AU2005289169B2/en not_active Ceased
- 2005-09-08 RU RU2007116037/04A patent/RU2383532C2/ru not_active IP Right Cessation
- 2005-09-08 KR KR1020077006952A patent/KR20070057872A/ko not_active Ceased
- 2005-09-08 CA CA002581834A patent/CA2581834A1/en not_active Abandoned
- 2005-09-08 CN CN2005800326518A patent/CN101027284B/zh not_active Expired - Fee Related
- 2005-09-08 WO PCT/EP2005/009647 patent/WO2006034774A1/de not_active Ceased
- 2005-09-23 TW TW094133161A patent/TW200616952A/zh unknown
- 2005-09-26 PE PE2005001111A patent/PE20060964A1/es not_active Application Discontinuation
- 2005-09-28 AR ARP050104084A patent/AR051043A1/es unknown
-
2007
- 2007-04-26 ZA ZA200703440A patent/ZA200703440B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5160892B2 (ja) | 2013-03-13 |
| CN101027284A (zh) | 2007-08-29 |
| JP2008514558A (ja) | 2008-05-08 |
| AU2005289169A1 (en) | 2006-04-06 |
| CA2581834A1 (en) | 2006-04-06 |
| ZA200703440B (en) | 2008-08-27 |
| US7981897B2 (en) | 2011-07-19 |
| CN101027284B (zh) | 2010-09-29 |
| US20070259885A1 (en) | 2007-11-08 |
| AR051043A1 (es) | 2006-12-13 |
| DE102004047517A1 (de) | 2006-03-30 |
| AU2005289169B2 (en) | 2011-07-14 |
| RU2007116037A (ru) | 2008-11-10 |
| EP1794121B1 (de) | 2013-12-25 |
| WO2006034774A1 (de) | 2006-04-06 |
| KR20070057872A (ko) | 2007-06-07 |
| PE20060964A1 (es) | 2006-10-02 |
| RU2383532C2 (ru) | 2010-03-10 |
| TW200616952A (en) | 2006-06-01 |
| MX2007003471A (es) | 2007-05-10 |
| EP1794121A1 (de) | 2007-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2166 DE 10/07/2012. |