BRPI0515893A - peptìdeos da proteìna humana de estresse térmico, composição farmacêutica e método de tratamento da artrite reumatóide - Google Patents
peptìdeos da proteìna humana de estresse térmico, composição farmacêutica e método de tratamento da artrite reumatóideInfo
- Publication number
- BRPI0515893A BRPI0515893A BRPI0515893-1A BRPI0515893A BRPI0515893A BR PI0515893 A BRPI0515893 A BR PI0515893A BR PI0515893 A BRPI0515893 A BR PI0515893A BR PI0515893 A BRPI0515893 A BR PI0515893A
- Authority
- BR
- Brazil
- Prior art keywords
- rheumatoid arthritis
- peptides
- stress protein
- pharmaceutical composition
- heat stress
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000002812 Heat-Shock Proteins Human genes 0.000 title abstract 3
- 108010004889 Heat-Shock Proteins Proteins 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 206010039073 rheumatoid arthritis Diseases 0.000 title abstract 3
- 230000008642 heat stress Effects 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 230000007246 mechanism Effects 0.000 abstract 2
- 206010011968 Decreased immune responsiveness Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
- 230000008646 thermal stress Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
"PEPTìDEOS DA PROTEìNA HUMANA DE ESTRESSE TéRMICO, COMPOSIçãO FARMACêUTICA E MéTODO DE TRATAMENTO DA ARTRITE REUMATóIDE". Peptídeos da proteína humana de estresse térmico de 60 kDa que constituem epítopos para células T, assim como peptídeos derivados deles, os quais estão modificados nos sítios de contato com a molécula MHC, úteis para induzir mecanismos de tolerância periférica, em particular mecanismos indutores de anergia ou mediados por clones de células T regulatórias em pacientes com artrite reumatóide. A invenção também se refere a composições farmacêuticas que compreendem tais peptídeos para tratamento da artrite reumatóide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR122018077204A BR122018077204B8 (pt) | 2004-09-24 | 2005-09-22 | peptídeos da proteína humana de estresse térmico, composição farmacêutica, e, uso do peptídeo e da composição farmacêutica |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20040207A CU23504A1 (es) | 2004-09-24 | 2004-09-24 | Péptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas |
| CU2004-0207 | 2004-09-24 | ||
| PCT/CU2005/000008 WO2006032216A2 (es) | 2004-09-24 | 2005-09-22 | Peptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0515893A true BRPI0515893A (pt) | 2008-08-12 |
| BRPI0515893A8 BRPI0515893A8 (pt) | 2019-01-02 |
| BRPI0515893B1 BRPI0515893B1 (pt) | 2020-09-15 |
| BRPI0515893B8 BRPI0515893B8 (pt) | 2021-05-25 |
Family
ID=40273413
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122018077204A BR122018077204B8 (pt) | 2004-09-24 | 2005-09-22 | peptídeos da proteína humana de estresse térmico, composição farmacêutica, e, uso do peptídeo e da composição farmacêutica |
| BRPI0515893A BRPI0515893B8 (pt) | 2004-09-24 | 2005-09-22 | peptídeos da proteína humana de estresse térmico, composição farmacêutica, e, uso do peptídeo e da composição farmacêutica. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122018077204A BR122018077204B8 (pt) | 2004-09-24 | 2005-09-22 | peptídeos da proteína humana de estresse térmico, composição farmacêutica, e, uso do peptídeo e da composição farmacêutica |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8383771B2 (pt) |
| EP (2) | EP1803732B1 (pt) |
| JP (1) | JP4755649B2 (pt) |
| KR (2) | KR101035283B1 (pt) |
| CN (2) | CN101935345B (pt) |
| AR (2) | AR051928A1 (pt) |
| AT (1) | ATE546462T1 (pt) |
| AU (2) | AU2005287757B2 (pt) |
| BR (2) | BR122018077204B8 (pt) |
| CA (2) | CA2797769C (pt) |
| CU (1) | CU23504A1 (pt) |
| DK (2) | DK1803732T3 (pt) |
| ES (2) | ES2445707T3 (pt) |
| MX (1) | MX2007003624A (pt) |
| RU (1) | RU2361877C2 (pt) |
| WO (1) | WO2006032216A2 (pt) |
| ZA (1) | ZA200702938B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2423220B1 (en) * | 2007-01-30 | 2015-04-29 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
| CU23701A1 (es) * | 2008-12-29 | 2011-09-21 | Ct Ingenieria Genetica Biotech | Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i |
| US8680241B2 (en) * | 2009-09-06 | 2014-03-25 | Protab Ltd. | Humanized antibodies specific for HSP65-derived peptide-6 methods and uses thereof |
| WO2011059758A2 (en) * | 2009-10-28 | 2011-05-19 | Argentis Pharmaceuticals, Llc | Apls for treating arthritis |
| CU24508B1 (es) * | 2017-12-29 | 2021-04-07 | Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma | Composición farmacéutica que comprende péptido tipo apl |
| CU20200026A7 (es) * | 2020-04-13 | 2021-11-04 | Ct Ingenieria Genetica Biotecnologia | Péptido para el tratamiento del síndrome de la tormenta de citocinas |
| CN111870697B (zh) * | 2020-09-18 | 2022-09-09 | 山东鲁抗医药股份有限公司 | 糖类物质在提高apl型衍生肽稳定性中的应用和冻干组合物 |
| KR102333645B1 (ko) | 2021-07-27 | 2021-12-02 | (주)문화전기 | 각도조절이 용이한 엘이디조명시스템 |
| CN115671253B (zh) * | 2021-07-30 | 2024-02-27 | 河北菲尼斯生物技术有限公司 | Se-dr亲和肽在制备治疗风湿疾病的药物中的用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8701163A (nl) | 1986-09-09 | 1988-04-05 | Nederlanden Staat | Gebruik van een peptide voor de bereiding van preparaten voor het verlichten, het behandelen en de diagnose van autoimmuunziekten, in het bijzonder arthritische toestanden, verbindingen die met dit peptide verwant zijn, alsmede farmaceutische en diagnostische preparaten en testkits. |
| NL8703107A (nl) | 1987-12-22 | 1989-07-17 | Nederlanden Staat | Polypeptiden en derivaten daarvan, alsmede de toepassing daarvan in farmaceutische en diagnostische preparaten. |
| US5773570A (en) | 1994-05-20 | 1998-06-30 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
| GB9419553D0 (en) | 1994-09-27 | 1994-11-16 | Univ Bristol | Polypeptides and their use in the treatment of auto-immune disease |
| US6180103B1 (en) | 1994-12-21 | 2001-01-30 | Yeda Research And Development Co., Ltd. | Peptide p277 analogs, and pharmaceutical compositions comprising them for treatment or diagnosis of diabetes |
| GB9519737D0 (en) * | 1995-09-27 | 1995-11-29 | Peptide Therapeutics Ltd | Polypeptides and their use in treatment and prophylaxis of auto-immune |
| US5993803A (en) | 1996-08-30 | 1999-11-30 | Yeda Research And Development Co., Ltd. | Method of reducing the severity of host vs graft reaction by down-regulating hsp60 autoimmunity |
| GB9911772D0 (en) | 1999-05-21 | 1999-07-21 | Semmelweis University Of Medic | Diagnosis and treatment of atherosclerosis |
| US20020169302A1 (en) * | 1999-08-23 | 2002-11-14 | Genesis Research And Development Corp. Ltd. | Compositions isolated from bovine mammary gland and methods for their use |
| CA2394504A1 (en) * | 1999-12-15 | 2001-06-21 | Peptor Ltd. | Fragments and antagonists of heat shock protein 60 |
| JP2005503533A (ja) | 2001-01-19 | 2005-02-03 | ケンブリッジ サイエンティフィック， インコーポレイテッド | 骨粗鬆症の診断方法および処置方法 |
-
2004
- 2004-09-24 CU CU20040207A patent/CU23504A1/es active IP Right Grant
-
2005
- 2005-09-21 AR ARP050103950A patent/AR051928A1/es active IP Right Grant
- 2005-09-22 CA CA2797769A patent/CA2797769C/en active Active
- 2005-09-22 AU AU2005287757A patent/AU2005287757B2/en not_active Ceased
- 2005-09-22 CN CN2010100038161A patent/CN101935345B/zh active Active
- 2005-09-22 KR KR1020107001135A patent/KR101035283B1/ko active IP Right Grant
- 2005-09-22 EP EP05794474A patent/EP1803732B1/en active Active
- 2005-09-22 DK DK05794474.6T patent/DK1803732T3/da active
- 2005-09-22 MX MX2007003624A patent/MX2007003624A/es active IP Right Grant
- 2005-09-22 ES ES10189769.2T patent/ES2445707T3/es active Active
- 2005-09-22 WO PCT/CU2005/000008 patent/WO2006032216A2/es active Application Filing
- 2005-09-22 RU RU2007115411/04A patent/RU2361877C2/ru active
- 2005-09-22 CN CN2005800403891A patent/CN101065398B/zh active Active
- 2005-09-22 DK DK10189769.2T patent/DK2371847T3/da active
- 2005-09-22 BR BR122018077204A patent/BR122018077204B8/pt active IP Right Grant
- 2005-09-22 CA CA2581110A patent/CA2581110C/en active Active
- 2005-09-22 EP EP10189769.2A patent/EP2371847B1/en active Active
- 2005-09-22 ES ES05794474T patent/ES2386498T3/es active Active
- 2005-09-22 AT AT05794474T patent/ATE546462T1/de active
- 2005-09-22 US US11/663,603 patent/US8383771B2/en active Active
- 2005-09-22 JP JP2007532752A patent/JP4755649B2/ja active Active
- 2005-09-22 BR BRPI0515893A patent/BRPI0515893B8/pt active IP Right Grant
- 2005-09-22 KR KR1020077008682A patent/KR101054332B1/ko active IP Right Grant
-
2007
- 2007-04-10 ZA ZA200702938A patent/ZA200702938B/xx unknown
-
2009
- 2009-12-28 AR ARP090105137A patent/AR074924A2/es active IP Right Grant
- 2009-12-30 US US12/649,687 patent/US8324164B2/en active Active
-
2010
- 2010-09-06 AU AU2010219312A patent/AU2010219312B2/en not_active Ceased
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/09/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/09/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |